Current Opinion in Colloid & Interface Science最新文献

英文中文

Recent progress in AIE-dots by nanoprecipitation 纳米沉淀法制备AIE-dots的最新进展

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-04-01 Epub Date: 2025-12-23 DOI: 10.1016/j.cocis.2025.101988

Yanning Xu, Feng Gao, Zijie Qiu, Ben Zhong Tang

Aggregation-induced emission luminogens (AIEgens) have garnered significant attention in nanomedicine owing to their unique photophysical properties, particularly enhanced fluorescence quantum yields and superior photostability in aggregated states. This review summarizes recent progress in leveraging nanoprecipitation techniques for the fabrication of AIE nanoparticles, with emphasis on their translational applications in targeted drug delivery and advanced bioimaging platforms. By elucidating fundamental mechanistic principles governing AIE phenomena alongside methodological innovations in nanoparticle synthesis, we systematically classify diverse AIE molecular architectures tailored for specific biomedical contexts. The analysis underscores how AIE nanoparticles overcome intrinsic limitations of conventional systems through amplified imaging precision and therapeutic efficacy. Scalable manufacturing and long-term biocompatibilities as persistent challenges are delineated to propose prioritized research trajectories. Finally, emerging clinical trends are discussed to advance the practical implementation of AIE nanoparticle technology in integrated theranostic paradigms.

聚集诱导发射发光原（AIEgens）由于其独特的光物理性质，特别是增强的荧光量子产率和聚集状态下优越的光稳定性，在纳米医学中引起了极大的关注。本文综述了利用纳米沉淀技术制备AIE纳米颗粒的最新进展，重点介绍了它们在靶向药物传递和先进生物成像平台中的转化应用。通过阐明控制AIE现象的基本机制原理以及纳米颗粒合成的方法创新，我们系统地分类了针对特定生物医学背景量身定制的不同AIE分子结构。该分析强调了AIE纳米颗粒如何通过提高成像精度和治疗效果来克服传统系统的固有局限性。可扩展的制造和长期的生物相容性作为持续的挑战被描绘，以提出优先的研究轨迹。最后，讨论了新兴的临床趋势，以推进AIE纳米颗粒技术在综合治疗范例中的实际实施。

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引用次数: 0

Preparation of liposomes, lipid nanoparticles, or polymer nanoparticles by nanoprecipitation and their purification: Where are membrane processes? 通过纳米沉淀法制备脂质体、脂质纳米颗粒或聚合物纳米颗粒及其纯化：膜过程在哪里？

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-04-01 Epub Date: 2025-12-24 DOI: 10.1016/j.cocis.2025.101989

Laurie Trémouille, Catherine Charcosset

Nanoprecipitation is a key method to prepare colloids such as liposomes, lipid and polymer nanoparticles. Obtaining a final formulation requires three main steps, the first one consists in mixing the aqueous and organic phases, the solute to be precipitated being added to one of the two phases, according to its solubility. In a second step, the colloidal suspension obtained is concentrated and diafiltrated with an appropriate buffer to remove the solvent required for nanoprecipitation. The last step is sterilization of the resulting concentrated and diafiltrated colloidal suspension. Membrane processes can be used during the three stages. First, a membrane is an option for mixing both phases, although classical micromixers are generally preferred. Tangential flow filtration is used for concentration and diafiltration of the colloidal suspension obtained by nanoprecipitation. Finally, sterile filtration removes potential contaminants before the final use of the colloidal suspension in the delivery of active principle(s). In the following, principles and applications of these three membrane processes are presented and their advantages, limits and some perspectives are discussed.

纳米沉淀法是制备脂质体、脂质和聚合物纳米颗粒等胶体的关键方法。得到最终配方需要三个主要步骤，第一步是将水相和有机相混合，根据溶质的溶解度，将要沉淀的溶质加入到两相中的一个中。在第二步中，将获得的胶体悬浮液浓缩并用适当的缓冲液滤除纳米沉淀所需的溶剂。最后一步是对浓缩和滤过的胶体悬浮液进行灭菌。在这三个阶段中都可以使用膜工艺。首先，膜是混合两相的一种选择，尽管经典的微混合器通常是首选。切向流过滤对纳米沉淀法得到的胶体悬浮液进行浓缩和滤除。最后，在最终使用胶体悬浮液输送活性原理之前，无菌过滤去除潜在的污染物。下面介绍了这三种膜工艺的原理和应用，并讨论了它们的优点、局限性和一些展望。

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引用次数: 0

Third-generation solar cells: The next qualitative leap in photovoltaics 第三代太阳能电池：光伏发电的下一个质的飞跃

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-04-01 Epub Date: 2026-01-12 DOI: 10.1016/j.cocis.2025.101985

Sule Erten-Ela, Juan Luis Delgado

引用次数: 0

Recent advances in stimulus-assisted nanoprecipitation for nanoparticle synthesis 刺激辅助纳米沉淀法合成纳米颗粒的研究进展

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-02-01 Epub Date: 2025-11-21 DOI: 10.1016/j.cocis.2025.101972

Mingbo Li , Junhao Cai , Yawen Gao

Nanoprecipitation, the rapid solvent-displacement route to nanoscale phase separation, has matured from a simple batch operation into a versatile platform for nanomaterial synthesis. This review synthesizes recent progress in stimulus-assisted nanoprecipitation, wherein externally applied triggers (ultrasonic, electrical, supergravity, thermal, chemical, and photonic/other stimuli) are integrated with contemporary mixing technologies (batch, flash, microfluidic, membrane, and high-shear reactors) to decouple and selectively control over nucleation, growth kinetics, and assembly processes. These methods allow for the precise tuning of the size, morphology, stability, and functionality of nanoparticles (NPs), thereby broadening their applications in drug delivery, catalysis and materials science. We distill mechanistic principles by which each stimulus alters local supersaturation, chain mobility, interfacial instabilities, or droplet/film microreactor dynamics, and compare advantages and limitations by surveying research works from recent years. We also explore the potential development trends of multiscale coupling models, design rules for stimulus-compatible continuous reactors, and adoption of data-driven optimization frameworks to expand the capabilities of nanoprecipitation for advanced nanomaterial design.

纳米沉淀法是一种快速的溶剂置换纳米级相分离方法，已经从简单的批处理操作发展成为纳米材料合成的通用平台。本文综述了刺激辅助纳米沉淀的最新进展，其中外部触发（超声波，电，超重力，热，化学和光子/其他刺激）与现代混合技术（批处理，闪蒸，微流体，膜和高剪切反应器）相结合，以解耦和选择性地控制成核，生长动力学和组装过程。这些方法可以精确调整纳米颗粒（NPs）的大小、形态、稳定性和功能，从而扩大其在药物输送、催化和材料科学中的应用。我们总结了每种刺激改变局部过饱和、链迁移率、界面不稳定性或液滴/膜微反应器动力学的机理原理，并通过调查近年来的研究工作比较了优点和局限性。我们还探讨了多尺度耦合模型的潜在发展趋势，刺激兼容连续反应器的设计规则，以及采用数据驱动的优化框架来扩展纳米沉淀的能力，以实现先进的纳米材料设计。

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引用次数: 0

Editorial on emulsions and microemulsions 2025 乳剂和微乳剂社论2025

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.cocis.2025.101984

Carlos Rodríguez-Abreu, Kenji Aramaki

引用次数: 0

Colloidal insights into acid dairy gels: Role of exocellular polysaccharides from lactic acid bacteria 胶体洞察酸性乳凝胶：从乳酸菌胞外多糖的作用

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-02-01 Epub Date: 2025-11-07 DOI: 10.1016/j.cocis.2025.101970

Sigrid Nørgaard Beldring , Vojislav Vojinović , Milena Corredig

Texture-building lactic acid bacteria (LAB) cultures are widely employed in dairy products to improve the structure of fermented milk matrices. Despite the large body of knowledge available, there is still very little understood about the mechanisms underpinning the texturizing properties of LAB. During fermentation, LAB simultaneously reduce the pH by secreting lactic acid and produce exocellular polysaccharides (ExoPS). Colloidal biomolecules interact dynamically in this environment creating evolving supramolecular structures at various length and time scales, resulting in the final rheological properties of the bulk fermented milk product. The simplified model systems used so far have developed a mechanistic understanding of the impact of LAB in texturizing yogurt, but grossly overlook the colloidal interactions at play between the various components within the fermentation matrix, during LAB growth and ExoPS production, as well as their importance at the various stage of the acidification, gel formation, cooling and post-processing. This review builds on the great advances made in the last two decades in understanding how to select and control texturizing LAB during fermentation, and focuses on the remaining research challenges, with a focus on the recent research efforts which could aid in linking the mechanisms of structure formation at various length scales to the final, bulk quality of the fermented products.

乳酸菌（LAB）培养物广泛应用于乳制品中，以改善发酵乳基质的结构。尽管有大量可用的知识，但对于支撑LAB织构特性的机制仍然知之甚少。发酵过程中，乳酸菌通过分泌乳酸降低pH值，同时产生胞外多糖（ExoPS）。胶体生物分子在这种环境中动态地相互作用，在不同的长度和时间尺度上产生进化的超分子结构，从而导致散装发酵乳制品的最终流变性能。迄今为止使用的简化模型系统已经对乳酸在酸奶构化中的影响进行了机制理解，但严重忽视了发酵基质中各种成分之间的胶体相互作用，在乳酸生长和ExoPS生产过程中，以及它们在酸化，凝胶形成，冷却和后处理的各个阶段的重要性。这篇综述建立在过去二十年来在了解如何选择和控制发酵过程中的结构化LAB方面取得的巨大进展的基础上，并着重于剩余的研究挑战，重点是最近的研究工作，这些研究可以帮助将不同长度尺度的结构形成机制与发酵产品的最终批量质量联系起来。

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引用次数: 0

Polymeric colloidal motors prepared by nanoprecipitation-based processes 纳米沉淀法制备聚合物胶体马达

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-02-01 Epub Date: 2025-12-09 DOI: 10.1016/j.cocis.2025.101986

Xuanhao Wang , Ao Hou , Shuishun Liu , Jianchun Xie , Xibo Yan

Polymeric colloidal motors are polymer-made tiny machines capable of converting external energy into mechanical motion. Their compositions and architectures have shown a critical effect on controlling the spontaneous creation of energy gradients in response to chemical or physical stimuli for driving autonomous movement in various liquid media or biological microenvironments, holding significant potential for biomedical applications. Advances in nanofabrication have enabled the engineering of polymeric colloidal motors with a variety of compositions and architectures. Recently, nanoprecipitation due to its simple and straightforward process has been exploited to construct polymeric colloidal motors that have the appealing convenience of tuning their compositions, architectures and properties, allowing customization of their motion performance to adapt to various application scenarios. This review highlights the most recent advances in polymeric colloidal motors prepared by nanoprecipitation-based processes. It illustrates the synthesis of polymeric colloidal motors via a programmable solvent-shifting and post-organic solvent removal process, their stimuli-responsive motion behaviors and application performance in biomedical fields. A future perspective on the construction of polymeric colloidal motors through nanoprecipitation is also proposed.

聚合物胶体马达是由聚合物制成的微型机器，能够将外部能量转化为机械运动。它们的组成和结构在控制能量梯度的自发产生以响应化学或物理刺激，在各种液体介质或生物微环境中驱动自主运动方面显示出关键作用，在生物医学应用方面具有重大潜力。纳米制造技术的进步使得聚合物胶体马达具有多种组成和结构成为可能。最近，纳米沉淀法由于其简单和直接的过程被用于构建聚合物胶体马达，这些马达具有调整其成分、结构和性能的吸引力，允许定制其运动性能以适应各种应用场景。本文综述了利用纳米沉淀法制备聚合物胶体马达的最新进展。通过可编程溶剂转移和后有机溶剂去除工艺合成聚合物胶体马达，阐述了其刺激响应运动行为及其在生物医学领域的应用性能。展望了利用纳米沉淀法构建聚合物胶体马达的前景。

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引用次数: 0

Rheology of rod-like chains in the isotropic phase 棒状链在各向同性相中的流变学

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.cocis.2025.101983

Zhi-Chao Yan , Jiyun Xie , Xiaofei Tian , Qinhang Liu , Minne Paul Lettinga

Rod-like chains (RLCs) recently came back in the spotlights due to the development of new systems and applications such as the demand for the replacement of flexible polymers as viscosifiers or the development of suited extra cellular matrices. The advantage of RLC systems is their high mechanical susceptibility. However, the interpretation of the mechanical properties is not straightforward as slow dynamics can be due to extreme sterical hindrance, glassy behavior, or due to attractions that yield gel formation. In this review we identify the open questions for repulsive RLCs and discuss how recent developments in terms of new model systems, experiments, and theory help to identify the huge impact that the morphology of the RLCs can have on the mechanical properties.

棒状链（rlc）最近重新成为人们关注的焦点，这是由于新系统和新应用的发展，例如需要替代柔性聚合物作为增粘剂或开发合适的细胞外基质。RLC系统的优点是机械敏感性高。然而，机械性能的解释并不简单，因为缓慢的动力学可能是由于极端的位阻，玻璃状行为或由于产生凝胶形成的吸引力。在这篇综述中，我们确定了排斥性rlc的开放性问题，并讨论了新模型系统、实验和理论方面的最新发展如何帮助确定rlc的形态对力学性能的巨大影响。

引用次数: 0

Nanoprecipitation and nanoemulsification: A focus on the strategies to control hybrid nanoparticle morphology 纳米沉淀和纳米乳化：重点研究控制混合纳米颗粒形态的策略

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-02-01 Epub Date: 2025-12-10 DOI: 10.1016/j.cocis.2025.101982

Baptiste Amouroux , Fabienne Gauffre , Olivier Gazil , Clément Goubault , Silvia Argelia Peraza Ku

In this short review, we seek to illustrate how nanoprecipitation can be used as a simple (often one-pot) though powerful method to elaborate nanoparticles with a designed shape or composition. We focus on the case of hybrid organic/inorganic materials, and make the parallel with the more familiar case of polymer-based nanoparticles, leading to either full or core–shell particles. The mechanisms and strategies that allow control of the morphology are discussed. In addition, we connect the concepts of spontaneous emulsification, which was developed in the framework of the nanoprecipitation of organic compounds and polymers, and of co-precipitation related to the synthesis of inorganic nanoparticles.

在这篇简短的综述中，我们试图说明纳米沉淀法如何作为一种简单（通常是一锅）但功能强大的方法来制作具有设计形状或成分的纳米颗粒。我们将重点放在有机/无机杂化材料的情况下，并将其与更熟悉的聚合物基纳米粒子的情况进行比较，从而导致完整或核壳粒子。讨论了允许控制形态的机制和策略。此外，我们将自发乳化的概念（在有机化合物和聚合物的纳米沉淀框架中发展起来）和与无机纳米颗粒合成相关的共沉淀的概念联系起来。

引用次数: 0

Evaporation-induced phase separation: Coupled mechanisms and applications 蒸发诱导相分离：耦合机制和应用

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science

Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.cocis.2025.101987

Yuki Wakata , Mingbo Li , Chao Sun

Evaporation of multicomponent liquids produces complex, far-from-equilibrium phenomena spanning spatial scales from nanometers in aerosols to meters in coating films. A notable outcome of this phenomenon is the evaporation-induced phase separation (EIPS), where the initially homogeneous liquid phase spontaneously separates into multiple phases during the evaporation process. This phenomenon has attracted considerable attention due to its critical role in atmospheric aerosol chemistry, membrane fabrication, biological systems, and advanced materials processing. This review examines the fundamental mechanisms of EIPS, which couple multicomponent evaporation, flow, and phase transitions in multicomponent liquids, highlighting the large spatial scale span and the transient nature of EIPS systems. EIPS-related research and applications across diverse fields will be surveyed, followed by a discussion on open challenges and future opportunities.

多组分液体的蒸发产生复杂的、远离平衡的现象，从纳米级的气溶胶到米级的涂层。这种现象的一个显著结果是蒸发诱导相分离（EIPS），在蒸发过程中，最初均匀的液相自发地分离成多个相。这一现象由于其在大气气溶胶化学、膜制造、生物系统和先进材料加工中的重要作用而引起了相当大的关注。本文综述了多组分蒸发、流动和相变在多组分液体中的耦合作用，强调了EIPS系统的大空间尺度跨度和瞬态性。本次会议将调查不同领域的eips相关研究和应用，然后讨论开放的挑战和未来的机遇。

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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Current Opinion in Colloid & Interface Science

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