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Safety of Ultra-rush Schedule of Subcutaneous Allergen Immunotherapy With House Dust Mite Extract Conducted in an Outpatient Clinic in Patients With Atopic Dermatitis and Allergic Rhinitis. 在门诊对特应性皮炎和过敏性鼻炎患者进行屋尘螨提取物皮下过敏原免疫疗法的超快速时间表的安全性
IF 4.1 Pub Date : 2019-11-01 DOI: 10.4168/aair.2019.11.6.846
So Hee Lee, Myoung Eun Kim, Yoo Seob Shin, Young Min Ye, Hae Sim Park, Dong Ho Nahm

Purpose: Ultra-rush schedule of subcutaneous allergen immunotherapy (UR-SCIT) administering maximum maintenance dose of allergen extract within one day can save time and effort for allergen immunotherapy in patients with allergic disease. However, UR-SCIT is associated with an increased risk of systemic reaction (SR) and typically has been conducted in a hospital admission setting. To overcome disadvantages of UR-SCIT, we evaluated the safety of UR-SCIT conducted in an outpatient clinic in patients with atopic dermatitis (AD) and allergic rhinitis (AR).

Methods: UR-SCIT was performed in 538 patients with AD and/or AR sensitized to house dust mite (HDM). A maximum maintenance dose of tyrosine-adsorbed HDM extract (1 mL of maintenance concentration) was divided into 4 increasing doses (0.1, 0.2, 0.3, and 0.4 mL) and administered to the patients by subcutaneous injection at 2-hour intervals for 8 hours in an outpatient clinic. SRs associated with UR-SCIT were classified according to the World Allergy Organization grading system.

Results: SR was observed in 12 of 538 patients (2.2%) with AD and/or AR during UR-SCIT. The severity grades of the observed SRs were mild-to-moderate (grade 1 in 7 patients, grade 2 in 4 patients, and grade 3 in 1 patient). The scheduled 4 increasing doses of HDM extract could be administered in 535 of 538 patients (99.4%) except 3 patients who experienced SR before administration of the last scheduled dose. SR was observed within 2 hours in 11 patients after administration of the scheduled doses of HDM extract except one patient who experienced a grade 2 SR at 5.5 hours after administration of the last scheduled dose.

Conclusions: UR-SCIT with tyrosine-adsorbed HDM extract conducted in an outpatient clinic was tolerable in patients with AD and AR. UR-SCIT can be a useful method to start a SCIT in patients with AD and AR.

目的:超快速皮下过敏原免疫疗法(UR-SCIT)可在一天内给予最大维持剂量的过敏原提取物,可为过敏性疾病患者的过敏原免疫疗法节省时间和精力。然而,UR-SCIT 会增加全身反应(SR)的风险,而且通常在入院环境中进行。为了克服 UR-SCIT 的缺点,我们对特应性皮炎(AD)和过敏性鼻炎(AR)患者在门诊进行 UR-SCIT 的安全性进行了评估:对538名对家尘螨(HDM)过敏的特应性皮炎和/或过敏性鼻炎患者进行了UR-SCIT治疗。将最大维持剂量的酪氨酸吸附HDM提取物(1 mL维持浓度)分为4个递增剂量(0.1、0.2、0.3和0.4 mL),在门诊中每隔2小时皮下注射一次,连续注射8小时。与 UR-SCIT 相关的 SR 根据世界过敏组织分级系统进行分类:结果:在 538 例 AD 和/或 AR 患者中,有 12 例(2.2%)在 UR-SCIT 期间观察到 SR。观察到的SR的严重程度为轻度至中度(7名患者为1级,4名患者为2级,1名患者为3级)。538 例患者中有 535 例(99.4%)可以按计划服用 4 个递增剂量的 HDM 提取物,只有 3 例患者在服用最后一个计划剂量之前出现了 SR。11名患者在服用预定剂量的HDM提取物后2小时内出现SR,只有一名患者在服用最后一个预定剂量后5.5小时出现2级SR:结论:在门诊中使用酪氨酸吸附的HDM提取物进行UR-SCIT治疗,AD和AR患者的耐受性良好。UR-SCIT可以作为AD和AR患者开始SCIT的有效方法。
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引用次数: 0
Articles and Publications 文章和出版物
Pub Date : 2018-06-02 DOI: 10.1353/qkh.2018.0004
Julie C. Swierczek
Sally Bruyneel,Margaret Fell and the End of Time: The Theology of the Mother of Quakerism, Waco, TX: Baylor University Press, 2010, examines the religious thought of Margaret Fell (1614–1702). Kenneth A. Shelton, The Way Cast Up: The Keithian Schism in an English Enlightenment Context, Thesis (Ph.D.)—Boston College, 2009, uses the schism of the 1690s to reveal, in the words of the author’s abstract, “how very modern the Quakers were in their handling of honor culture, public dispute, identity, and public authority.“
Sally Bruyneel,Margaret Fell和时间的终结:贵格会之母的神学,德克萨斯州韦科:贝勒大学出版社,2010,研究了Margaret Fell(1614-1702)的宗教思想。肯尼斯·A·谢尔顿(Kenneth A.Shelton),《抛弃的方式:英国启蒙语境中的凯西亚分裂主义》(The Way Cast Up:The Keithian Schism in A English Enlightment Context),论文(Ph.D.)——波士顿学院,2009年,用作者的抽象话来说,用1690年代的分裂来揭示“贵格会在处理荣誉文化、公共纠纷、身份认同和公共权威方面是多么现代。”
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引用次数: 0
The Fearless Benjamin Lay: The Quaker Dwarf Who Became the First Revolutionary Abolitionist by Marcus Rediker (review) 《无畏的本杰明·雷:成为第一个革命废奴主义者的贵格会矮人》作者:马库斯·雷迪克(书评)
Pub Date : 2018-06-02 DOI: 10.1353/QKH.2018.0002
Julie L. Holcomb
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引用次数: 1
Lessons from Quaker History: What’s an Historian To Say about Whittaker Chambers and Clarence Pickett? 贵格会历史的教训:历史学家如何评价惠特克·钱伯斯和克拉伦斯·皮克特?
Pub Date : 2018-06-02 DOI: 10.1353/QKH.2018.0000
H. Ingle
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引用次数: 0
The Blessed Channel of Work: Gender, Power and the Union of the Women’s Foreign Missionary Societies in the Religious Society of Friends 工作的神圣渠道:性别、权力与女性外国传教士协会在朋友宗教协会中的联盟
Pub Date : 2018-06-02 DOI: 10.1353/QKH.2018.0001
I. May
Abstract:Historians have portrayed American Quakers as one of the most progressive groups on the issue of women’s rights, citing their commitment to women’s ministry and their extensive involvement at Seneca Falls. Yet there is a need for additional research into gender roles in the denomination during the nineteenth century, which were decidedly less ideal than historians have imagined. This paper examines the internal denominational battle among Gurneyite Quakers over the consolidation of local women’s foreign mission societies into a single unified women’s foreign mission organization, and argues that women endeavored to construct this organization as a counterbalance to increasingly powerful male assertions of authority within the denomination.The women who created the Women’s Foreign Missionary Union (WFMU) perceived Quakerism making a turn toward evangelicalism, and saw its increasing acceptance of mainstream Protestant practices, like having only male clergy, as eroding women’s authority. Holding leadership posts in the WFMU served as an outlet for a generation of women who in early periods would have been able to enter the ministry. These leaders conceived of the organization not as simply a missionary enterprise, but as a training ground for developing the talents of Quaker women before they could eventually achieve full equality with their male counterparts.
摘要:历史学家将美国贵格会描述为妇女权利问题上最进步的团体之一,理由是他们致力于妇女事工,并广泛参与塞内卡瀑布事件。然而,有必要对19世纪该教派的性别角色进行进一步的研究,这显然没有历史学家想象的那么理想。本文考察了格尼派贵格会内部关于将当地女性海外宣教社团整合为一个统一的女性海外宣教组织的宗派斗争,并认为女性努力构建这个组织是为了抗衡教派内日益强大的男性权威主张。创建女性外国传教士联盟(WFMU)的女性认为贵格会正在转向福音主义,并且认为贵格会越来越多地接受主流新教的做法,比如只有男性神职人员,正在侵蚀女性的权威。在WFMU担任领导职位,为早期能够进入国防部的一代女性提供了一个出口。这些领导人认为贵格会不仅仅是一个传教企业,而是一个培训基地,在贵格会女性最终实现与男性完全平等之前,培养她们的才能。
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引用次数: 0
Nixon’s First Cover-Up: The Religious Life of a Quaker President by H. Larry Ingle (review) 尼克松的第一次掩饰:贵格会总统的宗教生活作者:H.拉里·英格尔
Pub Date : 2018-06-02 DOI: 10.1353/qkh.2018.0003
Thomas D. Hamm
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引用次数: 0
A Call to Conscience: The Anti-Contra War Campaign by Roger Peace (review) 良心的呼唤:罗杰·皮斯的反反战争运动(评论)
Pub Date : 2017-10-10 DOI: 10.1353/qkh.2017.0013
Joanna Swanger
strategies across New York, Pennsylvania, Ohio and North Carolina, and by addressing the tensions and controversies within and between Quaker communities, Holcomb has also helped to blow away some of the clouds around glib generalizations that “the Quakers” were uniformly “anti-slavery.” In the tradition so effectively employed by Brycchan Carey’s From Peace to Freedom, Holcomb examines “process” as well as “product,” thereby spinning a tale that “names names,” and highlights personalities as it interweaves race, gender, politics, theology, and economics into a seamless and riveting narrative. Despite a few proof-reading glitches (e.g., chapter 8, footnote 43), Moral Commerce has cut away some of the underbrush, to expose intriguing pathways for future scholars to explore. For example, Holcomb has largely focused on documents that tell the story of Britain and the eastern United States. We await a deeper investigation of American mid-western networks—such as those described in Thomas Hamm’s God’s Government Begun—which also flirted with “free produce” tactics as part of a larger “Universal Inquiry and Reform,” publishing their perspectives in such publications as Cincinnati’s Philanthropist. And how did anti-slavery networks in other Atlantic-world locations as Canada and Europe fit into the free-produce matrix? Such questions are particularly intriguing with respect to France, where historian Lawrence Jennings tells us that the anti-slavery impulse was shaped by contact with British reformers’ ideas. By providing a multi-textured exploration of the free-produce phenomenon, Holcomb has pointed to some inviting leads for future scholars to follow.
在纽约、宾夕法尼亚、俄亥俄和北卡罗莱纳的策略,以及通过解决贵格会社区内部和社区之间的紧张关系和争议,霍尔科姆还帮助驱散了围绕“贵格会”一致“反对奴隶制”的油嘴油舌的概括的一些阴云。在布瑞奇·凯里的《从和平到自由》一书中,霍尔科姆有效地运用了这一传统,他考察了“过程”和“产品”,从而编织了一个“点名”的故事,并在将种族、性别、政治、神学和经济交织在一起的同时,突出了人物的个性,形成了一个无缝衔接、引人入胜的叙事。尽管有一些校对错误(例如,第8章,脚注43),《道德商业》已经删去了一些晦涩难懂的内容,为未来的学者探索揭示了有趣的途径。例如,霍尔科姆主要关注讲述英国和美国东部故事的文件。我们期待着对美国中西部网络进行更深入的调查——就像托马斯·哈姆在《上帝的政府开始》中所描述的那样——这些网络也将“免费生产”策略作为更大的“普遍调查与改革”的一部分,并在辛辛那提的《慈善家》等出版物上发表他们的观点。另外,加拿大和欧洲等大西洋沿岸其他地区的反奴隶制网络是如何融入自由农产品矩阵的?这些问题在法国尤其引人入胜,历史学家劳伦斯·詹宁斯告诉我们,法国反奴隶制的动力是由与英国改革者的思想接触而形成的。通过对自由农产品现象进行多层面的探索,霍尔科姆为未来的学者指出了一些诱人的线索。
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引用次数: 0
From Modern to Apostolic: Two Schismatic Quaker Groups in Indiana 从现代到使徒:印第安纳州的两个Schismatic贵格会团体
Pub Date : 2017-10-10 DOI: 10.1353/QKH.2017.0010
Gregory P. Hinshaw
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引用次数: 0
Articles and Publications 文章及刊物
Pub Date : 2017-10-10 DOI: 10.1353/qkh.2017.0014
Julie C. Swierczek, Christopher Densmore
Many of the current books and articles examine the first period of Quakerism. Stephen W. Angell, “An Early Version of George Fox’s ‘Letter to the Governor of Barbados’,” Quaker Studies 19, no. 2 (March 2015): 277-294, compares the earliest publication of this influential Quaker statement in 1672 to the version published in the 1694 edition of Fox’s journal. Angell’s other contributions include Stephen W. Angell, “Richard Farnworth, Samuel Fisher, and the Authority of Scripture among Early Quakers,” Quaker Studies 19, no. 2 (March 2015): 207-228, and Stephen W. Angell and Pink Dandelion, eds., Early Quakers and Their Theological Thought (New York: Cambridge University Press, 2015). Rex Ambler considers “Light” as used by both early and contemporary Quakers in The Light Within: Then and Now, Pendle Hill pamphlet 425 (Wallingford, PA: Pendle Hill Publications, 2013). Others examining the early period include Michael Birkel, “Robert Barclay and Kabbalah,” Quaker Studies 21, no. 1 (September 2016): 3-13; Marjon Ames, Margaret Fell, Letters, and the Making of Quakerism (New York: Routledge, 2017); Madeleine Ward, “Transformative Faith and the Theological Response of the Quakers to the Boston Executions,” Quaker Studies 21, no. 1 (September 2016): 15-32; Bernard Capp, “The Religious Marketplace: Public Disputations in Civil War and Interregnum England,” English Historical Review 129, no. 536 (February 2014): 47-78; and Jonathan Warren, “‘Out of Whose Hive the Quakers Swarm’d’: Polemics and the Justification of Infant Baptism in the Early Restoration,” Perichoresis 13, no. 1 (June 2015): 97113. Judith Roads, “Incantational and Catechetical Style in Early Quaker Prose Writings,” Quaker Studies 19, no. 1 (September 2014): 172-181, concludes that Quakers used both styles in the 17th century, though the incantational style was less used at the end of the century. Kate Peters, “The Quakers and the Politics of the Army in the Crisis of 1659,” Past & Present 231, no. 1 (May 2016): 97-128, includes an analysis of Quaker merchant George Bishop. Nicholas Seager, “John Bunyan and Socinianism,” Journal of Ecclesiastical History 65, no. 3 (July 2014): 580-600, draws on Bunyan’s disputes with Quakers.
目前的许多书籍和文章都探讨了贵格会主义的第一个时期。Stephen W.Angell,“乔治·福克斯‘致巴巴多斯总督的信’的早期版本”,《贵格会研究》19,第2期(2015年3月):277-294,将1672年最早发表的这一有影响力的贵格会声明与1694年福克斯杂志上发表的版本进行了比较。Angell的其他贡献包括Stephen W.Angell,“Richard Farnworth,Samuel Fisher,and the Authority of Scripture in Early Quakers”,《贵格会研究》19,第2期(2015年3月):207-228,以及Stephen W.安吉尔和Pink Dandelion编辑的《早期贵格会教徒及其神学思想》(纽约:剑桥大学出版社,2015)。Rex Ambler认为早期和当代贵格会教徒在《内在的光:当时和现在》(The Light Within:Then and Now)中都使用了“光”,彭德尔山小册子425(宾夕法尼亚州沃林福德:彭德尔山出版社,2013)。其他研究早期的人包括Michael Birkel,“Robert Barclay and Kabbalah”,贵格会研究21,第1期(2016年9月):3-13;Marjon Ames,Margaret Fell,《书信与桂克主义的形成》(纽约:Routledge,2017);马德琳·沃德,“转变信仰和贵格会教徒对波士顿处决的神学反应”,《贵格会研究21》,第1期(2016年9月):15-32;Bernard Capp,“宗教市场:内战和国家间英格兰的公共争端”,《英国历史评论》第129期,第536期(2014年2月):47-78;乔纳森·沃伦,《贵格会教徒从谁的巢穴中蜂拥而出:早期复辟中的Polemics和婴儿洗礼的正当性》,《Perichorisis 13》,第1期(2015年6月):97113。Judith Roads,《早期贵格会散文中的咒语和范畴风格》,《贵格会研究》第19期,第1期(2014年9月):172-181,得出结论,贵格会在17世纪使用了这两种风格,尽管咒语风格在本世纪末使用较少。Kate Peters,《1659年危机中的贵格会与军队政治》,《过去与现在》231,第1期(2016年5月):97-128,包括对贵格会商人George Bishop的分析。Nicholas Seager,“John Bunyan和Socinianism”,《教会历史杂志》第65期,第3期(2014年7月):580-600,借鉴了Bunyan与贵格会教徒的争端。
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引用次数: 0
“Times of Peril”: Quakers in British-Occupied New York During the American Revolution, 1775–1783 “危险时代”:1775-1783年美国革命期间英国占领的纽约贵格会教徒
Pub Date : 2017-10-10 DOI: 10.1353/QKH.2017.0011
J. J. Crotty
*Joseph Crotty is a special education teacher at The Wheatley School in The East Williston School District, located in Old Westbury, NY. He graduated from Long Island University with a Master of Arts Degree in History. His thesis dealt with New York Quakers during the American Revolution and Early Republic periods. “Times of Peril”: Quakers in BritishOccupied New York During the American Revolution, 1775-1783
*Joseph Crotty是纽约州老韦斯特伯里东威利斯顿学区惠特利学校的一名特殊教育教师。他毕业于长岛大学,获得历史文学硕士学位。他的论文涉及美国革命和共和国早期的纽约贵格会教徒。“危险时代”:1775-1783年美国革命期间英国贵格会教徒占领纽约
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引用次数: 0
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Quaker history
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