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Distal Migration of a REBOA Catheter After Balloon Deflation 球囊放气后REBOA导管远端移位
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-26 DOI: 10.1002/ams2.70175
Keisuke Suzuki, Ayane Fukami, Ayako Iijima, Kenji Dohi

An 81-year-old woman presented with hemorrhagic shock. Contrast-enhanced computed tomography (CT) revealed a ruptured abdominal aortic aneurysm with aortic tortuosity and a large retroperitoneal hematoma (Figure 1A,B). As endovascular aneurysm repair (EVAR) was not available, transfer was arranged. During preparation, a 7-Fr resuscitative endovascular balloon occlusion of the aorta (REBOA; Rescue Balloon; Tokai Medical Products, Aichi, Japan) catheter was inserted via the right femoral artery. Inflation in Zone I, proximal to the aneurysm, stabilized hemodynamics despite shaft angulation (Figure 1C). Twenty minutes later, deflation to restore distal perfusion lowered systolic blood pressure to 50 mmHg; reinflation within seconds did not improve it. The catheter remained secured to the skin with a suture and stylet in place, without intentional manipulation. Fluoroscopy was not used immediately before or during these maneuvers. Subsequent fluoroscopy revealed catheter shaft kinking and looping, with distal migration of the balloon by approximately two vertebral body heights to the L2–L3 vertebral level, corresponding approximately to the upper extent of the aneurysm on preprocedural contrast-enhanced CT (Figure 1D). Failed guidewire advancement beyond the aneurysm from the femoral approach prompted replacement via the left brachial artery to avoid the tortuous aneurysmal segment. After transfer, the patient underwent successful EVAR.

Low-profile REBOA devices may reduce access-related vascular complications [1], but migration and looping remain possible [2]. Loss of balloon anchoring, restored aortic flow, and shaft tension release may contribute to migration and deformation within the tortuous aorta, although the mechanism remains unconfirmed. Therefore, assessing shaft configuration and reconfirming balloon position fluoroscopically after deflation/reinflation may facilitate early migration detection.

The authors have nothing to report.

The authors have nothing to report.

Informed consent was obtained from the patient's family.

Kenji Dohi is an Editorial Board member of Acute Medicine & Surgery and a co-author of this article. The other authors declare no conflicts of interest.

The data that support the findings of this study are available from the corresponding author upon reasonable request.

81岁女性失血性休克。对比增强计算机断层扫描(CT)显示腹主动脉瘤破裂伴主动脉扭曲和腹膜后大血肿(图1A,B)。由于无法进行血管内动脉瘤修复(EVAR),故安排转移。在准备过程中,通过右股动脉插入7-Fr复苏血管内球囊阻断主动脉(REBOA; Rescue balloon; Tokai Medical Products,爱知,日本)导管。尽管轴成角,但动脉瘤近端I区肿胀稳定了血流动力学(图1C)。20分钟后,放气恢复远端灌注使收缩压降至50 mmHg;几秒钟内的再次通货膨胀并没有改善它。在没有人为操作的情况下,通过缝线和导管固定在皮肤上。在这些操作之前或期间不立即使用透视检查。随后的x线检查显示导管轴扭结和环状,球囊远端移动约两个椎体高度至L2-L3椎体水平,大致对应于术前CT造影显示的动脉瘤上部范围(图1D)。从股动脉入路将导丝推进到动脉瘤外失败,提示通过左肱动脉进行置换,以避免弯曲的动脉瘤段。转移后,患者进行了成功的EVAR。低调的REBOA装置可以减少通路相关的血管并发症,但仍有可能发生迁移和循环。球囊锚定丧失、主动脉血流恢复和轴张力释放可能导致弯曲主动脉内的迁移和变形,但其机制尚未得到证实。因此,在放气/再充气后,在透视下评估轴的结构和重新确认球囊位置可能有助于早期迁移检测。作者没有什么可报告的。作者没有什么可报告的。获得患者家属的知情同意。土井健二是《急症医学与外科学》的编辑委员会成员,也是本文的作者之一。其他作者声明没有利益冲突。支持本研究结果的数据可根据通讯作者的合理要求提供。
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引用次数: 0
Early Adrenaline Administration After Implementation of the Japanese Anaphylaxis Guideline 2014: A Single-Center Retrospective Cohort Study 2014年日本过敏反应指南实施后早期肾上腺素给药:一项单中心回顾性队列研究
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-26 DOI: 10.1002/ams2.70174
Kenji Kawai, Kazuhiko Omori, Tomohisa Nomura, Manabu Sugita, Yutaka Kondo

Background

Early administration of adrenaline is the cornerstone of anaphylaxis treatment; however, delays in its administration remain common in clinical practice. The Japanese Anaphylaxis Guideline, published in 2014, aimed to standardize the diagnosis and early treatment of anaphylaxis, but its impact on clinical practice has not been fully evaluated.

Aim

To evaluate the impact of guideline implementation on time to adrenaline, incidence of biphasic reactions, and length of hospital stay (LOS).

Methods

This single-center retrospective cohort study included 131 adult inpatients with anaphylaxis admitted between 2011 and 2022, categorized into a pre-guideline group (Group A, n = 55) and a post-guideline group (Group B, n = 76). Outcomes included time to adrenaline administration, incidence of biphasic reactions, and length of hospital stay (LOS).

Results

Following guideline implementation, the median time to adrenaline administration was shorter (6.0–5.0 min, p = 0.040). The incidence of biphasic reactions decreased from 16.5% to 6.6%, although the difference was not statistically significant (p = 0.074). The median LOS decreased from 20.1 to 18.7 h, but this difference was also not statistically significant (p = 0.080).

Conclusions

Guideline implementation was associated with significantly earlier adrenaline administration, indicating improved treatment processes, whereas reductions in biphasic reactions and length of hospital stay did not reach statistical significance.

背景:早期给药肾上腺素是过敏反应治疗的基石;然而,在临床实践中,延迟给药仍然很常见。2014年发布的《日本过敏反应指南》旨在规范过敏反应的诊断和早期治疗,但其对临床实践的影响尚未得到充分评估。目的评价指南实施对患者肾上腺素到达时间、双相反应发生率和住院时间(LOS)的影响。方法本研究为单中心回顾性队列研究,纳入2011 - 2022年间131例成人过敏反应住院患者,分为指南前组(a组,n = 55)和指南后组(B组,n = 76)。结果包括肾上腺素给药时间、双相反应发生率和住院时间(LOS)。结果:指南实施后,肾上腺素给药的中位时间缩短(6.0-5.0 min, p = 0.040)。双相反应发生率由16.5%降至6.6%,差异无统计学意义(p = 0.074)。中位LOS从20.1 h降至18.7 h,但差异也无统计学意义(p = 0.080)。结论:指南的实施与肾上腺素给药的早期显著相关,表明治疗过程得到改善,而双相反应和住院时间的减少没有统计学意义。
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引用次数: 0
Heat-Related Deaths During School-Supervised Activities in Japan: A 19-Year Nationwide Study Using the Japan Sport Council Database 在日本学校监督的活动中与热相关的死亡:一项使用日本体育委员会数据库的19年全国研究
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-26 DOI: 10.1002/ams2.70169
Soshiro Saito, Yutaka Igarashi, Ryu Mori, Wakako Sakamoto, Shoji Yokobori

Aim

Children and adolescents in school sports are vulnerable to exertional heat illness, but detailed information on fatal events under school supervision in Japan is limited. This study aimed to characterize the circumstances of fatal heat-related illness in this setting.

Methods

We conducted a nationwide retrospective observational study using the Japan Sport Council School Accident Search Database. We included deaths among preschool to high school students between April 2005 and March 2024 attributed to heat illness during school-supervised activities. Demographics, school type, setting, activity at collapse, and first aid at the scene were abstracted.

Results

Of 1151 school-related deaths, 27 (2.3%) were attributed to heat illness. Median age was 16 years (interquartile range: 15–17); 25 students (93%) were male, and 19 (70%) were high school students. First-year high school students represented the largest subgroup (n = 8, 30%). Nineteen deaths (70%) occurred outdoors and eight (30%) indoors, most commonly in gymnasiums. Extracurricular sports accounted for 21 deaths (78%), including judo, soccer/futsal, rugby, and baseball. Running preceded collapse in 13 cases (48%). Witnesses were present in 21 cases (78%), yet cooling was documented in 9 cases (33%), while whether cooling was performed could not be determined in 12 cases (44%).

Conclusion

Fatal heat-related illness in Japanese schools predominantly affects first-year high school students engaged in strenuous conditioning during extracurricular sports and occurs in outdoor and indoor environments. Limited documentation of cooling despite witnesses indicates an urgent need to strengthen school-based prevention and emergency response systems, including preparedness for rapid on-site cooling.

目的:参加学校体育运动的儿童和青少年容易患运动性中暑,但在日本,关于学校监督下的致命事件的详细信息有限。本研究旨在描述在这种情况下与热有关的致命疾病的情况。方法:我们使用日本体育会学校事故检索数据库进行了一项全国性的回顾性观察研究。我们纳入了2005年4月至2024年3月期间因学校监督活动期间中暑而死亡的学龄前至高中学生。对人口统计、学校类型、环境、坍塌时的活动和现场急救进行了抽象化分析。结果在1151例与学校有关的死亡中,27例(2.3%)归因于中暑。中位年龄为16岁(四分位数间距:15-17岁);男性25人(93%),高中生19人(70%)。高中一年级学生是最大的亚组(n = 8,30%)。19例死亡(70%)发生在室外,8例(30%)发生在室内,最常见的是在体育馆。课外运动占21例死亡(78%),包括柔道、足球/五人制足球、橄榄球和棒球。13例(48%)先跑后倒。21例(78%)有证人在场,9例(33%)有冷却记录,12例(44%)无法确定是否进行了冷却。结论日本学校致命热相关疾病主要发生在课外运动中进行剧烈运动的高一学生,发生在室外和室内环境中。尽管有目击者,但关于冷却的有限文件表明,迫切需要加强以学校为基础的预防和应急反应系统,包括为现场快速冷却做好准备。
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引用次数: 0
Serial Serum Nicotine Concentration During VA-ECMO for Nicotine-Induced Cardiac Arrest: A Case Report VA-ECMO治疗尼古丁引起的心脏骤停期间的连续血清尼古丁浓度:1例报告。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-20 DOI: 10.1002/ams2.70173
Kensuke Minami, Takeshi Ebihara, Kazuo Harada, Hikaru Tamagawa, Yuto Sugimoto, Shunichiro Nakao, Ryosuke Takegawa, Tomoya Hirose, Hiroshi Matsumoto, Jun Oda

Background

Acute nicotine intoxication can cause cardiac arrest. We report a case of cardiac arrest managed with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) alongside serial serum nicotine monitoring.

Case Presentation

A 36-year-old woman collapsed after ingesting an unknown amount of liquid nicotine, up to 20 g. Emergency medical services found her in cardiac arrest with pulseless electrical activity (PEA). On arrival, she remained in cardiac arrest with PEA/asystole and severe acidosis, and VA-ECMO was established 82 min after ingestion. Cardiac function gradually improved, and VA-ECMO was discontinued on Day 3. However, she died on Day 28 from post-cardiac arrest brain injury. Liquid chromatography–mass spectrometry (LC/MS) revealed an admission serum nicotine concentration of 6.44 μg/mL, declining to 0.057 μg/mL within 18 h. This decline paralleled hemodynamic recovery.

Conclusion

Although neurological outcome was unfavorable, VA-ECMO may provide temporary circulatory support during the toxic phase of massive nicotine intoxication.

背景:急性尼古丁中毒可引起心脏骤停。我们报告一例心脏骤停与静脉-动脉体外膜氧合(VA-ECMO)和连续血清尼古丁监测。病例介绍:一名36岁妇女在摄入不明数量的液体尼古丁后晕倒,最多20克。紧急医疗服务发现她心脏骤停无脉电活动(PEA)。到达时,患者仍处于心脏骤停,伴有PEA/骤停和严重酸中毒,并在摄入后82分钟建立VA-ECMO。心功能逐渐改善,于第3天停用VA-ECMO。然而,她在第28天死于心脏骤停后的脑损伤。液相色谱-质谱(LC/MS)检测结果显示,入院血清尼古丁浓度为6.44 μg/mL,在18h内降至0.057 μg/mL。这种下降与血流动力学的恢复是平行的。结论:虽然神经系统预后不佳,但VA-ECMO可在大量尼古丁中毒的毒性期提供暂时的循环支持。
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引用次数: 0
Influenza-Induced Rhabdomyolysis Leading to Hyperkalemic Cardiac Arrest Managed With Venoarterial Extracorporeal Membrane Oxygenation: A Case Report 流感诱导的横纹肌溶解导致高钾血症性心脏骤停,经静脉体外膜氧合治疗:一例报告。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-19 DOI: 10.1002/ams2.70172
Yoshihiro Miyake, Tomohiro Abe, Kei Tokunaga, Shihoko Shimazu, Tatsuya Tanaka, Akira Sasaki, Masaru Hiyoshi, Toshiki Tanahashi, Kohei Moribayashi, Koichi Kaikita, Hidenobu Ochiai

Background

Influenza-induced rhabdomyolysis is an uncommon but serious complication that can cause life-threatening hyperkalemia. The use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) for hyperkalemic cardiac arrest has rarely been described.

Case Presentation

A 48-year-old woman with influenza A developed severe rhabdomyolysis (creatine kinase: 255,240 U/L) and progressive hyperkalemia despite improved renal function and continuous renal replacement therapy. On hospital day 3, the patient experienced a hyperkalemic cardiac arrest and VA-ECMO was initiated after 29 min of low-flow time. Treatment for hyperkalemia was continued, and cardiac function gradually recovered, allowing the removal of ECMO on day 8. However, she later developed hemorrhagic complications related to mechanical circulatory support and died on hospital day 89.

Conclusion

Influenza-induced rhabdomyolysis can cause rapid, life-threatening hyperkalemia, even in patients with improving renal function. Temporary mechanical circulatory support may serve as a bridge through the acute reversible phase, and device-related complications should be considered.

背景:流感诱导的横纹肌溶解是一种罕见但严重的并发症,可导致危及生命的高钾血症。静脉动脉体外膜氧合(VA-ECMO)用于高钾性心脏骤停的报道很少。病例介绍:一名48岁的甲型流感女性,尽管肾功能得到改善和持续的肾脏替代治疗,但仍出现严重的横纹肌溶解(肌酸激酶:255,240 U/L)和进行性高钾血症。住院第3天,患者出现高钾血症性心脏骤停,低流量时间29分钟后开始VA-ECMO。继续治疗高钾血症,心功能逐渐恢复,允许在第8天移除ECMO。然而,她后来出现了与机械循环支持有关的出血性并发症,并于住院第89天死亡。结论:流感诱导的横纹肌溶解可引起快速的、危及生命的高钾血症,即使在肾功能改善的患者中也是如此。临时机械循环支持可作为急性可逆期的桥梁,应考虑设备相关并发症。
{"title":"Influenza-Induced Rhabdomyolysis Leading to Hyperkalemic Cardiac Arrest Managed With Venoarterial Extracorporeal Membrane Oxygenation: A Case Report","authors":"Yoshihiro Miyake,&nbsp;Tomohiro Abe,&nbsp;Kei Tokunaga,&nbsp;Shihoko Shimazu,&nbsp;Tatsuya Tanaka,&nbsp;Akira Sasaki,&nbsp;Masaru Hiyoshi,&nbsp;Toshiki Tanahashi,&nbsp;Kohei Moribayashi,&nbsp;Koichi Kaikita,&nbsp;Hidenobu Ochiai","doi":"10.1002/ams2.70172","DOIUrl":"10.1002/ams2.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Influenza-induced rhabdomyolysis is an uncommon but serious complication that can cause life-threatening hyperkalemia. The use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) for hyperkalemic cardiac arrest has rarely been described.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 48-year-old woman with influenza A developed severe rhabdomyolysis (creatine kinase: 255,240 U/L) and progressive hyperkalemia despite improved renal function and continuous renal replacement therapy. On hospital day 3, the patient experienced a hyperkalemic cardiac arrest and VA-ECMO was initiated after 29 min of low-flow time. Treatment for hyperkalemia was continued, and cardiac function gradually recovered, allowing the removal of ECMO on day 8. However, she later developed hemorrhagic complications related to mechanical circulatory support and died on hospital day 89.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Influenza-induced rhabdomyolysis can cause rapid, life-threatening hyperkalemia, even in patients with improving renal function. Temporary mechanical circulatory support may serve as a bridge through the acute reversible phase, and device-related complications should be considered.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sepsis Mimics in the ICU: A Qualitative Study of Physicians' Diagnostic Experiences in Japan 脓毒症模拟在ICU:在日本的医生诊断经验的定性研究
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-15 DOI: 10.1002/ams2.70171
Daisuke Kasugai, Michiko Higashi, Kasumi Satoh, Genki Nakamura, Hiroaki Hiraiwa, Naruhiro Jingushi, Takanori Yamamoto, Yutaka Kondo

Background

Sepsis mimics are non-infectious conditions that resemble sepsis, leading to diagnostic uncertainty, delayed disease-specific therapy, and unnecessary antibiotics.

Methods

We conducted semi-structured online interviews with seven physicians with experience in adult general intensive care unit (ICU) practice in Japan (October–December 2023) and analyzed data using Reflexive Thematic Analysis.

Results

Four themes were generated: (1) Spectrum—participants described sepsis mimics as spanning hematologic malignancy, autoimmune/inflammatory disease, endocrine/metabolic crises, drug/toxic states, and other acute non-infectious conditions. (2) Diagnostic challenges—participants described phenotypic overlap, missing or fragmented history, organizational barriers to definitive testing in unstable patients, competing pathophysiology, and diagnostic masking by early corticosteroids. (3) Therapeutic and diagnostic strategies—participants described a sepsis-oriented initial approach with broad antibiotics and organ support, followed by reactive re-evaluation for nonresponse or early parallel work-up for selected mimics. (4) Triggers for re-evaluation—participants described reconsidering sepsis when the clinical course or physiology diverged from expectations, including discrepant hemodynamics, atypical fever patterns, focal physical signs, and metabolic abnormalities not readily explained by presumed infection.

Conclusion

Sepsis mimics were described as diagnostically challenging in ICU practice because clinical trajectories can initially resemble sepsis and because diagnostic work-up is shaped by local organizational constraints. By mapping clinicians' reasoning processes and re-evaluation cues, our findings provide a framework for understanding diagnostic uncertainty and may inform educational efforts and future research on timely recognition of sepsis mimics.

脓毒症模拟是类似脓毒症的非感染性疾病,导致诊断不确定、疾病特异性治疗延迟和不必要的抗生素。方法对日本7名具有成人普通重症监护病房(ICU)执业经验的医生(2023年10 - 12月)进行半结构化在线访谈,并使用自反性主题分析对数据进行分析。结果产生了四个主题:(1)频谱参与者将脓毒症模拟描述为跨越血液恶性肿瘤,自身免疫性/炎症性疾病,内分泌/代谢危象,药物/毒性状态和其他急性非感染性疾病。(2)诊断挑战——参与者描述了表型重叠、缺失或碎片化的病史、不稳定患者明确检测的组织障碍、竞争性病理生理学和早期皮质类固醇的诊断掩盖。(3)治疗和诊断策略——参与者描述了一种以败血症为导向的初始方法,采用广泛的抗生素和器官支持,随后对无反应的反应性重新评估或对选定的模拟患者进行早期平行检查。(4)重新评估的触发因素——参与者描述当临床过程或生理与预期不同时重新考虑败血症,包括血流动力学差异、非典型发热模式、局灶性体征和代谢异常,这些不容易用假定的感染来解释。结论脓毒症模拟在ICU实践中具有诊断挑战性,因为临床轨迹最初可能与脓毒症相似,并且诊断工作受当地组织约束。通过绘制临床医生的推理过程和重新评估线索,我们的发现为理解诊断不确定性提供了一个框架,并可能为及时识别脓毒症模拟的教育工作和未来研究提供信息。
{"title":"Sepsis Mimics in the ICU: A Qualitative Study of Physicians' Diagnostic Experiences in Japan","authors":"Daisuke Kasugai,&nbsp;Michiko Higashi,&nbsp;Kasumi Satoh,&nbsp;Genki Nakamura,&nbsp;Hiroaki Hiraiwa,&nbsp;Naruhiro Jingushi,&nbsp;Takanori Yamamoto,&nbsp;Yutaka Kondo","doi":"10.1002/ams2.70171","DOIUrl":"https://doi.org/10.1002/ams2.70171","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sepsis mimics are non-infectious conditions that resemble sepsis, leading to diagnostic uncertainty, delayed disease-specific therapy, and unnecessary antibiotics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted semi-structured online interviews with seven physicians with experience in adult general intensive care unit (ICU) practice in Japan (October–December 2023) and analyzed data using Reflexive Thematic Analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four themes were generated: (1) Spectrum—participants described sepsis mimics as spanning hematologic malignancy, autoimmune/inflammatory disease, endocrine/metabolic crises, drug/toxic states, and other acute non-infectious conditions. (2) Diagnostic challenges—participants described phenotypic overlap, missing or fragmented history, organizational barriers to definitive testing in unstable patients, competing pathophysiology, and diagnostic masking by early corticosteroids. (3) Therapeutic and diagnostic strategies—participants described a sepsis-oriented initial approach with broad antibiotics and organ support, followed by reactive re-evaluation for nonresponse or early parallel work-up for selected mimics. (4) Triggers for re-evaluation—participants described reconsidering sepsis when the clinical course or physiology diverged from expectations, including discrepant hemodynamics, atypical fever patterns, focal physical signs, and metabolic abnormalities not readily explained by presumed infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sepsis mimics were described as diagnostically challenging in ICU practice because clinical trajectories can initially resemble sepsis and because diagnostic work-up is shaped by local organizational constraints. By mapping clinicians' reasoning processes and re-evaluation cues, our findings provide a framework for understanding diagnostic uncertainty and may inform educational efforts and future research on timely recognition of sepsis mimics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ams2.70171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sports-Related Out-of-Hospital Cardiac Arrest due to External Causes, Including Commotio Cordis, at Schools in Japan 日本学校因外因(包括心梗)引起的与运动相关的院外心脏骤停
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-14 DOI: 10.1002/ams2.70168
Kosuke Kiyohara, Mamoru Ayusawa, Masahiko Nitta, Taku Iwami, Ken Nakata, Yuri Kitamura, Tetsuhisa Kitamura

Introduction

To describe the characteristics and outcomes of sports-related out-of-hospital cardiac arrest (OHCA) due to external causes, including commotio cordis, during school-supervised sports activities in Japan's elementary schools, junior high schools, high schools, and technical colleges.

Methods

OHCA data (2008–2022) were obtained from the Stop and Prevent cardIac aRrest, Injury, and Trauma in Schools (SPIRITS)—a nationwide database of OHCAs occurring under school supervision across Japan. We identified sports-related OHCAs with external causes and summarized patients' characteristics, bystander interventions, available response intervals, and survival outcomes.

Results

We identified 30 sports-related OHCA cases due to external causes. The most frequently played sports were soccer/futsal (n = 8), baseball (n = 8), and swimming (n = 4). The leading etiology was commotio cordis (n = 15), followed by drowning (n = 8). Among the 15 cases meeting our operational definition of commotio cordis, automated external defibrillator (AED) pads were applied in 14 (93%), shocks were delivered in 13 (87%), and 12 (80%) achieved a favorable neurological outcome. Among other external causes (n = 15), ventricular fibrillation occurred in 4/15 (27%), AED pads were applied in 7/15 (47%), shocks were rare (1/15, 7%), and 1/15 (7%) achieved favorable neurological outcomes.

Conclusions

Nationwide case-level reconstruction revealed distinct mechanism-to-response pathways. Although these descriptive data cannot establish the causal effects of the public access defibrillation programs or other interventions on outcomes, they highlight potentially actionable, mechanism-specific opportunities for emergency response and prevention.

前言:描述日本小学、初中、高中和技术学院在学校监督的体育活动中,由于外因(包括心梗)引起的与运动相关的院外心脏骤停(OHCA)的特征和结果。方法:OHCA数据(2008-2022年)来自学校停止和预防心脏骤停、伤害和创伤(SPIRITS),这是日本学校监督下发生的OHCA的全国性数据库。我们确定了与运动相关的外因ohca,并总结了患者的特征、旁观者干预、可用的反应间隔和生存结果。结果:我们确定了30例由外因引起的与运动相关的OHCA病例。最常参加的运动是足球/五人制足球(n = 8)、棒球(n = 8)和游泳(n = 4)。主要病因是心功能紊乱(n = 15),其次是溺水(n = 8)。在符合我们对心梗的操作定义的15例患者中,14例(93%)使用了自动体外除颤器(AED)垫,13例(87%)接受了电击,12例(80%)获得了良好的神经预后。在其他外因(n = 15)中,4/15例发生心室颤动(27%),7/15例使用AED垫(47%),电击罕见(1/15,7%),1/15例(7%)获得良好的神经系统预后。结论:全国范围的病例重建揭示了不同的机制-反应途径。尽管这些描述性数据不能确定公共除颤器项目或其他干预措施对结果的因果影响,但它们强调了应急响应和预防的潜在可操作、特定机制的机会。
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引用次数: 0
Apixaban-Associated Sublingual Hematoma Causing Pseudo-Ludwig's Angina 阿哌沙班相关舌下血肿引起假性路德维希心绞痛。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-12 DOI: 10.1002/ams2.70170
Eiryu Sakihara, Masahiro Kashiura, Takashi Moriya

Apixaban-associated sublingual hematoma can mimic Ludwig's angina and cause delayed airway obstruction despite a stable initial presentation. Clinicians should prioritize airway monitoring and anticoagulation reversal and avoid routine surgical drainage unless infection is suspected.

阿哌沙班相关的舌下血肿可以模拟路德维希心绞痛,并引起迟发性气道阻塞,尽管最初表现稳定。临床医生应优先考虑气道监测和抗凝逆转,避免常规手术引流,除非怀疑感染。
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引用次数: 0
Serial Calcium Monitoring Revealed Primary Hyperparathyroidism in Severe Acute Pancreatitis: A Case Report 系列钙监测显示原发性甲状旁腺功能亢进在严重急性胰腺炎:1例报告。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-10 DOI: 10.1002/ams2.70167
Mitsuki Yokota, Hajime Nakajima, Takeshi Ebihara, Kensuke Minami, Kazuhiro Yoneda, Yusuke Katayama, Jun Oda

Background

Hypocalcemia is commonly monitored as a severity marker in acute pancreatitis, whereas hypercalcemia is an uncommon but important clue to primary hyperparathyroidism (PHPT).

Case Presentation

A 42-year-old man without gallstones, tumor, or alcohol use developed severe acute pancreatitis, with organ failure persisting beyond 48 h. His corrected calcium level was at the lower reference limit on admission but rose from Day 3, exceeded the upper reference limit on Day 4, and reached a peak of 18 mg/dL on Day 21. Intact parathyroid hormone was elevated, and cervical ultrasonography showed a parathyroid mass. PHPT was diagnosed on Day 24. Severe hypercalcemia with concomitant renal dysfunction required continuous hemodiafiltration, cinacalcet, elcatonin, and zoledronic acid. Parathyroidectomy on Day 35 confirmed parathyroid adenoma, and serum calcium normalized on Day 36. He required drainage of intra-abdominal abscesses and was transferred for rehabilitation on Day 170.

Conclusion

In patients with severe acute pancreatitis, a calcium level that is not elevated on admission does not exclude PHPT. A rise in serum calcium during the clinical course can be an important diagnostic clue prompting re-evaluation for PHPT.

背景:低钙血症通常被监测为急性胰腺炎的严重程度标志,而高钙血症是原发性甲状旁腺功能亢进(PHPT)的不常见但重要的线索。病例介绍:一名42岁男性,无胆结石、肿瘤或酒精使用,并发严重急性胰腺炎,器官衰竭持续48小时以上。他的校正钙水平在入院时处于参考下限,但从第3天开始上升,第4天超过参考上限,并在第21天达到18 mg/dL的峰值。完整的甲状旁腺激素升高,宫颈超声显示甲状旁腺肿块。第24天诊断为PHPT。严重的高钙血症并伴有肾功能不全需要持续的血液滤过,cinacalcet, elcatonin和唑来膦酸。第35天行甲状旁腺切除术证实甲状旁腺瘤,第36天血清钙恢复正常。患者需要引流腹腔内脓肿,并于第170天转院康复。结论:在重症急性胰腺炎患者中,入院时钙水平未升高并不排除PHPT。在临床过程中血清钙升高可作为提示重新评估PHPT的重要诊断线索。
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引用次数: 0
Perioperative Airway Strategy for Madelung's Disease With Severe Obstructive Sleep Apnea 马德隆病伴严重阻塞性睡眠呼吸暂停的围手术期气道策略
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-10-06 DOI: 10.1002/ams2.70166
Taiga Ishihara, Gaku Kawamura, Michiko Ushio, Kanji Uchida

A 61-year-old man with Madelung's disease presented for excision of a cervical lipoma (Figure 1A,B). Fiberoptic examination revealed posterior pharyngeal wall bulging with airway narrowing (Figure 1C), and computed tomography showed diffuse fat surrounding the anterior neck and spine (Figure 1D). Severe obstructive sleep apnea, a perioperative risk factor [1, 2], prompted preoperative continuous positive airway pressure initiation.

Cervical lipomatosis predicted failure of emergency front-of-neck access [3], and a maximum mouth opening of two fingerbreadths indicated difficult direct laryngoscopy [4]. Awake oral fiberoptic intubation was performed under nebulized lidocaine with intravenous fentanyl-droperidol sedation, and a 7-mm endotracheal tube was advanced without resistance. Had intubation failed, the plan was to abort while maintaining spontaneous ventilation and postpone surgery [5].

An initial absent cuff leak prompted continued intubation with daily retesting, while diuretics corrected positive fluid balance, gradually restoring the leak. Methylprednisolone was administered on postoperative Day 6; a spontaneous breathing trial confirmed readiness. On Day 7, extubation proceeded with extracorporeal membrane oxygenation on standby and pre-secured vascular access.

In Madelung's disease, where both intubation and emergency surgical airway may fail, awake intubation, which allows abortion if needed, should be chosen at induction, and extubation should not proceed without considering extracorporeal rescue.

This work was supported by the Japan Society for the Promotion of Science, JP26K11829.

The authors have nothing to report.

Written informed consent for publication was obtained from the patient.

The authors declare no conflicts of interest.

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

61岁男性马德隆病患者因宫颈脂肪瘤切除而就诊(图1A,B)。纤维检查显示咽后壁膨出伴气道狭窄(图1C),计算机断层扫描显示颈部和脊柱前壁周围弥漫性脂肪(图1D)。重度阻塞性睡眠呼吸暂停是围手术期的危险因素[1,2],可促使术前开始持续气道正压通气。颈部脂肪增多症预示着紧急颈前通道[3]的失败,而最大开口两个指宽表明直接喉镜检查[4]困难。醒时口服纤维气管插管,雾化利多卡因,静脉注射芬太尼-哌啶醇镇静,气管插管7mm,无阻力。如果插管失败,计划流产,同时保持自发通气,并推迟手术。最初无袖漏提示继续插管,每日复查,而利尿剂纠正阳性液体平衡,逐渐恢复泄漏。术后第6天给予甲强的松龙;自主呼吸试验确认准备就绪。在第7天,拔管进行备用体外膜氧合和预固定血管通路。在马德隆病中,插管和紧急手术气道都可能失败,在诱导时应选择清醒插管,以便在需要时流产,并且在不考虑体外抢救的情况下不应拔管。这项工作得到了日本科学促进会的支持,JP26K11829。作者没有什么可报告的。获得患者的书面知情同意发表。作者声明无利益冲突。支持本研究结果的数据可向通讯作者索取。由于隐私或道德限制,这些数据不会公开。
{"title":"Perioperative Airway Strategy for Madelung's Disease With Severe Obstructive Sleep Apnea","authors":"Taiga Ishihara,&nbsp;Gaku Kawamura,&nbsp;Michiko Ushio,&nbsp;Kanji Uchida","doi":"10.1002/ams2.70166","DOIUrl":"10.1002/ams2.70166","url":null,"abstract":"<p>A 61-year-old man with Madelung's disease presented for excision of a cervical lipoma (Figure 1A,B). Fiberoptic examination revealed posterior pharyngeal wall bulging with airway narrowing (Figure 1C), and computed tomography showed diffuse fat surrounding the anterior neck and spine (Figure 1D). Severe obstructive sleep apnea, a perioperative risk factor [<span>1, 2</span>], prompted preoperative continuous positive airway pressure initiation.</p><p>Cervical lipomatosis predicted failure of emergency front-of-neck access [<span>3</span>], and a maximum mouth opening of two fingerbreadths indicated difficult direct laryngoscopy [<span>4</span>]. Awake oral fiberoptic intubation was performed under nebulized lidocaine with intravenous fentanyl-droperidol sedation, and a 7-mm endotracheal tube was advanced without resistance. Had intubation failed, the plan was to abort while maintaining spontaneous ventilation and postpone surgery [<span>5</span>].</p><p>An initial absent cuff leak prompted continued intubation with daily retesting, while diuretics corrected positive fluid balance, gradually restoring the leak. Methylprednisolone was administered on postoperative Day 6; a spontaneous breathing trial confirmed readiness. On Day 7, extubation proceeded with extracorporeal membrane oxygenation on standby and pre-secured vascular access.</p><p>In Madelung's disease, where both intubation and emergency surgical airway may fail, awake intubation, which allows abortion if needed, should be chosen at induction, and extubation should not proceed without considering extracorporeal rescue.</p><p>This work was supported by the Japan Society for the Promotion of Science, JP26K11829.</p><p>The authors have nothing to report.</p><p>Written informed consent for publication was obtained from the patient.</p><p>The authors declare no conflicts of interest.</p><p>The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.</p>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Acute Medicine & Surgery
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