Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis最新文献

In 56 patients with simple obesity blood glucose and insulin levels were assessed under fasting conditions and after oral glucose tolerance test. Besides, several lipid metabolism parameters like triglycerides, HDL--and LDL--cholesterol were estimated, too. Direct relationship was found between the impairment of glucose tolerance and the duration of obesity and the overweight. Obese persons with higher overweight and an average duration of obesity exhibited fasting hyperinsulinemia. Irrespective of the overweight magnitude and the degree of glucose tolerance impairment a more pronounced insulin reaction to glucose was observed. The same was found in the groups of persons with the history of obesity not exceeding 15 years. Moreover, in the group of obese persons with normal glucose tolerance, in those with overweight reaching 70% and with short and moderate duration of. Fasting obese hyperinsulinemic persons showed reduced concentration of HDL--obesity the levels of triglycerides were found to be elevated.

Rat fibrosarcoma induced by methylcholanthrene exhibited proteolytic activity against type I collagen at acidic range of pH values. This activity was not only collagen-specific as it was able to cause hemoglobin degradation to low-molecular products. No collagenolytic activity was found near physiological values pH.

Urodynamic measurements including sphincterometry and cystometry were made in 36 women with stress urinary incontinence (SUI). Out of this number in 32 affected with SUI of stages I, II and III surgical treatment was applied. Control group were 7 women without SUI symptoms. Marshall-Marchetti operation in the modification of Durfée or of Burch was made in the space of Retzius. The procedure was followed by simultaneous pararectal suturing of the wedges of levator ani muscle. The mean values of urodynamic measurements were compared using Student's "t" test and paired test. No evident difference was found when average values of pre-operative +cystic manometry were compared in particular groups of patients using statistical analysis. Sphincterometry made in women who had been effectively operated on showed statistically significant higher values of urethral closure pressure. Higher values of post-operative urodynamic measurements can speak for a complete recovery of the patients.

Assessment of working conditions in small slaughter-butcher workshops was based on the measurements of microclimate, illumination intensity, noise level, physical work, load, health risk factors and of other parameters which increased the work strenuousness. The analysis showed that the working conditions were harmful, mainly due to unfavourable microclimate, too poor illumination and the magnitude of physical load which reached mid-heavy and heavy levels. Based on performed analysis of occupational hazards a list of simple technical procedures which could improve working conditions was established by the authors.

Adaptation of "Spekol 10" with Ti Mi attachment for measurement of platelet aggregation (by the turbidimetric method) in small samples of platelet suspensions (0.2-0.4 ml) is described. This set can be further easily modified for simultaneous recording of aggregation and ion concentration in the same platelet sample.

Representative sociomedical studies included inhabitants of the Białystok 3 housing estates. The inhabitants have been under the care of district dispensaries. Most of the inhabitants do not attend the dispensaries or make so irregularly and at limited manner. Only pediatric out-patient clinics accomplish the generality of health care in their districts while general out-patient clinics are attending on those over 60 years old. Assessment of dispensaries according to formal-administrative criteria does not agree with the appraisal of the residents showing astonishing discrepancy.

Post-operation results of stress urinary incontinence treatment have been assessed and subjected to statistical analysis in 667 patients. The elaboration of the results was based on case history data, inquiries and control ambulatory examinations. Diagnostic procedures included sphincterometry, cystometry, cystoscopy, cystography and provocation test like coughing. Vaginal and urine biocenosis was always assessed microbiologically. The Marshall-Marchetti operation as modified by Durfée and Burch was made within the space of Retzius. Complementary procedure consisted in suturing levator ani muscles after previous bilateral opening of pararectal space within perineum. Third pair of sutures was placed according to the authors' own modification during the Durfée operations. The results of surgical treatment of SUI performed by the authors do not differ in principle from those reported by others. A small number of relapses the authors ascribe to local and systemic processes of aging which diminish the effectiveness and the value of previously made correction of urethra and of the bladder bottom topography.

Rats fed standard diet were intoxicated during 4 weeks with ethanol at the dose of 0.6 g/100 g of the body weight. This poisoning causes vacuolar degeneration, disappearance of glycogen granules, steatosis of hepatocytes and focal necrosis changes in the liver. The intake of food with cysteine at the dose of 0.012 and 0.024 g/100 g/24 hrs markedly prevents histopathological changes in the liver of rats intoxicated with ethanol. Larger amounts of cysteine (0.044 g/100 g/24 hrs) intensify histopathological changes caused by ethanol in the liver of rats.

Homogenate is prepared in 0.25 M sucrose. Cellular organelles are precipitated by acidification to pH 5.0 and removed by centrifugation at 1500 x g during 30 minutes. In the obtained cytosol which does not contain lysosomes free activity of cathepsin D is determined.