Pub Date : 2023-10-29DOI: 10.30565/medalanya.1274708
Şükriye TAŞÇI KARAGÖL, Sevil TURHAN, Hülya COŞKUN, Seher KIR, Yusuf Emre. BOSTAN, Raziye YILDIZ
Aim: The most important reason for vitamin D deficiency is the lack of synthesis in the skin. The synthesis of vitamin D can be affected by many variables such as geographical region, race, season, monthly average daily sun exposure (MADSD), monthly average daily global horizontal solar radiation (MADGHSR). In this study, we aimed to investigate possible association between vitamin D levels and MADSD and MADGHSR in young women. Methods: This is a retrospective study evaluating the levels of Vitamin D classified by age, seasons, months, MADGHSR and MADSD in women aged between 15-45 years admitted to a secondary state hospital. Results: All of the women involved were at reproductive age and approximately 94.6% of them had vitamin D levels below 30 ng/mL. The median (minimum-maximum) vitamin D level was 16.1 (3.6-49.4) ng/mL in summer and 14.3 (3.2-49.8) ng/mL in winter (p=0.001). The rate of vitamin D deficiency (<20 ng/mL) was 68.1% in summer and 75.1% in winter (p<0.001). The median MADGHSR was 4.6 (3.4-5.7) hours in winter and 6.9 (5.2-7.2) hours in summer and the median MADSD was 3.3 (1.6-3.5) watt/m²/day in winter and 15.2 (12.2-15.8) watt/m²/day in summer. Vitamin D level was weakly correlated with age (r=0.082, p=0.002), MADSD (r=0.075, p=0.001) and MADGHSR (r=0.062, p=0.006). Conclusion: We found that MADGHSR and MADSD had an effect on vitamin D synthesis in addition to factors related with personal and environmental situations. We suggest that routine optimal dose vitamin D replacement is necessary in geographies similar to the population in our study.
{"title":"The effect of monthly mean global horizontal solar radiation and sunshine duration on vitamin d levels in young women","authors":"Şükriye TAŞÇI KARAGÖL, Sevil TURHAN, Hülya COŞKUN, Seher KIR, Yusuf Emre. BOSTAN, Raziye YILDIZ","doi":"10.30565/medalanya.1274708","DOIUrl":"https://doi.org/10.30565/medalanya.1274708","url":null,"abstract":"Aim: The most important reason for vitamin D deficiency is the lack of synthesis in the skin. The synthesis of vitamin D can be affected by many variables such as geographical region, race, season, monthly average daily sun exposure (MADSD), monthly average daily global horizontal solar radiation (MADGHSR). In this study, we aimed to investigate possible association between vitamin D levels and MADSD and MADGHSR in young women. Methods: This is a retrospective study evaluating the levels of Vitamin D classified by age, seasons, months, MADGHSR and MADSD in women aged between 15-45 years admitted to a secondary state hospital. Results: All of the women involved were at reproductive age and approximately 94.6% of them had vitamin D levels below 30 ng/mL. The median (minimum-maximum) vitamin D level was 16.1 (3.6-49.4) ng/mL in summer and 14.3 (3.2-49.8) ng/mL in winter (p=0.001). The rate of vitamin D deficiency (&lt;20 ng/mL) was 68.1% in summer and 75.1% in winter (p&lt;0.001). The median MADGHSR was 4.6 (3.4-5.7) hours in winter and 6.9 (5.2-7.2) hours in summer and the median MADSD was 3.3 (1.6-3.5) watt/m²/day in winter and 15.2 (12.2-15.8) watt/m²/day in summer. Vitamin D level was weakly correlated with age (r=0.082, p=0.002), MADSD (r=0.075, p=0.001) and MADGHSR (r=0.062, p=0.006). Conclusion: We found that MADGHSR and MADSD had an effect on vitamin D synthesis in addition to factors related with personal and environmental situations. We suggest that routine optimal dose vitamin D replacement is necessary in geographies similar to the population in our study.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1313745
Ahmet KOÇAK, Anıl GÜLCÜ, İshak Suat ÖVEY
Aim: We aimed to reveal the role of doxorubicin (Dox), melatonin (Mel) and transient receptor potential Vanilloid 1 (TRPV1) channels in bone and cartilage cancer cells during the treatment process. Human Bone Osteosarcoma (Saos-2/An1) and Human Chondrosarcoma (Hs 819.T) cell lines were used to prepare in-vitro experiment models. Methods: Both cell lines were cultured at 37°C. We have separated each cell line into five groups as follows: Controls, Dox, Dox+Capsazepine (Cpz), Dox+Melatonin (Mel), and combined Dox+Mel+Cpz given group. Capsaicin and capsazepine were added to cell culture mediums to activate or inactivate the TRPV1 channels, respectively. Cytosolic calcium, apoptosis, intracellular reactive oxygen, mitochondrial depolarization, caspase-3 and caspase-9 levels were measured. Results: Increased apoptotic activity was detected in doxorubicin given cell lines (Group II) when compared with the controls (p˂0.001). There was also a significantly higher apoptotic level in Dox+Mel group (Group IV), when compared with only Dox given group (p˂0.001). TRPV1 inhibition applied groups (Group III and V) have had lower apoptotic levels than other drug administered groups (p˂0.001). Conclusion: This study has indicated that apoptotic effects of Dox and Mel on both osteosarcoma and chondrosarcoma were strictly associated to TRPV1 channels, and that TRPV1 channels played an important role in whole mitochondria dependent pathways of apoptosis, which in turn may lead to increased intracellular Ca+2 levels and mitochondrial depolarization.
{"title":"Apoptosis Induction Through Increased TRPV1 Activation by Synergic Effect of Melatonin and Doxorubicin in Human Osteosarcoma and Chondrosarcoma Cell Lines","authors":"Ahmet KOÇAK, Anıl GÜLCÜ, İshak Suat ÖVEY","doi":"10.30565/medalanya.1313745","DOIUrl":"https://doi.org/10.30565/medalanya.1313745","url":null,"abstract":"Aim: We aimed to reveal the role of doxorubicin (Dox), melatonin (Mel) and transient receptor potential Vanilloid 1 (TRPV1) channels in bone and cartilage cancer cells during the treatment process. Human Bone Osteosarcoma (Saos-2/An1) and Human Chondrosarcoma (Hs 819.T) cell lines were used to prepare in-vitro experiment models. Methods: Both cell lines were cultured at 37°C. We have separated each cell line into five groups as follows: Controls, Dox, Dox+Capsazepine (Cpz), Dox+Melatonin (Mel), and combined Dox+Mel+Cpz given group. Capsaicin and capsazepine were added to cell culture mediums to activate or inactivate the TRPV1 channels, respectively. Cytosolic calcium, apoptosis, intracellular reactive oxygen, mitochondrial depolarization, caspase-3 and caspase-9 levels were measured. Results: Increased apoptotic activity was detected in doxorubicin given cell lines (Group II) when compared with the controls (p˂0.001). There was also a significantly higher apoptotic level in Dox+Mel group (Group IV), when compared with only Dox given group (p˂0.001). TRPV1 inhibition applied groups (Group III and V) have had lower apoptotic levels than other drug administered groups (p˂0.001). Conclusion: This study has indicated that apoptotic effects of Dox and Mel on both osteosarcoma and chondrosarcoma were strictly associated to TRPV1 channels, and that TRPV1 channels played an important role in whole mitochondria dependent pathways of apoptosis, which in turn may lead to increased intracellular Ca+2 levels and mitochondrial depolarization.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"17 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1262518
Mustafa ÖZTÜRK, Erdoğan UNUR, Niyazi ACER, Tolga ERTEKİN, Serife ALPA, Mesut MEKER, Yahya TAHTA
Aim: In our study, we aimed to determine the morphological development of the bones of the anterior and posterior extremity by staining the rat fetus and offspring skeletons with the double staining method. Method: In the current study, seven groups three prenatal (16th, 18th, and 20th days) and four postnatal (0th, 3th, 7th and 12th days) were formed from the foetuses and offsprings obtained from 13 pregnant rats. Then, it was stained with double staining method. Anterior and posterior extremity images of the fetuses and offsprings were examined under a stereo microscope, and ossification findings were determined. Total bone and ossification lengths as well as ossification areas were measured using the ImageJ software. Results: The first cartilage destruction in fetuses occurred on the 16th day of pregnancy in the clavicle, scapula, humerus, radius and ulna; It was seen in the femur, tibia and fibula on the 18th day of pregnancy. The first ossification centres were in the clavicle, scapula and humerus on the 18th day of pregnancy; It was seen in the radius, ulna, femur, tibia, fibula and 2-5 metatarsal bones on the 20th day of pregnancy. The secondary ossification centre was seen on the 0th day (birthday) in the scapula and humerus, on the 7th day after birth in the ulna and radius, and on the 12th day after birth in the femur and tibia. In the study, while the ossification rate in 20-day-old foetuses was 48.9% in the humerus, 53.2% in the radius, 55.7% in the ulna, 33.6% in the femur, 43.2% in the tibia, 44.3% in the fibula, it was determined that it reached 69.7% in the humerus, 78.4% in the radius, 73.3% in the ulna, 63.5% in the femur, 75.5% in the tibia, and 69.2% in the fibula on the 12th day after birth. Conclusion: In this study, we revealed the morphological changes of the anterior and posterior extremity bones of fetuses and offsprings in the normal developmental course. We think that these results will shed light on the studies to be conducted on the detection of skeletal anomalies in teratological studies and contribute to a more comprehensive evaluation of the findings to be obtained from the studies to be conducted.
{"title":"Determination of Bone Developments of Rat Anterior and Posterior Extremity Bones in Prenatal and Postnatal Period by Double Staining Method","authors":"Mustafa ÖZTÜRK, Erdoğan UNUR, Niyazi ACER, Tolga ERTEKİN, Serife ALPA, Mesut MEKER, Yahya TAHTA","doi":"10.30565/medalanya.1262518","DOIUrl":"https://doi.org/10.30565/medalanya.1262518","url":null,"abstract":"Aim: In our study, we aimed to determine the morphological development of the bones of the anterior and posterior extremity by staining the rat fetus and offspring skeletons with the double staining method. Method: In the current study, seven groups three prenatal (16th, 18th, and 20th days) and four postnatal (0th, 3th, 7th and 12th days) were formed from the foetuses and offsprings obtained from 13 pregnant rats. Then, it was stained with double staining method. Anterior and posterior extremity images of the fetuses and offsprings were examined under a stereo microscope, and ossification findings were determined. Total bone and ossification lengths as well as ossification areas were measured using the ImageJ software. Results: The first cartilage destruction in fetuses occurred on the 16th day of pregnancy in the clavicle, scapula, humerus, radius and ulna; It was seen in the femur, tibia and fibula on the 18th day of pregnancy. The first ossification centres were in the clavicle, scapula and humerus on the 18th day of pregnancy; It was seen in the radius, ulna, femur, tibia, fibula and 2-5 metatarsal bones on the 20th day of pregnancy. The secondary ossification centre was seen on the 0th day (birthday) in the scapula and humerus, on the 7th day after birth in the ulna and radius, and on the 12th day after birth in the femur and tibia. In the study, while the ossification rate in 20-day-old foetuses was 48.9% in the humerus, 53.2% in the radius, 55.7% in the ulna, 33.6% in the femur, 43.2% in the tibia, 44.3% in the fibula, it was determined that it reached 69.7% in the humerus, 78.4% in the radius, 73.3% in the ulna, 63.5% in the femur, 75.5% in the tibia, and 69.2% in the fibula on the 12th day after birth. Conclusion: In this study, we revealed the morphological changes of the anterior and posterior extremity bones of fetuses and offsprings in the normal developmental course. We think that these results will shed light on the studies to be conducted on the detection of skeletal anomalies in teratological studies and contribute to a more comprehensive evaluation of the findings to be obtained from the studies to be conducted.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"57 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1167930
Tülay KUŞ, Mahmut ÇORAPLI, Baran YUSUFOĞLU, Gökmen AKTAŞ, Cemil OKTAY
Aim:Skeletal muscle loss is an indicator of cachexia and a strong prognostic factor for some types of cancer. After strict standardization, we aim to evaluate both the predictive and prognostic value of low muscle mass (LMM) in common cancer types for first-line chemotherapy. Methods: This retrospective single-center study was conducted in a regional hospital between 2015 and 2020. Patients diagnosed with distant metastatic cancer were screened and included in the study if they had abdominal computed tomography 45 days prior to first-line chemotherapy. The relationship between LMM and progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) was evaluated. Results: Initially, 289 patients with metastatic cancer were included. The median duration of follow-up was 17 months, with a mean age of 61.09±13.03 years (range 25 to 95), and 45.9% of patients were female. In total, 50.5% of patients had LMM, which was adjusted for gender. LMM was associated with worse OS and PFS in univariate analysis (HR:1.598;1.216-2.100; p=0.001 for OS and HR:1.583;1.216-2.059; p=0.001 for PFS), and this positive association was maintained after adjusted for diagnosis and age. Better ORRs were obtained in respiratory and gastrointestinal tract cancers, breast, prostate and gynecological cancer in non-LMM groups. Conclusion:LMM has not only prognostic value but also predictive value for many types of cancer. Therefore, the assessment of muscle loss should be incorporated as part of the initial routine clinical evaluation.
{"title":"Uzak metastazlı kanser hastalarında iskelet kası kütlesinin prediktif ve prognostik değeri","authors":"Tülay KUŞ, Mahmut ÇORAPLI, Baran YUSUFOĞLU, Gökmen AKTAŞ, Cemil OKTAY","doi":"10.30565/medalanya.1167930","DOIUrl":"https://doi.org/10.30565/medalanya.1167930","url":null,"abstract":"Aim:Skeletal muscle loss is an indicator of cachexia and a strong prognostic factor for some types of cancer. After strict standardization, we aim to evaluate both the predictive and prognostic value of low muscle mass (LMM) in common cancer types for first-line chemotherapy. Methods: This retrospective single-center study was conducted in a regional hospital between 2015 and 2020. Patients diagnosed with distant metastatic cancer were screened and included in the study if they had abdominal computed tomography 45 days prior to first-line chemotherapy. The relationship between LMM and progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) was evaluated. Results: Initially, 289 patients with metastatic cancer were included. The median duration of follow-up was 17 months, with a mean age of 61.09±13.03 years (range 25 to 95), and 45.9% of patients were female. In total, 50.5% of patients had LMM, which was adjusted for gender. LMM was associated with worse OS and PFS in univariate analysis (HR:1.598;1.216-2.100; p=0.001 for OS and HR:1.583;1.216-2.059; p=0.001 for PFS), and this positive association was maintained after adjusted for diagnosis and age. Better ORRs were obtained in respiratory and gastrointestinal tract cancers, breast, prostate and gynecological cancer in non-LMM groups. Conclusion:LMM has not only prognostic value but also predictive value for many types of cancer. Therefore, the assessment of muscle loss should be incorporated as part of the initial routine clinical evaluation.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"57 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1325564
Saniye BAŞAK OKTAY, Ferhat HANİKOĞLU
Aim: In this study, we aimed to evaluate the preanalytical errors over a five year period using the Six Sigma methodology and Pareto Principle in the clinical biochemistry laboratory. Methods: Five-year sample rejection data between January 2015 and December 2019 in the clinical biochemistry laboratory were analyzed and classified according to the reasons for rejection. Six Sigma levels for the total and each preanalytical error were calculated with Westgard online formula. Preanalytical errors were evaluated according to their frequencies ranks and percentages with Pareto's principle. Results: The overall rate of five-year total critical preanalytical errors was 1.91% and the sigma level was 3.6. According to Pareto's chart, the three most common errors among the five-year preanalytical rejections were clotted sample (42.49%, sigma value:4), insufficient sample (23.53%, sigma value:4.2), and wrong container (8.01%, sigma value:4.5). Conclusion: Six Sigma is a quality management methodology used to evaluate laboratory performance processes according to universal quality criteria. Calculated sigma values of preanalytical errors in our laboratory were within the acceptable range. However, planned regulatory activities for frequently observed preanalytical errors should be a laboratory management strategy to reduce these error rates and improve our laboratory performance.
{"title":"Assessment of Preanalytical Errors by Six Sigma Method and Pareto‘s Principle","authors":"Saniye BAŞAK OKTAY, Ferhat HANİKOĞLU","doi":"10.30565/medalanya.1325564","DOIUrl":"https://doi.org/10.30565/medalanya.1325564","url":null,"abstract":"Aim: In this study, we aimed to evaluate the preanalytical errors over a five year period using the Six Sigma methodology and Pareto Principle in the clinical biochemistry laboratory. Methods: Five-year sample rejection data between January 2015 and December 2019 in the clinical biochemistry laboratory were analyzed and classified according to the reasons for rejection. Six Sigma levels for the total and each preanalytical error were calculated with Westgard online formula. Preanalytical errors were evaluated according to their frequencies ranks and percentages with Pareto's principle. Results: The overall rate of five-year total critical preanalytical errors was 1.91% and the sigma level was 3.6. According to Pareto's chart, the three most common errors among the five-year preanalytical rejections were clotted sample (42.49%, sigma value:4), insufficient sample (23.53%, sigma value:4.2), and wrong container (8.01%, sigma value:4.5). Conclusion: Six Sigma is a quality management methodology used to evaluate laboratory performance processes according to universal quality criteria. Calculated sigma values of preanalytical errors in our laboratory were within the acceptable range. However, planned regulatory activities for frequently observed preanalytical errors should be a laboratory management strategy to reduce these error rates and improve our laboratory performance.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1342908
Hasan MAY, Abdullahi Yusuf MOHAMED
Aim: The aim of this study was to investigate whether the frequency of palmaris longus (PL) absence in Somali population differed from other populations in Africa and the rest of the world and to evaluate its association with sex and side of the limb involved. Methods: Totally 1,000 participants (713 males and 287 females; age range: 7 to 80 years) were tested for the absence of PL tendon using Schaffer’s test. In those with a negative Schaffer's test result, Thompson's test, Mishra's test I, Mishra's test II, and Pushpakumar's "two-finger sign" method were used to confirm its absence. Results: Absence of PL tendon was found in 95 (9.5%) participants. The PL muscle was absent bilaterally in 42 (4.4%) and unilaterally in 53 (5.5%) participants. Unilateral absence of PL was higher in the right hand (3.0%) (p>0.05). Agenesis of the right side in males was significantly correlated with the left side in males (rs=0.556, p<0.01). Right agenesis in females was significantly correlated with its left side (rs=0.625, p<0.01). The incidence of right and left agenesis in females was more strongly correlated than that in males. Age was significantly correlated with left agenesis (rs=0.154, p<0.01) and right agenesis (rs=0.145, p<0.05) in females. Conclusion: The prevalence of PL agenesis in the Somali population is lower than the reported incidence of 15%, but more significantly higher than some of the other African populations. These findings may be helpful, particularly for the surgeons in the region, for orthopedic and reconstructive surgeries using PL grafting.
{"title":"Clinical Detection of Presence and Absence of Palmaris Longus Tendon in Somali Population","authors":"Hasan MAY, Abdullahi Yusuf MOHAMED","doi":"10.30565/medalanya.1342908","DOIUrl":"https://doi.org/10.30565/medalanya.1342908","url":null,"abstract":"Aim: The aim of this study was to investigate whether the frequency of palmaris longus (PL) absence in Somali population differed from other populations in Africa and the rest of the world and to evaluate its association with sex and side of the limb involved. Methods: Totally 1,000 participants (713 males and 287 females; age range: 7 to 80 years) were tested for the absence of PL tendon using Schaffer’s test. In those with a negative Schaffer's test result, Thompson's test, Mishra's test I, Mishra's test II, and Pushpakumar's \"two-finger sign\" method were used to confirm its absence. Results: Absence of PL tendon was found in 95 (9.5%) participants. The PL muscle was absent bilaterally in 42 (4.4%) and unilaterally in 53 (5.5%) participants. Unilateral absence of PL was higher in the right hand (3.0%) (p&gt;0.05). Agenesis of the right side in males was significantly correlated with the left side in males (rs=0.556, p&lt;0.01). Right agenesis in females was significantly correlated with its left side (rs=0.625, p&lt;0.01). The incidence of right and left agenesis in females was more strongly correlated than that in males. Age was significantly correlated with left agenesis (rs=0.154, p&lt;0.01) and right agenesis (rs=0.145, p&lt;0.05) in females. Conclusion: The prevalence of PL agenesis in the Somali population is lower than the reported incidence of 15%, but more significantly higher than some of the other African populations. These findings may be helpful, particularly for the surgeons in the region, for orthopedic and reconstructive surgeries using PL grafting.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"57 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1341821
Durkadın DEMİR EKŞİ, Hüseyin GÜNİZİ
Aim: Allergic rhinitis (AR) is an inflammatory nasal mucosa disease caused by type 1 immunoglobulin E-mediated reactions to allergen exposure. Irisin is a hormone released by skeletal muscles in response to exercise. There are studies that demonstrate the relationship of irisin with inflammation. We aimed to investigate the potential association between irisin coding fibronectin type III domain 5 (FNDC5) gene polymorphisms, serum irisin levels, and AR. Method: A case-control study was designed, involving 100 AR patients and 100 healthy controls. Genotyping of rs726344 and rs1746661 SNPs within the FNDC5 gene was performed using PCR-RFLP method. Serum irisin levels were measured using ELISA. Results: Genotyping of rs726344 SNP in patients revealed 90% GG and 10% GA genotypes, while in controls, it was 94% GG and 6% GA. The AA genotype was not detected in any case. For rs1746661 SNP, patients had 57% GG, 39% GT, and 4% TT genotypes, while controls had 58% GG, 36% GT, and 6% TT genotypes. No significant difference was found in rs726344 and rs1746661 SNPs between the patients and the control group. Serum irisin level was 406.3±56.09 ng/ml in patients and 354.3±46.06 ng/ml in controls with no significant difference. Conclusion: This is the first study aiming to investigate the relationship between the irisin protein, its encoding gene, and AR. No significant association was identified between FNDC5 gene polymorphisms, serum irisin levels, and allergic rhinitis. While these findings suggest a limited role of these factors in AR, further studies are needed for more comprehensive understanding of the irisin-AR relationship.
{"title":"Lack of Association Between FNDC5 Gene Polymorphisms, Serum Irisin Levels and Allergic Rhinitis","authors":"Durkadın DEMİR EKŞİ, Hüseyin GÜNİZİ","doi":"10.30565/medalanya.1341821","DOIUrl":"https://doi.org/10.30565/medalanya.1341821","url":null,"abstract":"Aim: Allergic rhinitis (AR) is an inflammatory nasal mucosa disease caused by type 1 immunoglobulin E-mediated reactions to allergen exposure. Irisin is a hormone released by skeletal muscles in response to exercise. There are studies that demonstrate the relationship of irisin with inflammation. We aimed to investigate the potential association between irisin coding fibronectin type III domain 5 (FNDC5) gene polymorphisms, serum irisin levels, and AR. Method: A case-control study was designed, involving 100 AR patients and 100 healthy controls. Genotyping of rs726344 and rs1746661 SNPs within the FNDC5 gene was performed using PCR-RFLP method. Serum irisin levels were measured using ELISA. Results: Genotyping of rs726344 SNP in patients revealed 90% GG and 10% GA genotypes, while in controls, it was 94% GG and 6% GA. The AA genotype was not detected in any case. For rs1746661 SNP, patients had 57% GG, 39% GT, and 4% TT genotypes, while controls had 58% GG, 36% GT, and 6% TT genotypes. No significant difference was found in rs726344 and rs1746661 SNPs between the patients and the control group. Serum irisin level was 406.3±56.09 ng/ml in patients and 354.3±46.06 ng/ml in controls with no significant difference. Conclusion: This is the first study aiming to investigate the relationship between the irisin protein, its encoding gene, and AR. No significant association was identified between FNDC5 gene polymorphisms, serum irisin levels, and allergic rhinitis. While these findings suggest a limited role of these factors in AR, further studies are needed for more comprehensive understanding of the irisin-AR relationship.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"57 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1358781
İbrahim ETLİ
Aim: In this study we reported the functional results and complications of patients with scapula fractures who underwent open reduction and internal fixation. Methods: The study included 16 patients with scapula fractures who were treated with open reduction and internal fixation(ORIF) between September 2015 and March 2022. Radiologic examination (AP in the scapular plane, lateral and axillary radiography) and computed tomography (CT) scans were performed in all patients. Fractures were classified according to the revised (AO/OTA) classification system. The patients underwent deltopectoral and posterior approaches described by Judet. Functional outcomes were measured using Constant-Murley scores. Results: Ten patients had a scapular neck fracture, or glenoid fossa fracture, five patients had a scapular trunk fracture affecting the glenohumeral joint, and one patient had a scapula process fracture. It was accompanied by clavicle shaft fracture in five patients. The mean follow-up period after injury was 42 months (6-92 months). The mean Constant-Murley score (CMS) for the shoulder with scapula fracture was 93.8 (±8.93). Conclusion: Open reduction and internal fixation of displaced scapular fractures is an effective treatment option in terms of union rate and functional outcome.
{"title":"Which scapula fractures should we operate on and what are the functional outcomes?","authors":"İbrahim ETLİ","doi":"10.30565/medalanya.1358781","DOIUrl":"https://doi.org/10.30565/medalanya.1358781","url":null,"abstract":"Aim: In this study we reported the functional results and complications of patients with scapula fractures who underwent open reduction and internal fixation. Methods: The study included 16 patients with scapula fractures who were treated with open reduction and internal fixation(ORIF) between September 2015 and March 2022. Radiologic examination (AP in the scapular plane, lateral and axillary radiography) and computed tomography (CT) scans were performed in all patients. Fractures were classified according to the revised (AO/OTA) classification system. The patients underwent deltopectoral and posterior approaches described by Judet. Functional outcomes were measured using Constant-Murley scores. Results: Ten patients had a scapular neck fracture, or glenoid fossa fracture, five patients had a scapular trunk fracture affecting the glenohumeral joint, and one patient had a scapula process fracture. It was accompanied by clavicle shaft fracture in five patients. The mean follow-up period after injury was 42 months (6-92 months). The mean Constant-Murley score (CMS) for the shoulder with scapula fracture was 93.8 (±8.93). Conclusion: Open reduction and internal fixation of displaced scapular fractures is an effective treatment option in terms of union rate and functional outcome.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1314292
Onur Yazdan BALÇIK, Ali AYTAÇ, Tugay AVCI, Bilgin DEMİR, Yusuf İLHAN, Gökhan KARAKYA, Atike Pinar ERDOĞAN
Aim: Non-small cell lung cancer (NSCLC) is one of the 3 most common and deadly cancers. The aim of the current study is to investigate whether Prognostic Nutritional Index /PNI), Systemic Immune-Inflammation Index (SIRI), Lung Immune Prognostic Index (LIPI) has a prognostic significance in patients with metastatic NSLCL. Methods: Patients diagnosed with pathologically confirmed metastatic NSCLC in 5 different hospitals in Turkey between 2016-2022 were included in our study and analyzed retrospectively. overall survival (OS) and progression-free survival (PFS) were recorded. Results: The median PFS was 5.50 months, while the median OS was 16.03 months. Median OS was 14.86 months for the PNI-Low group and 17.2 months for the PNI-High group (p: <0.121). The median OS of the PNI-Low group was shorter than the PNI-High group, but there was no statistically significant difference between the groups. Median OS was 19.86 months for the SIRI-Low group and 14.23 months for the SIRI-High group (p: <0.112). Median OS was 17.76, 15.13, 13.73 months for the LIPI-Low, LIPI-intermediate group and LIPI-high group, there was no statistically significant difference between the groups (p: <0.391) Conclusion: In conclusion, PNI and SIRI may be significant in a prospective study in a specific patient group to be performed with a larger number of patients to predict the prognosis of patients with metastatic NSCLC.
{"title":"Prognostic significance of PNI, SIRI and LIPI in non small-cell lung cancer","authors":"Onur Yazdan BALÇIK, Ali AYTAÇ, Tugay AVCI, Bilgin DEMİR, Yusuf İLHAN, Gökhan KARAKYA, Atike Pinar ERDOĞAN","doi":"10.30565/medalanya.1314292","DOIUrl":"https://doi.org/10.30565/medalanya.1314292","url":null,"abstract":"Aim: Non-small cell lung cancer (NSCLC) is one of the 3 most common and deadly cancers. The aim of the current study is to investigate whether Prognostic Nutritional Index /PNI), Systemic Immune-Inflammation Index (SIRI), Lung Immune Prognostic Index (LIPI) has a prognostic significance in patients with metastatic NSLCL. Methods: Patients diagnosed with pathologically confirmed metastatic NSCLC in 5 different hospitals in Turkey between 2016-2022 were included in our study and analyzed retrospectively. overall survival (OS) and progression-free survival (PFS) were recorded. Results: The median PFS was 5.50 months, while the median OS was 16.03 months. Median OS was 14.86 months for the PNI-Low group and 17.2 months for the PNI-High group (p: &lt;0.121). The median OS of the PNI-Low group was shorter than the PNI-High group, but there was no statistically significant difference between the groups. Median OS was 19.86 months for the SIRI-Low group and 14.23 months for the SIRI-High group (p: &lt;0.112). Median OS was 17.76, 15.13, 13.73 months for the LIPI-Low, LIPI-intermediate group and LIPI-high group, there was no statistically significant difference between the groups (p: &lt;0.391) Conclusion: In conclusion, PNI and SIRI may be significant in a prospective study in a specific patient group to be performed with a larger number of patients to predict the prognosis of patients with metastatic NSCLC.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"17 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.30565/medalanya.1350671
Gökçe ZEYTİN DEMİRAL
Aim : Multiple Sclerosis (MS) is a chronic, progressive, and neurodegenerative disorder of the central nervous system. It frequently leads to symptoms such as disability, cognitive impairment, fatigue, and depression. This study aims to examine the relationship between fatigue, cognitive functions, depression, and disability among individuals with MS. Methods: Seventy-four MS patients were evaluated by using the Cognitive Failure Questionnaire (CFQ) battery. The Expanded Disability Status Scale (EDSS) was used in determining the level of disability, whereas the Fatigue Severity Scale (FSS) and the Beck Depression Inventory (BDI) were utilized in measuring the levels of fatigue and depression, respectively. Results :Moderate positive correlations were found between EDSS and BDI (r1=0.342; p<0.001), between EDSS and FSS (r1=0.392; p<0.001), between CFQ and BDI (r1=0.451; p<0.001), between CFQ and FSS (r1=0.425; p<0.001), and between FSS and BDI (r1=0.424; p<0.001). Conclusion :The results achieved in this study indicate that fatigue and depression increase as disability increases among Multiple Sclerosis patients and cognitive impairment is associated with both depression and fatigue.
{"title":"Relationship Between Fatigue, Cognitive Functions, Depression, and Disability in Multiple Sclerosis Patients","authors":"Gökçe ZEYTİN DEMİRAL","doi":"10.30565/medalanya.1350671","DOIUrl":"https://doi.org/10.30565/medalanya.1350671","url":null,"abstract":"Aim : Multiple Sclerosis (MS) is a chronic, progressive, and neurodegenerative disorder of the central nervous system. It frequently leads to symptoms such as disability, cognitive impairment, fatigue, and depression. This study aims to examine the relationship between fatigue, cognitive functions, depression, and disability among individuals with MS. Methods: Seventy-four MS patients were evaluated by using the Cognitive Failure Questionnaire (CFQ) battery. The Expanded Disability Status Scale (EDSS) was used in determining the level of disability, whereas the Fatigue Severity Scale (FSS) and the Beck Depression Inventory (BDI) were utilized in measuring the levels of fatigue and depression, respectively. Results :Moderate positive correlations were found between EDSS and BDI (r1=0.342; p&lt;0.001), between EDSS and FSS (r1=0.392; p&lt;0.001), between CFQ and BDI (r1=0.451; p&lt;0.001), between CFQ and FSS (r1=0.425; p&lt;0.001), and between FSS and BDI (r1=0.424; p&lt;0.001). Conclusion :The results achieved in this study indicate that fatigue and depression increase as disability increases among Multiple Sclerosis patients and cognitive impairment is associated with both depression and fatigue.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"57 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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