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FAMM Flap in Reconstructing Postsurgical Nasopharyngeal Airway Stenosis. FAMM皮瓣重建术后鼻咽气道狭窄。
Pub Date : 2014-01-01 Epub Date: 2014-09-21 DOI: 10.1155/2014/276058
Ferdinand Wanjala Nangole, Stanley Ominde Khainga

Introduction. Postsurgical nasopharyngeal airway stenosis can be a challenge to manage. The stenosis could be as a result of any surgical procedure in the nasopharyngeal region that heals extensive scarring and fibrosis. Objective. To evaluate patients with nasopharyngeal stenosis managed with FAMM flap. Study Design. Prospective study of patients with nasopharyngeal stenosis at the Kenyatta National Hospital between 2010 and 2013 managed with FAMM flap. Materials and Methods. Patients with severe nasopharyngeal airway stenosis were reviewed and managed with FAMM flaps at the Kenyatta National Hospital. Postoperatively they were assessed for symptomatic improvement in respiratory distress, patency of the nasopharyngeal airway, and donor site morbidity. Results. A total of 8 patients were managed by the authors in a duration of 4 years with nasopharyngeal stenosis. Five patients were managed with unilateral FAMM flaps in a two-staged surgical procedure. Four patients had complete relieve of the airway obstruction with a patent airway created. One patient had a patent airway created though with only mild improvement in airway obstruction. Conclusion. FAMM flap provides an alternative in the management of postsurgical severe nasopharyngeal stenosis. It is a reliable flap that is easy to raise and could provide adequate epithelium for the stenosed pharynx.

介绍。术后鼻咽气道狭窄可能是一个挑战,以管理。狭窄可能是任何外科手术在鼻咽区愈合广泛的疤痕和纤维化的结果。目标。目的探讨FAMM皮瓣治疗鼻咽部狭窄的疗效。研究设计。2010年至2013年在肯雅塔国家医院接受FAMM皮瓣治疗的鼻咽狭窄患者的前瞻性研究材料与方法。在肯雅塔国家医院对严重鼻咽气道狭窄的患者进行复查,并使用FAMM皮瓣进行治疗。术后评估呼吸窘迫症状改善、鼻咽气道通畅和供区发病率。结果。作者在4年的时间里处理了8例鼻咽狭窄患者。5例患者采用单侧FAMM皮瓣进行两阶段手术。4例患者气道阻塞完全缓解,气道通畅。一名患者建立了通畅的气道,尽管气道阻塞只有轻微改善。结论。FAMM皮瓣提供了一种治疗术后严重鼻咽狭窄的方法。它是一种可靠的皮瓣,易于提起,可以为狭窄的咽提供足够的上皮。
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引用次数: 9
Clinical Outcomes for Breast Cancer Patients Undergoing Mastectomy and Reconstruction with Use of DermACELL, a Sterile, Room Temperature Acellular Dermal Matrix. 使用DermACELL(一种无菌的室温脱细胞真皮基质)进行乳房切除术和乳房重建的乳腺癌患者的临床结果
Pub Date : 2014-01-01 Epub Date: 2014-03-11 DOI: 10.1155/2014/704323
Christopher Vashi

Background. Decellularized human skin has been used in a variety of medical applications, primarily involving soft tissue reconstruction, wound healing, and tendon augmentation. Theoretically, decellularization removes potentially immunogenic material and provides a clean scaffold for cellular and vascular in growth. The use of acellular dermal matrix in two-stage postmastectomy breast reconstruction is described. Methods. Ten consecutive breast cancer patients were treated with mastectomies and immediate reconstruction from August to November 2011. There were 8 bilateral and 1 unilateral mastectomies for a total of 17 breasts, with one exclusion for chronic tobacco use. Reconstruction included the use of a new 6 × 16 cm sterile, room temperature acellular dermal matrix patch (DermACELL) soaked in a cefazolin bath. Results. Of the 17 breasts, 15 reconstructions were completed; 14 of them with expander to implant sequence and acellular dermal matrix. Histological analysis of biopsies obtained during trimming of the matrix at the second stage appeared nonremarkable with evidence of normal healing, cellularity, and vascular infiltration. Conclusion. Postoperative observations showed that this cellular dermal matrix appears to be an appropriate adjunct to reconstruction with expanders. This acellular dermal matrix appeared to work well with all patients, even those receiving postoperative chemotherapy, postoperative radiation, prednisone, or warfarin sodium.

背景。脱细胞人皮肤已用于各种医疗应用,主要涉及软组织重建,伤口愈合和肌腱增强。理论上,脱细胞去除潜在的免疫原性物质,为细胞和血管的生长提供了一个干净的支架。使用脱细胞真皮基质在两期乳房切除术后乳房重建描述。方法。2011年8月至11月,连续10例乳腺癌患者行乳房切除术并立即重建。共有17个乳房进行了8例双侧和1例单侧乳房切除术,其中一例因长期吸烟而被排除在外。重建包括使用新的6 × 16 cm无菌室温脱细胞真皮基质贴片(DermACELL)浸泡在头孢唑林浴液中。结果。在17个乳房中,完成了15个乳房的重建;其中14例采用扩展器植入序列和脱细胞真皮基质。在第二阶段对基质进行修剪时获得的活检组织进行组织学分析,发现愈合、细胞结构和血管浸润正常。结论。术后观察表明,这种细胞真皮基质似乎是一个适当的辅助重建与扩张。这种脱细胞真皮基质似乎对所有患者都有效,即使是那些接受术后化疗、术后放疗、强的松或华法林钠的患者。
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引用次数: 20
Skin sparing mastectomy with preservation of nipple areola complex and immediate breast reconstruction in patients with breast cancer: a single centre prospective study. 乳腺癌患者保留皮肤乳房切除术保留乳头乳晕复体和立即乳房重建:一项单中心前瞻性研究。
Pub Date : 2014-01-01 Epub Date: 2014-11-11 DOI: 10.1155/2014/589068
Debarati Chattopadhyay, Souradip Gupta, Prabir Kumar Jash, Marang Buru Murmu, Sandipan Gupta

Background. Skin and nipple areola sparing mastectomy (NASM) has recently gained popularity as the management of breast cancer. This study aims to evaluate the aesthetic outcome, patient satisfaction, and oncological safety of NASM. Methods. The study prospectively analyzes the results of NASM and immediate breast reconstruction in 34 women with breast cancer. The criteria for inclusion were core biopsy-proven, peripherally located breast cancer of any tumor size and with any "N" status, with documented negative intraoperative frozen section biopsy of retroareolar tissue, and distance from the nipple to tumor margin >2 cm on mammography. Results. The median age of the patients was 45 years. The majority had either stage II or stage III breast cancer. The median mammographic distance of tumor from nipple areola complex (NAC) was 3.8 cm. The overall operative morbidity was minimal. The NAC could be preserved in all the patients. There was no local recurrence of tumor at median follow-up of 28.5 months. The aesthetic outcomes were satisfactory. Conclusion. NASM and immediate breast reconstruction can be successfully achieved with minimal morbidity and very low risk of local recurrence in appropriately selected breast cancer patients, with acceptable aesthetic results and good patient satisfaction.

背景。保留皮肤和乳头乳晕的乳房切除术(NASM)最近在乳腺癌的治疗中得到了广泛的应用。本研究旨在评估NASM的美学效果、患者满意度和肿瘤安全性。方法。本研究前瞻性分析了34例乳腺癌患者的NASM和即刻乳房重建术的结果。纳入的标准是经核心活检证实的、位于周围的任何肿瘤大小和任何“N”状态的乳腺癌,术中乳晕后组织冷冻切片活检记录为阴性,乳房x光检查乳头到肿瘤边缘的距离> 2cm。结果。患者的中位年龄为45岁。大多数人患有II期或III期乳腺癌。肿瘤距乳头乳晕复合体(NAC)中位距离为3.8 cm。手术总发病率极低。所有患者均可保留NAC。中位随访28.5个月无肿瘤局部复发。美学效果令人满意。结论。在适当选择的乳腺癌患者中,NASM和立即乳房重建可以成功地以最小的发病率和极低的局部复发风险实现,具有可接受的美学效果和良好的患者满意度。
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引用次数: 21
One-stop outpatient management of accessory auricle in children with titanium clip. 钛夹儿童副耳廓一站式门诊管理。
Pub Date : 2014-01-01 Epub Date: 2014-04-01 DOI: 10.1155/2014/780394
Phui Yee Wong, Tereze Laing, Catherine Milroy

Introduction. Literature on ideal management of accessory auricles is limited. Traditionally, accessory auricles are managed by paediatricians with suture ligation at the base of the accessory auricle to induce ischaemic necrosis (Mehmi et al, 2007). This method can be associated with complications and poor cosmesis thus leading to the vogue of surgical excision ( Frieden et al, 1995; Sebben, 1989). We present our experience in managing these lesions in children with the application of a titanium clip in a one-stop outpatient setting. Methods. Data was collected retrospectively through review of patient records and telephone questionnaire identifying outcomes from the parents' perspective. Results. Of 42 patients, 24 (57.1%) responded. Eleven (26.2%) underwent surgical excision, 6 (14.3%) had no intervention, and 1 (2.4%) was not contactable. All parents were happy with the outcome and would recommend this management to other parents. Twenty-three (96%) had no complications apart from a tiny residual nubbin, which was considered cosmetically acceptable. One child had a residual nubbin that grew in size requiring surgical excision at later stage. Conclusion. Management of accessory auricles by the application of a titanium clip in one-stop outpatient setting is safe, simple, quick, and well tolerated with no need for admission, anaesthesia, or followup due to the low complication rate.

介绍。关于副耳廓理想治疗的文献有限。传统上,副耳廓由儿科医生在副耳廓底部缝合结扎以诱导缺血性坏死(Mehmi et al, 2007)。这种方法可能会导致并发症和美容不良,从而导致手术切除的流行(Frieden et al ., 1995;Sebben, 1989)。我们介绍我们的经验,在管理这些病变的儿童应用钛夹在一站式门诊设置。方法。通过回顾患者记录和电话问卷,从父母的角度确定结果,回顾性收集数据。结果。42例患者中,24例(57.1%)有反应。11例(26.2%)行手术切除,6例(14.3%)未进行干预,1例(2.4%)未接触。所有家长都对结果感到满意,并将这种管理方法推荐给其他家长。23例(96%)患者除了残留的小结节外没有其他并发症,这在美容上是可以接受的。一名儿童有残留的结节,其大小越来越大,需要在后期进行手术切除。结论。在一站式门诊环境中应用钛夹处理副耳廓安全、简单、快速、耐受性好,由于并发症发生率低,不需要入院、麻醉或随访。
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引用次数: 4
Risk factors and surgical refinements of postresective mandibular reconstruction: a retrospective study. 危险因素和术后下颌骨重建的外科改进:一项回顾性研究。
Pub Date : 2014-01-01 Epub Date: 2014-08-06 DOI: 10.1155/2014/893746
Akiko Sakakibara, Kazunobu Hashikawa, Satoshi Yokoo, Shunsuke Sakakibara, Takahide Komori, Shinya Tahara

Background. Postresective mandibular reconstruction is common in cases of oral and mandibular tumors. However, complications such as infection, plate exposure, or plate fracture can occur. We identified several significant risk factors of complications after reconstructive surgery and compared the effectiveness of different surgical techniques for reducing the incidence of complications. Methods. This study is a retrospective analysis of 28 oromandibular cancer cases that required reconstructive surgery between January 1999 and December 2011 at Kobe University Graduate School of Medicine in Japan. All cases were classified using Hashikawa's CAT and Eichner's classification methods. Then, we determined whether these classifications and different treatment or surgical methods were significantly related to complications. Results. Complications after mandibular reconstruction occurred in 10/28 patients (36%). Specifically, five patients had plate fractures, four had plate exposures, and one had an infection. Radiation therapy and closure without any flaps were significantly related to infection or plate exposure. The wrap-around technique of securing reconstruction plates was used in 14 cases, whereas the run-through technique was used in two cases. Conclusions. The success of mandibular reconstruction depends on both mechanical and biological factors, such as the location of defects, presence of occlusions, and the amount of vascularization of the flap.

背景。切除后的下颌骨重建是常见的情况下,口腔和下颌骨肿瘤。然而,感染、钢板暴露或钢板骨折等并发症也可能发生。我们确定了重建手术后并发症的几个重要危险因素,并比较了不同手术技术在减少并发症发生率方面的有效性。方法。本研究回顾性分析了1999年1月至2011年12月在日本神户大学医学研究生院接受重建手术的28例口腔下颌骨癌病例。所有病例均采用Hashikawa's CAT和Eichner分类法进行分类。然后,我们确定这些分类和不同的治疗或手术方法是否与并发症有显著关系。结果。10/28例(36%)患者出现下颌重建术并发症。具体来说,5名患者有钢板骨折,4名患者有钢板暴露,1名患者有感染。放射治疗和无皮瓣闭合与感染或钢板暴露显著相关。14例采用环绕技术固定重建钢板,2例采用贯穿技术。结论。下颌骨重建的成功取决于机械和生物因素,如缺损的位置、咬合的存在和皮瓣的血管化程度。
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引用次数: 20
The effectiveness of modified cottle maneuver in predicting outcomes in functional rhinoplasty. 改良鼻翼手法预测功能性鼻整形预后的有效性。
Pub Date : 2014-01-01 Epub Date: 2014-08-25 DOI: 10.1155/2014/618313
Elaine Fung, Paul Hong, Corey Moore, S Mark Taylor

Objective. To assess the outcomes of functional rhinoplasty for nasal valve incompetence and to evaluate an in-office test used to select appropriate surgical techniques. Methods. Patients with nasal obstruction due to nasal valve incompetence were enrolled. The modified Cottle maneuver was used to assess the internal and external nasal valves to help select the appropriate surgical method. The rhinoplasty outcomes evaluation (ROE) form and a 10-point visual analog scale (VAS) of nasal breathing were used to compare preoperative and postoperative symptoms. Results. Forty-nine patients underwent functional rhinoplasty evaluation. Of those, 35 isolated batten or spreader grafts were inserted without additional procedures. Overall mean ROE score increased significantly (P < 0.0001) from 41.9 ± 2.4 to 81.7 ± 2.5 after surgery. Subjective improvement in nasal breathing was also observed with the VAS (mean improvement of 4.5 (95% CI 3.8-5.2) from baseline (P = 0.000)). Spearman rank correlation between predicted outcomes using the modified Cottle maneuver and postoperative outcomes was strong for the internal nasal valve (Rho = 0.80; P = 0.0029) and moderate for the external nasal valve (Rho = 0.50; P = 0.013). Conclusion. Functional rhinoplasty improved subjective nasal airflow in our population. The modified Cottle maneuver was effective in predicting positive surgical outcomes.

目标。目的评估鼻瓣膜功能不全的功能性鼻成形术的效果,并评估用于选择合适手术技术的室内试验。方法。本研究纳入了因鼻瓣膜功能不全导致鼻塞的患者。采用改良的Cottle手法评估内、外鼻瓣,选择合适的手术方法。采用鼻成形术结果评估表(ROE)和鼻腔呼吸10分视觉模拟量表(VAS)比较术前和术后症状。结果。49例患者接受了功能性鼻成形术评估。其中,35例游离木条或散条移植物无附加手术。术后总平均ROE评分从41.9±2.4分显著升高至81.7±2.5分(P < 0.0001)。VAS也观察到主观鼻呼吸改善(平均改善4.5 (95% CI 3.8-5.2),较基线(P = 0.000))。改良的Cottle手法预测结果与鼻内瓣术后结果的Spearman等级相关性很强(Rho = 0.80;P = 0.0029),鼻外瓣膜为中度(Rho = 0.50;P = 0.013)。结论。功能性鼻整形术改善了我们人群的主观鼻腔气流。改良的Cottle手法能有效预测手术结果。
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引用次数: 46
Treatment of early-stage pressure ulcers by using autologous adipose tissue grafts. 自体脂肪组织移植治疗早期压疮。
Pub Date : 2014-01-01 Epub Date: 2014-04-10 DOI: 10.1155/2014/817283
Giovanni Francesco Marangi, Tiziano Pallara, Barbara Cagli, Emiliano Schena, Francesco Giurazza, Elio Faiella, Bruno Beomonte Zobel, Paolo Persichetti

Assessing pressure ulcers (PUs) in early stages allows patients to receive safer treatment. Up to now, in addition to clinical evaluation, ultrasonography seems to be the most suitable technique to achieve this goal. Several treatments are applied to prevent ulcer progression but none of them is totally effective. Furthermore, the in-depth knowledge of fat regenerative properties has led to a wide use of it. With this study the authors aim at introducing a new approach to cure and prevent the worsening of early-stage PUs by using fat grafts. The authors selected 42 patients who showed clinical and ultrasonographic evidence of early-stage PUs. Values of skin thickness, fascial integrity, and subcutaneous vascularity were recorded both on the PU area and the healthy trochanteric one, used as control region. Fat grafting was performed on all patients. At three months, abnormal ultrasonographic findings, such as reduction of cutaneous and subcutaneous thickness, discontinuous fascia, and decrease in subcutaneous vascularity, all were modified with respect to almost all the corresponding parameters of the control region. Results highlight that the use of fat grafts proved to be an effective treatment for early-stage PUs, especially in the care of neurological and chronic bedridden patients.

在早期阶段评估压疮(pu)可以让患者接受更安全的治疗。到目前为止,除了临床评估外,超声检查似乎是实现这一目标的最合适的技术。有几种治疗方法可以防止溃疡恶化,但没有一种是完全有效的。此外,对脂肪再生特性的深入了解使其得到了广泛的应用。在这项研究中,作者旨在介绍一种通过脂肪移植治疗和预防早期脓肿恶化的新方法。作者选择了42例有早期脓肿临床和超声证据的患者。以健康粗隆为对照区,记录PU区皮肤厚度、筋膜完整性和皮下血管密度。所有患者均行脂肪移植术。在3个月时,超声异常表现,如皮肤和皮下厚度减少,筋膜不连续,皮下血管减少,相对于控制区的几乎所有相应参数都得到了修改。结果强调,脂肪移植被证明是早期脓液的有效治疗方法,特别是在神经和慢性卧床病人的护理中。
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引用次数: 25
Outcome of split thickness skin grafting and multiple z-plasties in postburn contractures of groin and perineum: a 15-year experience. 分厚皮移植和多次z形成形术治疗烧伤后腹股沟和会阴挛缩的疗效:15年的经验。
Pub Date : 2014-01-01 Epub Date: 2014-05-21 DOI: 10.1155/2014/358526
Wani Sajad, Raashid Hamid

Background. Groin and perineal burn contracture is a rare postburn sequel. Such postburn contractures causes distressing symptoms to the patients and in the management of these contractures, both functional and cosmetic appearance should be the primary concern. Aims. To study the outcome of surgical treatment (STSG and multiple Z-plasties) in postburn contractures of groin and perineum. Material and Methods. We conducted a study of 49 patients, with postburn groin and perineal contractures. Release of contracture with split thickness skin grafting (STSG) was done in 44 (89.79%) patients and release of contracture and closure by multiple Z-plasties was done in 5 (10.21%) patients. Results. Satisfactory functional and cosmetic outcome was seen in 44 (89.79%) patients. Minor secondary contractures of the graft were seen in 3 (6.81%) patients who were managed by physiotherapy and partial recurrence of the contracture in 4 (8.16%) patients required secondary surgery. Conclusion. We conclude that postburn contractures of the groin and perineum can be successfully treated with release of contracture followed by STSG with satisfactory functional and cosmetic results. Long term measures like regular physiotherapy, use of pressure garments, and messaging with emollient creams should not be neglected and should be instituted postoperatively to prevent secondary contractures of the graft and recurrence of the contracture.

背景。腹股沟和会阴烧伤挛缩是一种罕见的烧伤后后遗症。这种烧伤后挛缩会给患者带来痛苦的症状,在治疗这些挛缩时,应首先考虑功能和外观。目标目的:探讨烧伤后腹股沟会阴挛缩的手术治疗(STSG和多种z形成形术)的效果。材料和方法。我们对49例烧伤后腹股沟和会阴挛缩患者进行了研究。44例(89.79%)患者采用裂厚皮移植(STSG)解除挛缩,5例(10.21%)患者采用多次z -成形术解除挛缩并闭合。结果。44例(89.79%)患者功能和美容效果满意。3例(6.81%)患者经物理治疗后出现移植物轻微继发挛缩,4例(8.16%)患者部分挛缩复发,需二次手术治疗。结论。我们的结论是,腹股沟和会阴烧伤后挛缩可以通过释放挛缩后STSG成功治疗,并获得满意的功能和美容效果。不应忽视长期措施,如常规物理治疗、使用压力服和使用润肤膏,并应在术后建立,以防止移植物继发挛缩和挛缩复发。
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引用次数: 3
Catastrophic Outcomes in Free Tissue Transfer: A Six-Year Review of the NSQIP Database. 游离组织移植的灾难性结果:NSQIP 数据库六年回顾。
Pub Date : 2014-01-01 Epub Date: 2014-11-16 DOI: 10.1155/2014/704206
David W Grant, Alexei Mlodinow, Jon P Ver Halen, John Y S Kim

Background. No studies report robust data on the national incidence and risk factors associated with catastrophic medical outcomes following free tissue transfer. Methods. The American College of Surgeons (ACS) multicenter, prospective National Surgical Quality Improvement Program (NSQIP) database was used to identify patients who underwent free tissue transfer between 2006 and 2011. Multivariable logistic regression was used for statistical analysis. Results. Over the 6-year study period 2,349 patients in the NSQIP database underwent a free tissue transfer procedure. One hundred and twenty-two patients had at least one catastrophic medical outcome (5.2%). These 122 patients had 151 catastrophic medical outcomes, including 93 postoperative respiratory failure events (4.0%), 14 pulmonary emboli (0.6%), 13 septic shock events (0.5%), 12 myocardial infarctions (0.5%), 6 cardiac arrests (0.3%), 4 strokes (0.2%), 1 coma (0.0%), and 8 deaths (0.3%). Total length of hospital stay was on average 14.7 days longer for patients who suffered a catastrophic medical complication (P < 0.001). Independent risk factors were identified. Conclusions. Free tissue transfer is a proven and safe technique. Catastrophic medical complications were infrequent but added significantly to length of hospital stay and patient morbidity.

背景。目前还没有研究报告有关游离组织移植后灾难性医疗后果的全国发生率和相关风险因素的可靠数据。方法。使用美国外科学院(ACS)多中心、前瞻性国家外科质量改进计划(NSQIP)数据库来识别 2006 年至 2011 年期间接受游离组织转移的患者。采用多变量逻辑回归进行统计分析。结果。在 6 年的研究期间,NSQIP 数据库中有 2349 名患者接受了游离组织转移手术。122 名患者至少出现了一次灾难性医疗后果(5.2%)。这122名患者出现了151次灾难性医疗后果,包括93次术后呼吸衰竭事件(4.0%)、14次肺栓塞(0.6%)、13次脓毒性休克事件(0.5%)、12次心肌梗塞(0.5%)、6次心脏骤停(0.3%)、4次中风(0.2%)、1次昏迷(0.0%)和8次死亡(0.3%)。发生灾难性医疗并发症的患者住院总时间平均延长了 14.7 天(P < 0.001)。发现了独立的风险因素。结论游离组织移植是一项成熟、安全的技术。灾难性医疗并发症并不常见,但会显著增加住院时间和患者发病率。
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引用次数: 0
The effect of different topical agents (silver sulfadiazine, povidone-iodine, and sodium chloride 0.9%) on burn injuries in rats. 不同外用药物(磺胺嘧啶银、聚维酮碘和 0.9%氯化钠)对大鼠烧伤的影响。
Pub Date : 2014-01-01 Epub Date: 2014-09-29 DOI: 10.1155/2014/907082
Emir Burak Yüksel, Alpagan Mustafa Yıldırım, Ali Bal, Tuncay Kuloglu

It was aimed to comparatively evaluate the effects of dressing methods with silver sulfadiazine, povidone-iodine, and saline which have a common use in routine practices for burn injuries. Twenty-eight Sprague Dawley adult female rats were used in this study. All the rats were divided into 4 groups: the control group, the povidone-iodine group, the saline group, and the silver sulfadiazine group. On each rat, a second degree burn which covered less than 10% of the body surface area was created under general anesthesia by a metal comb including four probes with 2 × 1 cm area. The control group did not have any treatment during the experiment. Povidone-iodine, saline, and silver sulfadiazine administrations were performed under ether anesthesia every day. On 0, 7th, 14th, and 21st days of the study, tissue samples were taken for histological analyses. The sections taken from the paraffin blocks were stained and avidin-biotin-peroxidase method was used for collagen immune-reactivity. In the light microscope analyses, number of inflammatory cells, vascularization, fibroblast proliferation, collagen formation and epithelialization were evaluated histologically in all groups and analysed statistically. The agents that we used for injury healing in the treatment groups did not show any significant better results in comparison with the control group. In conclusion, further studies with the use of sodium chloride, silver sulfadiazine, and povidone-iodine by creating deeper and/or larger burn injury models are needed in order to accept these agents in routine treatment.

研究的目的是比较评估磺胺嘧啶银、聚维酮碘和生理盐水包扎方法的效果。本研究使用了 28 只 Sprague Dawley 成年雌性大鼠。所有大鼠分为 4 组:对照组、聚维酮碘组、生理盐水组和磺胺嘧啶银组。在全身麻醉的情况下,用一把金属梳子(包括四个面积为 2 × 1 厘米的探针)在每只大鼠身上造成二度烧伤,烧伤面积小于体表面积的 10%。对照组在实验期间不做任何处理。每天在乙醚麻醉下注射聚维酮碘、生理盐水和磺胺嘧啶银。在研究的第 0 天、第 7 天、第 14 天和第 21 天,采集组织样本进行组织学分析。石蜡切片经染色后,采用阿维菌素-生物素-过氧化物酶法检测胶原蛋白的免疫反应性。在光镜分析中,对所有组的炎症细胞数量、血管形成、成纤维细胞增殖、胶原形成和上皮化进行了组织学评估和统计学分析。与对照组相比,我们在治疗组中使用的损伤愈合剂没有显示出明显的更好效果。总之,需要通过创建更深和/或更大的烧伤模型,对氯化钠、磺胺嘧啶银和聚维酮碘的使用进行进一步研究,以便在常规治疗中使用这些药物。
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引用次数: 0
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