Dillenia ochreata is a traditional medicine used to treat wounds and scabies. In wound healing, one of the treatments is to reduce pain (analgesic). Some compounds of triterpenoid groups have been known to be active as analgesic compounds. The leaf of D. ochrea was reported to contain secondary metabolites triterpenoid centulic acid and 3β-glucopyranosyl-lup-20(29)-en-28 oat. This study aimed to evaluate the analgesic activity and standardization of the ethanol extract of D. ochreata leaf and determine the mechanism of action. Analgesic activity was determined by a hot plate method and formalin test, and the mechanism of action was through muscarinic, dopamine, and opiate receptors, standardization of extract using the method issued by the Indonesian Ministry of Health. The ethanol extract of D. ochreata leaf at a 400 mg/kg bw dose has higher analgesic activity (24.85%) than the positive control (18.32%). Statistical analysis showed a significant difference in analgesic activity percentage between the positive group and those with a 400 mg/kg bw group dose. The 400 mg/kg bw dose also showed a significant difference (p<0.05) between neurogenic pain (46.92%) and inflammation (61.19%) in the formalin test caused by opioid receptors. The evaluation of the analgesic mechanism showed the ethanol extract of D. ochreata leaf works through opioid receptors. The extract meets the requirements of the standard parameters. The leaf extract of D. ochreata can be developed as an anti-analgesic from natural medicine.
{"title":"Analgesic Effect of Ethanol Extract of Dillenia ochreata (Miq.) Teijsm. & Binn. Ex Martelli in Wistar Rats","authors":"Heni Yohandini, Fahdelaa Ghaniya, Muharni Muharni, Fitrya Fitrya","doi":"10.22437/chp.v9i1.43080","DOIUrl":"https://doi.org/10.22437/chp.v9i1.43080","url":null,"abstract":"Dillenia ochreata is a traditional medicine used to treat wounds and scabies. In wound healing, one of the treatments is to reduce pain (analgesic). Some compounds of triterpenoid groups have been known to be active as analgesic compounds. The leaf of D. ochrea was reported to contain secondary metabolites triterpenoid centulic acid and 3β-glucopyranosyl-lup-20(29)-en-28 oat. This study aimed to evaluate the analgesic activity and standardization of the ethanol extract of D. ochreata leaf and determine the mechanism of action. Analgesic activity was determined by a hot plate method and formalin test, and the mechanism of action was through muscarinic, dopamine, and opiate receptors, standardization of extract using the method issued by the Indonesian Ministry of Health. The ethanol extract of D. ochreata leaf at a 400 mg/kg bw dose has higher analgesic activity (24.85%) than the positive control (18.32%). Statistical analysis showed a significant difference in analgesic activity percentage between the positive group and those with a 400 mg/kg bw group dose. The 400 mg/kg bw dose also showed a significant difference (p<0.05) between neurogenic pain (46.92%) and inflammation (61.19%) in the formalin test caused by opioid receptors. The evaluation of the analgesic mechanism showed the ethanol extract of D. ochreata leaf works through opioid receptors. The extract meets the requirements of the standard parameters. The leaf extract of D. ochreata can be developed as an anti-analgesic from natural medicine.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"9 1","pages":"120-129"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Fikriansyah, Nelson Nelson, Madyawati Latief, Indra Lasmana Tarigan
Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.
{"title":"Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies","authors":"Muhammad Fikriansyah, Nelson Nelson, Madyawati Latief, Indra Lasmana Tarigan","doi":"10.22437/chp.v7i1.23726","DOIUrl":"https://doi.org/10.22437/chp.v7i1.23726","url":null,"abstract":"Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135397883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
High levels of hardness can lead to increased cases of kidney stones. Hardness levels can be reduced by using activated carbon from the cocoa rind as an adsorbent. The purpose of this research was to determine the variation of activated carbon thickness and optimum retention time in reducing the calcium content of dug well water, to determine the percent decrease in calcium ion levels at the optimum variation, and to determine the significance of the difference in the decreased in calcium levels between the treatment groups. The research method used the principle of adsorption of activated carbon from cocoa shells to calcium ions, which are activated by KOH. There were ten treatment samples with different variations of activated carbon thickness and retention time. The results showed that the thickness of activated carbon of 60 cm with a retention time of 50 minutes had the optimum ability to reduce the calcium content of dug well water. The percentage decrease in calcium levels reached 89,041 % with a decreased concentration of 234 ppm. The result of the statistical test showed a significance value of 0,05. The conclusion of the research is that activated carbon of cocoa shells can reduce calcium levels to the levels of soft water hardness, with variations in activated carbon thickness and retention time having a significant effect.
{"title":"Calcium Reduction Using Variations of Thickness and Retention Time of Cocoa Shell Activated Carbon","authors":"Afidatul Muadifah, Arif Santoso, Khoirul Ngibad, Rahma Diyan Martha, Siti Nurriyatul Kholifah","doi":"10.22437/chp.v7i1.24768","DOIUrl":"https://doi.org/10.22437/chp.v7i1.24768","url":null,"abstract":"High levels of hardness can lead to increased cases of kidney stones. Hardness levels can be reduced by using activated carbon from the cocoa rind as an adsorbent. The purpose of this research was to determine the variation of activated carbon thickness and optimum retention time in reducing the calcium content of dug well water, to determine the percent decrease in calcium ion levels at the optimum variation, and to determine the significance of the difference in the decreased in calcium levels between the treatment groups. The research method used the principle of adsorption of activated carbon from cocoa shells to calcium ions, which are activated by KOH. There were ten treatment samples with different variations of activated carbon thickness and retention time. The results showed that the thickness of activated carbon of 60 cm with a retention time of 50 minutes had the optimum ability to reduce the calcium content of dug well water. The percentage decrease in calcium levels reached 89,041 % with a decreased concentration of 234 ppm. The result of the statistical test showed a significance value of 0,05. The conclusion of the research is that activated carbon of cocoa shells can reduce calcium levels to the levels of soft water hardness, with variations in activated carbon thickness and retention time having a significant effect.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135399407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Molecular docking study of 6 chalcone analogues with protein target from the crystallographic structure modeling of Bcl-2 protein with PDB code 2W3L was carried out using computational media using the Molecular Operating Environment (MOE) program. The aim of this study is to determine the potentiality of the 6 chalcone analogue compounds as Bcl-2 inhibitors using molecular docking studies. In this study, venetoclax was used as positive control. Based on docking results, binding free energy was used as information to know which wheather chalcone analogue compounds are active or not as Bcl-2 inhibitors. According to the docking results that have been carried out, it showed that the 6 chalcone analogue compounds have no potential as Bcl-2 inhibitors. Due to the superimposition of the 6 compounds that did not stick to the positive control and most importantly the binding free energy values (S) of the 6 chalcone analogue compounds were higher than the binding free energy values of the positive control (Venetoclax).
{"title":"Molecular Docking Study of Chalcone Analogue Compounds with Hydroxy and Methoxy Subtituents as Bcl-2 Inhibitors","authors":"Neni Frimayanti, Rahma Dona, Tabah Solihin","doi":"10.22437/chp.v7i1.17487","DOIUrl":"https://doi.org/10.22437/chp.v7i1.17487","url":null,"abstract":"Molecular docking study of 6 chalcone analogues with protein target from the crystallographic structure modeling of Bcl-2 protein with PDB code 2W3L was carried out using computational media using the Molecular Operating Environment (MOE) program. The aim of this study is to determine the potentiality of the 6 chalcone analogue compounds as Bcl-2 inhibitors using molecular docking studies. In this study, venetoclax was used as positive control. Based on docking results, binding free energy was used as information to know which wheather chalcone analogue compounds are active or not as Bcl-2 inhibitors. According to the docking results that have been carried out, it showed that the 6 chalcone analogue compounds have no potential as Bcl-2 inhibitors. Due to the superimposition of the 6 compounds that did not stick to the positive control and most importantly the binding free energy values (S) of the 6 chalcone analogue compounds were higher than the binding free energy values of the positive control (Venetoclax).","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135399408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans. Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5% b/v. The positive control used amoxicillin and DMSO as a negative control. Potency as an anticaries drug of drived compound from Temu Kunci and Serai were evaluated by molecular docking using glucosyltransferase (3AIC). The results showed that the combination of temu kunci and serai with concentration 10% b/v: 5% b/v has potential as anticaries against Streptococcus mutans. Molecular studies depicted that Panduratin A, Isopanduratin, and 1,3-O-di-p-coumaroylglycerol have great activity toward 3AIC, respectively. Especially for Panduratin A and Isopanduratin, those compound depicted great and similar binding affinity (-8.4 kcal mol-1) that lower than Acarbose as native ligand (-8.3 kcal mol-1). Furthermore, those compound binding similarity ilustrated activity mechanism similarly with native ligand toward receptor. Additionally, the profiling drug-target interaction suggested Temu Kunci’s derived compounds have great potential as anticaries treatment.
{"title":"Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach","authors":"Muhammad Priyadi, Rizki Rachmad Saputra","doi":"10.22437/chp.v7i1.26098","DOIUrl":"https://doi.org/10.22437/chp.v7i1.26098","url":null,"abstract":"Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans. Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5% b/v. The positive control used amoxicillin and DMSO as a negative control. Potency as an anticaries drug of drived compound from Temu Kunci and Serai were evaluated by molecular docking using glucosyltransferase (3AIC). The results showed that the combination of temu kunci and serai with concentration 10% b/v: 5% b/v has potential as anticaries against Streptococcus mutans. Molecular studies depicted that Panduratin A, Isopanduratin, and 1,3-O-di-p-coumaroylglycerol have great activity toward 3AIC, respectively. Especially for Panduratin A and Isopanduratin, those compound depicted great and similar binding affinity (-8.4 kcal mol-1) that lower than Acarbose as native ligand (-8.3 kcal mol-1). Furthermore, those compound binding similarity ilustrated activity mechanism similarly with native ligand toward receptor. Additionally, the profiling drug-target interaction suggested Temu Kunci’s derived compounds have great potential as anticaries treatment.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135399411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sunlight has been known to provide many benefits to human life. However, behind these benefits, there are some negative effects along with the destruction of the ozone layer and the environment on earth. One of them is exposure to ultraviolet (UV) rays which can cause several diseases such as skin cancer. One way to overcome this is by using sunscreen substances. In this study, dibenzalacetone immobilization on TiO2 has been carried out for anti-UV applications. Based on the test results using UV-Vis spectrometry, TiO2, and dibenzalacetone both have anti-UV properties with maximum peaks at wavelengths of 335 nm and 346 nm with absorbance values of 0.871 and 1.197. Immobilization of TiO2 with dibenzalacetone gives an absorbance with a value of 1.221 at a wavelength of 329. These results indicate that TiO2 immobilization with dibenzalacetone provides better anti-UV A properties than TiO2 because of the higher absorbance value.
{"title":"Immobilization of Dibenzalacetone on TiO2 Surface and its Potential as Anti-UV Material","authors":"Mokhamat Ariefin, Rokiy Alfanaar","doi":"10.22437/chp.v7i1.26109","DOIUrl":"https://doi.org/10.22437/chp.v7i1.26109","url":null,"abstract":"Sunlight has been known to provide many benefits to human life. However, behind these benefits, there are some negative effects along with the destruction of the ozone layer and the environment on earth. One of them is exposure to ultraviolet (UV) rays which can cause several diseases such as skin cancer. One way to overcome this is by using sunscreen substances. In this study, dibenzalacetone immobilization on TiO2 has been carried out for anti-UV applications. Based on the test results using UV-Vis spectrometry, TiO2, and dibenzalacetone both have anti-UV properties with maximum peaks at wavelengths of 335 nm and 346 nm with absorbance values of 0.871 and 1.197. Immobilization of TiO2 with dibenzalacetone gives an absorbance with a value of 1.221 at a wavelength of 329. These results indicate that TiO2 immobilization with dibenzalacetone provides better anti-UV A properties than TiO2 because of the higher absorbance value.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135399013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Fadli, Komalasari Komalasari, Irdoni Irdoni, Wan Elsa Novtari Adiani
Porous bioceramics have been used in biomedical field, especially for bone implant. To generate pores in bioceramics, pore creating substances are added into the process of making ceramic bodies. The purpose of this study is to make porous bioceramics with tri calcium phosphate (TCP) raw material using albumin with variation in the amount of albumin in the raw material and drying temperature on the physical and chemical properties of TCP. Raw material slurry was made by mixing 7 g of TCP, 2 g of starch and 1.5 g of Darvan 821A with 5 g, 7 g and 9 g of albumin in a beaker glass while stirring at a rate of 150 rpm for 3 hours. The slurry was poured into a mold and heated in an oven at 180°C, 200°C and 220°C for 1 hour. Subsequently the sample was burned at 600˚C for 1 hour, following with sintering at 1.100°C for 2 hours. Bioceramic porosity is greater by increasing the amount of albumin and drying temperature, while the compressive strength decreases. Obtained TCP porosity is in the ranges of 68% -78% and compressive strength 0.14-1.4 MPa.
多孔生物陶瓷已广泛应用于生物医学领域，尤其是骨植入材料。为了在生物陶瓷中产生孔隙，在制作陶瓷体的过程中加入了造孔物质。本研究的目的是利用白蛋白制备多孔生物陶瓷，考察原料中白蛋白含量和干燥温度的变化对三磷酸钙(TCP)理化性能的影响。将7 g TCP、2 g淀粉、1.5 g Darvan 821A与5 g、7 g、9 g白蛋白在烧杯中以150转/分的速度搅拌3小时制成原料浆。将浆料倒入模具中，在180℃、200℃和220℃的烤箱中加热1小时。随后，样品在600℃下燃烧1小时，然后在1.100℃下烧结2小时。随着白蛋白用量的增加和干燥温度的升高，生物陶瓷的孔隙率增大，抗压强度降低。获得的TCP孔隙率为68% ~ 78%，抗压强度为0.14 ~ 1.4 MPa。
{"title":"Porous Bioceramics use Albumin as a Pore-Forming Material","authors":"Ahmad Fadli, Komalasari Komalasari, Irdoni Irdoni, Wan Elsa Novtari Adiani","doi":"10.22437/chp.v7i1.8131","DOIUrl":"https://doi.org/10.22437/chp.v7i1.8131","url":null,"abstract":"Porous bioceramics have been used in biomedical field, especially for bone implant. To generate pores in bioceramics, pore creating substances are added into the process of making ceramic bodies. The purpose of this study is to make porous bioceramics with tri calcium phosphate (TCP) raw material using albumin with variation in the amount of albumin in the raw material and drying temperature on the physical and chemical properties of TCP. Raw material slurry was made by mixing 7 g of TCP, 2 g of starch and 1.5 g of Darvan 821A with 5 g, 7 g and 9 g of albumin in a beaker glass while stirring at a rate of 150 rpm for 3 hours. The slurry was poured into a mold and heated in an oven at 180°C, 200°C and 220°C for 1 hour. Subsequently the sample was burned at 600˚C for 1 hour, following with sintering at 1.100°C for 2 hours. Bioceramic porosity is greater by increasing the amount of albumin and drying temperature, while the compressive strength decreases. Obtained TCP porosity is in the ranges of 68% -78% and compressive strength 0.14-1.4 MPa.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135397884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ihsanul Huda, Retno Kusumaningrum, Mi'raj Shabrin Jamil, W. B. Widayatno, A. S. Wismogroho, Nurul Taufiqu Rochman, Alfian Noviyanto
Kalsium pirofospat telah berhasil disintesis dengan menggunakan metode solvothermal. Bahan dasar yang digunakan adalah limbah cangkang telur ayam dan bebek. Cangkang telur ayam dan bebek dibersihkan dan digerus, kemudian dikalsinasi pada temperatur 1000°C selama 2 jam untuk mendapatkan serbuk CaO. Serbuk CaO kemudian dicampurkan dengan H3PO4 dan dimasukkan ke dalam bejana solvothermal. Proses solvothermal dilakukan pada temperatur 130°C selama 16 jam. Fasa tunggal CaHPO4 diperoleh setelah proses solvothermal. Kalsinasi serbuk CaHPO4 dilakukan pada tungku muffle dengan temperatur 800°C selama 2 jam dan kondisi atmosfir biasa. Hasil analisa fasa menunjukkan terbentuknya fasa tunggal kalsium pirofospat (Ca2P2O7) tanpa adanya fasa pengotor lainnya. Hasil ini menunjukkan perbandingan Ca dan P adalah 1. Mikrostruktur kalsium pirofospat yang terbentuk agak kasar dengan ukuran partikel rata-rata 590 ± 43 nm untuk cangkang telur ayam dan 455 ± 32 nm untuk cangkang telur bebek. Studi lebih lanjut diperlukan untuk mendapatkan kondisi optimum dari proses solvothermal limbah cangkang telur sehingga bisa didapatkan kalsium pirofospat yang mempunyai ukuran lebih halus dan seragam.
{"title":"Sintesis kalsium pirofospat (Ca2P2O7) dari limbah cangkang telur dengan metode solvothermal","authors":"Ihsanul Huda, Retno Kusumaningrum, Mi'raj Shabrin Jamil, W. B. Widayatno, A. S. Wismogroho, Nurul Taufiqu Rochman, Alfian Noviyanto","doi":"10.22437/CHP.V5I1.8669","DOIUrl":"https://doi.org/10.22437/CHP.V5I1.8669","url":null,"abstract":"Kalsium pirofospat telah berhasil disintesis dengan menggunakan metode solvothermal. Bahan dasar yang digunakan adalah limbah cangkang telur ayam dan bebek. Cangkang telur ayam dan bebek dibersihkan dan digerus, kemudian dikalsinasi pada temperatur 1000°C selama 2 jam untuk mendapatkan serbuk CaO. Serbuk CaO kemudian dicampurkan dengan H3PO4 dan dimasukkan ke dalam bejana solvothermal. Proses solvothermal dilakukan pada temperatur 130°C selama 16 jam. Fasa tunggal CaHPO4 diperoleh setelah proses solvothermal. Kalsinasi serbuk CaHPO4 dilakukan pada tungku muffle dengan temperatur 800°C selama 2 jam dan kondisi atmosfir biasa. Hasil analisa fasa menunjukkan terbentuknya fasa tunggal kalsium pirofospat (Ca2P2O7) tanpa adanya fasa pengotor lainnya. Hasil ini menunjukkan perbandingan Ca dan P adalah 1. Mikrostruktur kalsium pirofospat yang terbentuk agak kasar dengan ukuran partikel rata-rata 590 ± 43 nm untuk cangkang telur ayam dan 455 ± 32 nm untuk cangkang telur bebek. Studi lebih lanjut diperlukan untuk mendapatkan kondisi optimum dari proses solvothermal limbah cangkang telur sehingga bisa didapatkan kalsium pirofospat yang mempunyai ukuran lebih halus dan seragam.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84101460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Refilda Suhaili, Lucy Prima Ardi, E. Salim, Mai Efdi
Analysis of active compounds in fermented plant extract (FPE) from the ngapi nut peel using Effective Microorganism-4 (EM-4) has been done by Gas Chromatography-Mass Spectroscopy (GC-MS). There were 88 compounds found in fermented plant extract, the major content with the area above 1% were 7 compounds such as succinic acid; ethyl hydrogen succinate; 1,2,3-benzetriol; 3,3-dimethylhexanal; L-proline, 1-methyl-5-oxo-methyl ester; 3-methoxycinnamic acid and hexadecanoic acid. Based GC-MS analysis, fermented plant extract indicated that several compounds that have potential as biopesticides.
{"title":"Analisis GC-MS ekstrak tanaman terfermentasi (ETT) dari kulit buah jengkol (Pithecellobium jiringa Prain)","authors":"Refilda Suhaili, Lucy Prima Ardi, E. Salim, Mai Efdi","doi":"10.22437/CHP.V5I1.7957","DOIUrl":"https://doi.org/10.22437/CHP.V5I1.7957","url":null,"abstract":"Analysis of active compounds in fermented plant extract (FPE) from the ngapi nut peel using Effective Microorganism-4 (EM-4) has been done by Gas Chromatography-Mass Spectroscopy (GC-MS). There were 88 compounds found in fermented plant extract, the major content with the area above 1% were 7 compounds such as succinic acid; ethyl hydrogen succinate; 1,2,3-benzetriol; 3,3-dimethylhexanal; L-proline, 1-methyl-5-oxo-methyl ester; 3-methoxycinnamic acid and hexadecanoic acid. Based GC-MS analysis, fermented plant extract indicated that several compounds that have potential as biopesticides.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80409158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rhodamine B adalah pewarna sintetis yang digunakan sebagai zat pewarna untuk tekstil, cat, dan kertas tetapi banyak disalahgunakan dalam makanan, salah satunya adalah kerupuk merah. Rhodamine B dapat mengiritasi saluran pernapasan, kulit, mata, saluran pencernaan, keracunan, dan gangguan hati, dan dalam jangka panjang, dapat menyebabkan kanker dan tumor. Secara kualitatif dan kuantitatif kandungan pewarna Rhodamine B dalam kerupuk merah ditentukan menggunakan TLC dan UV-Vis Spectrophotometry. Tujuh sampel dari produsen menunjukkan bahwa Rhodamine B atau negatif tidak ditemukan pada kerupuk merah. Itu artinya kerupuk merah yang diproduksi oleh industri rumah tangga di Payakumbuh aman untuk dikonsumsi.
{"title":"Analisis pewarna Rhodamin B pada kerupuk merah di Payakumbuh","authors":"Linda Hevira, Desmi Alwinda, Najmi Hilaliyati","doi":"10.22437/CHP.V5I1.7912","DOIUrl":"https://doi.org/10.22437/CHP.V5I1.7912","url":null,"abstract":"Rhodamine B adalah pewarna sintetis yang digunakan sebagai zat pewarna untuk tekstil, cat, dan kertas tetapi banyak disalahgunakan dalam makanan, salah satunya adalah kerupuk merah. Rhodamine B dapat mengiritasi saluran pernapasan, kulit, mata, saluran pencernaan, keracunan, dan gangguan hati, dan dalam jangka panjang, dapat menyebabkan kanker dan tumor. Secara kualitatif dan kuantitatif kandungan pewarna Rhodamine B dalam kerupuk merah ditentukan menggunakan TLC dan UV-Vis Spectrophotometry. Tujuh sampel dari produsen menunjukkan bahwa Rhodamine B atau negatif tidak ditemukan pada kerupuk merah. Itu artinya kerupuk merah yang diproduksi oleh industri rumah tangga di Payakumbuh aman untuk dikonsumsi.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79045659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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