Pub Date : 2014-01-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.012
Xue-ying Wang, Shi-chun Li
Objective To analyze and observe the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression before and after treatment with olanzapine.Methods 64 patients with depression in our hospital from October 2011 to February 2013 were selected as research object,and they were randomly divided into control group 32 cases and observation group 32 cases,the control group were treated with only sertraline,the observation group were treated with olanzapine based on the treatment of control group,then the serum trace elements and BDNF,Hcy,Cor,neural function related factors of two groups before the treatment and at 3rd and 6th week after the treatment were compared.Results The serum Cu and Fe of observation group at 3rd and 6th week after the treatment were lower than those of control group,Zn and Mn were higher than those of control group,Hcy,Cor and neural function related factors were lower than those of control group,BDNF were higher than those of control group,all P＜0.05,there were all significant differences.Conclusion The olanzapine can effectively adjust the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression,and it shows a continuous improvement state. Key words: Depression; Olanzapine; Trace elements; Brain-derived neurotrophic factor, BDNF; Homocysteine,Hcy; Cortisol,COR; Neural function related factors; Change
{"title":"Study on the change of serum trace elements and BDNF, Hcy, Cor, neural function related factors of patients with depression before and after treatment with Olanzapine","authors":"Xue-ying Wang, Shi-chun Li","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.012","url":null,"abstract":"Objective To analyze and observe the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression before and after treatment with olanzapine.Methods 64 patients with depression in our hospital from October 2011 to February 2013 were selected as research object,and they were randomly divided into control group 32 cases and observation group 32 cases,the control group were treated with only sertraline,the observation group were treated with olanzapine based on the treatment of control group,then the serum trace elements and BDNF,Hcy,Cor,neural function related factors of two groups before the treatment and at 3rd and 6th week after the treatment were compared.Results The serum Cu and Fe of observation group at 3rd and 6th week after the treatment were lower than those of control group,Zn and Mn were higher than those of control group,Hcy,Cor and neural function related factors were lower than those of control group,BDNF were higher than those of control group,all P＜0.05,there were all significant differences.Conclusion The olanzapine can effectively adjust the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression,and it shows a continuous improvement state. \u0000 \u0000Key words: \u0000Depression; Olanzapine; Trace elements; Brain-derived neurotrophic factor, BDNF; Homocysteine,Hcy; Cortisol,COR; Neural function related factors; Change","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"27-29"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.006
Rui Zhang, B. Bai
Objective To know the motion compensation regulation of each segments after single segmental cervical spine fusion surgery.Methods With the help of 3D motion information collecting system,the movement angle of each segment was recorded before and after single segmental cervical spine fusion surgery.Results All the statistics are dealed with normalization,we got the statistics of the motion compensation regulation of each segments after single segmental cervical spine fusion surgery,range of motion of each segment increased diversely,especially the lower adjacent segment,with statistical significance(P＜0.05).Conclusion Compensatory enhancement of the range of motion of adjacent segments is one of the important reasons lead to the degeneration. Key words: Cervical spine; Fusion surgery; Adjacent segment; Motion compensation
{"title":"Research of the motion compensation after single segmental cervical spine fusion surgery","authors":"Rui Zhang, B. Bai","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.006","url":null,"abstract":"Objective To know the motion compensation regulation of each segments after single segmental cervical spine fusion surgery.Methods With the help of 3D motion information collecting system,the movement angle of each segment was recorded before and after single segmental cervical spine fusion surgery.Results All the statistics are dealed with normalization,we got the statistics of the motion compensation regulation of each segments after single segmental cervical spine fusion surgery,range of motion of each segment increased diversely,especially the lower adjacent segment,with statistical significance(P＜0.05).Conclusion Compensatory enhancement of the range of motion of adjacent segments is one of the important reasons lead to the degeneration. \u0000 \u0000Key words: \u0000Cervical spine; Fusion surgery; Adjacent segment; Motion compensation","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.014
Zhenwei Hu, Jiansheng Liu
Objective To research the expression levels,clinical significance and the correlation of PCNA and IRF2 in human pancreatic cancer.Methods The expression levels of PCNA and IRF2 in 60 different cases of pancreatic cancer tissues and 30 different cases of para-pancreatic cancer tissues were investigated by Immunohistochemical SP staining and then analyzed through clinicopathological data.Results Immunohistochemical results:the positive expression rates of PCNA and IRF2 in pancreatic cancer tissues were 83.3％ and 78.3％ respectively,which were significantly higher than those in the adjacent pancreatic tissues,of which were 20.0％ and 23.3％ respectively.The differences were statistically significant (P＜0.001).The factors of age,gender,tumor site of patients with pancreatic carcinoma were not statistically significant with the expression of PCNA (P＞0.05),but other factors,such as the differentiation of pancreatic tissue,TNM stage and lymph node metastasis,were statistically significant (P＜O.05).The factors of age,sex,tumor location and lymph node metastasis of pancreatic carcinoma patients were not statistically significant with the expression of PCNA (P＞0.05),but the factors of differentiation of pancreatic tissue and TNM stage were statistically significant (P＜0.05).Moreover,the expression of PCNA and IRF2 was positively correlated (γ =0.416,P=0.001).Conclusion The abnormal expression of PCNA and IRF2 is correlated with occurrence of pancreatic cancer and the cancer cell proliferation activity. Key words: Pancreatic Cancer; PCNA; IRF2; Immunohistochemistry
{"title":"Expression and clinical significance of PCNA and IRF2 in human pancreatic cancer","authors":"Zhenwei Hu, Jiansheng Liu","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.014","url":null,"abstract":"Objective To research the expression levels,clinical significance and the correlation of PCNA and IRF2 in human pancreatic cancer.Methods The expression levels of PCNA and IRF2 in 60 different cases of pancreatic cancer tissues and 30 different cases of para-pancreatic cancer tissues were investigated by Immunohistochemical SP staining and then analyzed through clinicopathological data.Results Immunohistochemical results:the positive expression rates of PCNA and IRF2 in pancreatic cancer tissues were 83.3％ and 78.3％ respectively,which were significantly higher than those in the adjacent pancreatic tissues,of which were 20.0％ and 23.3％ respectively.The differences were statistically significant (P＜0.001).The factors of age,gender,tumor site of patients with pancreatic carcinoma were not statistically significant with the expression of PCNA (P＞0.05),but other factors,such as the differentiation of pancreatic tissue,TNM stage and lymph node metastasis,were statistically significant (P＜O.05).The factors of age,sex,tumor location and lymph node metastasis of pancreatic carcinoma patients were not statistically significant with the expression of PCNA (P＞0.05),but the factors of differentiation of pancreatic tissue and TNM stage were statistically significant (P＜0.05).Moreover,the expression of PCNA and IRF2 was positively correlated (γ =0.416,P=0.001).Conclusion The abnormal expression of PCNA and IRF2 is correlated with occurrence of pancreatic cancer and the cancer cell proliferation activity. \u0000 \u0000Key words: \u0000Pancreatic Cancer; PCNA; IRF2; Immunohistochemistry","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"33-35"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.007
Zeng-bin Xu, Xianglian Li, Shenghua Wan
Objective To explore the relationship among different types of Helicobacter pylori (HP),the gastroduodenal disease type and the severity of gastric mucosal inflammation in childhood.Methods By western blot method to detect serum antibodies of CagA and VacA obtained from 112 patients infected by HP-related Chronic Gastritis (CG) and Peptic ulcer (PU).and observe the pathologic changes of gastric mucosa.Results In 112 cases,the CagA,VacA antibody detection rate was 82.14％ and 82.14％,no significant difference (P＞0.05).The detection rate of CagA,VacA antibodies in patients with chronic gastritis (CG) was 79.10％ and 83.58％,and in patients with Peptic ulcer (PU) was 86.67％ and 91.11％,The detection rate of CagA,VacA antibody in PU,CG had no obvious difference (P＞0.05).Of 112 cases of children with Hp infection,I type HP accounted for 80.36％,Ⅱ type HP accounted for 11.61％ and intermediate type accounted for 8.03％,No significant differences existed in the detection rate of these three types of HP in CG or PU (P＞0.05); Among the 90 patients with Ⅰ type HP,92.22％ of them caused severe gastric mucosal inflammation,7.78％ of them got mild inflammation.23.08％of 13 patients with Ⅱ type HP and 55.56％ of 9 patients with intermediate type HP got severe gastric mucosal inflammation,which showed that the differences are significant (P＜0.01).Conclusion CagA and VaCA are closely related to the onset of CG and PU,but can not be used as the basis for judging the onset of CG and PU,when children infected with Ⅰ type HP,their gastric mucosa suffers the greatest damage,they should be treated actively. Key words: Helicobacter pylori,children; Cytotoxin associated protein; Vacuolating toxin protein; Antibody; Chronic Gastritis; Ulcer
{"title":"The relationship between children with Helicobacter pylori infection and gastroduodenal disease","authors":"Zeng-bin Xu, Xianglian Li, Shenghua Wan","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.007","url":null,"abstract":"Objective To explore the relationship among different types of Helicobacter pylori (HP),the gastroduodenal disease type and the severity of gastric mucosal inflammation in childhood.Methods By western blot method to detect serum antibodies of CagA and VacA obtained from 112 patients infected by HP-related Chronic Gastritis (CG) and Peptic ulcer (PU).and observe the pathologic changes of gastric mucosa.Results In 112 cases,the CagA,VacA antibody detection rate was 82.14％ and 82.14％,no significant difference (P＞0.05).The detection rate of CagA,VacA antibodies in patients with chronic gastritis (CG) was 79.10％ and 83.58％,and in patients with Peptic ulcer (PU) was 86.67％ and 91.11％,The detection rate of CagA,VacA antibody in PU,CG had no obvious difference (P＞0.05).Of 112 cases of children with Hp infection,I type HP accounted for 80.36％,Ⅱ type HP accounted for 11.61％ and intermediate type accounted for 8.03％,No significant differences existed in the detection rate of these three types of HP in CG or PU (P＞0.05); Among the 90 patients with Ⅰ type HP,92.22％ of them caused severe gastric mucosal inflammation,7.78％ of them got mild inflammation.23.08％of 13 patients with Ⅱ type HP and 55.56％ of 9 patients with intermediate type HP got severe gastric mucosal inflammation,which showed that the differences are significant (P＜0.01).Conclusion CagA and VaCA are closely related to the onset of CG and PU,but can not be used as the basis for judging the onset of CG and PU,when children infected with Ⅰ type HP,their gastric mucosa suffers the greatest damage,they should be treated actively. \u0000 \u0000Key words: \u0000Helicobacter pylori,children; Cytotoxin associated protein; Vacuolating toxin protein; Antibody; Chronic Gastritis; Ulcer","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"15-17"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To found out a suitable method for the repairing of the eyebrow area soft tissue defect based on research and the clinical application of the ‘Hatchet Skin Flap’.Methods All 23 patients with eyebrow area soft tissue defect was included.The skin flap was designed along the longitudinal axle of the defect and with the curve of the ‘Hatchet Skin Flap’ parallel to the curve of the eyebrow.The scale of the width to the length of the flap should not less than 1:3.The flap was dissected and transferred to the defected area.The unnecessary skin in the tip area of the flap was dissected.The skin flap was sutured in different layer and without any tension in the sutured area.Results All 23 skin flaps was survived well and without any necrosis and blood supply disorder.The eyebrow was tot be influnced.After 6 months to 3 years follow up all of the skin flap with a satisfactory appearance.Conclusion Having the advantages as easy to design,no influence to the eyebrow,well-distributed tension and without obvious scar,the ‘Hatched Skin Flap’is suitable for the repairing of the soft tissue defect in the eyebrow area. Key words: Hatched skin flap; Eyebrow area; Soft tissue defect; Repairing
{"title":"The repairing of the soft tissue defect in the eyebrow area with hatchet skin flap","authors":"Wei Feng, N. Luo, Tairan Li, Yiping Xiu, Xu Zhang, Qingyan Meng","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.017","url":null,"abstract":"Objective To found out a suitable method for the repairing of the eyebrow area soft tissue defect based on research and the clinical application of the ‘Hatchet Skin Flap’.Methods All 23 patients with eyebrow area soft tissue defect was included.The skin flap was designed along the longitudinal axle of the defect and with the curve of the ‘Hatchet Skin Flap’ parallel to the curve of the eyebrow.The scale of the width to the length of the flap should not less than 1:3.The flap was dissected and transferred to the defected area.The unnecessary skin in the tip area of the flap was dissected.The skin flap was sutured in different layer and without any tension in the sutured area.Results All 23 skin flaps was survived well and without any necrosis and blood supply disorder.The eyebrow was tot be influnced.After 6 months to 3 years follow up all of the skin flap with a satisfactory appearance.Conclusion Having the advantages as easy to design,no influence to the eyebrow,well-distributed tension and without obvious scar,the ‘Hatched Skin Flap’is suitable for the repairing of the soft tissue defect in the eyebrow area. \u0000 \u0000Key words: \u0000Hatched skin flap; Eyebrow area; Soft tissue defect; Repairing","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"40-42"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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