Pub Date : 2026-10-12DOI: 10.1038/s41587-026-03338-3
Prakriti Karki, Sudarshan GC
Democratizing synthetic biology requires reducing costs, improving logistics and distribution, developing local expertise, and motivating educators and students.
合成生物学的民主化需要降低成本，改善物流和配送，发展当地专业知识，并激励教育工作者和学生。
{"title":"Expanding global access to synthetic biology","authors":"Prakriti Karki, Sudarshan GC","doi":"10.1038/s41587-026-03338-3","DOIUrl":"10.1038/s41587-026-03338-3","url":null,"abstract":"Democratizing synthetic biology requires reducing costs, improving logistics and distribution, developing local expertise, and motivating educators and students.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 10","pages":"1736-1740"},"PeriodicalIF":44.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-10-12DOI: 10.1038/s41587-026-03324-9
Recent patents relating to systems, methods and compositions for use in genome editing.
涉及基因组编辑系统、方法和组合物的最新专利。
{"title":"Genome editing","authors":"","doi":"10.1038/s41587-026-03324-9","DOIUrl":"10.1038/s41587-026-03324-9","url":null,"abstract":"Recent patents relating to systems, methods and compositions for use in genome editing.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 10","pages":"1616-1616"},"PeriodicalIF":44.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-10-12DOI: 10.1038/s41587-026-03341-8
Recent moves of note in and around the biotech and pharma industries.
生物技术和制药行业的最新动向。
{"title":"People","authors":"","doi":"10.1038/s41587-026-03341-8","DOIUrl":"10.1038/s41587-026-03341-8","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 10","pages":"1744-1744"},"PeriodicalIF":44.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-10-12DOI: 10.1038/s41587-026-03340-9
Michael Francisco
A true multidisciplinary scientist, Bowen Li finds that some of the most interesting questions are located precisely at the boundaries between fields.
作为一名真正的多学科科学家，李博文发现，一些最有趣的问题恰恰位于不同领域之间的边界。
{"title":"Five questions with Bowen Li","authors":"Michael Francisco","doi":"10.1038/s41587-026-03340-9","DOIUrl":"10.1038/s41587-026-03340-9","url":null,"abstract":"A true multidisciplinary scientist, Bowen Li finds that some of the most interesting questions are located precisely at the boundaries between fields.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 10","pages":"1741-1742"},"PeriodicalIF":44.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-10-12DOI: 10.1038/s41587-026-03353-4
Dario Ummarino
{"title":"Tracing the origins of CRISPR–Cas","authors":"Dario Ummarino","doi":"10.1038/s41587-026-03353-4","DOIUrl":"10.1038/s41587-026-03353-4","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 10","pages":"1617-1617"},"PeriodicalIF":44.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-10-12DOI: 10.1038/s41587-026-03346-3
Laura DeFrancesco
The newly approved antibody stops abnormal bone growth in patients with the devastating disease fibrodysplasia ossificans.
新批准的抗体可以阻止骨化纤维发育不良患者的异常骨生长。
{"title":"Regeneron approval brings relief for ‘second skeleton’ bone disorder","authors":"Laura DeFrancesco","doi":"10.1038/s41587-026-03346-3","DOIUrl":"10.1038/s41587-026-03346-3","url":null,"abstract":"The newly approved antibody stops abnormal bone growth in patients with the devastating disease fibrodysplasia ossificans.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 10","pages":"1592-1593"},"PeriodicalIF":44.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-10-06DOI: 10.1038/s41587-026-03318-7
Julie Trolle, Sofia Sessa, Aleksandra Wudzinska, Mark Grivainis, Katerina Rincones, Tori Rodrick, Drew R. Jones, David Fenyö, Sudarshan Pinglay, Jef D. Boeke
Mammalian metabolic engineering advances basic biology, bioproduction and cell therapy. However, as pathway complexity increases, so does the size of the combinatorial design space and required DNA constructs, rendering unbiased screens intractable. Here, we developed shotgun genetic engineering (SGE), which exploits the ease of delivering many barcoded small constructs—rather than a single large one—into mammalian cells. Each cell serves as an independent experiment, carrying a synthetic pathway that explores gene content, stoichiometry and organellar localization. Functional pathways are identified by sequencing barcodes from cells exhibiting the desired phenotype. Using SGE, we screened millions of pathway combinations to engineer essential amino acid biosynthesis, achieving near-wild-type growth without valine and enabling isoleucine-free growth in Chinese hamster ovary cells, as well as valine-free growth in Jurkat cells. Functional pathways favored mitochondrial localization and required the integration of tens of kilobases of synthetic DNA, beyond the scale of conventional screening. The resulting datasets support machine-learning-guided decoding and engineering of complex biosynthetic traits in mammalian systems.
{"title":"Highly multiplexed mammalian metabolic engineering with a shotgun approach","authors":"Julie Trolle, Sofia Sessa, Aleksandra Wudzinska, Mark Grivainis, Katerina Rincones, Tori Rodrick, Drew R. Jones, David Fenyö, Sudarshan Pinglay, Jef D. Boeke","doi":"10.1038/s41587-026-03318-7","DOIUrl":"https://doi.org/10.1038/s41587-026-03318-7","url":null,"abstract":"Mammalian metabolic engineering advances basic biology, bioproduction and cell therapy. However, as pathway complexity increases, so does the size of the combinatorial design space and required DNA constructs, rendering unbiased screens intractable. Here, we developed shotgun genetic engineering (SGE), which exploits the ease of delivering many barcoded small constructs—rather than a single large one—into mammalian cells. Each cell serves as an independent experiment, carrying a synthetic pathway that explores gene content, stoichiometry and organellar localization. Functional pathways are identified by sequencing barcodes from cells exhibiting the desired phenotype. Using SGE, we screened millions of pathway combinations to engineer essential amino acid biosynthesis, achieving near-wild-type growth without valine and enabling isoleucine-free growth in Chinese hamster ovary cells, as well as valine-free growth in Jurkat cells. Functional pathways favored mitochondrial localization and required the integration of tens of kilobases of synthetic DNA, beyond the scale of conventional screening. The resulting datasets support machine-learning-guided decoding and engineering of complex biosynthetic traits in mammalian systems.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"23 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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