Revista do Instituto de Antibioticos, Universidade Federal de Pernambuco最新文献

This paper deals with the stimulatory effect of the compound 2-methyl-1,4-naphthoquinone, Menadione (vit. K3), in young chicken, during the growing period. That's the case of other products like Bacitracin, Actinomycin D and Terramycin, whose hormetic activity is supplanted by the referred Menadione. Authors present the experimental data with analytical discussion of the results.

In this paper we present the healing of 100 patients with chronic cervicitis and cervico-vaginitis by the antiinflammatory effect of hidroalcoolic extract of Schinus aroeira Vell.

Eleven cases of patients bearing basic cellular carcinoma, and one case of patient bearing Kaposi's sarcomatosis, all treated with antibiotics isolated by Goncalves de Lima and Co-workers at the Instituto de Antibióticos, are presented by the authors. Primin, an antibiotic extracted from a vegetal named Miconia sp. (Herb. I.A.-1903) with a 2-metoxi-6-n-pentil-p benzoquinone structure, presented a strong antineoplastic action in the cases treated. Plumbagin isolated from Plumbago scandens in local use, was responsible for a complete healing of the injuries treated. Maytenin extracted from Maytenus sp. (Herb. I.A.-1750) showed less activity than the two previous mentioned, but with a low irritant action and late antineoplastic properties. The authors are going on these experiments. They believe that these antibodies, in local use, may advantageously substitute the surgery and the radiotherapy, meanly in those external ear tumidities and back of the nose, owing to a hurtful action in cartilage, provoked by radiotherapy.

We have been studying the antagonistic activity of the Streptoverticillium griseocarneum, strain IA-7527. It produces a strong antifungal substance which we named griseocarnin. Its antimicrobial power to Neurospora crassa, Rhodotorula, rubra, Hansenula suaveolens and Candida albicans deserves to be exceled. The isolated substance was compared with other antifungal antibiotics presenting close similarity with the heptaens Ascosin and PA-150. The production, extraction and purification methods as well as physical, chemical and biological properties are included in this work.

The authors present the first observations on the isolation of two quinonoid compounds from Hyptis fructicosa Salzm ex Benth; Labiatae. The referred naturally compounds present antimicrobial and antineoplastic activity against Gram-positive microrganisms and mouse Erlich carcionama, respectivelly.

A strain of Streptoverticillium (IA-7527) which produces an antibiotic complex formed at least by two substances--one active against fungi and another active against bacteria--has been identified as Stv. griseocarneum. The methods and the results of the International Streptomyces Project were used. By comparing the results obtained, i.e., the description of the sample IA-7527, with ISP standard descriptions of the related species, and attributing percentual values of similarity to each corresponding item, the overall similarity between the strains compared was obtained. The main result of the study is the conclusion that the ISP descriptions of STV. EHIMENSE, Stv. kentuckense, Stv. mashuense, Stv. parvisporogenes, Stv. takataense and Stv. griseocarneum are so similar, that the cited species--and the strain ISP-5464, IMRU 3631, labeled Stv. rubireticuli--should be considered as synonyms of Stv. griseocarneum, the first species described in the group.

In this paper the authors present the first report concerning the biological effects of a diterpene isolated from Croton aff. argyrophylloides Muell. Arg (Euphorbiaceae). Some biological and physiochemical properties of the antibiotic, named argyrophillic acid, were appreciated in comparison with those presented by cunabic acid, an antibiotic isolated from Icthyothere cunabi. The authors still show the microbial action of the abietic acid and confront it with that of the argyrophilic acid, the new antibiotic here reported.

In the course of our program on the antimicrobial and antineoplastic substances from higher plants we have studied many flavonoid compounds isolated from root back of Lonchocarpus neuroscapha Benth. In the present paper a slight effect on sarcoma 180 and Ehrlich carcinoma of cordoin, 4-hydroxy-cordoin and 4-hydroxy-derricin, as well as the only observed effect of derricin on sarcoma 180 were observed. The antimicrobial action of four prenylated chalcones, i.e. 4-hydroxy-derricin, 4-hydroxy-lonchocarpin, 4-hydroxy-cordoin and 4-hydroxy-isocordoin is reported.

Pharmacological properties of a substance extracted from the roots of Miconia sp. (Herb. I.A.U.F.Pe-1903) named as primin (2-metoxi-6-n-pentil-benzoquinone), are described. Median lethal dose was evaluated in 12.78 mg/kg, intraperitoneally, by Thompson and Weil method. Local irritation on rat skin and rabbit vascular endothelium, were positive. In doses up to 8 mg/kg it did not affect rat respiratory mechanism. Primin (1 mg) induced to decrease the dropping of a nutrient flux through isolated peribronchial tissue. Normal flux was obtained when adrenalin (100 mcg) was administered. Urinary excretion and blood level of this substance, was detected by microbiological method, after the fourth and the fifth hour of the drug application. Doses of 1 and 3 mg/kg i.p. were tested.