首页 > 最新文献

全部最新文献

英文 中文
IF:
Issue 3-The occupational burden of respiratory diseases, an update. 第 3 期--呼吸系统疾病的职业负担,最新情况。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-10-24 DOI: 10.1016/j.pulmoe.2024.03.004
N Murgia, M Akgun, P D Blanc, J T Costa, S Moitra, X Muñoz, K Toren, A J Ferreira

Introduction and aims: Workplace exposures are widely known to cause specific occupational diseases such as silicosis and asbestosis, but they also can contribute substantially to causation of common respiratory diseases. In 2019, the American Thoracic Society (ATS) and the European Respiratory Society (ERS) published a joint statement on the occupational burden of respiratory diseases. Our aim on this narrative review is to summarise the most recent evidence published after the ATS/ERS statement as well as to provide information on traditional occupational lung diseases that can be useful for clinicians and researchers.

Results: Newer publications confirm the findings of the ATS/ERS statement on the role of workplace exposure in contributing to the aetiology of the respiratory diseases considered in this review (asthma, COPD, chronic bronchitis, idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, infectious pneumonia). Except for COPD, chronic bronchitis and infectious pneumonia, the number of publications in the last 5 years for the other diseases is limited. For traditional occupational lung diseases such as silicosis and asbestosis, there are old as well as novel sources of exposure and their burden continues to be relevant, especially in developing countries.

Conclusions: Occupational exposure remains an important risk factor for airways and interstitial lung diseases, causing occupational lung diseases and contributing substantially in the aetiology of common respiratory diseases. This information is critical for public health professionals formulating effective preventive strategies but also for clinicians in patient care. Effective action requires shared knowledge among clinicians, researchers, public health professionals, and policy makers.

导言和目的:众所周知,工作场所暴露会导致矽肺病和石棉沉滞症等特定职业病,但它们也会在很大程度上导致常见呼吸系统疾病。2019 年,美国胸科学会(ATS)和欧洲呼吸学会(ERS)发表了一份关于呼吸系统疾病职业负担的联合声明。我们撰写这篇叙述性综述的目的是总结美国胸科学会/欧洲呼吸学会声明发表后的最新证据,并提供对临床医生和研究人员有用的传统职业性肺病信息:新近发表的文章证实了 ATS/ERS 声明中关于工作场所暴露对本综述所涉及的呼吸系统疾病(哮喘、慢性阻塞性肺病、慢性支气管炎、特发性肺纤维化、超敏性肺炎、感染性肺炎)病因的作用的结论。除慢性阻塞性肺病、慢性支气管炎和传染性肺炎外,其他疾病在过去 5 年中发表的论文数量有限。对于矽肺病和石棉沉滞症等传统职业性肺部疾病,既有旧的接触源,也有新的接触源,其负担仍然很重,尤其是在发展中国家:结论:职业暴露仍然是气道疾病和间质性肺病的重要风险因素,不仅会导致职业性肺病,还会对常见呼吸系统疾病的病因产生重大影响。这些信息对公共卫生专业人员制定有效的预防策略至关重要,对临床医生的病人护理也是如此。有效的行动需要临床医生、研究人员、公共卫生专业人员和政策制定者共享知识。
{"title":"Issue 3-The occupational burden of respiratory diseases, an update.","authors":"N Murgia, M Akgun, P D Blanc, J T Costa, S Moitra, X Muñoz, K Toren, A J Ferreira","doi":"10.1016/j.pulmoe.2024.03.004","DOIUrl":"10.1016/j.pulmoe.2024.03.004","url":null,"abstract":"<p><strong>Introduction and aims: </strong>Workplace exposures are widely known to cause specific occupational diseases such as silicosis and asbestosis, but they also can contribute substantially to causation of common respiratory diseases. In 2019, the American Thoracic Society (ATS) and the European Respiratory Society (ERS) published a joint statement on the occupational burden of respiratory diseases. Our aim on this narrative review is to summarise the most recent evidence published after the ATS/ERS statement as well as to provide information on traditional occupational lung diseases that can be useful for clinicians and researchers.</p><p><strong>Results: </strong>Newer publications confirm the findings of the ATS/ERS statement on the role of workplace exposure in contributing to the aetiology of the respiratory diseases considered in this review (asthma, COPD, chronic bronchitis, idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, infectious pneumonia). Except for COPD, chronic bronchitis and infectious pneumonia, the number of publications in the last 5 years for the other diseases is limited. For traditional occupational lung diseases such as silicosis and asbestosis, there are old as well as novel sources of exposure and their burden continues to be relevant, especially in developing countries.</p><p><strong>Conclusions: </strong>Occupational exposure remains an important risk factor for airways and interstitial lung diseases, causing occupational lung diseases and contributing substantially in the aetiology of common respiratory diseases. This information is critical for public health professionals formulating effective preventive strategies but also for clinicians in patient care. Effective action requires shared knowledge among clinicians, researchers, public health professionals, and policy makers.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":" ","pages":"2416808"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Alveolar stem cell exhaustion, fibrosis and bronchiolar proliferation" related entities. A narrative review. "肺泡干细胞衰竭、纤维化和支气管增生 "相关实体。叙述性综述。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-11-04 DOI: 10.1016/j.pulmoe.2024.05.005
M Chilosi, S Piciucchi, C Ravaglia, P Spagnolo, N Sverzellati, S Tomassetti, W Wuyts, V Poletti
{"title":"\"Alveolar stem cell exhaustion, fibrosis and bronchiolar proliferation\" related entities. A narrative review.","authors":"M Chilosi, S Piciucchi, C Ravaglia, P Spagnolo, N Sverzellati, S Tomassetti, W Wuyts, V Poletti","doi":"10.1016/j.pulmoe.2024.05.005","DOIUrl":"10.1016/j.pulmoe.2024.05.005","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":" ","pages":"2416847"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological effects of nasal high flow therapy during exercise in patients with chronic obstructive pulmonary disease: A crossover randomised controlled trial.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-11-20 DOI: 10.1080/25310429.2024.2424649
Tristan Bonnevie, Francis-Edouard Gravier, Pauline Smondack, Emeline Fresnel, Isabelle Rivals, Helena Brunel, Yann Combret, Clément Médrinal, Guillaume Prieur, Fairuz Boujibar, Thomas Similowski, Jean-François Muir, Antoine Cuvelier, Maxime Patout

Background: Nasal high flow (NHF) has been proposed to sustain high intensity exercise in people with COPD, but we have a poor understanding of its physiological effects in this clinical setting.

Research question: What is the effect of NHF during exercise on dynamic respiratory muscle function and activation, cardiorespiratory parameters, endurance capacity, dyspnoea and leg fatigue as compared to control intervention.

Study design and methods: Randomized single-blind crossover trial including COPD patients. Two constant workload exercise testing were performed at 75% of peak power with NHF (30L/min, 34°C) or with control intervention. Pressure time product of the transdiaphragmatic pressure (PTPdi/min) and other physiological measurements were continuously monitored. Dyspnoea and lower limb fatigue were assessed using the 10-Borg scale.

Results: 14 patients with severe obstruction (median FEV1: 40 (IQR 28 to 52) %) were included. Their median age was 70 (IQR 57 to 72) years. At isotime, NHF had little to no effect on PTPdi/min (MD -15cmH2O.s/min, 95% CI -62 to 33) but increased tidal volume (MD 77mL, 95% CI 21 to 133). NHF also improved endurance capacity (MD 20s, 95% CI 2 to 40) and dyspnoea at isotime (MD -1.1, 95% CI -2.1 to -0.1). NHF had no or uncertain effect on other outcomes.

Conclusion: NHF has little to no effect on dynamic respiratory muscle function and activation but improves Vt. It leads to a trivially small increase in endurance capacity but a worthwhile improvement in dyspnoea. NHF may be beneficial for individuals experiencing critical inspiratory constraints and significant dyspnoea.

背景:有人提出用鼻腔高流量(NHF)来维持慢性阻塞性肺病患者的高强度运动,但我们对其在这种临床环境中的生理效应了解甚少:研究问题:与对照干预相比,NHF 在运动过程中对动态呼吸肌功能和激活、心肺参数、耐力能力、呼吸困难和腿部疲劳的影响如何?随机单盲交叉试验,包括慢性阻塞性肺病患者。在使用 NHF(30 升/分钟,34°C)或对照干预的情况下,以峰值功率的 75% 进行了两次恒定工作量运动测试。连续监测横膈膜压力时间乘积(PTPdi/min)和其他生理指标。呼吸困难和下肢疲劳采用 10-Borg 量表进行评估:结果:14 名重度阻塞患者(中位数 FEV1:结果:共纳入 14 名重度阻塞患者(中位数 FEV1:40(IQR 28 至 52)%)。他们的中位年龄为 70 岁(IQR 57 至 72)。在等时状态下,NHF 对 PTPdi/min 几乎没有影响(MD -15cmH2O.s/min,95% CI -62-33),但可增加潮气量(MD 77mL,95% CI 21-133)。NHF 还提高了耐力(MD 20s,95% CI 2 至 40)和等时呼吸困难(MD -1.1, 95% CI -2.1 至 -0.1)。NHF对其他结果没有影响或影响不确定:结论:NHF 对动态呼吸肌功能和激活几乎没有影响,但能改善 Vt。NHF 对动态呼吸肌功能和激活几乎没有影响,但能改善 Vt,对耐力的提高微乎其微,但对呼吸困难的改善值得肯定。NHF 可能对吸气严重受限和呼吸困难严重的患者有益。
{"title":"Physiological effects of nasal high flow therapy during exercise in patients with chronic obstructive pulmonary disease: A crossover randomised controlled trial.","authors":"Tristan Bonnevie, Francis-Edouard Gravier, Pauline Smondack, Emeline Fresnel, Isabelle Rivals, Helena Brunel, Yann Combret, Clément Médrinal, Guillaume Prieur, Fairuz Boujibar, Thomas Similowski, Jean-François Muir, Antoine Cuvelier, Maxime Patout","doi":"10.1080/25310429.2024.2424649","DOIUrl":"https://doi.org/10.1080/25310429.2024.2424649","url":null,"abstract":"<p><strong>Background: </strong>Nasal high flow (NHF) has been proposed to sustain high intensity exercise in people with COPD, but we have a poor understanding of its physiological effects in this clinical setting.</p><p><strong>Research question: </strong>What is the effect of NHF during exercise on dynamic respiratory muscle function and activation, cardiorespiratory parameters, endurance capacity, dyspnoea and leg fatigue as compared to control intervention.</p><p><strong>Study design and methods: </strong>Randomized single-blind crossover trial including COPD patients. Two constant workload exercise testing were performed at 75% of peak power with NHF (30L/min, 34°C) or with control intervention. Pressure time product of the transdiaphragmatic pressure (PTPdi/min) and other physiological measurements were continuously monitored. Dyspnoea and lower limb fatigue were assessed using the 10-Borg scale.</p><p><strong>Results: </strong>14 patients with severe obstruction (median FEV1: 40 (IQR 28 to 52) %) were included. Their median age was 70 (IQR 57 to 72) years. At isotime, NHF had little to no effect on PTPdi/min (MD -15cmH2O.s/min, 95% CI -62 to 33) but increased tidal volume (MD 77mL, 95% CI 21 to 133). NHF also improved endurance capacity (MD 20s, 95% CI 2 to 40) and dyspnoea at isotime (MD -1.1, 95% CI -2.1 to -0.1). NHF had no or uncertain effect on other outcomes.</p><p><strong>Conclusion: </strong>NHF has little to no effect on dynamic respiratory muscle function and activation but improves Vt. It leads to a trivially small increase in endurance capacity but a worthwhile improvement in dyspnoea. NHF may be beneficial for individuals experiencing critical inspiratory constraints and significant dyspnoea.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2424649"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Launching a debate: Physical activity in people with chronic respiratory diseases. 发起一场辩论:慢性呼吸道疾病患者的身体活动。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-12-23 DOI: 10.1080/25310429.2024.2445408
Mara Paneroni, Michele Vitacca, Nicolino Ambrosino
{"title":"Launching a debate: Physical activity in people with chronic respiratory diseases.","authors":"Mara Paneroni, Michele Vitacca, Nicolino Ambrosino","doi":"10.1080/25310429.2024.2445408","DOIUrl":"https://doi.org/10.1080/25310429.2024.2445408","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2445408"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of exercise training on modulating the TH17/TREG imbalance in individuals with severe COPD: A randomized controlled trial. 运动训练对调节重度COPD患者TH17/TREG失衡的影响:一项随机对照试验
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2025-01-07 DOI: 10.1080/25310429.2024.2441069
Juliana Tiyaki Ito, Luan Henrique Vasconcelos Alves, Luana de Mendonça Oliveira, Rafaella Fagundes Xavier, Regina Maria Carvalho-Pinto, Iolanda de Fátima Lopes Calvo Tibério, Maria Notomi Sato, Celso R F Carvalho, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes

Background: Chronic obstructive pulmonary disease (COPD) induces an imbalance in T helper (Th) 17/regulatory T (Treg) cells that contributes to of the dysregulation of inflammation. Exercise training can modulate the immune response in healthy subjects.

Objective: We aimed to evaluate the effects of exercise training on Th17/Treg responses and the differentiation of Treg phenotypes in individuals with COPD.

Methods: This randomized controlled trial included 50 individuals with severe or very severe COPD who were allocated to the Exercise or Control groups. The Exercise group underwent eight weeks of aerobic and muscle strength training, whereas the Control group received usual care. The primary outcome was the change in the phenotypic characteristics of Tregs and Th17 profile differentiation in systemic inflammation.

Results: Exercise training increased the frequency of total and activated Tregs and decreased the frequency of Th17 cells in between-group comparisons. Additionally, Th17/Treg responses were moderately correlated with improvements in the six-minute walking test, muscle strength of the upper and lower limbs, and daily life physical activity levels.

Conclusion: Exercise training improved functional exercise capacity, muscle strength, and physical fitness, which was associated with a decrease in the Th17 inflammatory response and an increase in Treg cell phenotypes immunosuppressive activity.

背景:慢性阻塞性肺疾病(COPD)诱导辅助性T (Th) 17/调节性T (Treg)细胞失衡,导致炎症的失调。运动训练可以调节健康人的免疫反应。目的:我们旨在评估运动训练对慢性阻塞性肺病患者Th17/Treg反应和Treg表型分化的影响。方法:这项随机对照试验包括50名严重或极严重COPD患者,他们被分配到运动组或对照组。运动组接受了8周的有氧和肌肉力量训练,而对照组则接受常规护理。主要结果是全身性炎症中Tregs表型特征和Th17谱分化的变化。结果:运动训练增加了总treg和活化treg的频率,降低了Th17细胞的频率。此外,Th17/Treg反应与6分钟步行测试、上肢和下肢肌肉力量以及日常生活体力活动水平的改善中度相关。结论:运动训练提高了功能性运动能力、肌肉力量和体能,这与Th17炎症反应的减少和Treg细胞表型免疫抑制活性的增加有关。
{"title":"Effect of exercise training on modulating the TH17/TREG imbalance in individuals with severe COPD: A randomized controlled trial.","authors":"Juliana Tiyaki Ito, Luan Henrique Vasconcelos Alves, Luana de Mendonça Oliveira, Rafaella Fagundes Xavier, Regina Maria Carvalho-Pinto, Iolanda de Fátima Lopes Calvo Tibério, Maria Notomi Sato, Celso R F Carvalho, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes","doi":"10.1080/25310429.2024.2441069","DOIUrl":"https://doi.org/10.1080/25310429.2024.2441069","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) induces an imbalance in T helper (Th) 17/regulatory T (Treg) cells that contributes to of the dysregulation of inflammation. Exercise training can modulate the immune response in healthy subjects.</p><p><strong>Objective: </strong>We aimed to evaluate the effects of exercise training on Th17/Treg responses and the differentiation of Treg phenotypes in individuals with COPD.</p><p><strong>Methods: </strong>This randomized controlled trial included 50 individuals with severe or very severe COPD who were allocated to the Exercise or Control groups. The Exercise group underwent eight weeks of aerobic and muscle strength training, whereas the Control group received usual care. The primary outcome was the change in the phenotypic characteristics of Tregs and Th17 profile differentiation in systemic inflammation.</p><p><strong>Results: </strong>Exercise training increased the frequency of total and activated Tregs and decreased the frequency of Th17 cells in between-group comparisons. Additionally, Th17/Treg responses were moderately correlated with improvements in the six-minute walking test, muscle strength of the upper and lower limbs, and daily life physical activity levels.</p><p><strong>Conclusion: </strong>Exercise training improved functional exercise capacity, muscle strength, and physical fitness, which was associated with a decrease in the Th17 inflammatory response and an increase in Treg cell phenotypes immunosuppressive activity.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2441069"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of asymmetric nasal high-flow cannula on carbon dioxide in hypercapnic patients: A randomised crossover physiological pilot study.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-11-05 DOI: 10.1080/25310429.2024.2411813
Lara Pisani, Maria Laura Vega, Elisa Ageno, Irene Prediletto, Roberto Dongilli, Vito Catalanotti, Gilda Giancotti, Stefano Nava

Nasal high flow (NHF) therapy is an established form of non invasive respiratory support used in acute and chronic care. Recently, a new high flow nasal cannula with asymmetric prongs was approved for clinical use. The clinical benefits of the new cannula have not yet been defined and no evidence are available on the use of asymmetric NHF support in patient with Chronic Obstructive Pulmonary Disease (COPD). We conducted a single-centre, prospective, physiologic, crossover, randomised study to investigate the effects on partial pressure of carbon dioxide (PaCO2) levels of two different nasal cannula ("asymmetric" vs "standard" nasal interface) in 20 COPD hypercapnic patients. All patients were recovering from an acute exacerbation that required hospitalisation and had persistent hypercapnia, despite having attained a stable pH. After enrolment, two 90-min trials with the asymmetric nasal high flow interface (Optiflow + Duet, Fisher & Paykel Healthcare Ltd., New Zealand) or the standard interface (Optiflow, Fisher & Paykel Healthcare Ltd., New Zealand) were randomly applied and a washout period of 60 min between the two treatments was performed for minimising the carryover effect. Study results suggested that the asymmetrical cannula did not significantly decrease PaCO2 compared with the standard cannula. Similar performances were also observed in terms of diaphragm activity, dyspnoea and patient's comfort. Interestingly, asymmetric NHF cannula performed significantly better in reducing the dead space ventilation and increasing the ventilatory efficiency in more advanced COPD patients with more severe hypercapnia higher baseline PaCO2 values (PaCO2 ≥ 65 mmHg at baseline).   .

{"title":"Effects of asymmetric nasal high-flow cannula on carbon dioxide in hypercapnic patients: A randomised crossover physiological pilot study.","authors":"Lara Pisani, Maria Laura Vega, Elisa Ageno, Irene Prediletto, Roberto Dongilli, Vito Catalanotti, Gilda Giancotti, Stefano Nava","doi":"10.1080/25310429.2024.2411813","DOIUrl":"https://doi.org/10.1080/25310429.2024.2411813","url":null,"abstract":"<p><p>Nasal high flow (NHF) therapy is an established form of non invasive respiratory support used in acute and chronic care. Recently, a new high flow nasal cannula with asymmetric prongs was approved for clinical use. The clinical benefits of the new cannula have not yet been defined and no evidence are available on the use of asymmetric NHF support in patient with Chronic Obstructive Pulmonary Disease (COPD). We conducted a single-centre, prospective, physiologic, crossover, randomised study to investigate the effects on partial pressure of carbon dioxide (PaCO<sup>2</sup>) levels of two different nasal cannula (\"asymmetric\" vs \"standard\" nasal interface) in 20 COPD hypercapnic patients. All patients were recovering from an acute exacerbation that required hospitalisation and had persistent hypercapnia, despite having attained a stable pH. After enrolment, two 90-min trials with the asymmetric nasal high flow interface (Optiflow + Duet, Fisher & Paykel Healthcare Ltd., New Zealand) or the standard interface (Optiflow, Fisher & Paykel Healthcare Ltd., New Zealand) were randomly applied and a washout period of 60 min between the two treatments was performed for minimising the carryover effect. Study results suggested that the asymmetrical cannula did not significantly decrease PaCO<sup>2</sup> compared with the standard cannula. Similar performances were also observed in terms of diaphragm activity, dyspnoea and patient's comfort. Interestingly, asymmetric NHF cannula performed significantly better in reducing the dead space ventilation and increasing the ventilatory efficiency in more advanced COPD patients with more severe hypercapnia higher baseline PaCO<sup>2</sup> values (PaCO<sup>2</sup> ≥ 65 mmHg at baseline).   .</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2411813"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of High Intensity Interval Training on workload exercise progression in COPD with chronic respiratory failure: A pilot, feasibility, randomised trial.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-10-30 DOI: 10.1080/25310429.2024.2411802
Michele Vitacca, Ioannis Vogiatzis, Beatrice Salvi, Laura Bertacchini, Mara Paneroni
{"title":"Impact of High Intensity Interval Training on workload exercise progression in COPD with chronic respiratory failure: A pilot, feasibility, randomised trial.","authors":"Michele Vitacca, Ioannis Vogiatzis, Beatrice Salvi, Laura Bertacchini, Mara Paneroni","doi":"10.1080/25310429.2024.2411802","DOIUrl":"https://doi.org/10.1080/25310429.2024.2411802","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2411802"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of helmet CPAP using different configurations: Turbine-driven ventilators vs Venturi devices. 使用不同配置的头盔CPAP的性能:涡轮驱动呼吸机与文丘里装置。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-10-24 DOI: 10.1016/j.pulmoe.2023.04.009
A Noto, A Cortegiani, G Genoese, L Appendini, C Gregoretti, A Carlucci, C Crimi

Background: Traditionally, Venturi-based flow generators have been preferred over mechanical ventilators to provide continuous positive airway pressure (CPAP) through the helmet (h-CPAP). Recently, modern turbine-driven ventilators (TDVs) showed to be safe and effective in delivering h-CPAP. We aimed to compare the pressure stability during h-CPAP delivered by Venturi devices and TDVs and assess the impact of High Efficiency Particulate Air (HEPA) filters on their performance.

Methods: We performed a bench study using an artificial lung simulator set in a restrictive respiratory condition, simulating two different levels of patient effort (high and low) with and without the interposition of the HEPA filter. We calculated the average of minimal (Pmin), maximal (Pmax) and mean (Pmean) airway pressure and the time product measured on the airway pressure curve (PTPinsp). We defined the pressure swing (Pswing) as Pmax - Pmin and pressure drop (Pdrop) as End Expiratory Pressure - Pmin.

Results: Pswing across CPAP levels varied widely among all the tested devices. During "low effort", no difference in Pswing and Pdrop was found between Venturi devices and TDVs; during high effort, Pswing (p<0.001) and Pdrop (p<0.001) were significantly higher in TDVs compared to Venturi devices, but the PTPinsp was lower (1.50 SD 0.54 vs 1.67 SD 0.55, p<0.001). HEPA filter addition almost doubled Pswing and PTPinsp (p<0.001) but left unaltered the differences among Venturi and TDVs systems in favor of the latter (p<0.001).

Conclusions: TDVs performed better than Venturi systems in delivering a stable positive pressure level during h-CPAP in a bench setting.

背景:传统上,文丘里流发生器比机械呼吸机更适合通过头盔(h-CPAP)提供持续气道正压(CPAP)。最近,现代涡轮驱动通气机(TDVs)在提供h-CPAP方面显示出安全有效。我们的目的是比较文丘里装置和TDVs在h-CPAP期间的压力稳定性,并评估高效微粒空气(HEPA)过滤器对其性能的影响。方法:我们在限制性呼吸条件下使用人工肺模拟器进行了实验研究,模拟患者在有和没有HEPA过滤器的情况下两种不同程度的努力(高和低)。计算最小气道压力(Pmin)、最大气道压力(Pmax)、平均气道压力(Pmean)的平均值及气道压力曲线(PTPinsp)测量的时间积。我们将压力波动(Pswing)定义为Pmax - Pmin,压降(Pdrop)定义为呼气末压力- Pmin。结果:在所有测试设备中,CPAP水平的Pswing差异很大。在“低努力”阶段,文丘里装置与tdv之间的Pswing和Pdrop没有差异;结论:在h-CPAP试验中,TDVs在提供稳定的正压水平方面优于文丘里系统。
{"title":"Performance of helmet CPAP using different configurations: Turbine-driven ventilators <i>vs</i> Venturi devices.","authors":"A Noto, A Cortegiani, G Genoese, L Appendini, C Gregoretti, A Carlucci, C Crimi","doi":"10.1016/j.pulmoe.2023.04.009","DOIUrl":"10.1016/j.pulmoe.2023.04.009","url":null,"abstract":"<p><strong>Background: </strong>Traditionally, Venturi-based flow generators have been preferred over mechanical ventilators to provide continuous positive airway pressure (CPAP) through the helmet (h-CPAP). Recently, modern turbine-driven ventilators (TDVs) showed to be safe and effective in delivering h-CPAP. We aimed to compare the pressure stability during h-CPAP delivered by Venturi devices and TDVs and assess the impact of High Efficiency Particulate Air (HEPA) filters on their performance.</p><p><strong>Methods: </strong>We performed a bench study using an artificial lung simulator set in a restrictive respiratory condition, simulating two different levels of patient effort (high and low) with and without the interposition of the HEPA filter. We calculated the average of minimal (Pmin), maximal (Pmax) and mean (Pmean) airway pressure and the time product measured on the airway pressure curve (PTPinsp). We defined the pressure swing (Pswing) as Pmax - Pmin and pressure drop (Pdrop) as End Expiratory Pressure - Pmin.</p><p><strong>Results: </strong>Pswing across CPAP levels varied widely among all the tested devices. During \"low effort\", no difference in Pswing and Pdrop was found between Venturi devices and TDVs; during high effort, Pswing (p<0.001) and Pdrop (p<0.001) were significantly higher in TDVs compared to Venturi devices, but the PTPinsp was lower (1.50 SD 0.54 vs 1.67 SD 0.55, p<0.001). HEPA filter addition almost doubled Pswing and PTPinsp (p<0.001) but left unaltered the differences among Venturi and TDVs systems in favor of the latter (p<0.001).</p><p><strong>Conclusions: </strong>TDVs performed better than Venturi systems in delivering a stable positive pressure level during h-CPAP in a bench setting.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":" ","pages":"2416789"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9542198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can we rely on single use bronchoscopes in central airway obstruction management? A preliminary, open label randomised controlled trial. 在中央气道阻塞的治疗中,我们能否依靠一次性支气管镜?一项初步、开放标签随机对照试验。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2024-12-20 DOI: 10.1080/25310429.2024.2443218
Filip Popovic, Goran Glodic, Denis Baricevic, Viktor Domislovic, Miroslav Samarzija, Sonja Badovinac
{"title":"Can we rely on single use bronchoscopes in central airway obstruction management? A preliminary, open label randomised controlled trial.","authors":"Filip Popovic, Goran Glodic, Denis Baricevic, Viktor Domislovic, Miroslav Samarzija, Sonja Badovinac","doi":"10.1080/25310429.2024.2443218","DOIUrl":"https://doi.org/10.1080/25310429.2024.2443218","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2443218"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of modifications to pertussis case definition on epidemiological characteristics of pertussis in mainland China.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 Epub Date: 2025-02-07 DOI: 10.1080/25310429.2024.2448079
Jian Shen, Ying Yuan, Lilin Le
{"title":"Impact of modifications to pertussis case definition on epidemiological characteristics of pertussis in mainland China.","authors":"Jian Shen, Ying Yuan, Lilin Le","doi":"10.1080/25310429.2024.2448079","DOIUrl":"https://doi.org/10.1080/25310429.2024.2448079","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2448079"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1