Pub Date : 2024-03-11DOI: 10.1101/2023.03.15.532843
Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev, Elena O Gracheva
Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) lasts for 5-7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24-48-hour periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger during IBAs. These squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons exhibit reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.
{"title":"Hypothalamic hormone deficiency enables physiological anorexia.","authors":"Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev, Elena O Gracheva","doi":"10.1101/2023.03.15.532843","DOIUrl":"10.1101/2023.03.15.532843","url":null,"abstract":"<p><p>Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels <i>(Ictidomys tridecemlineatus)</i> lasts for 5-7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24-48-hour periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger during IBAs. These squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons exhibit reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.</p>","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10979886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73960092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Fawcett, T. Seekins, P. L. Whang, Y. Suarez de Balcazar, Charles Muiu, M. Johnson
{"title":"A Role for Universities in Creating and Disseminating Tools for Community Development","authors":"S. Fawcett, T. Seekins, P. L. Whang, Y. Suarez de Balcazar, Charles Muiu, M. Johnson","doi":"10.1007/BF03449109","DOIUrl":"https://doi.org/10.1007/BF03449109","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"2-7"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using Each Other: An Analysis of Leadership as Operant Conditioning","authors":"J. A. Barlow","doi":"10.1007/BF03449113","DOIUrl":"https://doi.org/10.1007/BF03449113","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"20-23"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Dandelion Community","authors":"Richard Graham","doi":"10.1007/BF03449111","DOIUrl":"https://doi.org/10.1007/BF03449111","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to: Toward a United Front: a Class Analysis of Social and Political Action","authors":"J. Ulman","doi":"10.1007/BF03449115","DOIUrl":"https://doi.org/10.1007/BF03449115","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Old Dogs and New Tricks: Disarmament and Alternatives to War","authors":"J. Nevin","doi":"10.1007/BF03449110","DOIUrl":"https://doi.org/10.1007/BF03449110","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"68 1","pages":"8-10"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91396011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BFSA Statement of Purpose","authors":"","doi":"10.1007/BF03449118","DOIUrl":"https://doi.org/10.1007/BF03449118","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"1984 BFSA Symposium at ABA: “Animal Rights and Behavior Analysis: Constraints on Learning About Behavior”","authors":"R. Rakos","doi":"10.1007/BF03449116","DOIUrl":"https://doi.org/10.1007/BF03449116","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addendum: Dandelion Community Behavior Code","authors":"","doi":"10.1007/BF03449112","DOIUrl":"https://doi.org/10.1007/BF03449112","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03449112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52337254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toward a United Front: a Class Analysis of Social and Political Action","authors":"J. Ulman","doi":"10.1007/BF03406169","DOIUrl":"https://doi.org/10.1007/BF03406169","url":null,"abstract":"","PeriodicalId":80628,"journal":{"name":"Behaviorists for Social Action journal","volume":"4 1","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"1983-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03406169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52336874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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