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Acupuncture for erectile dysfunction: a randomized controlled trial. 针灸治疗勃起功能障碍:随机对照试验。
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20231005-0001
Min Zhu, Fei Quan, Kaiyang Xue, Cai-hong Xiao, Jin Cui
OBJECTIVESTo observe the clinical efficacy of acupuncture in treating erectile dysfunction (ED).METHODSA total of 64 ED patients were randomly divided into an acupuncture group (32 cases, 2 case dropped out) and a western medication group (32 cases, 2 cases dropped out). In the acupuncture group, acupuncture treatment was applied at Baihui (GV 20), Qihai (CV 6), Guanyuan (CV 4), Zhongji (CV 3), Dahe (KI 12), Qugu (CV 2), Zusanli (ST 36), and etc., two groups of acupoints were used alternately, 30 min each time, once every other day. In the western medication group, 50 mg of sildenafil tablet was took orally 1 h before sexual activity. Both groups were treated for 30 d. The international index of erectile function citrate (IIEF-5) score, self rating anxiety scale (SAS) score, self rating depression scale (SDS) score, TCM syndrome score were observed before and after treatment, and in follow-up of 2 weeks after treatment completion, the serum testosterone (T) level was detected before and after treatment, and the clinical efficacy was evaluated in the two groups.RESULTSAfter treatment and in follow-up, the IIEF-5 scores were increased compared with those before treatment in the two groups (P<0.01). In follow-up, the IIEF-5 score in the acupuncture group was ascended compared with that in the western medication group (P<0.05). Except for the SDS and TCM syndrome scores in the western medication group of follow-up, the SAS scores, SDS scores, and the TCM syndrome scores were decreased after treatment and in follow-up compared with those before treatment in the two groups (P<0.01, P<0.05); in the acupuncture group, the SAS scores, SDS scores and the TCM syndrome scores after treatment and in follow-up were lower than those in the western medication group (P<0.01). After treatment, the serum T levels were increased compared with those before treatment in the two groups (P<0.01). The total effective rate of the acupuncture group was 83.3% (25/30), and it was 86.7% (26/30) in the western medication group, there was no significant difference in total effective rate between the two groups (P>0.05).CONCLUSIONSAcupuncture can effectively improve erectile function, anxiety and depression state, and TCM syndrome in ED patients, and has a advantage of posterior effect compared with western medication treatment.
目的观察针灸治疗勃起功能障碍(ED)的临床疗效。方法将64例ED患者随机分为针灸组(32例,2例退出)和西药组(32例,2例退出)。针刺组针刺百会(GV 20)、气海(CV 6)、关元(CV 4)、中极(CV 3)、大热(KI 12)、曲谷(CV 2)、足三里(ST 36)等穴位,两组穴位交替使用,每次 30 分钟,隔日 1 次。西药组在性生活前 1 h 口服 50 mg 西地那非片剂。观察两组患者治疗前后的枸橼酸国际勃起功能指数(IIEF-5)评分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、中医综合征评分,治疗结束后随访2周,检测两组患者治疗前后的血清睾酮(T)水平,评价临床疗效。结果治疗后及随访中,两组患者的IIEF-5评分均较治疗前有所提高(P0.05)。结论针灸能有效改善ED患者的勃起功能、焦虑抑郁状态及中医综合征,与西药治疗相比具有后发优势。
{"title":"Acupuncture for erectile dysfunction: a randomized controlled trial.","authors":"Min Zhu, Fei Quan, Kaiyang Xue, Cai-hong Xiao, Jin Cui","doi":"10.13703/j.0255-2930.20231005-0001","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20231005-0001","url":null,"abstract":"OBJECTIVES\u0000To observe the clinical efficacy of acupuncture in treating erectile dysfunction (ED).\u0000\u0000\u0000METHODS\u0000A total of 64 ED patients were randomly divided into an acupuncture group (32 cases, 2 case dropped out) and a western medication group (32 cases, 2 cases dropped out). In the acupuncture group, acupuncture treatment was applied at Baihui (GV 20), Qihai (CV 6), Guanyuan (CV 4), Zhongji (CV 3), Dahe (KI 12), Qugu (CV 2), Zusanli (ST 36), and etc., two groups of acupoints were used alternately, 30 min each time, once every other day. In the western medication group, 50 mg of sildenafil tablet was took orally 1 h before sexual activity. Both groups were treated for 30 d. The international index of erectile function citrate (IIEF-5) score, self rating anxiety scale (SAS) score, self rating depression scale (SDS) score, TCM syndrome score were observed before and after treatment, and in follow-up of 2 weeks after treatment completion, the serum testosterone (T) level was detected before and after treatment, and the clinical efficacy was evaluated in the two groups.\u0000\u0000\u0000RESULTS\u0000After treatment and in follow-up, the IIEF-5 scores were increased compared with those before treatment in the two groups (P<0.01). In follow-up, the IIEF-5 score in the acupuncture group was ascended compared with that in the western medication group (P<0.05). Except for the SDS and TCM syndrome scores in the western medication group of follow-up, the SAS scores, SDS scores, and the TCM syndrome scores were decreased after treatment and in follow-up compared with those before treatment in the two groups (P<0.01, P<0.05); in the acupuncture group, the SAS scores, SDS scores and the TCM syndrome scores after treatment and in follow-up were lower than those in the western medication group (P<0.01). After treatment, the serum T levels were increased compared with those before treatment in the two groups (P<0.01). The total effective rate of the acupuncture group was 83.3% (25/30), and it was 86.7% (26/30) in the western medication group, there was no significant difference in total effective rate between the two groups (P>0.05).\u0000\u0000\u0000CONCLUSIONS\u0000Acupuncture can effectively improve erectile function, anxiety and depression state, and TCM syndrome in ED patients, and has a advantage of posterior effect compared with western medication treatment.","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"2 2","pages":"418-422"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postpartum uterine involution promoted by penetrating-moxibustion therapy: a randomized controlled trial. 渗透艾灸疗法促进产后子宫复旧:随机对照试验。
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20220609-0005
Ling Gao, Wanglu Chen, Xiyan Gao, Xinwang Chen, Yali Fan, Xuguang Yang, Wenming Chu, Yuan Cao
OBJECTIVESTo observe the effect of penetrating-moxibustion therapy on postpartum uterine involution.METHODSEighty puerpera were randomized into an observation group and a control group, 40 cases in each one. In the control group, oxytocin injection was administered by intravenous drip, 20 U each time, once daily. In the observation group, on the base of the treatment as the control group, the penetrating-moxibustion therapy was used at Shenque (GV 8), Qihai (CV 6) and Guanyuan (CV 4), 30 min to 40 min each time, twice a day. The intervention of each group started from the first day after childbirth and lasted 3 days. The uterine volume before and after treatment, and in 42 days of postpartum, the height decrease of the fundus of the uterus, the score of visual analogue scale (VAS) for uterine contraction, the volume of lochia rubra in 1 to 3 days of treatment, and lochia duration were compared between the two groups; and the clinical effect was evaluated.RESULTSThe uterine volume in the observation group was smaller than that of the control group after treatment (P<0.01). In 1 to 3 days of treatment, the height decrease of the fundus of the uterus in the observation group was larger (P<0.01), VAS scores of uterine contraction were lower (P<0.05, P<0.01), the lochia rubra volume was less (P<0.01) than those in the control group. The duration of lochia rubra and lochia was shorter (P<0.01) in the observation group when compared with that of the control group. The favorable rate of uterine involution in the observation group was 95.0% (38/40), higher than that of the control group (75.0%, 30/40, P<0.05).CONCLUSIONSPenetrating-moxibustion therapy accelerates the recovery of the uterine volume, relieves uterine contraction, shortens the duration of lochia, reduces the lochia volume and promotes the postpartum uterine involution.
方法将 80 例产妇随机分为观察组和对照组,各 40 例。对照组采用催产素静脉滴注,每次 20 U,每日 1 次。观察组在对照组治疗的基础上,在神阙穴(龙脉 8)、气海穴(龙脉 6)和关元穴(龙脉 4)进行透穴灸治疗,每次 30 至 40 分钟,每天 2 次。各组干预从产后第一天开始,持续 3 天。比较两组治疗前后及产后 42 天的子宫容积、宫底高度下降情况、子宫收缩视觉模拟量表(VAS)评分、治疗 1~3 天的红黄塬液量、黄塬液持续时间,并评价临床效果。治疗 1~3 天,观察组宫底高度下降幅度大于对照组(P<0.01),子宫收缩 VAS 评分低于对照组(P<0.05,P<0.01),红斑面积小于对照组(P<0.01)。与对照组相比,观察组的红黄水和黄水持续时间更短(P<0.01)。观察组子宫复旧良好率为 95.0%(38/40),高于对照组(75.0%,30/40,P<0.05)。
{"title":"Postpartum uterine involution promoted by penetrating-moxibustion therapy: a randomized controlled trial.","authors":"Ling Gao, Wanglu Chen, Xiyan Gao, Xinwang Chen, Yali Fan, Xuguang Yang, Wenming Chu, Yuan Cao","doi":"10.13703/j.0255-2930.20220609-0005","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20220609-0005","url":null,"abstract":"OBJECTIVES\u0000To observe the effect of penetrating-moxibustion therapy on postpartum uterine involution.\u0000\u0000\u0000METHODS\u0000Eighty puerpera were randomized into an observation group and a control group, 40 cases in each one. In the control group, oxytocin injection was administered by intravenous drip, 20 U each time, once daily. In the observation group, on the base of the treatment as the control group, the penetrating-moxibustion therapy was used at Shenque (GV 8), Qihai (CV 6) and Guanyuan (CV 4), 30 min to 40 min each time, twice a day. The intervention of each group started from the first day after childbirth and lasted 3 days. The uterine volume before and after treatment, and in 42 days of postpartum, the height decrease of the fundus of the uterus, the score of visual analogue scale (VAS) for uterine contraction, the volume of lochia rubra in 1 to 3 days of treatment, and lochia duration were compared between the two groups; and the clinical effect was evaluated.\u0000\u0000\u0000RESULTS\u0000The uterine volume in the observation group was smaller than that of the control group after treatment (P<0.01). In 1 to 3 days of treatment, the height decrease of the fundus of the uterus in the observation group was larger (P<0.01), VAS scores of uterine contraction were lower (P<0.05, P<0.01), the lochia rubra volume was less (P<0.01) than those in the control group. The duration of lochia rubra and lochia was shorter (P<0.01) in the observation group when compared with that of the control group. The favorable rate of uterine involution in the observation group was 95.0% (38/40), higher than that of the control group (75.0%, 30/40, P<0.05).\u0000\u0000\u0000CONCLUSIONS\u0000Penetrating-moxibustion therapy accelerates the recovery of the uterine volume, relieves uterine contraction, shortens the duration of lochia, reduces the lochia volume and promotes the postpartum uterine involution.","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"15 2","pages":"400-404"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of electroacupuncture with "intestinal disease prescription" on NLRP3 inflammasome and intestinal mucosal barrier in rats with acute ulcerative colitis. 电针配合 "肠病方 "对急性溃疡性结肠炎大鼠NLRP3炎性体和肠黏膜屏障的影响
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20230716-k0001
Ziwen Jiang, Ronglin Wu, Hui-Chao Xu, Haijun Wang, Aiai Dong, Laixi Ji
OBJECTIVESTo observe the effects of electroacupuncture (EA) with "intestinal disease prescription" on the intestinal mucosal barrier and NLRP3 inflammasome in rats with dextran sulfate sodium (DSS)-induced acute ulcerative colitis (UC), and explore the underlying mechanism of EA with "intestinal disease prescription" for the treatment of UC.METHODSThirty-two healthy male SPF-grade SD rats were randomly divided into a blank group, a model group, a medication group, and an EA group, with 8 rats in each group. Except for the blank group, the UC model was established by administering 5% DSS solution for 7 days. After modeling, the rats in the medication group were treated with mesalazine suspension (200 mg/kg) by gavage, while the rats in the EA group were treated with acupuncture at bilateral "Tianshu" (ST 25), "Shangjuxu" (ST 37) and "Zhongwan" (CV 12), with the ipsilateral "Tianshu" (ST 25) and "Shangjuxu" (ST 37) connected to the electrodes of the EA instrument, using disperse-dense wave, with a frequency of 10 Hz/50 Hz, and each intervention lasted for 20 minutes. Both interventions were performed once daily for 3 days. The general conditions of rats were observed daily. After intervention, the disease activity index (DAI) score was calculated; colon tissue morphology was observed using HE staining; serum levels of pro-inflammatory cytokines (interleukin [IL]-18, IL-1β) were measured by ELISA; protein expression of NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), and Caspase-1 in colon tissues was detected by Western blot; positive expression of zonula occludens-1 (ZO-1) and Occludin in colon tissues was examined by immunofluorescence.RESULTSCompared with the blank group, the rats in the model group exhibited poor general conditions, slow body weight gain, shortened colon length (P<0.01), increased DAI score and spleen index (P<0.01), elevated serum IL-18 and IL-1β levels, and increased protein expression of NLRP3, ASC, and Caspase-1 in colon tissues (P<0.01), along with decreased positive expression of ZO-1 and Occludin in colon tissues (P<0.01). Compared with the model group, the rats in the medication group and the EA group exhibited improved general conditions, accelerated body weight gain, increased colon length (P<0.05), reduced DAI scores and spleen indexes (P<0.05), decreased serum IL-18 and IL-1β levels, and lower protein expression of NLRP3, ASC and Caspase-1 in colon tissues (P<0.05), as well as increased positive expression of ZO-1 and Occludin in colon tissues (P<0.05). There were no significant differences in the above indexes between the medication group and the EA group (P>0.05). Compared with the blank group, the rats in the model group exhibited disrupted colon mucosal morphology, disordered gland arrangement, and atrophy of crypts, along with significant inflammatory cell infiltration. Compared with the model group, the rats in both the medication group and the EA group showed relatively intact
目的观察电针配合 "肠病方 "对右旋糖酐硫酸钠(DSS)诱导的急性溃疡性结肠炎(UC)大鼠肠黏膜屏障和NLRP3炎性体的影响,探讨电针配合 "肠病方 "治疗UC的内在机制。方法将32只健康雄性SPF级SD大鼠随机分为空白组、模型组、药物组和EA组,每组8只。除空白组外,其他UC模型均通过连续7天注射5%的DSS溶液建立。建模后,药物组大鼠灌胃美沙拉嗪混悬液(200 毫克/千克),EA 组大鼠针刺双侧 "天枢"(ST 25)、"上巨虚"(ST 37)和 "中脘"(CV 12)、同侧 "天枢"(ST 25)和 "上巨虚"(ST 37)与 EA 仪的电极相连,使用频率为 10 赫兹/50 赫兹的分散密集波,每次干预持续 20 分钟。两种干预每天进行一次,持续 3 天。每天观察大鼠的一般状况。干预后,计算疾病活动指数(DAI)评分;用 HE 染色法观察结肠组织形态;用 ELISA 法测定血清促炎细胞因子(白细胞介素 [IL]-18、IL-1β)水平;采用 Western 印迹法检测结肠组织中 NLRP3、含 CARD 的凋亡相关斑点样蛋白(ASC)和 Caspase-1 的蛋白表达;采用免疫荧光法检测结肠组织中 zonula occludens-1 (ZO-1) 和 Occludin 的阳性表达。结果与空白组相比,模型组大鼠全身状况差,体重增长缓慢,结肠长度缩短(P0.05)。与空白组相比,模型组大鼠结肠粘膜形态紊乱,腺体排列失调,隐窝萎缩,并伴有明显的炎性细胞浸润。与模型组相比,药物组和 EA 组大鼠的结肠粘膜形态相对完整,腺体和隐窝结构得到恢复和改善,炎性细胞浸润减少。
{"title":"Effects of electroacupuncture with \"intestinal disease prescription\" on NLRP3 inflammasome and intestinal mucosal barrier in rats with acute ulcerative colitis.","authors":"Ziwen Jiang, Ronglin Wu, Hui-Chao Xu, Haijun Wang, Aiai Dong, Laixi Ji","doi":"10.13703/j.0255-2930.20230716-k0001","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20230716-k0001","url":null,"abstract":"OBJECTIVES\u0000To observe the effects of electroacupuncture (EA) with \"intestinal disease prescription\" on the intestinal mucosal barrier and NLRP3 inflammasome in rats with dextran sulfate sodium (DSS)-induced acute ulcerative colitis (UC), and explore the underlying mechanism of EA with \"intestinal disease prescription\" for the treatment of UC.\u0000\u0000\u0000METHODS\u0000Thirty-two healthy male SPF-grade SD rats were randomly divided into a blank group, a model group, a medication group, and an EA group, with 8 rats in each group. Except for the blank group, the UC model was established by administering 5% DSS solution for 7 days. After modeling, the rats in the medication group were treated with mesalazine suspension (200 mg/kg) by gavage, while the rats in the EA group were treated with acupuncture at bilateral \"Tianshu\" (ST 25), \"Shangjuxu\" (ST 37) and \"Zhongwan\" (CV 12), with the ipsilateral \"Tianshu\" (ST 25) and \"Shangjuxu\" (ST 37) connected to the electrodes of the EA instrument, using disperse-dense wave, with a frequency of 10 Hz/50 Hz, and each intervention lasted for 20 minutes. Both interventions were performed once daily for 3 days. The general conditions of rats were observed daily. After intervention, the disease activity index (DAI) score was calculated; colon tissue morphology was observed using HE staining; serum levels of pro-inflammatory cytokines (interleukin [IL]-18, IL-1β) were measured by ELISA; protein expression of NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), and Caspase-1 in colon tissues was detected by Western blot; positive expression of zonula occludens-1 (ZO-1) and Occludin in colon tissues was examined by immunofluorescence.\u0000\u0000\u0000RESULTS\u0000Compared with the blank group, the rats in the model group exhibited poor general conditions, slow body weight gain, shortened colon length (P<0.01), increased DAI score and spleen index (P<0.01), elevated serum IL-18 and IL-1β levels, and increased protein expression of NLRP3, ASC, and Caspase-1 in colon tissues (P<0.01), along with decreased positive expression of ZO-1 and Occludin in colon tissues (P<0.01). Compared with the model group, the rats in the medication group and the EA group exhibited improved general conditions, accelerated body weight gain, increased colon length (P<0.05), reduced DAI scores and spleen indexes (P<0.05), decreased serum IL-18 and IL-1β levels, and lower protein expression of NLRP3, ASC and Caspase-1 in colon tissues (P<0.05), as well as increased positive expression of ZO-1 and Occludin in colon tissues (P<0.05). There were no significant differences in the above indexes between the medication group and the EA group (P>0.05). Compared with the blank group, the rats in the model group exhibited disrupted colon mucosal morphology, disordered gland arrangement, and atrophy of crypts, along with significant inflammatory cell infiltration. Compared with the model group, the rats in both the medication group and the EA group showed relatively intact ","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"115 2","pages":"441-448"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of acupuncture on quality of life in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial. 针灸对慢性前列腺炎/慢性盆腔疼痛综合征患者生活质量的影响:随机对照试验。
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20230626-k0003
Huaiyu Wang, Yuan Ji, Shuo Zhang, Pengfei Yuan, Hongchao Zhao, Yan Guo, Xiaodi Xie, Yulong Ding
OBJECTIVESTo observe the effect and safety of acupuncture on quality of life, pain, and prostate symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).METHODSSeventy patients with CP/CPPS were randomly divided into an acupuncture group (35 cases, 1 case was eliminated) and a sham acupuncture group (35 cases, 3 cases dropped out). The patients in the acupuncture group were treated with routine acupuncture at bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6), while the patients in the sham acupuncture group were treated with shallow needling at non-meridian and non-acupoint points beside bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6),without manipulation to induce arrival of qi (deqi). Both groups retained the needles for 30 min, with one session every other day, three times a week, for a total of 8 weeks (24 sessions). Before and after treatment, and at the follow-up of 24 weeks after treatment completion, the scores of MOS 36-item short-form health survey (SF-36, including 8 dimensions of physical function [PF], role physical function [RP], bodily pain [BP], general health status [GH], vitality [VT], social function [SF], role emotional [RE], and mental health [MH], which can be summarized as physical component summary [PCS] and mental component summary [MCS]), pelvic pain visual analogue scale (VAS), National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), and international prostate symptom score (IPSS) were evaluated, and safety of both groups was assessed.RESULTSAfter treatment and at the follow-up, the scores of each dimension and PCS, MCS scores of SF-36 in the acupuncture group were higher than those before treatment (P<0.05, P<0.01); compared before treatment, the RP, BP, and SF scores and PCS score in the sham acupuncture group were increased after treatment (P<0.05, P<0.01). After treatment, the acupuncture group had higher scores in RP, BP, GH, MH and PCS, MCS than those in the sham acupuncture group (P<0.05, P<0.01); at the follow-up, except for PF and RE dimensions, the scores in each dimension and PCS, MCS scores in the acupuncture group were higher than those in the sham acupuncture group (P<0.05, P<0.01). After treatment and at the follow-up, pelvic pain VAS, NIH-CPSI, IPSS scores in the acupuncture group were lower than those before treatment (P<0.01); in the sham acupuncture group, pelvic pain VAS, NIH-CPSI scores were lower after treatment, and NIH-CPSI score at the follow-up was lower compared with those before treatment (P<0.01). After treatment and at the follow-up, pelvic pain VAS, NIH-CPSI, IPSS scores in the acupuncture group were lower than those in the sham acupuncture group (P<0.01, P<0.05). No significant adverse reactions were observed in both groups, and the incidence rates of adverse reactions had no significant difference (P>0.05).CONCLUSIONSAcupuncture could effectively improve the
目的观察针灸对慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)患者生活质量、疼痛和前列腺症状的影响及安全性。方法将70例CP/CPPS患者随机分为针灸组(35例,1例淘汰)和假针灸组(35例,3例退出)。针刺组患者在双侧中脘(BL 33)、惠阳(BL 35)、神阙(BL 23)和三阴交(SP 6)进行常规针刺治疗、而假针灸组的患者则在双侧中脘(BL 33)、会阳(BL 35)、神阙(BL 23)和三阴交(SP 6)旁的非经络和非腧穴进行浅针治疗,不进行引气(去气)操作。两组均留针 30 分钟,隔日一次,每周三次,共 8 周(24 次)。在治疗前后和治疗结束后 24 周的随访中,MOS 36 项短式健康调查(SF-36,包括身体功能[PF]、角色身体功能[RP]、身体疼痛[BP]、一般健康状况[GH]、活力[VT]、社会功能[SF]、角色情感[RE]8 个维度)的得分和心理健康[MH]的得分均高于对照组、对骨盆疼痛视觉模拟量表(VAS)、美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)和国际前列腺症状评分(IPSS)进行评估,并对两组的安全性进行评估。结果治疗后及随访期间,针刺组 SF-36 各维度评分及 PCS、MCS 评分均高于治疗前(P0.05)。
{"title":"Effect of acupuncture on quality of life in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial.","authors":"Huaiyu Wang, Yuan Ji, Shuo Zhang, Pengfei Yuan, Hongchao Zhao, Yan Guo, Xiaodi Xie, Yulong Ding","doi":"10.13703/j.0255-2930.20230626-k0003","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20230626-k0003","url":null,"abstract":"OBJECTIVES\u0000To observe the effect and safety of acupuncture on quality of life, pain, and prostate symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).\u0000\u0000\u0000METHODS\u0000Seventy patients with CP/CPPS were randomly divided into an acupuncture group (35 cases, 1 case was eliminated) and a sham acupuncture group (35 cases, 3 cases dropped out). The patients in the acupuncture group were treated with routine acupuncture at bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6), while the patients in the sham acupuncture group were treated with shallow needling at non-meridian and non-acupoint points beside bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6),without manipulation to induce arrival of qi (deqi). Both groups retained the needles for 30 min, with one session every other day, three times a week, for a total of 8 weeks (24 sessions). Before and after treatment, and at the follow-up of 24 weeks after treatment completion, the scores of MOS 36-item short-form health survey (SF-36, including 8 dimensions of physical function [PF], role physical function [RP], bodily pain [BP], general health status [GH], vitality [VT], social function [SF], role emotional [RE], and mental health [MH], which can be summarized as physical component summary [PCS] and mental component summary [MCS]), pelvic pain visual analogue scale (VAS), National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), and international prostate symptom score (IPSS) were evaluated, and safety of both groups was assessed.\u0000\u0000\u0000RESULTS\u0000After treatment and at the follow-up, the scores of each dimension and PCS, MCS scores of SF-36 in the acupuncture group were higher than those before treatment (P<0.05, P<0.01); compared before treatment, the RP, BP, and SF scores and PCS score in the sham acupuncture group were increased after treatment (P<0.05, P<0.01). After treatment, the acupuncture group had higher scores in RP, BP, GH, MH and PCS, MCS than those in the sham acupuncture group (P<0.05, P<0.01); at the follow-up, except for PF and RE dimensions, the scores in each dimension and PCS, MCS scores in the acupuncture group were higher than those in the sham acupuncture group (P<0.05, P<0.01). After treatment and at the follow-up, pelvic pain VAS, NIH-CPSI, IPSS scores in the acupuncture group were lower than those before treatment (P<0.01); in the sham acupuncture group, pelvic pain VAS, NIH-CPSI scores were lower after treatment, and NIH-CPSI score at the follow-up was lower compared with those before treatment (P<0.01). After treatment and at the follow-up, pelvic pain VAS, NIH-CPSI, IPSS scores in the acupuncture group were lower than those in the sham acupuncture group (P<0.01, P<0.05). No significant adverse reactions were observed in both groups, and the incidence rates of adverse reactions had no significant difference (P>0.05).\u0000\u0000\u0000CONCLUSIONS\u0000Acupuncture could effectively improve the ","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"5 12","pages":"411-417"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the body surface temperature of the lumbosacral region and relevant back-shu points in patients with lumbar disc herniation induced low back pain based on infrared thermography. 基于红外热成像技术探讨腰椎间盘突出症腰痛患者腰骶部体表温度及相关背俞穴。
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20230915-k0008
Xiao Yuan, Mengyu Fu, Xiaoyan Gong, Lingli Wang, Shumei Zhao, Cong Zhang, Hesheng Wang, Lanying Liu
OBJECTIVESTo observe the body surface temperature of the lumbosacral region and relevant back-shu points in patients with lumbar disc herniation (LDH) induced low back pain utilizing infrared thermography, and to explore the functional attribute changes of acupoints under pathological conditions.METHODSA total of 50 patients with LDH induced low back pain were included as the observation group, and 45 healthy subjects were included as the control group. Using infrared thermography, the body surface temperature of the lumbosacral region and bilateral Sanjiaoshu (BL 22), Shenshu (BL 23), Qihaishu (BL 24), Dachangshu (BL 25), Guanyuanshu (BL 26), Xiaochangshu (BL 27), and Pangguangshu (BL 28) was measured in both groups. The temperature difference values between the bilateral lumbosacral regions and back-shu points of the two groups were calculated. Additionally, the body surface temperature of the affected and healthy sides of the lumbosacral region and relevant back-shu points was compared in the observation group.RESULTSCompared with the control group, the body surface temperature of the lumbosacral region and the bilateral temperature difference values of the lumbosacral regions were increased in the observation group (P<0.001). The body surface temperature difference values of bilateral Shenshu (BL 23), Qihaishu (BL 24), Dachangshu (BL 25), Guanyuanshu (BL 26) and Xiaochangshu (BL 27) in the observation group were higher than those in the control group (P<0.05, P<0.01, P<0.001). In the observation group, the body surface temperature of the affected side of the lumbosacral region as well as Shenshu (BL 23) and Dachangshu (BL 25) was elevated compared with that of healthy side (P<0.001).CONCLUSIONSThe patients with LDH induced low back pain have imbalanced and asymmetrical distribution of body surface temperature in the lumbosacral region and related back-shu points, Shenshu (BL 23) and Dachangshu (BL 25) have the relative specificity.
方法选取50例腰椎间盘突出症(LDH)患者作为观察组,45例健康人作为对照组。采用红外热成像技术测量两组患者腰骶部及双侧三焦俞(BL 22)、神俞(BL 23)、气海俞(BL 24)、大椎穴(BL 25)、关元俞(BL 26)、小寒俞(BL 27)和庞光俞(BL 28)的体表温度。计算两组双侧腰骶部和背俞穴的温差值。结果与对照组相比,观察组的腰骶部体表温度和双侧腰骶部温差值均升高(P<0.001)。观察组双侧神阙穴(BL 23)、气海穴(BL 24)、大寒穴(BL 25)、关元穴(BL 26)和小寒穴(BL 27)的体表温差值均高于对照组(P<0.05,P<0.01,P<0.001)。结论LDH诱发腰痛患者腰骶部体表温度分布不平衡、不对称,相关背俞穴、神俞穴(BL 23)和大椎穴(BL 25)具有相对特异性。
{"title":"Exploring the body surface temperature of the lumbosacral region and relevant back-shu points in patients with lumbar disc herniation induced low back pain based on infrared thermography.","authors":"Xiao Yuan, Mengyu Fu, Xiaoyan Gong, Lingli Wang, Shumei Zhao, Cong Zhang, Hesheng Wang, Lanying Liu","doi":"10.13703/j.0255-2930.20230915-k0008","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20230915-k0008","url":null,"abstract":"OBJECTIVES\u0000To observe the body surface temperature of the lumbosacral region and relevant back-shu points in patients with lumbar disc herniation (LDH) induced low back pain utilizing infrared thermography, and to explore the functional attribute changes of acupoints under pathological conditions.\u0000\u0000\u0000METHODS\u0000A total of 50 patients with LDH induced low back pain were included as the observation group, and 45 healthy subjects were included as the control group. Using infrared thermography, the body surface temperature of the lumbosacral region and bilateral Sanjiaoshu (BL 22), Shenshu (BL 23), Qihaishu (BL 24), Dachangshu (BL 25), Guanyuanshu (BL 26), Xiaochangshu (BL 27), and Pangguangshu (BL 28) was measured in both groups. The temperature difference values between the bilateral lumbosacral regions and back-shu points of the two groups were calculated. Additionally, the body surface temperature of the affected and healthy sides of the lumbosacral region and relevant back-shu points was compared in the observation group.\u0000\u0000\u0000RESULTS\u0000Compared with the control group, the body surface temperature of the lumbosacral region and the bilateral temperature difference values of the lumbosacral regions were increased in the observation group (P<0.001). The body surface temperature difference values of bilateral Shenshu (BL 23), Qihaishu (BL 24), Dachangshu (BL 25), Guanyuanshu (BL 26) and Xiaochangshu (BL 27) in the observation group were higher than those in the control group (P<0.05, P<0.01, P<0.001). In the observation group, the body surface temperature of the affected side of the lumbosacral region as well as Shenshu (BL 23) and Dachangshu (BL 25) was elevated compared with that of healthy side (P<0.001).\u0000\u0000\u0000CONCLUSIONS\u0000The patients with LDH induced low back pain have imbalanced and asymmetrical distribution of body surface temperature in the lumbosacral region and related back-shu points, Shenshu (BL 23) and Dachangshu (BL 25) have the relative specificity.","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"12 34","pages":"423-427"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of transcutaneous electrical acupoint stimulation on postoperative urinary function in elderly patients undergoing total hip arthroplasty. 经皮穴位电刺激对老年全髋关节置换术患者术后排尿功能的影响
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20230302-k0005
Yuming Tu, Shanchong Qu, Shun-yan Lin, Shujing Gu, Ju Gao
OBJECTIVESTo observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative urinary function in elderly patients undergoing total hip arthroplasty (THA).METHODSOne hundred and eighty elderly patients undergoing unilateral THA without indwelling urinary catheters were randomly assigned to a TEAS group (90 cases, 3 cases dropped out, 4 cases were eliminated) and a sham TEAS group (90 cases, 1 case dropped out, 4 cases were eliminated). Both groups received fascia iliac block and subarachnoid block anesthesia under ultrasound guidance. The patients in the TEAS group were treated with TEAS at Zhongji (CV 3), Guanyuan (CV 4), and bilateral Huiyang (BL 35), Ciliao (BL 32) 30 minutes before anesthesia initiation, with dissperse-dense wave, frequency of 2 Hz/100 Hz, until 30 minutes after surgery. The patients in the sham TEAS group underwent the same procedure with the device applied at the same acupoints but without electrical stimulation. The incidence of postoperative urinary retention (POUR), time to first void, voiding threshold, urinary adenosine triphosphate (ATP) level, postoperative abnormal voiding status (bladder residual volume, re-catheterization rate, nocturia occurrence), and postoperative incidence of urinary tract infection (UTI) and prosthetic joint infection (PJI) were observed in both groups.RESULTSThe incidence of POUR in the TEAS group was lower than that in the sham TEAS group (P<0.05); the time to first void in the TEAS group was shorter than that in the sham TEAS group (P<0.05); the voiding threshold in the TEAS group was lower than that in the sham TEAS group (P<0.05); the urinary ATP level in the TEAS group was higher than that in the sham TEAS group (P<0.05); the bladder residual volume in the TEAS group was lower than that in the sham TEAS group (P<0.05); the nocturia occurrence in the TEAS group was lower than that in the sham TEAS group (P<0.05). However, there was no statistically significant difference in re-catheterization rate, incidence of UTI, and incidence of PJI between the two groups (P>0.05).CONCLUSIONSTEAS could effectively reduce the occurrence of postoperative urinary retention and improve the postoperative urinary function in elderly patients undergoing THA, which might be related with increasing the urinary ATP level.
目的观察经皮穴位电刺激(TEAS)对接受全髋关节置换术(THA)的老年患者术后排尿功能的影响。方法将180例接受单侧THA手术且未留置导尿管的老年患者随机分配到TEAS组(90例,3例退出,4例被淘汰)和假TEAS组(90例,1例退出,4例被淘汰)。两组患者均在超声引导下接受髂筋膜阻滞和蛛网膜下腔阻滞麻醉。TEAS组患者在麻醉开始前30分钟在中极(CV 3)、关元(CV 4)和双侧惠阳(BL 35)、泌寮(BL 32)进行TEAS治疗,频率为2 Hz/100 Hz的非分散致密波,直至术后30分钟。假 TEAS 组患者接受了相同的手术,在相同的穴位上使用了仪器,但没有电刺激。两组患者的术后尿潴留(POUR)发生率、首次排尿时间、排尿阈值、尿三磷酸腺苷(ATP)水平、术后排尿异常状况(膀胱残余容量、再次导尿率、夜尿发生率)以及术后尿路感染(UTI)和假体关节感染(PJI)发生率均接受了观察。结果TEAS组POUR发生率低于假TEAS组(P0.05)。
{"title":"Effect of transcutaneous electrical acupoint stimulation on postoperative urinary function in elderly patients undergoing total hip arthroplasty.","authors":"Yuming Tu, Shanchong Qu, Shun-yan Lin, Shujing Gu, Ju Gao","doi":"10.13703/j.0255-2930.20230302-k0005","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20230302-k0005","url":null,"abstract":"OBJECTIVES\u0000To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative urinary function in elderly patients undergoing total hip arthroplasty (THA).\u0000\u0000\u0000METHODS\u0000One hundred and eighty elderly patients undergoing unilateral THA without indwelling urinary catheters were randomly assigned to a TEAS group (90 cases, 3 cases dropped out, 4 cases were eliminated) and a sham TEAS group (90 cases, 1 case dropped out, 4 cases were eliminated). Both groups received fascia iliac block and subarachnoid block anesthesia under ultrasound guidance. The patients in the TEAS group were treated with TEAS at Zhongji (CV 3), Guanyuan (CV 4), and bilateral Huiyang (BL 35), Ciliao (BL 32) 30 minutes before anesthesia initiation, with dissperse-dense wave, frequency of 2 Hz/100 Hz, until 30 minutes after surgery. The patients in the sham TEAS group underwent the same procedure with the device applied at the same acupoints but without electrical stimulation. The incidence of postoperative urinary retention (POUR), time to first void, voiding threshold, urinary adenosine triphosphate (ATP) level, postoperative abnormal voiding status (bladder residual volume, re-catheterization rate, nocturia occurrence), and postoperative incidence of urinary tract infection (UTI) and prosthetic joint infection (PJI) were observed in both groups.\u0000\u0000\u0000RESULTS\u0000The incidence of POUR in the TEAS group was lower than that in the sham TEAS group (P<0.05); the time to first void in the TEAS group was shorter than that in the sham TEAS group (P<0.05); the voiding threshold in the TEAS group was lower than that in the sham TEAS group (P<0.05); the urinary ATP level in the TEAS group was higher than that in the sham TEAS group (P<0.05); the bladder residual volume in the TEAS group was lower than that in the sham TEAS group (P<0.05); the nocturia occurrence in the TEAS group was lower than that in the sham TEAS group (P<0.05). However, there was no statistically significant difference in re-catheterization rate, incidence of UTI, and incidence of PJI between the two groups (P>0.05).\u0000\u0000\u0000CONCLUSIONS\u0000TEAS could effectively reduce the occurrence of postoperative urinary retention and improve the postoperative urinary function in elderly patients undergoing THA, which might be related with increasing the urinary ATP level.","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"15 21","pages":"395-399"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment ideas of acupuncture and moxibustion for adenomyosis based on "etiology, location, nature and development of disease". 基于 "病因、病位、病性、病变 "的子宫腺肌症针灸治疗思路。
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20230726-k0001
Xinyu Xia, Yan Liang, Shijie Cao, Xujing Yao
Focusing on the syndrome/pattern differentiation to determine treatment, the approaches to the diagnosis and treatment of acupuncture and moxibustion for adenomyosis are explored by identifying the etiology, location, nature and development of disease. The syndromes/patterns of adenomyosis are differentiated in view of both zangfu and meridian theories. The treatment is delivered complying with the menstrual cycle and the basic rule of treatment, "treating the symptoms in the acute stage, while the root causes in the recovery stage". During menstrual period, stopping pain and eliminating stasis are dominant; while during the other days of menstrual cycle, regulating zangfu dysfunction (excess or deficiency) is emphasized. In general, the functions of the thoroughfare vessel and the conception vessel should be specially considered and adjusted, and the principles of treatment include strengthening the spleen, regulating the kidney and soothing the liver. Acupoints are selected mainly from the spleen meridian of foot-taiyin, the kidney meridian of foot-shaoyin and the conception vessel. Ciliao (BL 32), Shiqizhui (EX-B 8), Zigong (EX-CA 1), Diji (SP 8) and four-gate points (bilateral Hegu [LI 4] and Taichong [LR 3]) are used in menstrual period; Zusanli (ST 36), Sanyinjiao (SP 6) and Taixi (KI 3) in postmenstrual phase; Guanyuan (CV 4), Luanchao (Ovary, Extra) and Qihai (CV 6) in intermenstrual phase; while, Guanyuan (CV 4), Qihai (CV 6) and Shenque (CV 8), combined with Gongsun (SP 4), Neiguan (PC 6) and Jianshi (PC 5) in premenstrual phase. According to the dynamic development of patient's conditions, the reinforcing or reducing techniques of acupuncture and moxibustion are feasibly applied in treatment of adenomyosis.
以辨证论治为核心,通过辨病因、辨病位、辨病性、辨病变,探讨子宫腺肌症的针灸诊治方法。根据藏象学说和经络学说,对子宫腺肌症的证候/证型进行辨证论治。根据月经周期和 "急性期治标,恢复期治本 "的基本治疗原则进行治疗。月经期以止痛祛瘀为主,月经周期的其他日子则以调理藏府功能失调(过多或不足)为主。一般来说,应特别考虑和调整督脉和命门的功能,治疗原则包括健脾、调肾、舒肝。穴位主要选取足太阴脾经、足少阴肾经和督脉。月经期取慈辽(BL 32)、石决明(EX-B 8)、子午(EX-CA 1)、地机(SP 8)和四门穴(双侧合谷[LI 4]和太冲[LR 3]);经后期取足三里(ST 36)、三阴交(SP 6)和太溪(KI 3);关元(CV 4)、鸾巢(卵巢,外)、气海(CV 6)用于月经间期;关元(CV 4)、气海(CV 6)、神阙(CV 8)与公孙(SP 4)、内关(PC 6)、建石(PC 5)合用,用于月经前期。根据患者病情的动态发展,在子宫腺肌症的治疗中可行针灸加减法。
{"title":"Treatment ideas of acupuncture and moxibustion for adenomyosis based on \"etiology, location, nature and development of disease\".","authors":"Xinyu Xia, Yan Liang, Shijie Cao, Xujing Yao","doi":"10.13703/j.0255-2930.20230726-k0001","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20230726-k0001","url":null,"abstract":"Focusing on the syndrome/pattern differentiation to determine treatment, the approaches to the diagnosis and treatment of acupuncture and moxibustion for adenomyosis are explored by identifying the etiology, location, nature and development of disease. The syndromes/patterns of adenomyosis are differentiated in view of both zangfu and meridian theories. The treatment is delivered complying with the menstrual cycle and the basic rule of treatment, \"treating the symptoms in the acute stage, while the root causes in the recovery stage\". During menstrual period, stopping pain and eliminating stasis are dominant; while during the other days of menstrual cycle, regulating zangfu dysfunction (excess or deficiency) is emphasized. In general, the functions of the thoroughfare vessel and the conception vessel should be specially considered and adjusted, and the principles of treatment include strengthening the spleen, regulating the kidney and soothing the liver. Acupoints are selected mainly from the spleen meridian of foot-taiyin, the kidney meridian of foot-shaoyin and the conception vessel. Ciliao (BL 32), Shiqizhui (EX-B 8), Zigong (EX-CA 1), Diji (SP 8) and four-gate points (bilateral Hegu [LI 4] and Taichong [LR 3]) are used in menstrual period; Zusanli (ST 36), Sanyinjiao (SP 6) and Taixi (KI 3) in postmenstrual phase; Guanyuan (CV 4), Luanchao (Ovary, Extra) and Qihai (CV 6) in intermenstrual phase; while, Guanyuan (CV 4), Qihai (CV 6) and Shenque (CV 8), combined with Gongsun (SP 4), Neiguan (PC 6) and Jianshi (PC 5) in premenstrual phase. According to the dynamic development of patient's conditions, the reinforcing or reducing techniques of acupuncture and moxibustion are feasibly applied in treatment of adenomyosis.","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"11 23","pages":"455-459"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of moxibustion with wheat-grain size cone at "Zusanli" (ST 36) on vascular injury and oxidative stress in high-fat diet rats through mTOR/HIF-1α/VEGF signaling pathway. 麦粒大小的艾炷灸 "足三里"(ST 36)通过 mTOR/HIF-1α/VEGF 信号通路对高脂饮食大鼠血管损伤和氧化应激的影响。
Pub Date : 2024-04-12 DOI: 10.13703/j.0255-2930.20230510-k0003
Qian Xu, Liyuan Liu, Rongxian Zhang, Zhi-Jing Yu, Feng Hao, Jian-Bin Zhang
OBJECTIVESTo explore the effect mechanism of moxibustion with wheat-grain size cone at "Zusanli" (ST 36) on vascular injury and oxidative stress in hyperlipidemia through mammalian target of rapamycin (mTOR)/hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway.METHODSForty healthy male SD rats with SPF grade were randomly divided into a normal group, a model group, a moxibustion group, and an inhibitor group, with 10 rats in each one. The hyperlipidemia model was established by feeding a high-fat diet for 8 weeks in rats of the model group, the moxibustion group and the inhibitor group. The moxibustion with wheat-grain size cone was delivered at bilateral "Zusanli" (ST 36) of each rat in the moxibustion group and the inhibitor group, with 3 cones on each acupoint in each intervention, once daily for 4 weeks. In the inhibitor group, before each intervention with moxibustion, rapamycin solution was injected intraperitoneally, 2.0 mg/kg. After modeling and intervention, using ELISA, the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in the serum of rats were determined. After intervention, with HE staining and oil red O staining adopted, the abdominal aortic morphology and peripheral lipid deposition were observed. Separately, using WST-1, TBA and micro-plate method, the superoxide dismutase (SOD) activity and the levels of malondialdehyde (MDA) and nitric oxide (NO) in the serum were detected. The protein expression of mTOR, HIF-1α and VEGF in abdominal aorta were measured by Western blot method.RESULTSCompared with those in the normal group, the levels of TC, TG and LDL-C increased (P<0.01) and HDL-C decreased (P<0.01) in the serum of the rats in the model group, the moxibustion group and the inhibitor group after model establishment. When compared with the normal group after intervention, in the model group, the serum levels of TC, TG, LDL-C and MDA increased (P<0.01), HDL-C level, SOD activity and NO level were reduced (P<0.01); the cell structure of the abdominal arota was abnormal, the peripheral lipids deposited seriously; and the protein expression of mTOR, HIF-1α and VEGF of abdominal aorta was elevated (P<0.01, P<0.05). In comparison with the model group, the levels of TC, TG, LDL-C and MDA were reduced (P<0.01), HDL-C levels, SOD activities and NO levels elevated (P<0.01, P<0.05), as well as the protein expression of mTOR, HIF-1α and VEGF of abdominal aorta (P<0.01, P<0.05) in the moxibustion group and the inhibitor group; besides, the vascular structure was ameliorated and the lipid deposition reduced in the moxibustion group, while, the vascular structure was still abnormal and the lipid deposition declined in the inhibitor group. When compared with the inhibitor group, the serum SOD activity and NO level increased (P<0.05) and MDA decreased (P<0.05); and the protein expression of mTOR,
目的探讨麦粒大小的艾炷灸 "足三里"(ST 36)通过哺乳动物雷帕霉素靶标(mTOR)/缺氧诱导因子-1α(HIF-1α)/血管内皮生长因子(VEGF)信号通路对高脂血症血管损伤和氧化应激的影响机制。方法将40只SPF级健康雄性SD大鼠随机分为正常组、模型组、艾灸组和抑制剂组,每组10只。给模型组、艾灸组和抑制剂组大鼠喂食高脂饮食 8 周,建立高脂血症模型。艾灸组和抑制剂组每只大鼠的双侧足三里(ST 36)穴位,用麦粒大小的艾炷进行艾灸,每次每个穴位 3 根艾炷,每天一次,连续 4 周。抑制剂组在每次艾灸干预前腹腔注射雷帕霉素溶液(2.0 mg/kg)。建模和干预后,用酶联免疫吸附法测定大鼠血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平。干预后,采用 HE 染色和油红 O 染色观察腹主动脉形态和外周脂质沉积。此外,还采用 WST-1、TBA 和微孔板法检测了血清中超氧化物歧化酶(SOD)的活性、丙二醛(MDA)和一氧化氮(NO)的水平。结果与正常组相比,模型组、艾灸组和抑制剂组大鼠血清中 TC、TG、LDL-C 水平升高(P<0.01),HDL-C 水平降低(P<0.01)。与干预后的正常组相比,模型组大鼠血清中TC、TG、LDL-C和MDA水平升高(P<0.01),HDL-C水平、SOD活性和NO水平降低(P<0.01);腹主动脉细胞结构异常,外周脂质沉积严重;腹主动脉mTOR、HIF-1α和VEGF蛋白表达升高(P<0.01,P<0.05)。与模型组相比,艾灸组 TC、TG、LDL-C 和 MDA 水平降低(P<0.01),HDL-C 水平、SOD 活性和 NO 水平升高(P<0.01,P<0.05),腹主动脉 mTOR、HIF-1α 和 VEGF 蛋白表达也升高(P<0.01,P<0.05);此外,艾灸组血管结构改善,脂质沉积减少,而抑制剂组血管结构仍异常,脂质沉积减少。与抑制剂组相比,艾灸组血清 SOD 活性和 NO 水平升高(P<0.05),MDA 下降(P<0.05);艾灸组腹主动脉 mTOR、HIF-1α 和 VEGF 蛋白表达升高(P<0.01,P<0.05)。结论麦粒大小的艾炷灸 "足三里"(ST 36)可通过改善氧化应激修复高脂血症导致的血管损伤,这可能与 mTOR/HIF-1α/VEGF 信号通路的调节有关。
{"title":"Effects of moxibustion with wheat-grain size cone at \"Zusanli\" (ST 36) on vascular injury and oxidative stress in high-fat diet rats through mTOR/HIF-1α/VEGF signaling pathway.","authors":"Qian Xu, Liyuan Liu, Rongxian Zhang, Zhi-Jing Yu, Feng Hao, Jian-Bin Zhang","doi":"10.13703/j.0255-2930.20230510-k0003","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20230510-k0003","url":null,"abstract":"OBJECTIVES\u0000To explore the effect mechanism of moxibustion with wheat-grain size cone at \"Zusanli\" (ST 36) on vascular injury and oxidative stress in hyperlipidemia through mammalian target of rapamycin (mTOR)/hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway.\u0000\u0000\u0000METHODS\u0000Forty healthy male SD rats with SPF grade were randomly divided into a normal group, a model group, a moxibustion group, and an inhibitor group, with 10 rats in each one. The hyperlipidemia model was established by feeding a high-fat diet for 8 weeks in rats of the model group, the moxibustion group and the inhibitor group. The moxibustion with wheat-grain size cone was delivered at bilateral \"Zusanli\" (ST 36) of each rat in the moxibustion group and the inhibitor group, with 3 cones on each acupoint in each intervention, once daily for 4 weeks. In the inhibitor group, before each intervention with moxibustion, rapamycin solution was injected intraperitoneally, 2.0 mg/kg. After modeling and intervention, using ELISA, the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in the serum of rats were determined. After intervention, with HE staining and oil red O staining adopted, the abdominal aortic morphology and peripheral lipid deposition were observed. Separately, using WST-1, TBA and micro-plate method, the superoxide dismutase (SOD) activity and the levels of malondialdehyde (MDA) and nitric oxide (NO) in the serum were detected. The protein expression of mTOR, HIF-1α and VEGF in abdominal aorta were measured by Western blot method.\u0000\u0000\u0000RESULTS\u0000Compared with those in the normal group, the levels of TC, TG and LDL-C increased (P<0.01) and HDL-C decreased (P<0.01) in the serum of the rats in the model group, the moxibustion group and the inhibitor group after model establishment. When compared with the normal group after intervention, in the model group, the serum levels of TC, TG, LDL-C and MDA increased (P<0.01), HDL-C level, SOD activity and NO level were reduced (P<0.01); the cell structure of the abdominal arota was abnormal, the peripheral lipids deposited seriously; and the protein expression of mTOR, HIF-1α and VEGF of abdominal aorta was elevated (P<0.01, P<0.05). In comparison with the model group, the levels of TC, TG, LDL-C and MDA were reduced (P<0.01), HDL-C levels, SOD activities and NO levels elevated (P<0.01, P<0.05), as well as the protein expression of mTOR, HIF-1α and VEGF of abdominal aorta (P<0.01, P<0.05) in the moxibustion group and the inhibitor group; besides, the vascular structure was ameliorated and the lipid deposition reduced in the moxibustion group, while, the vascular structure was still abnormal and the lipid deposition declined in the inhibitor group. When compared with the inhibitor group, the serum SOD activity and NO level increased (P<0.05) and MDA decreased (P<0.05); and the protein expression of mTOR,","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"6 1","pages":"433-440"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of blistering cupping combined with thunder-fire moxibustion on the efficacy and airway remodeling of cold-wheezing syndrome in bronchial asthma]. 【泡罐联合雷火灸对支气管哮喘冷哮证疗效及气道重塑的影响】。
Pub Date : 2023-09-12 DOI: 10.13703/j.0255-2930.20221003-k0001
Ji-En Tao, Zhuo-Cheng Zou

Objective: To investigate the clinical efficacy of the combined application of blistering cupping with thunder-fire moxibustion in treating bronchial asthma of cold-wheezing syndrome, and its influences on airway remodeling, inflammatory factors, lung function, and quality of life on the base of conventional western medicine treatment.

Methods: A total of 76 patients with bronchial asthma of cold-wheezing syndrome were randomly divided into an observation group and a control group, 38 cases in each group. In the control group, the basic treatment was used, i.e. budesonide formoterol powder inhalation. In the observation group, on the basis of the treatment as the control group, blistering cupping combined with thunder-fire moxibustion was supplemented, Dazhui (GV 14), Danzhong (CV 17) and bilateral Feishu (BL 13), Gaohuang (BL 43), and Zhongfu (LU 1) were selected; blistering cupping was administered once a day and thunder-fire moxibustion was given twice a day. One course of treatment was composed of 7 days in both groups, and 2 courses of treatment were required. Before and after treatment, the airway remodeling indexes (matrix metalloproteinase-9 [MMP-9], tissue inhibitor of matrix metalloproteinase-1 [TIMP-1], and transforming growth factor-β1 [TGF-β1]) and inflammatory indexes (interleukin [IL] -1β、IL-25) were detected by using radioimmunoassay in the patients of the two groups. The lung function, traditional Chinese medicine symptom score, and asthma quality of life questionnaire (AQLQ) score were observed in the patients of the two groups.

Results: After treatment, the serum levels of MMP-9, TIMP-1, TGF-β1, IL-1β, IL-25, peak expiratory flow (PEFR), traditional Chinese medicine symptom scores, and AQLQ scores were decreased compared with those before treatment in the patients of the two groups (P<0.05), and the results in the observation group were lower than those in the control group (P<0.05). After treatment, the first second forced expiratory volume (FEV1) and peak expiratory flow rate (PEF) were increased compared with those before treatment in the two groups (P<0.05), and the results in the observation group were higher than those in the control group (P<0.05).

Conclusion: On the basis of the conventional western medicine treatment, the combination of blistering cupping with thunder-fire moxibustion can effectively ameliorate the clinical symptoms of patients, reduce inflammatory levels, inhibit airway remodeling and improve the lung function and quality of life in the patients with bronchial asthma.

目的:探讨泡罐结合雷火灸治疗支气管哮喘冷哮证的临床疗效,以及在常规西药治疗的基础上对气道重塑、炎症因子、肺功能和生活质量的影响。方法:将76例支气管哮喘合并冷哮综合征患者随机分为观察组和对照组,每组38例。对照组给予布地奈德福莫特罗粉末吸入基础治疗。观察组患者在对照组治疗的基础上,辅以泡罐加雷火艾灸,选择大椎(GV 14)、丹中(CV 17)及双侧肺俞(BL 13)、高黄(BL 43)、中复(LU 1);拔火罐1次/天,雷火灸2次/天。两组均为1个疗程,均为7 d,需2个疗程。治疗前后采用放射免疫法检测两组患者气道重塑指标(基质金属蛋白酶-9 [MMP-9]、基质金属蛋白酶-1组织抑制剂[TIMP-1]、转化生长因子-β1 [TGF-β1])和炎症指标(白细胞介素[IL] -1β、IL-25)。观察两组患者肺功能、中医症状评分、哮喘生活质量问卷(AQLQ)评分。结果:治疗后,两组患者血清MMP-9、TIMP-1、TGF-β1、IL-1β、IL-25水平、呼气峰流量(PEFR)、中医症状评分、AQLQ评分均较治疗前降低(ppppp)。在常规西药治疗的基础上,泡罐联合雷火灸可有效改善支气管哮喘患者的临床症状,降低炎症水平,抑制气道重塑,改善肺功能和生活质量。
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引用次数: 0
[Efficacy differences between electroacupuncture and moxibustion for neurogenic bladder after spinal cord injury: a randomized controlled trial]. [电针与艾灸治疗脊髓损伤后神经性膀胱的疗效差异:一项随机对照试验]。
Pub Date : 2023-09-12 DOI: 10.13703/j.0255-2930.20221027-k0005
Hui-Lin Wei, Ya-Feng Ren, Zhi-Lan Zhang, Xiao-Meng Huang, Bing Li

Objective: To compare the clinical efficacy between electroacupuncture(EA) and moxibustion for neurogenic bladder (NB) after spinal cord injury (SCI).

Methods: One hundred and twenty patients with NB after SCI were randomly divided into an EA group, a moxibustion group, and an intermittent catheterization group, with 40 patients in each group. The patients in the intermittent catheterization group were treated with routine treatment and intermittent catheterization, while the patients in the EA group and the moxibustion group were treated with additional treatments of EA (discontinuous wave, with a frequency of 1.3-1.6 Hz, and intensity based on patient tolerance) and moxibustion, respectively. The acupoints used in both groups were Zhongji (CV 3) and Guanyuan (CV 4), bilateral Zusanli (ST 36), Yinlingquan (SP 9), and Baliao points. Each session lasted for 30 min, once daily, six times a week, for a total of six weeks.The maximum bladder capacity (MBC), residual urine vdume (RUV), detrusor pressure (Pdet) during the filling phase, bladder compliance (BC), maximum renal pelvis separation width of both kidneys, urine white blood cell count, TCM syndrome score, and World Health Organization quality of life assessment-BREF (WHOQOL-BREF) score were compared before and after treatment in the 3 groups. The number of patients in each group who achieved bladder functional balance was recorded, and the clinical efficacy was assessed after treatment.

Results: After treatment, the MBC, Pdet, BC, and WHOQOL-BREF scores in the EA group and the moxibustion group were increased (P<0.05), while the RUV, maximum renal pelvis separation width of both kidneys, urine white blood cell count, and TCM syndrome scores were decreased (P<0.05, P<0.01). In the intermittent catheterization group, MBC, RUV, maximum renal pelvis separation width of both kidneys, and urine white blood cell count were decreased (P<0.05), while BC and WHOQOL-BREF score were increased (P<0.05) after treatment. After treatment, the MBC, Pdet, BC, and WHOQOL-BREF scores in the EA group and the moxibustion group were higher than those in the intermittent catheterization group (P<0.05), while the RUV and TCM syndrome scores were lower than those in the intermittent catheterization group (P<0.05). Moreover, after treatment, the MBC and Pdet in the moxibustion group were higher than those in the EA group (P<0.05), while the RUV, maximum renal pelvis separation width of both kidneys, and TCM syndrome score in the EA group were lower than those in the moxibustion group (P<0.05). The number of patients who achieved bladder functional balance after treatment in the EA group and the moxibustion group was higher than that in the intermittent catheterization group (P<0.05). The cured and effective rate was 85.0% (34/40) in the EA group and 82.5% (33/40) in the moxibusti

目的:比较电针与艾灸治疗脊髓损伤后神经性膀胱(NB)的临床疗效。方法:120例脊髓损伤后NB患者随机分为EA组、艾灸组和间歇置管组,每组40例。间歇置管组患者给予常规治疗和间歇置管,EA组和艾灸组患者分别加用EA(间断波,频率1.3 ~ 1.6 Hz,强度根据患者耐受性而定)和艾灸治疗。两组穴位分别为中脊穴(cv3)、观源穴(cv4)、双侧足三里穴(st36)、银灵泉穴(sp9)、八髎穴。每次30分钟,每天一次,每周6次,共6周。比较三组患者治疗前后最大膀胱容量(MBC)、剩余尿量(RUV)、尿逼尿压(Pdet)、膀胱顺应性(BC)、双肾最大肾盂分离宽度、尿白细胞计数、中医证候评分、世界卫生组织生活质量评分(WHOQOL-BREF)。记录各组达到膀胱功能平衡的患者人数,治疗后评估临床疗效。结果:治疗后,EA组和艾灸组的MBC、Pdet、BC、WHOQOL-BREF评分均升高(pppppppppppppp >0.05)。结论:电针联合艾灸能有效改善脊髓损伤后NB患者膀胱功能状态。EA在减少残余尿量和尿道括约肌过度活动、缓解中医证候方面效果更显著,而艾灸在增加充盈期逼尿肌压力、建立逼尿肌反射方面效果更显著。
{"title":"[Efficacy differences between electroacupuncture and moxibustion for neurogenic bladder after spinal cord injury: a randomized controlled trial].","authors":"Hui-Lin Wei,&nbsp;Ya-Feng Ren,&nbsp;Zhi-Lan Zhang,&nbsp;Xiao-Meng Huang,&nbsp;Bing Li","doi":"10.13703/j.0255-2930.20221027-k0005","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20221027-k0005","url":null,"abstract":"<p><strong>Objective: </strong>To compare the clinical efficacy between electroacupuncture(EA) and moxibustion for neurogenic bladder (NB) after spinal cord injury (SCI).</p><p><strong>Methods: </strong>One hundred and twenty patients with NB after SCI were randomly divided into an EA group, a moxibustion group, and an intermittent catheterization group, with 40 patients in each group. The patients in the intermittent catheterization group were treated with routine treatment and intermittent catheterization, while the patients in the EA group and the moxibustion group were treated with additional treatments of EA (discontinuous wave, with a frequency of 1.3-1.6 Hz, and intensity based on patient tolerance) and moxibustion, respectively. The acupoints used in both groups were Zhongji (CV 3) and Guanyuan (CV 4), bilateral Zusanli (ST 36), Yinlingquan (SP 9), and <i>Baliao</i> points. Each session lasted for 30 min, once daily, six times a week, for a total of six weeks.The maximum bladder capacity (MBC), residual urine vdume (RUV), detrusor pressure (Pdet) during the filling phase, bladder compliance (BC), maximum renal pelvis separation width of both kidneys, urine white blood cell count, TCM syndrome score, and World Health Organization quality of life assessment-BREF (WHOQOL-BREF) score were compared before and after treatment in the 3 groups. The number of patients in each group who achieved bladder functional balance was recorded, and the clinical efficacy was assessed after treatment.</p><p><strong>Results: </strong>After treatment, the MBC, Pdet, BC, and WHOQOL-BREF scores in the EA group and the moxibustion group were increased (<i>P</i><0.05), while the RUV, maximum renal pelvis separation width of both kidneys, urine white blood cell count, and TCM syndrome scores were decreased (<i>P</i><0.05, <i>P</i><0.01). In the intermittent catheterization group, MBC, RUV, maximum renal pelvis separation width of both kidneys, and urine white blood cell count were decreased (<i>P</i><0.05), while BC and WHOQOL-BREF score were increased (<i>P</i><0.05) after treatment. After treatment, the MBC, Pdet, BC, and WHOQOL-BREF scores in the EA group and the moxibustion group were higher than those in the intermittent catheterization group (<i>P</i><0.05), while the RUV and TCM syndrome scores were lower than those in the intermittent catheterization group (<i>P</i><0.05). Moreover, after treatment, the MBC and Pdet in the moxibustion group were higher than those in the EA group (<i>P</i><0.05), while the RUV, maximum renal pelvis separation width of both kidneys, and TCM syndrome score in the EA group were lower than those in the moxibustion group (<i>P</i><0.05). The number of patients who achieved bladder functional balance after treatment in the EA group and the moxibustion group was higher than that in the intermittent catheterization group (<i>P</i><0.05). The cured and effective rate was 85.0% (34/40) in the EA group and 82.5% (33/40) in the moxibusti","PeriodicalId":23967,"journal":{"name":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion","volume":"43 9","pages":"1036-41"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10220561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Zhongguo zhen jiu = Chinese acupuncture & moxibustion
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