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Evaluation of tortuosity: A radical tessellation-based method in porous spherical particle packing systems 弯曲度的评估:多孔球形颗粒填充系统中基于径向镶嵌的方法
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-03-01 Epub Date: 2026-02-21 DOI: 10.1016/j.apt.2026.105191
Zongli Chen, Chenzhe Li, Ying Zhao
Estimating the tortuosity of porous electrodes is important for understanding the performance of lithium-ion batteries and optimizing the design of electrode microstructures. In this work, an improved method for estimating the tortuosity of porous electrodes is proposed based on radical tessellation, and the results agree well with those calculated by empirical formulas and finite element simulations. Compared with empirical formulas, the proposed method can estimate tortuosity for more complicated microstructures, regardless of particle distribution and size dispersity; compared with finite element simulations, the proposed method offers a significant advantage in computational efficiency. Based on the method, the influence of different microstructure characters on the tortuosity is discussed. It is found that in addition to the porosity, the particle size and particle aggregation morphology are all critical in influencing the tortuosity of the porous electrode. Finally, the tortuosity obtained by this method is integrated into the Pseudo-2-dimension (P2D) model for the calculation of effective properties, and the results show that this method offers an efficient way in improving the prediction accuracy of P2D models.
估算多孔电极的弯曲度对于理解锂离子电池的性能和优化电极微结构设计具有重要意义。本文提出了一种基于径向镶嵌的多孔电极弯曲度估计方法,其计算结果与经验公式和有限元模拟结果吻合较好。与经验公式相比,该方法可以在不考虑颗粒分布和尺寸分散性的情况下估计更复杂的微观结构的扭曲度;与有限元模拟相比,该方法在计算效率上具有显著优势。在此基础上,讨论了不同微观结构特征对弯曲度的影响。研究发现,除孔隙率外,颗粒尺寸和颗粒聚集形态都是影响多孔电极弯曲度的关键因素。最后,将该方法得到的弯曲度整合到伪二维(P2D)模型中进行有效特性的计算,结果表明该方法为提高P2D模型的预测精度提供了一种有效的方法。
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引用次数: 0
Design and investigation on structural, dielectric and electrical features of novel ferrite based particulate composites 新型铁氧体基颗粒复合材料结构、介电特性及电学特性的设计与研究
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-03-01 Epub Date: 2026-02-06 DOI: 10.1016/j.apt.2026.105192
Khushboo Birra , Shraddha C. Shirbhate , Pranay R. Kautkar , Samir M. Khule , Sanjay B. Nagdeote , K. Pushpanjali Patra , Vishwajit M. Gaikwad
Zinc ferrite based (1-x)ZnFe2O4(ZFO)-xNiO(NO) (x = 0–40%) composites are synthesized via solid state sintering method. Structural studies reveal the lattice parameters of composites are significantly influenced by the interfacial strain induced at the interfaces of composites. Internal atomic surroundings of both ZFO and NO unit cells are getting modified by composite formation. FTIR spectra indicate structural stability without any structural modulation after the inclusion of NO phase into ZFO matrix. The homogeneous distribution of ZFO and NO grains with significant grain connectivity is noticed for all composite samples. Room temperature dielectric studies indicate the enhancement of dielectric constant and improvement in dielectric loss with the incorporation of NO phase into ZFO matrix. The low frequency dielectric constant values of composites follow effective medium approximation (EMA) model. The interfaces between ZFO and NO phases create conductive interfaces that are accountable for overall enhancement in electrical properties of composites.
采用固相烧结法合成了铁酸锌基(1-x)ZnFe2O4(ZFO)-xNiO(NO) (x = 0-40%)复合材料。结构研究表明,界面应变对复合材料的晶格参数有显著影响。ZFO和NO单元胞的内部原子环境都被复合材料的形成所改变。FTIR光谱表明,加入NO相后,ZFO基体结构稳定,无任何结构调制。ZFO和NO晶粒均匀分布,具有明显的晶粒连通性。室温介电特性研究表明,NO相掺入ZFO基体可以提高介电常数,改善介电损耗。复合材料的低频介电常数值遵循有效介质近似(EMA)模型。ZFO和NO相之间的界面产生导电界面,这是复合材料电性能整体增强的原因。
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引用次数: 0
Effect of counterpart material on glass particle morphology in binary component attrition milling evaluated by experiment and DEM simulation 通过实验和DEM模拟评价了双组份磨粒铣削过程中对应材料对玻璃颗粒形貌的影响
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2025-12-31 DOI: 10.1016/j.apt.2025.105150
Chiharu Tokoro , Yuki Murata , Yutaro Takaya , Hidehiro Kamiya , Kohei Komori , O Shourin
This study investigated the fragmentation of glass particles in binary mixtures with alumina, steel, and lead during attrition milling. The fragmentation kinetics, particle size distributions, and fragment morphologies were evaluated experimentally, and kinetic parameters were extracted using a population balance model. Discrete element method simulations clarified the dynamic interactions governing the material-dependent fragmentation. The results indicated that the mechanical properties of the counterpart materials strongly affected the collision intensity and fragment morphology. Alumina induces frequent high-energy collisions and efficient size reduction, producing irregular angular fragments. When lead was used, glass exhibited minimal fragmentation because the collision energy dissipated through plastic deformation during prolonged contact. Steel exhibited moderate fragmentation and generates fragments with low aspect ratios and high circularities suitable for recycling applications. The integration of experiments and simulations elucidated selective comminution mechanisms in heterogeneous systems and demonstrated that fragmentation efficiency and particle morphology can be tuned by the choice of counterpart material.
本研究考察了氧化铝、钢和铅二元混合物中玻璃颗粒在磨粒过程中的破碎情况。实验评估了破碎动力学、粒径分布和碎片形态,并利用种群平衡模型提取了动力学参数。离散元法模拟阐明了控制材料相关破碎的动态相互作用。结果表明,对应材料的力学性能对碰撞强度和碎片形貌有很大影响。氧化铝引起频繁的高能碰撞和有效的尺寸减小,产生不规则的角碎片。当使用铅时,玻璃表现出最小的碎片,因为碰撞能量在长时间接触期间通过塑性变形消散。钢表现出适度的破碎,产生的碎片具有低宽高比和高圆度,适合回收利用。实验和模拟的结合阐明了非均相系统中的选择性粉碎机制,并表明可以通过选择对应材料来调节破碎效率和颗粒形态。
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引用次数: 0
Neutron irradiation-enhanced orange-red emission in double perovskite phosphors for harsh radiation environments 中子辐照增强双钙钛矿荧光粉在恶劣辐射环境中的橙红色发射
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.1016/j.apt.2026.105173
Noor Zamin Khan , Zhe Qin , Sayed Ali Khan , Anqi Lin , Zhuan Zhao , Muhammad Amin Padhiar , Zakir Ullah , Sonehra Anjum , Shimao Wang , Gang Meng
In this study, double perovskite Ca2LuTaO6:Sm3+ oxide phosphors were subjected to 14 MeV neutron irradiation with a total fluence of 1 × 1013n/cm2 to evaluate their performance for space applications. A detailed investigation of photoluminescence (PL), crystal structure, X-ray photoelectron spectroscopy (XPS), and surface morphology for pre- and post-exposure to neutron irradiation. The PL results demonstrated that neutron-irradiated samples exhibit a significantly higher luminescence intensity compared to their non-irradiated counterparts. Notably, the sample with an 0.05Sm3+ doping concentration showed over 15% increase in luminescence intensity for the orange-red emission, peaking at 603 nm under 407 nm excitation, following irradiation. This observation challenges the conventional belief that high-energy radiation invariably degrades optical properties. Our results reveal that neutron irradiation induces beneficial defects, such as oxygen vacancies and lattice distortions, which effectively suppress non-radiative recombination and enhance Sm3+ emission. Furthermore, the Ca2LuTaO6:Sm3+ samples exhibit remarkable durability under neutron irradiation. The optical and structural characteristics indicate that Sm3+-doped Ca2LuTaO6 is a promising orange-red phosphorescent material for applications in harsh radiative environments.
本研究对双钙钛矿Ca2LuTaO6:Sm3+氧化物荧光粉进行了14 MeV中子辐照,总辐照量为1 × 1013n/cm2,以评估其空间应用性能。详细研究了中子辐照前后的光致发光(PL)、晶体结构、x射线光电子能谱(XPS)和表面形貌。PL结果表明,中子辐照样品的发光强度明显高于未辐照样品。值得注意的是,当掺杂浓度为0.05Sm3+时,样品在407 nm激发下的橘红色发光强度增加了15%以上,在603 nm处达到峰值。这一观察结果挑战了高能辐射必然会降低光学性能的传统观念。结果表明,中子辐照可诱导氧空位和晶格畸变等有利缺陷,有效抑制非辐射复合,增强Sm3+发射。此外,Ca2LuTaO6:Sm3+样品在中子辐照下表现出显著的耐久性。光学和结构特性表明,Sm3+掺杂的Ca2LuTaO6是一种很有前途的在恶劣辐射环境下应用的橘红色磷光材料。
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引用次数: 0
Dual role of redox-active V2O5/CeO2 nanocomposite electrodes in high-performance supercapacitor and battery applications 氧化还原活性V2O5/CeO2纳米复合电极在高性能超级电容器和电池中的双重作用
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1016/j.apt.2026.105185
K. Sutharthani, S.S. Pradeepa, R. Suba Devi, M. Sivakumar
Electrochemical attributes of transition metal oxide hybrids are an active domain of research for energy storage applications. This study strives to explore the plausible performance of V2O5/CeO2 nanocomposite in supercapacitor applications and their anode capabilities in Lithium-ion batteries (LIBs). Egg albumin is tapped as a bioreactor solvent for CeO2 synthesis. Microstructural analysis confirmed the successful integration of CeO2 into the V2O5 matrix, exhibiting a BET surface area of 32 m2 g−1 and excellent elemental homogeneity. Owing to their intriguing redox properties, the conjunction of V5+ and Ce4+ redox duos refines the diffusivity, thereby resulting in optimum performance in both applications. The discharge capacity of the V2O5/CeO2 nanocomposite was quantified as 1146.57 mAh g−1 at a current density of 0.1 A g−1. After 100 cycles at 1 A g−1, it retained 235.76 mAh g−1, exhibiting an 82.8 % capacity retention. As a supercapacitor electrode, it demonstrated a specific capacitance of 1173.05 F g−1 at 1 A g−1. The cyclic stability of the nanocomposite was verified over 5000 cycles with capacity retention of 97.4 %. The cumulative dissection of the V2O5/CeO2 nanocomposite showcased its strong potential in electrochemical applications.
过渡金属氧化物杂化材料的电化学性质是储能领域研究的热点。本研究旨在探索V2O5/CeO2纳米复合材料在超级电容器中的合理性能及其在锂离子电池(LIBs)中的负极性能。利用鸡蛋白蛋白作为生物反应器溶剂进行CeO2合成。显微结构分析证实CeO2成功地整合到V2O5基体中,表现出32 m2 g−1的BET表面积和良好的元素均匀性。由于其有趣的氧化还原特性,V5+和Ce4+氧化还原基团的结合改善了扩散率,从而在两种应用中都获得了最佳性能。在0.1 a g−1电流密度下,V2O5/CeO2纳米复合材料的放电容量为1146.57 mAh g−1。在1 A g−1下循环100次后,它保留了235.76 mAh g−1,容量保留率为82.8%。作为超级电容器电极,它在1ag−1时的比电容为1173.05 F g−1。经过5000次循环验证,纳米复合材料的容量保持率为97.4%。V2O5/CeO2纳米复合材料的累积解剖表明其具有很强的电化学应用潜力。
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引用次数: 0
Novel eccentric-pelletisation for rifampicin agglomerates: Process optimization and high-dose pulmonary delivery 利福平凝聚体的新型偏心颗粒化:工艺优化和大剂量肺给药
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2026-01-19 DOI: 10.1016/j.apt.2026.105178
Jianhui Liu , Hang Zhou , Jiale Chen , Ying Ma , Shuangxi Shao , Honglei Zhang , Xiang Luo , Kaiqi Shi , Chongjiang Cao , Jesse Zhu , Dechun Huang
High-dose inhaled therapy offers a promising approach for respiratory infections, requiring efficient particle engineering. While fine particles from the milling process improved lung deposition, their poor flowability and high cohesion posed significant challenges for handling and dosing. In this study, a novel eccentric-pelletisation machine was developed to transform purely fine rifampicin powders into spherical agglomerates, significantly improving their flowability, dispersibility, and handling properties. Key manufacturing parameters − including relative humidity (60–70%), eccentric speed (240 rpm), eccentric time (20 min), and sieve size (400 µm) − were systematically optimized using an L9(34) orthogonal design. The optimized rifampicin agglomerates exhibited favorable properties, including bulk density (∼0.35 g/cm3), flow rate (∼0.59 g/s), roundness (∼0.92), yield (∼89.68%), and fine particle fraction/mass (>55%/5 mg), ensuring efficient high-dose delivery. Furthermore, the optimized agglomerates from three batches demonstrated excellent reproducibility of aerodynamic and physical properties. This study highlights the potential of the eccentric-pellestisation machine as a robust and scalable platform for producing inhalable rifampicin formulations, providing a foundation for industrial production and clinical applications for respiratory infections.
高剂量吸入治疗为呼吸道感染提供了一种很有前途的方法,但需要有效的粒子工程。虽然研磨过程中产生的细颗粒改善了肺沉积,但它们的流动性差和高凝聚力给处理和给药带来了重大挑战。在这项研究中,开发了一种新型的偏心制粒机,将纯利福平粉末转化为球形团块,显著提高了它们的流动性、分散性和处理性能。关键的制造参数-包括相对湿度(60-70%),偏心转速(240 rpm),偏心时间(20分钟)和筛尺寸(400µm) -使用L9(34)正交设计进行系统优化。优化后的利福平团聚体具有良好的性能,包括堆积密度(~ 0.35 g/cm3)、流速(~ 0.59 g/s)、圆度(~ 0.92)、收率(~ 89.68%)和细颗粒分数/质量(>55%/ 5mg),确保了高效的高剂量递送。此外,三批优化后的团聚体表现出良好的空气动力学和物理性能的再现性。这项研究强调了离心吸药机作为生产可吸入利福平制剂的强大且可扩展的平台的潜力,为呼吸道感染的工业生产和临床应用提供了基础。
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引用次数: 0
Measurement and calibration of bonding parameters for a multi-scale DEM model of corn ears: experiment and simulation alignment 玉米穗多尺度DEM模型粘接参数的测量与标定:实验与仿真对准
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI: 10.1016/j.apt.2026.105175
Dandan Han , Tingyi Mo , Yunxia Wang , Chao Tang , Lin Chen , Lijia Xu
An innovative flexible corn ear Discrete Element Method (DEM) model was established to effectively capture hierarchical anatomical properties of the corncob. By embedding kernel apices within the interstitial voids of xylem annulus particles and establishing multi-point adhesive connections, the model facilitates detachable kernel mechanics and corncob fracture dynamics. Experimental quantification yielded circumferential and axial threshing forces of 19.24 N and 28.70 N for four kernels arranged in a 2 × 2 matrix pattern relative to the corncob. These measurements served as benchmark criteria for systematic bonding parameter calibration. Sequential application of optimization tests identified the optimal bonding parameter set governing kernel–corncob interactions. Model validation demonstrated simulated circumferential and axial threshing forces of 19.37 N and 28.83 N, yielding relative errors of 0.68 % and 0.42 %. Implementation of the calibrated ear DEM model for longitudinal axial flow threshing apparatus simulation successfully reproduced dynamic bond failure mechanisms between kernels and corncob, axial kernel distribution patterns within the cylinder, and the inverse correlation between unthreshed rate and cylinder rotational velocity. The developed flexible ear DEM model substantially advances simulation authenticity and accuracy for threshing processes, furnishing a robust computational platform and theoretical basis for investigating low-loss, high-efficiency threshing separation mechanisms.
建立了一种新颖的柔性玉米穗离散元法(DEM)模型,有效地捕捉了玉米穗轴的层次解剖特性。该模型通过将核尖嵌入木质部环颗粒的间隙空隙中,建立多点黏附连接,实现了核可分离力学和玉米芯断裂动力学。实验量化得到4粒玉米相对于玉米芯呈2 × 2矩阵排列时,圆周脱粒力为19.24 N,轴向脱粒力为28.70 N。这些测量结果作为系统键合参数校准的基准标准。优化试验的连续应用确定了控制玉米粒-玉米芯相互作用的最佳键合参数集。模型验证表明,模拟的周向和轴向脱粒力分别为19.37 N和28.83 N,相对误差分别为0.68%和0.42%。在纵向轴流脱粒装置模拟中,利用标定后的穗部DEM模型成功再现了玉米粒与玉米芯之间的动态粘结破坏机制、筒内轴向籽粒分布模式以及脱粒率与筒内转速的负相关关系。所开发的柔性脱粒DEM模型大大提高了脱粒过程仿真的真实性和准确性,为研究低损失、高效率脱粒分离机制提供了强大的计算平台和理论基础。
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引用次数: 0
Eco-friendly Typha latifolia gold quantum dots with microfluidic-boosted antimicrobial and antioxidant performance 生态友好型Typha latifolia金量子点与微流体增强抗菌和抗氧化性能
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2026-01-17 DOI: 10.1016/j.apt.2025.105161
Kimia Torabi , Fateme Aghamir , Zinab Moradi Alvand , Ghasem Eghlima
This study introduces a sustainable and green approach for synthesizing gold quantum dots (Au QDs) using an ultrasound–assisted method with Typha latifolia leaf extract serving as both the reducing and stabilizing agent. Optimization via Box–Behnken design yielded monodisperse nanoparticles with high crystallinity and a predominantly spherical morphology, exhibiting an average diameter of 6.8 ± 4.7 nm. Spectroscopic and microscopic analyses (XRD, UV–Vis, DLS, FTIR, TEM) confirmed successful formation and surface functionalization of the Au QDs. Antibacterial assessments revealed that the Au QDs achieved complete inhibition of Bacillus subtilis and Escherichia coli at MIC values of 0.20 and 0.40 mg/mL, representing a fold improvement over the crude extract. Integration with a microfluidic platform accelerated bactericidal action, enabling rapid detection of potassium ion leakage (1.57 ± 0.09 ppm for B. subtilis, 1.34 ± 0.06 ppm for E. coli) within 30 min—approximately 50 % faster than conventional assays. Antioxidant performance improved markedly, with DPPH, ABTS, and NO scavenging activities increasing by 28–46 % relative to the extract. Biosafety evaluations using Allium cepa, Artemia urmiana, and MTT assays indicated negligible cytotoxicity and genotoxicity across tested concentrations. Collectively, these results demonstrate that T. latifolia–derived Au QDs possess strong antimicrobial and antioxidant activities, rapid microfluidic–enabled responsiveness, and excellent biosafety, establishing them as promising candidates for translational biomedical and environmental applications.
本文介绍了一种可持续、绿色的超声辅助合成金量子点(Au QDs)的方法,该方法以蓖麻叶提取物为还原剂和稳定剂。通过Box-Behnken设计优化得到了高结晶度的单分散纳米颗粒,其平均直径为6.8±4.7 nm。光谱和微观分析(XRD, UV-Vis, DLS, FTIR, TEM)证实了Au量子点的成功形成和表面功能化。抑菌试验结果表明,在MIC值分别为0.20和0.40 mg/mL时,Au QDs对枯草芽孢杆菌和大肠杆菌具有完全抑制作用,比粗提物提高了1倍。与微流控平台的集成加速了杀菌作用,能够在30分钟内快速检测到钾离子泄漏(枯草芽孢杆菌为1.57±0.09 ppm,大肠杆菌为1.34±0.06 ppm),比常规检测快了约50%。抗氧化性能显著提高,DPPH、ABTS和NO清除活性较提取物提高28 - 46%。使用葱、青蒿和MTT测定的生物安全性评价表明,在不同的测试浓度下,细胞毒性和遗传毒性可以忽略不计。综上所述,这些研究结果表明,金针叶衍生的金量子点具有很强的抗菌和抗氧化活性,快速的微流体响应能力,以及出色的生物安全性,使其成为转化生物医学和环境应用的有希望的候选者。
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引用次数: 0
Effect of manufacturing route on powder biomaterial Co–Cr–Mo–W dental implants: microstructural and environmental assessment 制备工艺对粉末生物材料Co-Cr-Mo-W种植体的影响:显微结构和环境评价
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.apt.2026.105186
Deepak Sharma , Sanjeev Kumar , Varun Sharma
Microwave sintering, a form of powder metallurgy, and direct metal laser sintering, an additive manufacturing technique, have enhanced the efficiency and sustainability of processing CoCrMoW alloy powder biomaterials used in dental applications. This work examines the microstructural, mechanical, corrosion, and sustainability performance of CoCrMoW dental implants fabricated through two distinct routes. Dental implants fabricated with the direct rapid tooling route exhibited a fully melted, dense microstructure with smooth surfaces and low porosity (3.02%), which enhanced densification, reduced oxidation, and increased crystallinity. On the other hand, dental implants fabricated through the indirect rapid tooling route showed rougher surfaces and higher porosity (38.19%), as well as higher hardness due to the formation of an amorphous phase and oxide dispersion strengthening. Additionally, they exhibited improved corrosion resistance due to the formation of an effective protective oxide film. The direct rapid tooling route demonstrated a significantly lower potential for global warming (0.34 kg CO2 eq) and fewer repercussions on ecosystems, human health, and resource depletion compared to indirect rapid tooling (19.53 kg CO2 eq). This study has demonstrated that the direct rapid tooling approach offers a superior, more efficient, and environmentally responsible route for fabricating CoCrMoW alloy dental implants.
微波烧结是粉末冶金的一种形式,直接金属激光烧结是一种增材制造技术,提高了加工牙科用CoCrMoW合金粉末生物材料的效率和可持续性。本研究考察了通过两种不同途径制备的CoCrMoW牙种植体的显微结构、机械、腐蚀和可持续性性能。采用直接快速加工工艺制备的牙种植体具有完全熔化、致密的微观结构,表面光滑,孔隙率低(3.02%),增强了致密化,减少了氧化,提高了结晶度。另一方面,通过间接快速加工方法制备的种植体表面更粗糙,孔隙率更高(38.19%),由于非晶相的形成和氧化物弥散强化,硬度更高。此外,由于形成有效的氧化保护膜,它们表现出更好的耐腐蚀性。与间接快速加工(19.53 kg CO2当量)相比,直接快速加工路线对全球变暖的潜在影响显著降低(0.34 kg CO2当量),对生态系统、人类健康和资源枯竭的影响也更小。该研究表明,直接快速加工方法为制造CoCrMoW合金牙科种植体提供了一种更优越、更高效、更环保的途径。
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引用次数: 0
Internal geometry optimization of a vacuum rotary kiln for enhanced low-temperature drying of pharmaceutical solids 真空回转窑的内部几何结构优化,以提高低温干燥药物固体
IF 4.2 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-02-01 Epub Date: 2026-01-06 DOI: 10.1016/j.apt.2025.105162
Yuka Fukushima , Toshiki Nakamura , Fumihiko Kato , Shizuki Ohshima , Motoharu Suzuki , Kohei Tahara
Low-temperature drying is a critical step for ensuring the product quality and long-term stability of pharmaceutical solids such as granules and tablets. Vacuum rotary kilns have a wide range of industrial applications and are potentially applicable to the low-temperature drying of pharmaceutical solids. In this study, a vacuum rotary kiln was modified by the utilization of a hot-water circulation unit to improve the heat transfer efficiency and addition of internal structural components to the rotating cylinder to improve the powder flow characteristics. Experiments demonstrated that these components promoted the ideal cascading motion, which increased contact between the granules and heated cylinder wall and improved mixing uniformity throughout the powder bed. Numerical simulations were conducted to visualize particle trajectories and contact areas and quantify mixing indices. Among the internal structural components tested, flights with an axial gradient and high contact frequency with the powder bed as well as metal liners with high porosity enhanced the drying efficiency by reducing the drying time and minimizing localized overheating. These results demonstrate the potential applicability of vacuum rotary kilns to the low-temperature drying process of pharmaceutical solids by optimizing their internal geometry.
低温干燥是保证颗粒、片剂等药用固体产品质量和长期稳定性的关键步骤。真空回转窑具有广泛的工业应用,在医药固体的低温干燥中具有潜在的应用前景。本研究利用热水循环装置对真空回转窑进行了改造,提高了传热效率,并在旋转筒体上增加了内部结构部件,改善了粉体流动特性。实验表明,这些成分促进了理想的级联运动,增加了颗粒与加热圆筒壁的接触,提高了整个粉床的混合均匀性。数值模拟显示了颗粒轨迹和接触面积,量化了混合指数。在测试的内部结构部件中,轴向梯度高接触频率的飞片和高孔隙率的金属衬垫通过缩短干燥时间和减少局部过热来提高干燥效率。这些结果表明,通过优化真空回转窑的内部结构,真空回转窑在制药固体的低温干燥过程中具有潜在的适用性。
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引用次数: 0
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Advanced Powder Technology
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