Clinical and Experimental Hypertension最新文献_第7页

Red wine but not alcohol consumption improves cardiovascular function and oxidative stress of the hypertensive-SHR and diabetic-STZ rats 红酒而非酒精可改善高血压- shr和糖尿病- stz大鼠的心血管功能和氧化应激

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-06-14 DOI: 10.1080/10641963.2022.2085737

Guilherme Henrique Souza Bomfim, D. C. Musial, K. Rocha, A. Jurkiewicz, N. Jurkiewicz

ABSTRACT Hypertension and diabetes development had been characterized as idiopathic disorders tightly interconnected, and therefore it is essential to understand how the functionality of neurohormonal pathways are involved in both diseases. Hypertensive and diabetic patients have shown increased systolic blood pressure (SBP), oxidative stress, vascular hypertrophy, and remodeling. It is well established that the long-term consumption of red wine and/or polyphenol-stilbene causes cardioprotective and antihypertensive effects; however, some functions remain unrevealed. Downstream pathways such as reactive oxygen species (ROS), sympathoadrenal axis represented by β1-adrenoceptors, and renin–angiotensin system via angiotensin-II receptors critically contribute to hypertension development. Aims This raised the issue of whether in vivo long-term red wine treatment can act as a modulator of these targets. Main methods We monitored SBP, glucose tolerance, oxidative stress, and cardiovascular function. Aortic and atrial tissues from normotensive-WKY, hypertensive-SHR, and diabetic-STZ animals, chronically exposed to red wine (3.715 ml/kg/v.o/day) or alcohol (12%) for 21-days, were used to measure contractile/relaxation responses by force transducers. Key findings: red wine, but not alcohol, prevented the increase of SBP and hyperglycemic peak. Additionally, was observed prevention of oxidative stress metabolites formation and an improvement in ROS scavenging antioxidant capacity of SHR. We also revealed that red wine intake enhances the endothelium-dependent relaxation, decreases the hypercontractile mediated by angiotensin-II in the aorta, and via β1-adrenoceptors in the atrium. Significance The long-term consumption of red wine can improve oxidative stress and the functionality of angiotensin-II and β1-adrenoceptors, inspiring new pharmacologic and dietetic therapeutic approaches for the treatment of hypertension and diabetes. Abbreviation Acronyms and/or abbreviations: [Ca2+]cyt = Cytosolic Ca2+ Concentration; ACh = Acetylcholine; ANG II = Angiotensin II; AT1 = ANG II type 1 receptor; AUC = Area Under the Curve; Ca2+ = Calcium; Endo + = Endothelium Intact; Fen = Phenylephrine (1 μM); GTT = Glucose Tolerance Test; ISO = Isoprenaline (isoproterenol); KHN = Krebs-Henseleit Nutrient; LA = Left Atria; LH = Lipid Hydroperoxide; NO = Nitric Oxide; RA = Right Atria; RAS = Renin-Angiotensin System; ROS = Reactive Oxygen Species; SBP = Systolic Blood Pressure; SHR = Spontaneously Hypertensive Rats; STZ = Streptozotocin; WKY = Normotensive Wistar Kyoto Rats.

高血压和糖尿病的发展被认为是紧密相连的特发性疾病，因此了解神经激素通路的功能如何参与这两种疾病是至关重要的。高血压和糖尿病患者表现为收缩压(SBP)升高、氧化应激、血管肥大和重塑。长期饮用红酒和/或多酚二苯乙烯具有保护心脏和抗高血压的作用。然而，一些功能仍未被揭示。下游通路如活性氧(ROS)、以β1-肾上腺素受体为代表的交感肾上腺轴和通过血管紧张素- ii受体的肾素-血管紧张素系统对高血压的发展起着至关重要的作用。这就提出了一个问题，即体内长期红酒治疗是否可以作为这些靶标的调节剂。主要方法监测收缩压、葡萄糖耐量、氧化应激和心血管功能。正常血压- wky、高血压- shr和糖尿病- stz动物的主动脉和心房组织长期暴露于红葡萄酒(3.715 ml/kg/v / o/天)或酒精(12%)21天，通过力传感器测量收缩/松弛反应。主要发现:红酒，而不是酒精，可以防止收缩压和高血糖峰值的增加。此外，还可以防止氧化应激代谢物的形成，提高SHR清除ROS的抗氧化能力。我们还发现，红酒摄入增强了内皮依赖性松弛，降低了主动脉血管紧张素- ii和心房β1-肾上腺素受体介导的过度收缩。意义长期饮用红酒可以改善氧化应激，改善血管紧张素- ii和β1肾上腺素受体的功能，为高血压和糖尿病的治疗提供新的药理和饮食治疗方法。缩略语和/或缩写词:[Ca2+]cyt =胞质Ca2+浓度;乙酰胆碱;ANG II =血管紧张素II;AT1 = ANG II型1受体;AUC =曲线下面积;Ca2+ =钙;Endo + =内皮完整;Fen =苯肾上腺素(1 μM);葡萄糖耐量试验;异丙肾上腺素;KHN = Krebs-Henseleit营养素;LA =左心房;LH =过氧化脂质;NO =一氧化氮;RA =右心房;肾素-血管紧张素系统;活性氧;收缩压;自发性高血压大鼠;STZ =链脲佐菌素;WKY =正常血压Wistar京都大鼠。

{"title":"Red wine but not alcohol consumption improves cardiovascular function and oxidative stress of the hypertensive-SHR and diabetic-STZ rats","authors":"Guilherme Henrique Souza Bomfim, D. C. Musial, K. Rocha, A. Jurkiewicz, N. Jurkiewicz","doi":"10.1080/10641963.2022.2085737","DOIUrl":"https://doi.org/10.1080/10641963.2022.2085737","url":null,"abstract":"ABSTRACT Hypertension and diabetes development had been characterized as idiopathic disorders tightly interconnected, and therefore it is essential to understand how the functionality of neurohormonal pathways are involved in both diseases. Hypertensive and diabetic patients have shown increased systolic blood pressure (SBP), oxidative stress, vascular hypertrophy, and remodeling. It is well established that the long-term consumption of red wine and/or polyphenol-stilbene causes cardioprotective and antihypertensive effects; however, some functions remain unrevealed. Downstream pathways such as reactive oxygen species (ROS), sympathoadrenal axis represented by β1-adrenoceptors, and renin–angiotensin system via angiotensin-II receptors critically contribute to hypertension development. Aims This raised the issue of whether in vivo long-term red wine treatment can act as a modulator of these targets. Main methods We monitored SBP, glucose tolerance, oxidative stress, and cardiovascular function. Aortic and atrial tissues from normotensive-WKY, hypertensive-SHR, and diabetic-STZ animals, chronically exposed to red wine (3.715 ml/kg/v.o/day) or alcohol (12%) for 21-days, were used to measure contractile/relaxation responses by force transducers. Key findings: red wine, but not alcohol, prevented the increase of SBP and hyperglycemic peak. Additionally, was observed prevention of oxidative stress metabolites formation and an improvement in ROS scavenging antioxidant capacity of SHR. We also revealed that red wine intake enhances the endothelium-dependent relaxation, decreases the hypercontractile mediated by angiotensin-II in the aorta, and via β1-adrenoceptors in the atrium. Significance The long-term consumption of red wine can improve oxidative stress and the functionality of angiotensin-II and β1-adrenoceptors, inspiring new pharmacologic and dietetic therapeutic approaches for the treatment of hypertension and diabetes. Abbreviation Acronyms and/or abbreviations: [Ca2+]cyt = Cytosolic Ca2+ Concentration; ACh = Acetylcholine; ANG II = Angiotensin II; AT1 = ANG II type 1 receptor; AUC = Area Under the Curve; Ca2+ = Calcium; Endo + = Endothelium Intact; Fen = Phenylephrine (1 μM); GTT = Glucose Tolerance Test; ISO = Isoprenaline (isoproterenol); KHN = Krebs-Henseleit Nutrient; LA = Left Atria; LH = Lipid Hydroperoxide; NO = Nitric Oxide; RA = Right Atria; RAS = Renin-Angiotensin System; ROS = Reactive Oxygen Species; SBP = Systolic Blood Pressure; SHR = Spontaneously Hypertensive Rats; STZ = Streptozotocin; WKY = Normotensive Wistar Kyoto Rats.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72772339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mat Pilates training reduces blood pressure in both well-controlled hypertensive and normotensive postmenopausal women: a controlled clinical trial study 马特普拉提训练降低血压控制良好的高血压和正常绝经后妇女:一项对照临床试验研究

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-06-01 DOI: 10.1080/10641963.2022.2079670

J. Batista, J. B. Tavares, L. F. Gonçalves, T. D. de Souza, I. Mariano, A. Amaral, Mateus de Lima Rodrigues, L. Matias, Ana Paula Magalhães Resende, G. Puga

ABSTRACT Aim The aim of this study was to compare the Mat Pilates training-induced responses in resting and ambulatory blood pressure monitoring (ABPM), blood pressure variability (BPV), and heart rate variability (HRV) in well-controlled hypertensive and normotensive postmenopausal women. Methods Forty-seven postmenopausal women were allocated in well-controlled hypertensive (HT) and normotensive (NT) groups. The exercise program was performed three times a week for 12 weeks. Before and after the intervention resting, blood pressure (BP), ABPM, HRV, and BPV were analyzed. Results Student’s t-test showed no difference in baseline anthropometric and resting BP values between groups. The generalized estimation equation (GEE) showed no interactions (group*time), but time (p < .05) reductions in resting systolic, diastolic and mean BP after training in both groups. Sleep ambulatory systolic, diastolic and mean BP were higher overall in the HT group (p < .05 in group effect). We also found a time effect (p < .05) with significant increases in BPV in the mean diurnal and nocturnal deviations weighted for the duration of the daytime and nighttime interval (SDdn) in systolic, diastolic and mean BP, and in the average real variability (ARV) in diastolic and mean in both groups. In addition, HRV increases (p < .05 in time effect) through the percentage of pairs of adjacent RR intervals with a difference of at least 50 ms (pNN50) after training in both groups. Conclusion Both normotensive and well-controlled hypertensive postmenopausal women may have similar Mat Pilates exercise training-induced responses in ambulatory BP, BPV and HRV.

摘要目的本研究的目的是比较Mat Pilates训练诱导的静息和动态血压监测(ABPM)、血压变异性(BPV)和心率变异性(HRV)在控制良好的高血压和正常绝经后妇女中的反应。方法将47名绝经后妇女分为控制良好的高血压组(HT)和正常高血压组(NT)。这项锻炼计划每周进行三次，持续12周。分析干预前后静息血压(BP)、ABPM、HRV、BPV。结果学生t检验显示两组间基线人体测量值和静息血压值无差异。广义估计方程(GEE)无相互作用(组*时间)，但两组训练后静息收缩压、舒张压和平均血压(p < 0.05)降低。HT组睡眠动态收缩压、舒张压和平均血压均高于对照组(组效应p < 0.05)。我们还发现了时间效应(p < 0.05)，两组患者收缩压、舒张压和平均血压的昼夜平均偏差(SDdn)以及舒张压和平均平均实际变异性(ARV)均显著增加。此外，两组训练后HRV通过相邻RR区间相差至少50 ms的成对百分比(pNN50)增加(时间效应p < 0.05)。结论正常和控制良好的绝经后高血压妇女在动态血压、BPV和HRV方面可能有相似的普拉提运动训练引起的反应。

{"title":"Mat Pilates training reduces blood pressure in both well-controlled hypertensive and normotensive postmenopausal women: a controlled clinical trial study","authors":"J. Batista, J. B. Tavares, L. F. Gonçalves, T. D. de Souza, I. Mariano, A. Amaral, Mateus de Lima Rodrigues, L. Matias, Ana Paula Magalhães Resende, G. Puga","doi":"10.1080/10641963.2022.2079670","DOIUrl":"https://doi.org/10.1080/10641963.2022.2079670","url":null,"abstract":"ABSTRACT Aim The aim of this study was to compare the Mat Pilates training-induced responses in resting and ambulatory blood pressure monitoring (ABPM), blood pressure variability (BPV), and heart rate variability (HRV) in well-controlled hypertensive and normotensive postmenopausal women. Methods Forty-seven postmenopausal women were allocated in well-controlled hypertensive (HT) and normotensive (NT) groups. The exercise program was performed three times a week for 12 weeks. Before and after the intervention resting, blood pressure (BP), ABPM, HRV, and BPV were analyzed. Results Student’s t-test showed no difference in baseline anthropometric and resting BP values between groups. The generalized estimation equation (GEE) showed no interactions (group*time), but time (p < .05) reductions in resting systolic, diastolic and mean BP after training in both groups. Sleep ambulatory systolic, diastolic and mean BP were higher overall in the HT group (p < .05 in group effect). We also found a time effect (p < .05) with significant increases in BPV in the mean diurnal and nocturnal deviations weighted for the duration of the daytime and nighttime interval (SDdn) in systolic, diastolic and mean BP, and in the average real variability (ARV) in diastolic and mean in both groups. In addition, HRV increases (p < .05 in time effect) through the percentage of pairs of adjacent RR intervals with a difference of at least 50 ms (pNN50) after training in both groups. Conclusion Both normotensive and well-controlled hypertensive postmenopausal women may have similar Mat Pilates exercise training-induced responses in ambulatory BP, BPV and HRV.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80052235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension 新诊断高血压患者红细胞分布宽度、全身免疫炎症指数与不良心血管预后的关系

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-06-01 DOI: 10.1080/10641963.2022.2079668

F. Uzun, A. Güner, H. Pusuroğlu, A. Demir, S. Gündüz, İsmail Gürbak, S. Aslan, Gokhan Demirci, Ezgi Gültekin Güner, Enes Arslan, M. Erturk

ABSTRACT Background Red cell distribution width (RDW) and the systemic immune-inflammation index (SII) have been extensively studied as predictors of morbidity and mortality in several cardiovascular diseases. This prospective study aimed to investigate the relationship between long term major adverse cardiac events (MACEs) and simple hematological parameters in hypertensive patients. Methods The study included a total of 1202 patients with newly diagnosed HT. Of the patients, 662 (55.1%) were female and 540 (44.9%) were male, with a mean age of 53.0 ± 11.4 years. The primary endpoint of the study was long term MACE, including cardiac death, stroke, and myocardial infarction. This is the first study focusing on the association of SII with major adverse cardiovascular outcomes in patients with HT. Results Eighty-nine patients (8.7%) developed at least one MACE during a mean follow-up period of 82.2 ± 1.3 months. RDW (13.0 ± 0.9 vs. 13.5 ± 1.2%, p < .001) and SII [465.0 (353.4–609.4) vs. 584.4 (468.9–794.0) x103/µL, p < .001] were significantly higher in patients with MACEs. The prevalence of MACEs was significantly higher in patients with RDW>13.1% (10.4 vs. 5%; p < .001) and in patients with SII>465 x103/µL (11.8 vs. 3.1%; p < .001). The multivariate logistic regression analysis showed SII and RDW were independent predictors of MACEs. Conclusion The results of the study demonstrated that the RDW and SII were independent predictors of long-term cardiovascular events in hypertensive patients. These simple hematological parameters may be used as prognosticators of MACE in patients with newly diagnosed HT.

背景红细胞分布宽度(RDW)和全身免疫炎症指数(SII)作为几种心血管疾病发病率和死亡率的预测因子已被广泛研究。本前瞻性研究旨在探讨高血压患者长期主要心脏不良事件(mace)与单纯血液学参数的关系。方法纳入1202例新诊断的HT患者。其中女性662例(55.1%)，男性540例(44.9%)，平均年龄53.0±11.4岁。研究的主要终点是长期MACE，包括心源性死亡、中风和心肌梗死。这是第一个关注SII与HT患者主要不良心血管结局相关性的研究。结果89例(8.7%)患者在平均82.2±1.3个月的随访期间发生了至少一次MACE。MACEs患者的RDW(13.0±0.9比13.5±1.2%，p < 0.001)和SII[465.0(353.4-609.4)比584.4 (468.9-794.0)x103/µL, p < 0.001]显著升高。在RDW>13.1%的患者中，mace的患病率明显更高(10.4% vs. 5%;p < 0.001)， SII>465 x103/µL的患者(11.8 vs. 3.1%;P < 0.001)。多因素logistic回归分析显示SII和RDW是mace的独立预测因子。结论研究结果表明，RDW和SII是高血压患者长期心血管事件的独立预测因子。这些简单的血液学参数可作为新诊断HT患者MACE的预后指标。

{"title":"Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension","authors":"F. Uzun, A. Güner, H. Pusuroğlu, A. Demir, S. Gündüz, İsmail Gürbak, S. Aslan, Gokhan Demirci, Ezgi Gültekin Güner, Enes Arslan, M. Erturk","doi":"10.1080/10641963.2022.2079668","DOIUrl":"https://doi.org/10.1080/10641963.2022.2079668","url":null,"abstract":"ABSTRACT Background Red cell distribution width (RDW) and the systemic immune-inflammation index (SII) have been extensively studied as predictors of morbidity and mortality in several cardiovascular diseases. This prospective study aimed to investigate the relationship between long term major adverse cardiac events (MACEs) and simple hematological parameters in hypertensive patients. Methods The study included a total of 1202 patients with newly diagnosed HT. Of the patients, 662 (55.1%) were female and 540 (44.9%) were male, with a mean age of 53.0 ± 11.4 years. The primary endpoint of the study was long term MACE, including cardiac death, stroke, and myocardial infarction. This is the first study focusing on the association of SII with major adverse cardiovascular outcomes in patients with HT. Results Eighty-nine patients (8.7%) developed at least one MACE during a mean follow-up period of 82.2 ± 1.3 months. RDW (13.0 ± 0.9 vs. 13.5 ± 1.2%, p < .001) and SII [465.0 (353.4–609.4) vs. 584.4 (468.9–794.0) x103/µL, p < .001] were significantly higher in patients with MACEs. The prevalence of MACEs was significantly higher in patients with RDW>13.1% (10.4 vs. 5%; p < .001) and in patients with SII>465 x103/µL (11.8 vs. 3.1%; p < .001). The multivariate logistic regression analysis showed SII and RDW were independent predictors of MACEs. Conclusion The results of the study demonstrated that the RDW and SII were independent predictors of long-term cardiovascular events in hypertensive patients. These simple hematological parameters may be used as prognosticators of MACE in patients with newly diagnosed HT.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84877598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models 植物色素素在大鼠模型中的降压作用及其作用机制

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-05-29 DOI: 10.1080/10641963.2022.2079671

Imran Ul haq, T. Ahmad, T. Khan, A. Shah

ABSTRACT Background Phytolaccagenin, a natural triterpenoid, is reported for various biological activities that indicate its potential role in the management of hypertension. Methods Phytolaccagenin was evaluated for its antihypertensive activity in rat models via in vivo and in vitro experiments using polyethylene tubings for cannulation, organ bath bubbled with carbogen gas, and a pressure transducer connected to a PowerLab data acquisition system. Results Intravenous administration of phytolaccagenin decreased mean arterial pressure (MAP), significantly, in normotensive and hypertensive anesthetized rats. Pretreatment of rats with atropine (2 mg/kg) partially reversed the decrease in blood pressure due to phytolaccagenin at first tested doses. However, Nω-nitro-L-arginine methyl ester (L-NAME) (100 mg/kg) pretreatment modified the effect of phytolaccagenin on blood pressure with greater response. In isolated rat aortic rings precontracted with phenylephrine, cumulative addition of phytolaccagenin induced relaxation that is ablated (50%) with denudation and pre-incubation with atropine (1 μM) and L-NAME (10 μM). Phytolaccagenin also partially inhibited high K+ precontraction at initial doses, while an inhibitory effect was observed at higher concentrations, confirming its effect on voltage-dependent calcium channels. In isolated spontaneously beating rat atrial strips, phytolaccagenin suppressed the atrial tone that was reduced with isoprenaline and atropine pre-incubation, suggesting the role of cardiac adrenergic and muscarinic receptors. Interestingly, atenolol (1 μM) pretreatment also ablated the cardiac effects of phytolaccagenin. Conclusion The antihypertensive effect of phytolaccagenin is due to a decrease in vascular resistance and cardiac depressant effects. These effects are mediated via muscarinic receptors-linked NO pathway, inhibitory effect on Ca2+ movements (vascular), and activation of cardiac muscarinic and blockade of β-adrenergic receptors.

摘要背景:植物绿原素是一种天然的三萜，据报道具有多种生物活性，表明其在高血压治疗中的潜在作用。方法采用聚乙烯管插管、含二氧化碳的器官浴、压力传感器连接PowerLab数据采集系统，通过体内和体外实验对植草青素在大鼠模型中的降压活性进行评价。结果静脉注射植草青素可显著降低正常和高血压麻醉大鼠的平均动脉压(MAP)。用阿托品(2mg /kg)预处理大鼠，在第一次试验剂量时，部分逆转了由植藻绿原素引起的血压下降。而ω-硝基- l -精氨酸甲酯(L-NAME) (100 mg/kg)预处理可以改善植藻青素对血压的影响，且效果更明显。在用苯肾上腺素预收缩的离体大鼠主动脉环中，累积添加植草青素诱导松弛，剥皮消融(50%)，并用阿托品(1 μM)和L-NAME (10 μM)预孵育。植藻绿原素在初始剂量下也部分抑制高K+预收缩，而在较高浓度下观察到抑制作用，证实了其对电压依赖性钙通道的作用。在离体自发跳动的大鼠心房条带中，植草球蛋白抑制了异丙肾上腺素和阿托品在孵育前降低的心房张力，提示心脏肾上腺素和毒蕈碱受体的作用。有趣的是，阿替洛尔(1 μM)预处理也能消除植藻绿原素对心脏的影响。结论植物色素原素的降压作用是由于其降低血管阻力和抑制心脏的作用。这些作用是通过毒蕈碱受体连接的NO途径、对Ca2+运动(血管)的抑制作用、心脏毒蕈碱的激活和β-肾上腺素能受体的阻断介导的。

{"title":"Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models","authors":"Imran Ul haq, T. Ahmad, T. Khan, A. Shah","doi":"10.1080/10641963.2022.2079671","DOIUrl":"https://doi.org/10.1080/10641963.2022.2079671","url":null,"abstract":"ABSTRACT Background Phytolaccagenin, a natural triterpenoid, is reported for various biological activities that indicate its potential role in the management of hypertension. Methods Phytolaccagenin was evaluated for its antihypertensive activity in rat models via in vivo and in vitro experiments using polyethylene tubings for cannulation, organ bath bubbled with carbogen gas, and a pressure transducer connected to a PowerLab data acquisition system. Results Intravenous administration of phytolaccagenin decreased mean arterial pressure (MAP), significantly, in normotensive and hypertensive anesthetized rats. Pretreatment of rats with atropine (2 mg/kg) partially reversed the decrease in blood pressure due to phytolaccagenin at first tested doses. However, Nω-nitro-L-arginine methyl ester (L-NAME) (100 mg/kg) pretreatment modified the effect of phytolaccagenin on blood pressure with greater response. In isolated rat aortic rings precontracted with phenylephrine, cumulative addition of phytolaccagenin induced relaxation that is ablated (50%) with denudation and pre-incubation with atropine (1 μM) and L-NAME (10 μM). Phytolaccagenin also partially inhibited high K+ precontraction at initial doses, while an inhibitory effect was observed at higher concentrations, confirming its effect on voltage-dependent calcium channels. In isolated spontaneously beating rat atrial strips, phytolaccagenin suppressed the atrial tone that was reduced with isoprenaline and atropine pre-incubation, suggesting the role of cardiac adrenergic and muscarinic receptors. Interestingly, atenolol (1 μM) pretreatment also ablated the cardiac effects of phytolaccagenin. Conclusion The antihypertensive effect of phytolaccagenin is due to a decrease in vascular resistance and cardiac depressant effects. These effects are mediated via muscarinic receptors-linked NO pathway, inhibitory effect on Ca2+ movements (vascular), and activation of cardiac muscarinic and blockade of β-adrenergic receptors.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78606604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A potential model of systemic sclerosis with pulmonary hypertension induced by monocrotaline plus bleomycin 单芥碱加博来霉素致系统性硬化症合并肺动脉高压的潜在模型

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-05-27 DOI: 10.1080/10641963.2022.2079665

Xia Fang, Chao He, Xudong Ni, Tianli Zhang, Qianyu Li, Yi Luo, Wei-guo Long, R. Wu

ABSTRACT Objective The lack of a well-established animal model limits the clarification of the detailed mechanisms of the pathogenesis of systemic sclerosis with pulmonary hypertension (SSc-PH) and the development of effective treatments for it. Methods In this study, New Zealand rabbits were injected with monocrotaline (MCT), bleomycin (BLM), and MCT plus BLM, respectively. Three and six weeks after the first injection, the mean pulmonary artery pressure (mPAP) was measured. Skin and lung samples were isolated and the histological changes were analyzed by hematoxylin and eosin staining or Masson’s trichrome staining. Results All groups of rabbits showed an increased mean mPAP compared with the saline-injected rabbits. The high mPAP persisted until week six only in the MCT and MCT + BLM groups. Furthermore, persistent high Fulton’s indices were found in the MCT and MCT + BLM groups, indicating that these treatments successfully induced right ventricular hypertrophy. The rabbits in the MCT + BLM group developed severe lung inflammation, as evidenced by a high level of neutrophil infiltration in the pulmonary interstitium. Importantly, pathological changes of the skin in the MCT + BLM group were observed, and further damage to the skin was caused by additional exposure to MCT plus BLM. Meanwhile, an excessive production of cytokines, including tumor necrosis factor alpha (TNF-α), and transforming growth factor beta 1 (TGF-β1), were detected in the MCT + BLM group. Conclusion These data indicate that SSc-PH induced by co-injection with MCT plus BLM shows persistent fibrosis and progressive PH, constituting a potential study model for SSc-PH.

【摘要】目的由于缺乏完善的动物模型，限制了对系统性硬化症合并肺动脉高压(SSc-PH)发病机制的详细阐明和有效治疗方法的开发。方法以新西兰兔为实验对象，分别注射单藜碱(MCT)、博来霉素(BLM)和MCT + BLM。第一次注射后3周和6周，测量平均肺动脉压(mPAP)。分离皮肤和肺标本，采用苏木精和伊红染色或马松三色染色分析组织学变化。结果各组家兔的平均mPAP均高于盐水注射家兔。高mPAP仅在MCT和MCT + BLM组持续到第6周。此外，在MCT和MCT + BLM组中发现持续高富尔顿指数，表明这些治疗成功诱导了右心室肥厚。MCT + BLM组的家兔出现了严重的肺部炎症，肺间质有高水平的中性粒细胞浸润。重要的是，观察到MCT + BLM组皮肤的病理变化，并且额外暴露于MCT + BLM会对皮肤造成进一步的损伤。同时，MCT + BLM组检测到肿瘤坏死因子α (TNF-α)、转化生长因子β1 (TGF-β1)等细胞因子的过量产生。结论MCT + BLM共注射诱导的SSc-PH呈现持续纤维化和进行性PH，构成了潜在的SSc-PH研究模型。

{"title":"A potential model of systemic sclerosis with pulmonary hypertension induced by monocrotaline plus bleomycin","authors":"Xia Fang, Chao He, Xudong Ni, Tianli Zhang, Qianyu Li, Yi Luo, Wei-guo Long, R. Wu","doi":"10.1080/10641963.2022.2079665","DOIUrl":"https://doi.org/10.1080/10641963.2022.2079665","url":null,"abstract":"ABSTRACT Objective The lack of a well-established animal model limits the clarification of the detailed mechanisms of the pathogenesis of systemic sclerosis with pulmonary hypertension (SSc-PH) and the development of effective treatments for it. Methods In this study, New Zealand rabbits were injected with monocrotaline (MCT), bleomycin (BLM), and MCT plus BLM, respectively. Three and six weeks after the first injection, the mean pulmonary artery pressure (mPAP) was measured. Skin and lung samples were isolated and the histological changes were analyzed by hematoxylin and eosin staining or Masson’s trichrome staining. Results All groups of rabbits showed an increased mean mPAP compared with the saline-injected rabbits. The high mPAP persisted until week six only in the MCT and MCT + BLM groups. Furthermore, persistent high Fulton’s indices were found in the MCT and MCT + BLM groups, indicating that these treatments successfully induced right ventricular hypertrophy. The rabbits in the MCT + BLM group developed severe lung inflammation, as evidenced by a high level of neutrophil infiltration in the pulmonary interstitium. Importantly, pathological changes of the skin in the MCT + BLM group were observed, and further damage to the skin was caused by additional exposure to MCT plus BLM. Meanwhile, an excessive production of cytokines, including tumor necrosis factor alpha (TNF-α), and transforming growth factor beta 1 (TGF-β1), were detected in the MCT + BLM group. Conclusion These data indicate that SSc-PH induced by co-injection with MCT plus BLM shows persistent fibrosis and progressive PH, constituting a potential study model for SSc-PH.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82796498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between serum ferritin and blood pressure in adult women: a large cross-sectional study 成年女性血清铁蛋白与血压之间的关系:一项大型横断面研究

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-05-26 DOI: 10.1080/10641963.2022.2079667

Andong He, Xiaofeng Yang, Yuzhen Ding, Lu Sun, M. Shi, Ruiman Li

ABSTRACT Background Studies on the relationships between ferritin and blood pressure remain limited, especially in adult women. The aim of the present study was to investigate the associations between serum ferritin and blood pressure among adult women. Methods Using the National Health and Nutrition Examination Survey, a cross-sectional study, including 5521 adult women, was performed. Weighted multivariate regressions, subgroup analyses, threshold effect analyses, and sensitivity analysis were used. Results The authors found that serum ferritin was independently and positively correlated to diastolic blood pressure (DBP), and this positive correlation kept present among women who are 26–30 years old, non-pregnant women, Mexican American women, and women of other races in the subgroup analyses. Additionally, no significant association was found between serum ferritin and systolic blood pressure (SBP), except in women aged 26–30, Mexican American women, and women of other races. In pregnant women, the association between serum ferritin and SBP was an inverted U-shaped curve with an inflection point at 39.5 ng/mL. Conclusions The authors demonstrated that serum ferritin was positively correlated to DBP in adult women, which may provide a novel reference for clinical management.

背景关于铁蛋白与血压之间关系的研究仍然有限，特别是在成年女性中。本研究的目的是调查成年女性血清铁蛋白与血压之间的关系。方法采用全国健康与营养调查，对5521名成年妇女进行横断面研究。采用加权多元回归、亚组分析、阈值效应分析和敏感性分析。结果作者发现血清铁蛋白与舒张压(DBP)独立且正相关，并且在亚组分析中，这种正相关在26-30岁妇女、非孕妇、墨西哥裔美国妇女和其他种族妇女中保持存在。此外，除了26-30岁的女性、墨西哥裔美国女性和其他种族的女性外，血清铁蛋白与收缩压(SBP)之间没有明显的关联。在孕妇中，血清铁蛋白与收缩压呈倒u型曲线，拐点为39.5 ng/mL。结论血清铁蛋白与成年女性舒张电位呈正相关，可为临床治疗提供新的参考。

{"title":"The association between serum ferritin and blood pressure in adult women: a large cross-sectional study","authors":"Andong He, Xiaofeng Yang, Yuzhen Ding, Lu Sun, M. Shi, Ruiman Li","doi":"10.1080/10641963.2022.2079667","DOIUrl":"https://doi.org/10.1080/10641963.2022.2079667","url":null,"abstract":"ABSTRACT Background Studies on the relationships between ferritin and blood pressure remain limited, especially in adult women. The aim of the present study was to investigate the associations between serum ferritin and blood pressure among adult women. Methods Using the National Health and Nutrition Examination Survey, a cross-sectional study, including 5521 adult women, was performed. Weighted multivariate regressions, subgroup analyses, threshold effect analyses, and sensitivity analysis were used. Results The authors found that serum ferritin was independently and positively correlated to diastolic blood pressure (DBP), and this positive correlation kept present among women who are 26–30 years old, non-pregnant women, Mexican American women, and women of other races in the subgroup analyses. Additionally, no significant association was found between serum ferritin and systolic blood pressure (SBP), except in women aged 26–30, Mexican American women, and women of other races. In pregnant women, the association between serum ferritin and SBP was an inverted U-shaped curve with an inflection point at 39.5 ng/mL. Conclusions The authors demonstrated that serum ferritin was positively correlated to DBP in adult women, which may provide a novel reference for clinical management.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80702385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Short-term effects of modest salt reduction combined with DASH diet on changing salt eating habits in hypertensive patients with type II diabetes 适度减盐联合DASH饮食对改变高血压合并2型糖尿病患者盐饮食习惯的短期影响

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-05-25 DOI: 10.1080/10641963.2022.2079666

Dan Chen, Jie Tang, Tao Gong, Lisha Mu, Jing Li, Pi-Ching Yu, Hao Wang, X. Bu, L. Mu, Ying Mei

ABSTRACT Objective Excessive salt intake is currently the foremost universal risk factor for controllable chronic disease. This study evaluated the short-term effects of a modest salt intake reduction combined with the Chinese Modified Dietary Approaches to Stop Hypertension (CM-DASH) diet on sodium and potassium intake, mean arterial pressure (MAP), and pulse pressure (PP) in hypertensive patients with type II diabetes. Methods Sixty-one participants were randomized to the intervention group (52% low-sodium salt and DASH) and control group (normal salt and DASH). An 8-week dietary intervention was applied. Daily salt intake, blood pressure (BP), and drug use were recorded every week. Twenty-four-hour urine, casual urine, and blood samples were measured at baseline, the 4th week, and the end of the intervention. Results Fifty-nine patients (25 men) completed the entire study. Sodium intake decreased by 1259.66 (792.76, 1726.56)/705.80 (149.21, 1262.39) mg/day after 4 weeks (intervention: P < .001; control: P = .015). Potassium intake increased by 641.14 (73.31, 1208.96)/43.43 (−259.66, 346.53) mg/day (intervention: P = .028); MAP decreased by 9.06 (6.69, 11.43)/7.16 (4.03, 10.28) mmHg (both: P < .001); PP decreased by 7.97 (3.05, 12.88)/5.74 (2.55,8.94) mmHg (intervention: P = .002; control: P = .001) after 8 weeks. However, the difference between the two groups was not statistically significant. Conclusion Modest salt reduction and the CM-DASH diet for hypertensive patients with type II diabetes can achieve short-term salt reduction effects. The effect on changing salt-eating habits needs to be investigated with an extended follow-up.

【摘要】目的盐摄入过多是目前可控性慢性疾病的首要普遍危险因素。本研究评估了适度减少盐摄入量结合中国改良的高血压饮食方法(CM-DASH)饮食对2型糖尿病高血压患者钠、钾摄入量、平均动脉压(MAP)和脉压(PP)的短期影响。方法将61例患者随机分为干预组(52%低钠盐和DASH)和对照组(正常盐和DASH)。采用为期8周的饮食干预。每周记录每日盐摄入量、血压(BP)和药物使用情况。在基线、第4周和干预结束时测量24小时尿液、临时尿液和血液样本。结果59例患者(男性25例)完成了整个研究。4周后钠摄入量降低1259.66 (792.76,1726.56)/705.80 (149.21,1262.39)mg/d(干预:P < 0.001;对照:P = .015)。钾摄入量增加641.14 (73.31,1208.96)/43.43 (- 259.66,346.53)mg/d(干预:P = 0.028);MAP降低9.06 (6.69,11.43)/7.16 (4.03,10.28)mmHg(均P < 0.001);PP降低7.97 (3.05,12.88)/5.74 (2.55,8.94)mmHg(干预:P = 0.002;对照组:P = .001)。但两组间差异无统计学意义。结论高血压合并2型糖尿病患者适度减盐及CM-DASH饮食可取得短期减盐效果。改变吃盐习惯的效果需要进行长期随访研究。

{"title":"Short-term effects of modest salt reduction combined with DASH diet on changing salt eating habits in hypertensive patients with type II diabetes","authors":"Dan Chen, Jie Tang, Tao Gong, Lisha Mu, Jing Li, Pi-Ching Yu, Hao Wang, X. Bu, L. Mu, Ying Mei","doi":"10.1080/10641963.2022.2079666","DOIUrl":"https://doi.org/10.1080/10641963.2022.2079666","url":null,"abstract":"ABSTRACT Objective Excessive salt intake is currently the foremost universal risk factor for controllable chronic disease. This study evaluated the short-term effects of a modest salt intake reduction combined with the Chinese Modified Dietary Approaches to Stop Hypertension (CM-DASH) diet on sodium and potassium intake, mean arterial pressure (MAP), and pulse pressure (PP) in hypertensive patients with type II diabetes. Methods Sixty-one participants were randomized to the intervention group (52% low-sodium salt and DASH) and control group (normal salt and DASH). An 8-week dietary intervention was applied. Daily salt intake, blood pressure (BP), and drug use were recorded every week. Twenty-four-hour urine, casual urine, and blood samples were measured at baseline, the 4th week, and the end of the intervention. Results Fifty-nine patients (25 men) completed the entire study. Sodium intake decreased by 1259.66 (792.76, 1726.56)/705.80 (149.21, 1262.39) mg/day after 4 weeks (intervention: P < .001; control: P = .015). Potassium intake increased by 641.14 (73.31, 1208.96)/43.43 (−259.66, 346.53) mg/day (intervention: P = .028); MAP decreased by 9.06 (6.69, 11.43)/7.16 (4.03, 10.28) mmHg (both: P < .001); PP decreased by 7.97 (3.05, 12.88)/5.74 (2.55,8.94) mmHg (intervention: P = .002; control: P = .001) after 8 weeks. However, the difference between the two groups was not statistically significant. Conclusion Modest salt reduction and the CM-DASH diet for hypertensive patients with type II diabetes can achieve short-term salt reduction effects. The effect on changing salt-eating habits needs to be investigated with an extended follow-up.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88434298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats. 虾青素减轻大鼠与醋酸脱氧皮质酮盐诱导的高血压相关的心血管功能障碍。

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-05-19 DOI: 10.1080/10641963.2022.2055764

Suzan A Khodir, Eman Sweed, Marwa Gadallah, Anwaar Shabaan

Background: Hypertension is a major global health problem. It is a major risk factor of cardiovascular disease. One of the most used experimental models in studying antihypertensive action is the deoxycorticosterone acetate (DOCA)-salt hypertensive rat. This study aimed to investigate the cardiovascular protective effect of astaxanthin (ASX) in DOCA-salt-induced hypertension and its possible underlying mechanisms.

Methods: A total of 48 adult male Wistar albino rats were divided into three groups: control, DOCA, and DOCA + ASX. Blood pressure, serum cardiac enzyme levels, some oxidative stress and inflammatory biomarker levels, and lipid profile levels were measured. The weight of the left ventricle to tibial length ratio was calculated. Apoptosis detection and total genomic DNA extraction in aortic and cardiac tissues were investigated. The apoptotic marker BAX was also immunohistochemically assessed in the heart and aorta.

Results: Compared to the control group, the DOCA group was associated with a significant increase in blood pressure, serum cardiac enzyme levels, oxidative stress and inflammatory biomarker levels, lipid profile except serum high-density lipoprotein (HDL), weight of the left ventricle to tibial length, and total released DNA fragmentation level of the left ventricle and aorta and a significant decrease in reduced glutathione (GSH) and HDL. Compared to the DOCA group, the DOCA + ASX group significantly improved the DOCA-induced changes.

Conclusion: ASX has beneficial protective effects on DOCA-salt-induced hypertension via DNA fragmentation protection, apoptosis inhibition, antioxidant, anti-inflammatory, and its effects on lipid levels.

背景:高血压是一个主要的全球性健康问题。它是心血管疾病的主要危险因素。研究降压作用最常用的实验模型之一是醋酸脱氧皮质酮(DOCA)盐高血压大鼠。本研究旨在探讨虾青素(astaxanthin, ASX)在doca盐致高血压中的心血管保护作用及其可能的机制。方法:将48只成年雄性Wistar白化大鼠分为对照组、DOCA组和DOCA + ASX组。测量血压、血清心脏酶水平、一些氧化应激和炎症生物标志物水平以及血脂水平。计算左心室重量与胫骨长度之比。研究了主动脉组织和心脏组织的细胞凋亡检测和总基因组DNA提取。对心脏和主动脉的凋亡标志物BAX进行免疫组织化学检测。结果:与对照组相比，DOCA组血压、血清心酶水平、氧化应激和炎症生物标志物水平、血脂(除血清高密度脂蛋白)、左心室重量与胫骨长度、左心室和主动脉总释放DNA片段水平显著升高，还原性谷胱甘肽(GSH)和HDL显著降低。与DOCA组相比，DOCA + ASX组明显改善了DOCA引起的变化。结论:ASX通过DNA片段保护、细胞凋亡抑制、抗氧化、抗炎及对血脂水平的影响，对doca盐诱导的高血压具有有益的保护作用。

{"title":"Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats.","authors":"Suzan A Khodir, Eman Sweed, Marwa Gadallah, Anwaar Shabaan","doi":"10.1080/10641963.2022.2055764","DOIUrl":"https://doi.org/10.1080/10641963.2022.2055764","url":null,"abstract":"Background: Hypertension is a major global health problem. It is a major risk factor of cardiovascular disease. One of the most used experimental models in studying antihypertensive action is the deoxycorticosterone acetate (DOCA)-salt hypertensive rat. This study aimed to investigate the cardiovascular protective effect of astaxanthin (ASX) in DOCA-salt-induced hypertension and its possible underlying mechanisms.Methods: A total of 48 adult male Wistar albino rats were divided into three groups: control, DOCA, and DOCA + ASX. Blood pressure, serum cardiac enzyme levels, some oxidative stress and inflammatory biomarker levels, and lipid profile levels were measured. The weight of the left ventricle to tibial length ratio was calculated. Apoptosis detection and total genomic DNA extraction in aortic and cardiac tissues were investigated. The apoptotic marker BAX was also immunohistochemically assessed in the heart and aorta.Results: Compared to the control group, the DOCA group was associated with a significant increase in blood pressure, serum cardiac enzyme levels, oxidative stress and inflammatory biomarker levels, lipid profile except serum high-density lipoprotein (HDL), weight of the left ventricle to tibial length, and total released DNA fragmentation level of the left ventricle and aorta and a significant decrease in reduced glutathione (GSH) and HDL. Compared to the DOCA group, the DOCA + ASX group significantly improved the DOCA-induced changes.Conclusion: ASX has beneficial protective effects on DOCA-salt-induced hypertension via DNA fragmentation protection, apoptosis inhibition, antioxidant, anti-inflammatory, and its effects on lipid levels.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9872981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The prognostic role of intra-aortic pulse pressure measured before percutaneous coronary intervention in patients with chronic coronary syndrome: a single-center, retrospective, observational cohort study. 慢性冠脉综合征患者经皮冠状动脉介入治疗前主动脉内脉压测量的预后作用:一项单中心、回顾性、观察性队列研究

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-05-19 DOI: 10.1080/10641963.2022.2043893

Halil Aktas, Murat Gul

Background: The relationship between pulse pressure and prognosis in patients with chronic coronary syndrome (CCS) is contradictory. In the present study, we aimed to examine the relationship between intra-aortic pulse pressure (IAPP) and major adverse cardiovascular events (MACE) in patients with CCS undergoing percutaneous coronary intervention (PCI).

Methods: A total of 139 CCS patients who underwent elective PCI with regular one-year follow-up, were stratified into two subgroups according to IAPP. The primary outcomes included the occurrence of MACE, defined as cardiovascular death, acute myocardial infarction with ST-segment elevation (STEMI), acute myocardial infarction without ST-segment elevation (NSTEMI), target vessel revascularization (TVR), and stroke.

Results: The mean age of the patients was 57.6 ± 10.4 years, 32% of whom were female. The mean IAPP, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were 54.0 ± 17.6 mmHg, 129.7 ± 20 mmHg, and 75.8 ± 11.8 mmHg, respectively. SBP, IAPP, and left ventricular ejection fraction (LVEF) were significantly higher in the high IAPP group (p < .001, p < .001, p = .001, respectively). The MACE rate was significantly higher in the low IAPP group than in the high IAPP group (30.4% vs. 8.6%, p = 0,001). The LVEF (OR = 0.93, CI:0.88-0.99, p = .025) and IAPP (OR = 0.89, CI:0.83-0.95, p = .001) were found to be independent predictors of MACE. The IAPP value of 39.5 mmHg was identified as an effective cutoff point for prediction of MACE-free survival rates (AUC:0.853, CI:0.768-0.937).

Conclusion: Invasively measured IAPP has prognostic information about cardiovascular outcomes in patients with CCS. The risk of MACE is significantly greater in CCS patients with low IAPP compared with those who have high IAPP values.

背景:脉压与慢性冠状动脉综合征(CCS)患者预后的关系是矛盾的。在本研究中，我们旨在探讨经皮冠状动脉介入治疗(PCI)的CCS患者主动脉内脉压(IAPP)与主要不良心血管事件(MACE)之间的关系。方法:139例接受选择性PCI的CCS患者，定期随访一年，根据IAPP分为两个亚组。主要结局包括MACE的发生，定义为心血管死亡、急性心肌梗死伴st段抬高(STEMI)、急性心肌梗死无st段抬高(NSTEMI)、靶血管重建术(TVR)和卒中。结果:患者平均年龄57.6±10.4岁，女性占32%。平均IAPP、收缩压(SBP)和舒张压(DBP)分别为54.0±17.6 mmHg、129.7±20 mmHg和75.8±11.8 mmHg。高IAPP组收缩压、IAPP和左室射血分数(LVEF)显著升高(p)。结论:有创测量IAPP对CCS患者心血管结局有预后信息。与IAPP值高的CCS患者相比，IAPP值低的CCS患者发生MACE的风险明显更高。

{"title":"The prognostic role of intra-aortic pulse pressure measured before percutaneous coronary intervention in patients with chronic coronary syndrome: a single-center, retrospective, observational cohort study.","authors":"Halil Aktas, Murat Gul","doi":"10.1080/10641963.2022.2043893","DOIUrl":"https://doi.org/10.1080/10641963.2022.2043893","url":null,"abstract":"Background: The relationship between pulse pressure and prognosis in patients with chronic coronary syndrome (CCS) is contradictory. In the present study, we aimed to examine the relationship between intra-aortic pulse pressure (IAPP) and major adverse cardiovascular events (MACE) in patients with CCS undergoing percutaneous coronary intervention (PCI).Methods: A total of 139 CCS patients who underwent elective PCI with regular one-year follow-up, were stratified into two subgroups according to IAPP. The primary outcomes included the occurrence of MACE, defined as cardiovascular death, acute myocardial infarction with ST-segment elevation (STEMI), acute myocardial infarction without ST-segment elevation (NSTEMI), target vessel revascularization (TVR), and stroke.Results: The mean age of the patients was 57.6 ± 10.4 years, 32% of whom were female. The mean IAPP, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were 54.0 ± 17.6 mmHg, 129.7 ± 20 mmHg, and 75.8 ± 11.8 mmHg, respectively. SBP, IAPP, and left ventricular ejection fraction (LVEF) were significantly higher in the high IAPP group (p < .001, p < .001, p = .001, respectively). The MACE rate was significantly higher in the low IAPP group than in the high IAPP group (30.4% vs. 8.6%, p = 0,001). The LVEF (OR = 0.93, CI:0.88-0.99, p = .025) and IAPP (OR = 0.89, CI:0.83-0.95, p = .001) were found to be independent predictors of MACE. The IAPP value of 39.5 mmHg was identified as an effective cutoff point for prediction of MACE-free survival rates (AUC:0.853, CI:0.768-0.937).Conclusion: Invasively measured IAPP has prognostic information about cardiovascular outcomes in patients with CCS. The risk of MACE is significantly greater in CCS patients with low IAPP compared with those who have high IAPP values.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9511154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil count is a useful marker to predict the severity of preeclampsia. 中性粒细胞计数是预测子痫前期严重程度的有用指标。

IF 12.3 4区医学 Q3 Medicine

Clinical and Experimental Hypertension

Pub Date : 2022-05-19 DOI: 10.1080/10641963.2022.2043891

Miao Liu, Peng Lin, Miaomiao Qu, Ruixia Zhai, Liangjiao Zhang, Lihua Zhang, Liangxi Zhu, Chan Liu, Hua Shu, Xueqin Feng, Chunlong Su, Tiantian Yu, Fengge Wang, Dongmei Man

Background: At present, pre-eclampsia is a growing concern and still a diagnostic challenge for obstetricians.

Aims: This study aimed to evaluate whether the relationship of second trimester of pregnancy neutrophil count differed among pregnancies with mild preeclampsia, severe preeclampsia, and healthy status and explore whether or not neutrophil count in the second trimester of pregnancy would be useful as new predictors of subsequent preeclampsia.

Patients and methods: This study involved 933 pregnancies from 1 January 2018 to 30 January 2021, comprising 396 healthy pregnancies, 222 pregnancies with mild preeclampsia, and 315 pregnancies with severe preeclampsia. The relationship between preeclampsia and neutrophil count was analyzed by multiple logistic regression. In addition, maternal placental tissues of three groups were immunohistochemically stained for myeloperoxidase (MPO).

Results: Neutrophil count was significantly higher in pregnancies with preeclampsia (including pregnancies with mild and severe preeclampsia) than that in healthy pregnancies. The neutrophil count level was prominently higher in patients with severe preeclampsia compared with those with mild preeclampsia (p < .001). The neutrophil count level was significantly positively associated with preeclampsia after adjusting for gestational week at time of blood sampling, BMI, and age (β:1.23; 95%CI:1.09-1.36; p < .0001). In addition, MPO expressions of placental tissues in preeclamptic groups were significantly increased than these in healthy pregnant controls (p < .05).

Conclusions: Increased neutrophil count in the second trimester of pregnancy was significantly positively associated with preeclampsia. Hence, neutrophil count plays a role in predicting the severity of preeclampsia. At the same time, it may be an independent predictor of subsequent preeclampsia.Abbreviations: BMI: body mass index; MPO: myeloperoxidase.

背景:目前，先兆子痫是一个日益关注的问题，仍然是产科医生的诊断挑战。目的:本研究旨在评价妊娠中期中性粒细胞计数在轻度子痫前期、重度子痫前期和健康状况之间的关系，并探讨妊娠中期中性粒细胞计数是否可作为妊娠中期子痫前期的新预测指标。患者和方法:本研究涉及2018年1月1日至2021年1月30日的933例妊娠，其中396例健康妊娠，222例轻度子痫前期妊娠，315例重度子痫前期妊娠。采用多元logistic回归分析子痫前期与中性粒细胞计数的关系。此外，对三组孕妇胎盘组织进行骨髓过氧化物酶(MPO)免疫组织化学染色。结果:子痫前期妊娠(包括轻度和重度子痫前期妊娠)中性粒细胞计数明显高于正常妊娠。重度子痫前期患者中性粒细胞计数水平明显高于轻度子痫前期患者(p结论:妊娠中期中性粒细胞计数升高与子痫前期显著正相关。因此，中性粒细胞计数在预测子痫前期的严重程度中起作用。同时，它可能是随后子痫前期的独立预测因子。缩写:BMI:身体质量指数;MPO:髓过氧物酶。

{"title":"Neutrophil count is a useful marker to predict the severity of preeclampsia.","authors":"Miao Liu, Peng Lin, Miaomiao Qu, Ruixia Zhai, Liangjiao Zhang, Lihua Zhang, Liangxi Zhu, Chan Liu, Hua Shu, Xueqin Feng, Chunlong Su, Tiantian Yu, Fengge Wang, Dongmei Man","doi":"10.1080/10641963.2022.2043891","DOIUrl":"https://doi.org/10.1080/10641963.2022.2043891","url":null,"abstract":"Background: At present, pre-eclampsia is a growing concern and still a diagnostic challenge for obstetricians.Aims: This study aimed to evaluate whether the relationship of second trimester of pregnancy neutrophil count differed among pregnancies with mild preeclampsia, severe preeclampsia, and healthy status and explore whether or not neutrophil count in the second trimester of pregnancy would be useful as new predictors of subsequent preeclampsia.Patients and methods: This study involved 933 pregnancies from 1 January 2018 to 30 January 2021, comprising 396 healthy pregnancies, 222 pregnancies with mild preeclampsia, and 315 pregnancies with severe preeclampsia. The relationship between preeclampsia and neutrophil count was analyzed by multiple logistic regression. In addition, maternal placental tissues of three groups were immunohistochemically stained for myeloperoxidase (MPO).Results: Neutrophil count was significantly higher in pregnancies with preeclampsia (including pregnancies with mild and severe preeclampsia) than that in healthy pregnancies. The neutrophil count level was prominently higher in patients with severe preeclampsia compared with those with mild preeclampsia (p < .001). The neutrophil count level was significantly positively associated with preeclampsia after adjusting for gestational week at time of blood sampling, BMI, and age (β:1.23; 95%CI:1.09-1.36; p < .0001). In addition, MPO expressions of placental tissues in preeclamptic groups were significantly increased than these in healthy pregnant controls (p < .05).Conclusions: Increased neutrophil count in the second trimester of pregnancy was significantly positively associated with preeclampsia. Hence, neutrophil count plays a role in predicting the severity of preeclampsia. At the same time, it may be an independent predictor of subsequent preeclampsia.Abbreviations: BMI: body mass index; MPO: myeloperoxidase.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9872984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2