Comprehensive psychiatry最新文献

英文中文

Corrigendum to ‘Substance use behaviours among sexual and gender minorities with a history of adverse childhood experiences: a systematic review and narrative-synthesis’. [Comprehensive Psychiatry 146 (2026) 152669] 对“儿童期不良经历的性和性别少数群体的物质使用行为：系统回顾和叙述综合”的更正。[综合精神病学146(2026)152669]。

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-04-01 Epub Date: 2026-04-03 DOI: 10.1016/j.comppsych.2026.152693

Eleanor J. Ong , Kuhanesan N.C. Naidu , Mervin Tee , Rayner Kay Jin Tan , Natasha Howard

引用次数: 0

The effect of the menstrual cycle on obsessive-compulsive and related disorders: A scoping review 月经周期对强迫症及相关疾病的影响：范围综述。

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-04-01 Epub Date: 2026-04-05 DOI: 10.1016/j.comppsych.2026.152696

Juliette S. Mojgani , Anna M. Rzepka , Yejin Kang , Hashim Al-Bya , Beth Patterson , Michael Van Ameringen

Introduction

Anecdotal evidence suggests that the menstrual cycle influences symptoms of Obsessive-Compulsive and Related Disorders (OCRD), although scientific literature investigating this effect is scarce. The premenstrual phase has been associated with the exacerbation of certain psychiatric conditions, with some reports showing premenstrual worsening of OCD. This scoping review aimed to systematically synthesize the evidence on the effect of the menstrual cycle on OCRD symptoms.

Methods

Systematic searches were conducted on MEDLINE, EMBASE, APA PsycINFO, Cochrane Database of Systematic Reviews, and Web of Science for peer-reviewed studies investigating the menstrual cycle and OCRD. Data examining study methodology, participant demographics, OCRD symptoms, and menstrual cycles were extracted and analyzed.

Results

The systematic search identified 12 studies, where ten studies examined OCD symptoms across the menstrual cycle, one examined trichotillomania, and one examined both OCD and trichotillomania. Eight retrospective cross-sectional studies, one longitudinal study were included. Three case reports were identified but not included in the results. Symptom fluctuations were predominantly assessed through self-reports, except for the longitudinal study, which used the Yale-Brown Obsessive Compulsive Scale. In all the studies participants reported worsening OCRD symptoms during the premenstrual phase.

Conclusion

Preliminary research suggests OCRD symptoms fluctuate across the menstrual cycle, with premenstrual worsening of OCRD being reported in all studies. Significant gaps exist in the literature emphasizing the need for longitudinal study designs and reliable instruments to improve reliability and clarify the potential relationship between female sex hormones and OCD symptoms.

引言：轶事证据表明，月经周期影响强迫症及相关障碍（OCRD）的症状，尽管调查这种影响的科学文献很少。经前期与某些精神疾病的恶化有关，一些报告显示经前期强迫症恶化。本综述旨在系统地综合有关月经周期对强迫症症状影响的证据。方法：系统检索MEDLINE、EMBASE、APA PsycINFO、Cochrane系统综述数据库和Web of Science上关于月经周期和强迫症的同行评议研究。提取并分析研究方法学、参与者人口统计学、强迫症症状和月经周期的数据。结果：系统搜索确定了12项研究，其中10项研究检查了月经周期中的强迫症症状，一项检查了拔毛癖，另一项检查了强迫症和拔毛癖。包括8项回顾性横断面研究，1项纵向研究。确定了3例病例报告，但未纳入结果。除了使用耶鲁-布朗强迫症量表的纵向研究外，症状波动主要通过自我报告来评估。在所有的研究中，参与者都报告在经前期强迫症症状恶化。结论：初步研究表明，强迫症症状在月经周期中波动，所有研究都报道了强迫症经前加重。文献中存在明显的空白，强调需要纵向研究设计和可靠的工具来提高可靠性，并阐明女性性激素与强迫症症状之间的潜在关系。

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引用次数: 0

Insight, resistance, and control: Associations among CY-BOCS dimensions in pediatric obsessive-compulsive disorder with implications for treatment resistance 洞察、抵抗和控制：儿童强迫症CY-BOCS维度与治疗抵抗的关系

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-04-01 Epub Date: 2026-05-01 DOI: 10.1016/j.comppsych.2026.152679

Madeline A. Morton , Daniel A. Geller

引用次数: 0

Cognitive inflexibility adversely affects adherence to psychotherapy in individuals with obsessive-compulsive & related disorders and eating disorders 认知不灵活性对患有强迫症及相关障碍和饮食障碍的个体的心理治疗依从性产生不利影响

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-04-01 Epub Date: 2026-05-01 DOI: 10.1016/j.comppsych.2026.152682

Shaunak Deshpande , Keith Sullivan , Naomi A. Fineberg

引用次数: 0

A comparison of cognitive performance of individuals with anxiety and mood disorders with and without obsessive-compulsive personality disorder: A pilot study 有和没有强迫性人格障碍的焦虑和情绪障碍个体的认知表现比较：一项初步研究

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-04-01 Epub Date: 2026-05-01 DOI: 10.1016/j.comppsych.2026.152684

Agne Stanyte , Naomi A. Fineberg , Aurelija Podlipskyte , Julija Gecaite-Stonciene , Vilma Jakiene , Alicja Juskiene , Vesta Steibliene , Julius Burkauskas

引用次数: 0

Continuous theta burst stimulation (cTBS) as an augmentation strategy in a sample of patients with treatment-resistant obsessive-compulsive disorder (TR-OCD) 持续θ波爆发刺激（cTBS）在难治性强迫症（TR-OCD）患者样本中的增强策略

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-04-01 Epub Date: 2026-05-01 DOI: 10.1016/j.comppsych.2026.152678

Rodolfo Leuzzi , Beatrice Benatti , Michele Castiglioni , Luca Larini , Emma Rinaldi , Matteo Marcatili , Carlo Sala , Luciano Conti , Camilla Gesi , Nicolaja Girone , Matteo Vismara , Alessandra Minelli , Massimo Gennarelli , Bernardo Dell'Osso

引用次数: 0

Associations of personality traits and work-related stress with positive somatic symptom disorder screening – A cross-sectional study 人格特质和工作压力与阳性躯体症状障碍筛查的关联——一项横断面研究。

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-04-01 Epub Date: 2026-04-07 DOI: 10.1016/j.comppsych.2026.152695

Roland von Känel , Sebastian Euler , Anke Schneiders , Doris Straus , Gavin Brupbacher , Marc Dörner

Background

Empirical evidence on psychological factors associated with somatic symptom disorder (SSD) is scarce so far, but could provide a better understanding of the psychological embeddedness of SSD. The current study targeted this research gap.

Methods

This cross-sectional study included 1536 participants of an inpatient psychosomatic unit between 2018 and 2024. A set of different self-report questionnaires was applied to evaluate SSD, depression and anxiety, narcissism, alexithymia, overcommitment, effort-reward imbalance (ERI), and burnout. A hierarchical multivariable binary logistic regression, applying a multiple imputation (MI) model considering missing data and a complete case model, was used to analyse associations between positive SSD screening and these psychological factors. Complementary analyses were conducted to further assess associations with the self-report questionnaires' subscales.

Results

547 (35.6%) participants indicated a diagnosis of SSD. In the final MI model, alexithymia (OR 1.02, 95% CI 1.01–1.03), narcissism (1.06, 1.03–1.08), and ERI (1.76, 1.10–2.82) were significantly associated with a higher risk for positive SSD screening. Complementary analyses revealed significant associations with the alexithymia subscales difficulty identifying feelings (1.08, 1.01–1.15) and difficulty describing feelings (0.96, 0.92–0.99), the narcissism subscales threatened self (0.97, 0.94–0.99) and hypochondriac self (1.25, 1.15–1.35), and the burnout subscales emotional exhaustion (1.07, 1.01–1.13) and cynicism (0.94, 0.90–0.98).

Conclusions

Positive SSD screening was common in the observed population. Future studies may strive to unravel the mechanisms linking SSD potentially with alexithymia, narcissism, ERI, and burnout. A deeper understanding of the relationship between these psychological factors' subscales and SSD might be a key element in this endeavour.

背景：目前关于躯体症状障碍相关心理因素的经验证据较少，但可以更好地理解躯体症状障碍的心理嵌入性。目前的研究正是针对这一研究空白。方法：本横断面研究纳入了2018年至2024年间住院心身病房的1536名参与者。采用一套不同的自我报告问卷来评估SSD、抑郁和焦虑、自恋、述情障碍、过度承诺、努力-奖励不平衡（ERI）和倦怠。采用分层多变量二元逻辑回归，采用考虑缺失数据和完整病例模型的多重imputation （MI）模型，分析SSD阳性筛查与这些心理因素之间的关系。进行补充分析以进一步评估与自我报告问卷子量表的关联。结果：547名（35.6%）参与者被诊断为SSD。在最后的MI模型中，述情障碍（OR 1.02, 95% CI 1.01-1.03）、自恋（1.06,1.03-1.08）和ERI（1.76, 1.10-2.82）与SSD筛查阳性的高风险显著相关。互补性分析显示，与述情障碍量表识别情感困难（1.08,1.01-1.15）和描述情感困难（0.96,0.92-0.99）、自恋量表威胁自我（0.97,0.94-0.99）和疑病症自我（1.25,1.15-1.35）、倦怠量表情绪耗竭（1.07,1.01-1.13）和愤世嫉俗（0.94,0.90-0.98）存在显著相关。结论：SSD筛查阳性在观察人群中很常见。未来的研究可能会努力揭示SSD与述情障碍、自恋、ERI和倦怠之间的潜在联系机制。更深入地了解这些心理因素的子量表与SSD之间的关系可能是这一努力的关键因素。

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引用次数: 0

Esports bettors versus traditional sports bettors: Differences in demographics, impulsivity, psychopathological symptoms, and gaming and gambling behavior 电子竞技投注者与传统体育投注者：人口统计学、冲动性、精神病理症状以及游戏和赌博行为的差异。

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.comppsych.2026.152667

Harshdeep S. Mangat , Orsolya Király , Róbert Urbán , Shu M. Yu , Mark D. Griffiths , Borbála Paksi , Katalin Felvinczi , Zsolt Demetrovics , Andrea Czakó

Background and aims

Esports betting (i.e., betting on the outcome of professional competitive videogaming matches) has become a regular feature of most online gambling websites in recent years. The present study compared differences between esports bettors and traditional sports bettors, in addition to exploring factors that predict participation in esports betting.

Methods

Data regarding demographics, impulsivity, psychopathological symptoms, gaming, and gambling among 359 esports bettors (mean age = 37.98 years [SD = 13.64]; 86.9% male) and 326 sports bettors (mean age = 43.79 years [SD = 13.75]; 91.7% male) from the United Kingdom, Hungary, and Canada were collected through surveys via two gambling service providers (Betway and Midnite) and a gaming magazine.

Results

Compared to sports bettors, esports bettors were significantly younger, scored higher on gambling risk severity, and had more gaming disorder symptoms. Esports bettors were also more likely than sports bettors to report higher levels of stress, anxiety, and depression symptoms, and impulsivity, as well as be driven by coping, social, and financial motives to engage in betting. In an unadjusted binary regression model, being younger, being driven by coping, social, and financial motives, and reporting elevated levels of impulsivity, depression, anxiety, and stress symptoms were predictors of esports betting. Higher rates of problem gambling severity and gaming disorder symptoms were also predictors of esports betting.

Conclusions

The findings suggest that esports bettors are a distinct betting group, and vulnerable to multiple gaming/gambling-related harms and psychopathological harms.

背景和目的：近年来，电子竞技博彩（即对专业竞技电子游戏比赛的结果下注）已成为大多数在线赌博网站的常规功能。本研究比较了电子竞技投注者和传统体育投注者之间的差异，并探索了预测电子竞技投注参与的因素。方法：通过两家赌博服务提供商（between and Midnite）和一本游戏杂志，收集来自英国、匈牙利和加拿大的359名电子竞技投注者（平均年龄37.98岁[SD = 13.64]，男性占86.9%）和326名体育投注者（平均年龄43.79岁[SD = 13.75]，男性占91.7%）的人口统计学、冲动、精神病理症状、游戏和赌博数据。结果：与体育投注者相比，电子竞技投注者明显更年轻，赌博风险严重程度得分更高，并且有更多的游戏障碍症状。电子竞技投注者也比体育投注者更有可能报告更高水平的压力、焦虑、抑郁症状和冲动，并受到应对、社会和经济动机的驱使而参与投注。在未经调整的二元回归模型中，年轻、受应对、社会和经济动机驱动、冲动、抑郁、焦虑和压力症状水平升高是电竞投注的预测因素。问题赌博严重程度和游戏障碍症状的较高比率也是电子竞技赌博的预测因素。结论：研究结果表明，电子竞技投注者是一个独特的投注群体，容易受到多种游戏/赌博相关伤害和精神病理伤害。

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引用次数: 0

Loneliness in borderline personality disorder: The role of misalignments between self-view and social expectations in social value orientation and justice sensitivity 边缘型人格障碍患者的孤独感：自我观与社会期望错位在社会价值取向和正义敏感性中的作用。

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-03-01 Epub Date: 2026-01-11 DOI: 10.1016/j.comppsych.2026.152663

R. Vonderlin , C. Claus , S. Hanraths , A.S. Lerchl , B. Senyüz , N. Kleindienst , T. Boritz , S. McMain , T. Teismann , P. Kirsch , M. Bohus , S. Lis

Background

Loneliness is a pervasive and distressing feeling that characterizes social relationships in individuals with Borderline Personality Disorder (BPD). Previous research suggests that a misalignment between an individual's heightened prosocial self-view and their negative social expectations might contribute to loneliness. In the current quasi-experimental study, we investigated this discrepancy for social value orientation (SVO) and justice sensitivity (JS) and their relationship with loneliness.

Methods

A total of 120 participants (60 treatment-seeking individuals diagnosed with BPD, 60 non-clinical controls) assessed their SVO with the SVO-Slider-Task and their JS with the Justice-Sensitivity Inventory for experiencing injustice as a victim, observer, beneficiary and perpetrator. Additionally, participants rated their expectations about the SVO and JS of other people. We measured the individuals' level of loneliness with the UCLA Loneliness scale.

Results

Participants with BPD reported a stronger difference between self-view and social expectations compared to non-clinical controls for SVO (r = 0.18, p = .043) and other-oriented perspectives of JS (observer [r = 0.34], beneficiary [r = 0.48] and perpetrator [r = 0.27], all p ≤ .003). A greater difference in observer and beneficiary JS was associated with higher levels of loneliness in the BPD group (observer: r = 0.31, p = .017, beneficiary: r = 0.44, p < .001).

Conclusion

Alterations in self-views and social expectations in individuals with BPD might foster a vicious cycle of misunderstanding and disappointment in social relationships resulting in heightened feelings of loneliness. To improve interpersonal functioning and reduce loneliness, psychosocial interventions should target both the individual's heightened prosocial self-views and their negative expectations towards others.

背景：孤独感是边缘型人格障碍（BPD）患者在社会关系中普遍存在的令人痛苦的感觉。先前的研究表明，一个人高度亲社会的自我观和他们消极的社会期望之间的不一致可能会导致孤独。本研究旨在探讨社会价值取向（SVO）和正义敏感性（JS）的差异及其与孤独感的关系。方法：共120名参与者（60名诊断为BPD的寻求治疗个体，60名非临床对照）使用SVO-滑动任务评估他们的SVO，并使用正义敏感性量表评估他们作为受害者、观察者、受益者和加害者经历不公正的JS。此外，参与者还评估了他们对其他人的SVO和JS的期望。我们用加州大学洛杉矶分校的孤独感量表测量了个体的孤独感水平。结果：与非临床对照组相比，BPD患者在SVO （r = 0.18, p = 0.043）和JS（观察者[r = 0.34]，受益者[r = 0.48]和犯罪者[r = 0.27]）的自我观和社会期望方面存在更大差异，p≤0.003。观察者和受益人的JS差异越大，BPD组的孤独感水平越高（观察者：r = 0.31, p = 0.017，受益人：r = 0.44, p）。结论：BPD患者自我观点和社会期望的改变可能会促进社会关系中误解和失望的恶性循环，导致孤独感加剧。为了改善人际功能和减少孤独感，社会心理干预应针对个人提高的亲社会自我观和他们对他人的负面期望。

{"title":"Loneliness in borderline personality disorder: The role of misalignments between self-view and social expectations in social value orientation and justice sensitivity","authors":"R. Vonderlin , C. Claus , S. Hanraths , A.S. Lerchl , B. Senyüz , N. Kleindienst , T. Boritz , S. McMain , T. Teismann , P. Kirsch , M. Bohus , S. Lis","doi":"10.1016/j.comppsych.2026.152663","DOIUrl":"10.1016/j.comppsych.2026.152663","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness is a pervasive and distressing feeling that characterizes social relationships in individuals with Borderline Personality Disorder (BPD). Previous research suggests that a misalignment between an individual's heightened prosocial self-view and their negative social expectations might contribute to loneliness. In the current quasi-experimental study, we investigated this discrepancy for social value orientation (SVO) and justice sensitivity (JS) and their relationship with loneliness.</div></div><div><h3>Methods</h3><div>A total of 120 participants (60 treatment-seeking individuals diagnosed with BPD, 60 non-clinical controls) assessed their SVO with the SVO-Slider-Task and their JS with the Justice-Sensitivity Inventory for experiencing injustice as a victim, observer, beneficiary and perpetrator. Additionally, participants rated their expectations about the SVO and JS of other people. We measured the individuals' level of loneliness with the UCLA Loneliness scale.</div></div><div><h3>Results</h3><div>Participants with BPD reported a stronger difference between self-view and social expectations compared to non-clinical controls for SVO (<em>r</em> = 0.18, <em>p</em> = .043) and other-oriented perspectives of JS (observer [<em>r</em> = 0.34], beneficiary [<em>r</em> = 0.48] and perpetrator [<em>r</em> = 0.27], all <em>p ≤</em> .003). A greater difference in observer and beneficiary JS was associated with higher levels of loneliness in the BPD group (observer: <em>r</em> = 0.31, <em>p</em> = .017, beneficiary: <em>r</em> = 0.44, <em>p</em> < .001).</div></div><div><h3>Conclusion</h3><div>Alterations in self-views and social expectations in individuals with BPD might foster a vicious cycle of misunderstanding and disappointment in social relationships resulting in heightened feelings of loneliness. To improve interpersonal functioning and reduce loneliness, psychosocial interventions should target both the individual's heightened prosocial self-views and their negative expectations towards others.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152663"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric comorbidities of posttraumatic stress disorder among adolescent refugees in Uganda: A latent class analysis of patterns and covariates 乌干达青少年难民创伤后应激障碍的精神合并症：模式和协变量的潜在类分析。

IF 4.2 2区医学 Q1 PSYCHIATRY

Comprehensive psychiatry

Pub Date : 2026-03-01 Epub Date: 2026-02-16 DOI: 10.1016/j.comppsych.2026.152672

Herbert E. Ainamani , Anne Wanjiru Mbwayo , Muthoni Mathai , Jonathan Hall , Godfrey Z. Rukundo , Florian Scharpf

Background

Although psychiatric comorbidities are common among trauma-exposed individuals with PTSD, their patterns and covariates among refugee adolescents in low-resource settings remain understudied. This study aimed to identify distinct patterns of psychiatric comorbidities and their associated factors among adolescent refugees with PTSD in Nakivale refugee settlement, Uganda.

Methods

In this cross-sectional study, 325 refugee youth were assessed on various PTSD psychiatric comorbidities and covariates of (age, gender, war trauma, post-migration stressors) using MINI International Neuropsychiatric Interview 7.02 and standardized measures of war trauma and post-migration stressors. Latent class analysis (LCA) was used to identify patterns and covariates of comorbidity.

Results

Of 269 adolescents with PTSD, 97% had at least one comorbid disorder: panic disorder (88.9%), generalized anxiety disorder (84%), agoraphobia (75.1%), depressive disorder (62.8%), obsessive compulsive disorder (60.6%), attention deficit disorder (43.9%), oppositional defiant disorder (40.9%), conduct disorder (33.8%), and alcohol use disorder (10.8%). LCA revealed three classes: low-moderate comorbidity (n = 66, 24.5%), high internalizing comorbidity (n = 101, 37.5%) with high probabilities of depression and anxiety disorders, and high overall comorbidity (n = 102, 37.9%) with relatively high probabilities of all disorders. The high overall comorbidity class had more girls than the other two classes. Both high comorbidity classes had higher war trauma and post-migration stressors than the low-moderate comorbidity class.

Conclusions

Adolescent refugees with PTSD exhibit high psychiatric comorbidity that clusters in distinct patterns. These findings highlight the need for interventions that address the identified comorbidity patterns, consider gender disparities, and account for cumulative trauma and post-migration stressors to effectively support traumatized youth.

背景：虽然精神合并症在创伤暴露的PTSD患者中很常见，但在低资源环境下的难民青少年中，其模式和协变量仍未得到充分研究。本研究旨在确定乌干达Nakivale难民营中患有创伤后应激障碍的青少年难民的精神合并症及其相关因素的不同模式。方法：在本横断面研究中，采用MINI国际神经精神病学访谈7.02和战争创伤和移民后压力的标准化测量方法，评估325名难民青年的各种创伤后应激障碍精神合并症和协变量（年龄、性别、战争创伤、移民后压力）。使用潜类分析（LCA）来确定合并症的模式和协变量。结果：269例PTSD青少年患者中，97%至少有一种共病：惊恐障碍（88.9%）、广泛性焦虑障碍（84%）、旷野恐怖症（75.1%）、抑郁症（62.8%）、强迫症（60.6%）、注意缺陷障碍（43.9%）、对立违抗障碍（40.9%）、品行障碍（33.8%）和酒精使用障碍（10.8%）。LCA结果显示：低-中度共病（n = 66, 24.5%）、高内化共病（n = 101, 37.5%）和高整体共病（n = 102, 37.9%），共病发生率均较高。总体合并症高的班级比其他两个班级有更多的女孩。两种高共病等级的战争创伤和迁移后压力源均高于中低共病等级。结论：患有创伤后应激障碍的青少年难民表现出高的精神共病，并以不同的模式聚集在一起。这些发现强调需要采取干预措施，解决已确定的共病模式，考虑性别差异，并考虑累积创伤和移民后压力因素，以有效地支持受创伤的青年。

{"title":"Psychiatric comorbidities of posttraumatic stress disorder among adolescent refugees in Uganda: A latent class analysis of patterns and covariates","authors":"Herbert E. Ainamani , Anne Wanjiru Mbwayo , Muthoni Mathai , Jonathan Hall , Godfrey Z. Rukundo , Florian Scharpf","doi":"10.1016/j.comppsych.2026.152672","DOIUrl":"10.1016/j.comppsych.2026.152672","url":null,"abstract":"<div><h3>Background</h3><div>Although psychiatric comorbidities are common among trauma-exposed individuals with PTSD, their patterns and covariates among refugee adolescents in low-resource settings remain understudied. This study aimed to identify distinct patterns of psychiatric comorbidities and their associated factors among adolescent refugees with PTSD in Nakivale refugee settlement, Uganda.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 325 refugee youth were assessed on various PTSD psychiatric comorbidities and covariates of (age, gender, war trauma, post-migration stressors) using MINI International Neuropsychiatric Interview 7.02 and standardized measures of war trauma and post-migration stressors. Latent class analysis (LCA) was used to identify patterns and covariates of comorbidity.</div></div><div><h3>Results</h3><div>Of 269 adolescents with PTSD, 97% had at least one comorbid disorder: panic disorder (88.9%), generalized anxiety disorder (84%), agoraphobia (75.1%), depressive disorder (62.8%), obsessive compulsive disorder (60.6%), attention deficit disorder (43.9%), oppositional defiant disorder (40.9%), conduct disorder (33.8%), and alcohol use disorder (10.8%). LCA revealed three classes: low-moderate comorbidity (<em>n</em> = 66, 24.5%), high internalizing comorbidity (<em>n</em> = 101, 37.5%) with high probabilities of depression and anxiety disorders, and high overall comorbidity (<em>n</em> = 102, 37.9%) with relatively high probabilities of all disorders. The high overall comorbidity class had more girls than the other two classes. Both high comorbidity classes had higher war trauma and post-migration stressors than the low-moderate comorbidity class.</div></div><div><h3>Conclusions</h3><div>Adolescent refugees with PTSD exhibit high psychiatric comorbidity that clusters in distinct patterns. These findings highlight the need for interventions that address the identified comorbidity patterns, consider gender disparities, and account for cumulative trauma and post-migration stressors to effectively support traumatized youth.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152672"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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