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Prokaryotic biogeography across atmospheric, aquatic, and terrestrial ecosystems in the Mount Everest region 珠穆朗玛峰地区大气、水生和陆地生态系统的原核生物地理学。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-07-28 DOI: 10.1016/j.scib.2026.07.065

Yongqin Liu, Mukan Ji, Yuying Chen, Keshao Liu, Pengfei Liu, Yang Liu, Tandong Yao

The Mount Everest region encompasses one of the world’s most fragile cryospheric landscapes, comprising diverse and interconnected habitats across atmospheric, aquatic, and terrestrial ecosystems. Despite growing interest in high-mountain microbial ecology, basin-scale assessments remain scarce. Here, we conducted a microbial survey in the Rongbuk River basin (3699–7000 m a.s.l.), analyzing 677 samples from aerosols, snow, stream water, stream sediments, and soils via 16S rRNA gene amplicon sequencing. We identified 58,141 operational taxonomic units (OTUs) across 67 prokaryotic phyla, dominated by Pseudomonadota, Actinomycetota, and Bacteroidota. Elevational diversity patterns were ecosystem-specific: richness declined with elevation in aerosols and stream water, showed a U-shaped pattern in snow, peaked at mid-elevations in soils, and remained stable in stream sediments. Evenness and Shannon diversity, however, displayed distinct elevational trends and environmental determinants compared to richness. Community assembly was largely stochastic in snow, aquatic, and soils but strongly deterministic in aerosols. Source-tracking analysis revealed strong landscape-scale connectivity, with snow serving as a microbial vector linking atmospheric inputs to downstream ecosystems (contributing 1.4%–12.0%). Soils served as a potential microbial reservoir, harboring 42% of the unique OTUs and contributing 3%–11.8% of communities to other habitats. While stream water and sediments showed reciprocal exchange, aerosols remained largely uncharacterized in terms of their sources. Collectively, these findings demonstrate that although prokaryotic responses to elevation are ecosystem-specific, these habitats are ecologically interconnected across the high-mountain landscape, providing a comprehensive overview of the prokaryotic biogeography of the region.

珠穆朗玛峰地区拥有世界上最脆弱的冰冻圈景观之一，包括大气、水生和陆地生态系统中多种多样且相互关联的栖息地。尽管人们对高山微生物生态学的兴趣日益浓厚，但流域尺度的评估仍然很少。本研究在绒北江流域（海拔3699 ~ 7000米）开展了微生物调查，通过16S rRNA基因扩增子测序，分析了来自气溶胶、雪、溪水、溪流沉积物和土壤的677个样品。我们在67个原核生物门中鉴定出58,141个操作分类单位（OTUs），以假单胞菌门、放线菌门和拟杆菌门为主。海拔多样性模式具有生态系统特异性：气溶胶和溪流水的丰富度随海拔高度而下降，在雪中呈u形分布，在土壤中达到峰值，在溪流沉积物中保持稳定。与丰富度相比，均匀度和香农多样性表现出明显的海拔变化趋势和环境决定因素。群落聚集在雪、水和土壤中主要是随机的，但在气溶胶中具有很强的确定性。来源跟踪分析显示，景观尺度上的连通性很强，雪作为连接大气输入和下游生态系统的微生物载体（贡献6.6%-12.0%）。土壤是潜在的微生物库，拥有42%的独特otu，并为其他栖息地贡献了3%-11.8%的群落。虽然水流和沉积物表现出相互交换，但就其来源而言，气溶胶在很大程度上仍未得到表征。总的来说，这些发现表明，尽管原核生物对海拔的反应是生态系统特异性的，但这些栖息地在高山景观中具有生态联系，为该地区的原核生物地理学提供了全面的概述。

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引用次数: 0

Activation-optimized anti-CD3 valency control enables combinatorial discovery of multi-specific nanoantibodies for solid tumor immunotherapy 活化优化的抗cd3价控制能够组合发现用于实体瘤免疫治疗的多特异性纳米抗体。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-08-31 DOI: 10.1016/j.scib.2026.08.080

Long Zhu, Ya-Jing Ma, Jian-Kang Kang, Xiu-Hai Che, Dong-Kun Zhao, Yin-Yi Cai, Yao-Ru Yu, Song Shen, Jun Wang

Multi-specific antibodies that engage CD3 to redirect T cells have provided substantial clinical benefit in the treatment of hematologic malignancies, but their application to solid tumors remains constrained by a narrow therapeutic window and fixed molecular geometries that limit systematic optimization. Here we used a modular nano-adaptor framework to adjust anti-CD3 (αCD3) surface valency while maintaining antibody affinity, total antibody loading, and tumor-targeting capacity. By titrating the αCD3 stoichiometric fraction, we identified an activation-optimized conformation that preserves tumor-directed cytotoxicity while reducing non-specific immune activation and T cell exhaustion. This platform enabled rapid screening of 91 tetraspecific nanoantibody configurations that integrate immune checkpoint blockade, co-stimulatory signaling, and innate immune modulation. The lead candidates enhanced immune-tumor engagement, promoted intra-tumoral immune infiltration, and suppressed tumor growth in peripheral blood mononuclear cell (PBMC)-humanized mouse models with acceptable tolerability. These findings demonstrate that anti-CD3 valency control combined with modular combinatorial assembly is a potentially valuable and scalable strategy for the development of multi-specific immunotherapies against solid tumors.

利用CD3重定向T细胞的多特异性抗体在血液系统恶性肿瘤的治疗中提供了实质性的临床益处，但它们在实体肿瘤中的应用仍然受到狭窄的治疗窗口和固定的分子几何结构的限制，这限制了系统优化。在这里，我们使用模块化纳米适配器框架来调节抗cd3 （αCD3）表面价，同时保持抗体亲和力，抗体总负载和肿瘤靶向能力。通过滴定αCD3的化学计量分数，我们发现了一种激活优化的构象，它保留了肿瘤导向的细胞毒性，同时减少了非特异性免疫激活和T细胞衰竭。该平台能够快速筛选整合免疫检查点阻断、共刺激信号和先天免疫调节的91种四特异性纳米抗体配置。在外周血单核细胞（PBMC）人源化小鼠模型中，主要候选药物增强了免疫肿瘤结合，促进了肿瘤内免疫浸润，抑制了肿瘤生长，具有可接受的耐受性。这些发现表明，结合模块化组合组装的抗cd3价控制是开发针对实体瘤的多特异性免疫疗法的潜在有价值和可扩展的策略。

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引用次数: 0

A subset of endogenous P2X5 transcripts encodes ATP-sensitive receptor isoforms 内源性P2X5转录物的一个子集编码atp敏感受体同种异构体。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-07-28 DOI: 10.1016/j.scib.2026.07.067

Xiao-Na Yang, Dong-Ping Wang, Chen-Hui Shen, Xi Chen, Ai-Xin Zhang, Meng Zhang, Xing Zhou, Yun Tian, Peng Cao, Michael X. Zhu, Hui Yang, Chang-Run Guo, Ye Yu

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Drivers of the temporal and spatial variation in gully growth rates in Northeast China 东北沟壑生长速率时空变化的驱动因素

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-07-15 DOI: 10.1016/j.scib.2026.07.043

Yanru Wen, Jingyue Li, Zhufeng Wang, Karl Auerswald, Peter Fiener, Wim Cornelis, Peng Qi, Ting-Yong Li, Xinhua Peng, Liming Ye, Wenbin Wu, Ming Jiang, Jiabao Zhang

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Hydrodynamic twisting enables bioinspired cellulose metafibers with exceptional strength and toughness 流体动力扭转使生物启发纤维素超纤维具有特殊的强度和韧性。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-07-29 DOI: 10.1016/j.scib.2026.07.069

Tingting Yang, Zhaoxin Zhang, Zhiwei Liu, Xiaotong Fu, Shuze Zhu, Dongdong Ye

Replacing high-performance synthetic fibers with sustainable bio-derived alternatives is critical for mitigating microplastic pollution but remains limited by the inferior mechanical performance of biomass-derived fibers. Here, we present bioinspired cellulose metafibers (Meta-CFs) enabled by a scalable hydrodynamic twisting strategy, wherein an asymmetric microfluidic field precisely guides the formation of continuously twisted architectures within a chemically cross-linked network, thereby locking in the ordered configuration and markedly suppressing defect accumulation. Multiscale experiments and simulations reveal that this strategy promotes efficient stress delocalization and cooperative load transfer. The resulting Meta-CFs achieve an unprecedented maximum tensile strength of 3.29 GPa (average 3.06 ± 0.23 GPa) and a toughness of 349.5 MJ m⁻³, simultaneously rivaling the strength of high-performance synthetic fibers and the toughness of natural spider silk. Furthermore, encapsulating multiple individual Meta-CFs with calcium alginate effectively scales up the bundle diameter while preserving GPa-level strength and full biodegradability. This upscaling strategy enables large-diameter structural applications, as demonstrated by durable trimmer lines that avoid the generation of persistent agricultural microplastic residues, thereby establishing a viable pathway toward high-performance, sustainable material alternatives.

用可持续的生物衍生替代品取代高性能合成纤维对于减轻微塑料污染至关重要，但仍受到生物衍生纤维较差的机械性能的限制。在这里，我们提出了一种可扩展的流体动力学扭转策略支持的生物启发纤维素超纤维（meta - cf），其中不对称微流场精确地引导化学交联网络中连续扭曲结构的形成，从而锁定有序配置并显著抑制缺陷积累。多尺度实验和仿真结果表明，该策略促进了有效的应力离域和载荷协同传递。Meta-CFs的最大抗拉强度为3.29 GPa（平均3.06±0.23 GPa），韧性为349.5 MJ - m-3，可媲美高性能合成纤维的强度和天然蜘蛛丝的韧性。此外，用海藻酸钙包封多个单独的meta - cf可以有效地扩大束直径，同时保持gpa水平的强度和完全的生物降解性。这种升级策略可以实现大直径结构的应用，正如耐用的修剪线所证明的那样，避免了持久性农业微塑料残留物的产生，从而建立了通向高性能、可持续材料替代品的可行途径。

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引用次数: 0

Engineering heterostaple in atomically precise palladium cluster for efficient hydrogen peroxide electrosynthesis 用于高效过氧化氢电合成的原子精密钯团簇工程异长纤维。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-08-22 DOI: 10.1016/j.scib.2026.08.039

Jiachun Li, Yan Sun, Min Du, Shuguang Wang, Baoliang Han, Jiacheng Wang, Xiaoyi Yang, Fangkai Wu, Fuling Liu, Xiaofeng Lei, Afang Dai, Zibao Gan, Xiuwen Zheng, Di Sun

The deliberate construction of well-defined heterostaples within atomically precise metal clusters offers a powerful route to heterometallic systems with unconventional functionalities and promising catalytic potential. However, realizing such precise interface engineering in palladium-based clusters remains highly challenging. Here, we report the first successful synthesis of well-defined Pd₅Au₂ and Pd₅Cu₂ architectures featuring heterometallic interfaces by customizing dual-atom site (Au–Au or Cu–Cu) in atomically precise palladium cluster. Their structures were unambiguously determined by single crystal X-ray diffraction (SCXRD) and electrospray ionization mass spectrometry (ESI-MS). Both heterometallic clusters share a similar architecture, comprising a slightly folded Pd₅S hexatomic ring encapsulating a central antimony atom from PhSb²⁻ ligand, a M₂S₃ (M=Au or Cu) staple and four bridging thiolate ligands. Incorporation of the Au–Au or Cu–Cu subunit modulates the geometric and electronic environments of the palladium core to varying extents, leading to markedly distinct two-electron oxygen reduction reaction performances. Notably, Pd₅Au₂ achieves a nearly 100% H₂O₂ Faradaic efficiency at 25 mA cm⁻² and an exceptional H₂O₂ production rate of 1366.4 mmol g_cat⁻¹ h⁻¹ at 125 mA cm⁻². Its efficacy was further demonstrated in practical Fenton-type pollutant degradation. Density functional theory (DFT) calculations, corroborated by operando infrared spectroscopy, reveal that the introduction of an Au–Au dual-atom site induces an electronic redistribution that weakens the *OOH adsorption, thereby facilitating its hydrogenation step. This study represents the first realization of atomically precise palladium-based clusters equipped with heterometallic interfaces, providing new mechanistic insights and design principles for cluster-based catalysts in small-molecule energy conversion.

在原子级精确的金属团簇中精心构建定义明确的异质钉，为具有非常规功能和有前景的催化潜力的异质金属体系提供了一条强有力的途径。然而，在钯基簇中实现这种精确的界面工程仍然具有很大的挑战性。在这里，我们报告了首次成功合成具有异质金属界面的Pd5Au2和Pd5Cu2结构，通过定制原子精确钯簇中的双原子位点（Au-Au或Cu-Cu）。用单晶x射线衍射（SCXRD）和电喷雾电离质谱（ESI-MS）对其结构进行了分析。这两种异质金属簇具有相似的结构，包括一个稍微折叠的Pd5S六原子环，包覆一个来自PhSb2-配体的中心锑原子，一个M2S3 （M=Au或Cu）短链和四个桥接的硫酸盐配体。Au-Au或Cu-Cu亚基的加入在不同程度上调节了钯芯的几何和电子环境，导致明显不同的双电子氧还原反应性能。值得注意的是，Pd5Au2在25 mA cm-2条件下达到接近100%的H2O2法拉第效率，在125 mA cm-2条件下达到1366.4 mmol gcat-1 h-1的H2O2产率。在fenton型污染物的实际降解中，进一步验证了该方法的有效性。密度泛函理论（DFT）计算结果经operando红外光谱证实，表明Au-Au双原子位的引入诱导了电子重分布，减弱了*OOH的吸附，从而促进了其加氢步骤。该研究首次实现了具有异金属界面的原子级精确钯基团簇，为小分子能量转化中的团簇催化剂提供了新的机理见解和设计原则。

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引用次数: 0

Dark phonons as a polariton ruler for hidden interlayer deformations 暗声子作为隐藏层间变形的极化子标尺。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-09-01 DOI: 10.1016/j.scib.2026.09.003

Shengyu Hu, Jiahua Duan, Zhiwei Guo

引用次数: 0

From scar walls to neural bridges: a convergent paradigm for next-generation spinal cord injury repair 从瘢痕壁到神经桥：下一代脊髓损伤修复的趋同范式。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-07-07 DOI: 10.1016/j.scib.2026.07.016

Senyu Yao, Xu Huang, Jun Kang, Bin Liu, Limin Rong

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Elevation-dependent runoff shifts in the Mount Everest region 珠穆朗玛峰地区随海拔变化的径流变化。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-04-15 DOI: 10.1016/j.scib.2026.04.020

He Sun, Tandong Yao, Yi Zhang, Huabiao Zhao, Wei Yang, Zhongyan Wang, Zhenhua Xi, Weicai Wang

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Tumor empowered binary macrophages regulate T cell interferon signaling to mediate immunotherapy resistance in gastric cancer 肿瘤授权的双巨噬细胞调节T细胞干扰素信号介导胃癌免疫治疗耐药。

IF 20.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2026-10-15 Epub Date: 2026-07-20 DOI: 10.1016/j.scib.2026.07.049

Tong Xie, Bohan Zhang, Lei Jiang, Wenwen Zhang, Boxin Liu, Yang Shi, Xiaotian Zhang, Jian Li, Yifan Zhang, Jun Zhou, Yanshuo Cao, Yakun Wang, Changsong Qi, Yun Zhang, Pei Zhang, Zhirong Shen, Lanjun Xu, Wenyan Wang, Lin Shen, Zhi Peng

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