Nano-Micro Letters最新文献

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Highlights

Uncontrolled hemorrhage, resulting from trauma or surgery, presents a critical challenge in medical care. This study introduces a novel eutectogel, a multifunctional material synthesized using choline chloride/phytic acid derived deep eutectic solvents (CP-DES)-mediated cellulose-MXene polyacrylamide, aimed at addressing hemostatic needs. The eutectogel combines photothermal and thermoelectric effects to accelerate hemorrhage control, significantly reducing blood loss and hemostasis time. Unlike existing hemostatic materials, our design leverages the synergistic effects of photothermal heating and thermoelectric current, enhancing coagulation and promoting tissue repair. The innovation lies in the integration of DES to stabilize MXene, optimizing its photothermal and thermoelectric properties, and enabling rapid gelation, self-healing, and anti-freezing capabilities. In vitro and in vivo tests demonstrate the material’s superior performance in hemostasis compared to traditional gauze, highlighting its potential for trauma care and surgical applications. This approach sets a new paradigm in the development of advanced, multifunctional biomedical materials for hemostasis and beyond.

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The therapeutic potential of mesenchymal stem cells (MSCs) in regenerative medicine is frequently thwarted by hostile post-injury microenvironments characterized by oxidative stress, inflammation, and rapid clearance, which compromise cell survival and paracrine efficacy. Herein, we establish a universal bio-hybrid “stem cell backpack” platform designed to fundamentally overcome these bottlenecks through precise surface interface engineering. By tethering drug-loaded mesoporous silica nanoparticles onto the MSCs membrane via mild, biocompatible click chemistry, we create a programmable nanotherapeutic depot that endows host cells with dual, synergistic capabilities: (1) robust scavenging of reactive oxygen species (ROS) to ensure cellular resilience and (2) sustained, localized release of regenerative factors to amplify paracrine signaling. Using corneal chemical injury as a rigorous proof-of-concept model, this platform demonstrated unprecedented regenerative potency. The engineered cells markedly outperformed conventional therapies by simultaneously suppressing inflammatory cascades, preventing fibrosis and neovascularization, and orchestrating multi-lineage regeneration, including epithelial restoration, nerve reinnervation, and limbal stem cell reactivation. Quantitatively, this approach achieved a 63.6% enhancement in transparency restoration and a 76.9% greater reduction in tissue defects compared to cell monotherapy. Crucially, the modular design of this backpack system allows for the interchangeable loading of diverse therapeutics, extending its applicability beyond ophthalmology to other tissues facing similar microenvironmental challenges. This work presents a transformative paradigm in nanomedicine, shifting the focus from passive cell delivery to active microenvironmental modulation, thereby offering a versatile and scalable strategy for next-generation regenerative therapies across diverse clinical indications.

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Highlights

Highlights

With the trend toward high-power radio-frequency (RF) electronic devices, flexible thermally conductive composite films are regarded as a key engineering interfacial material to address the critical problem of signal transmission and heat dissipation. However, achieving simultaneous optimization of high thermal conductivity and low loss in the same material remains a significant challenge, particularly in films with high filler loading. Here, a bottom-up regulatory strategy is proposed to address this challenge. Through the synergistic optimization of interface modification design and spatial orientation arrangement of hexagonal boron nitride (BN), the fabricated composite film achieves an exceptional in-plane thermal conductivity of 78.50 W m⁻¹ K⁻¹, significantly surpassing that of the film with BN. This remarkable enhancement is primarily attributed to the altered surface properties of the aminated BN (BN-NH₂). The introduction of amine groups enhances the compatibility with the polymer matrix through electrostatic interactions to facilitate more efficient interfacial thermal transport. Furthermore, the highly oriented spatial arrangement of BN in the film not only preserves the electromagnetic wave transparency (99.94%), but also enhances its breakdown strength. This study underscores the critical role of molecular-level filler modification combined with micro-nanostructural engineering in synergistically strengthening the filler-matrix interface and boosting film thermal transport.

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