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Dual-Gate Al0.23Ga0.77N/GaN MOSHEMT-Based Biosensor for Simultaneous Detection of CEA and HER2 Cancer Biomarker 基于双栅Al0.23Ga0.77N/GaN moshemt的同时检测CEA和HER2肿瘤生物标志物的生物传感器
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-09-09 DOI: 10.1134/S1028335826600719
Rohit Ranjan, Harsh Vikram Singh, Sarvesh Dubey

This work presents a dual-gate Al0.23Ga0.77N/GaN MOSHEMT biosensor for the simultaneous detection of two significant CEA and HER2 cancer biomarkers. The proposed device employs two independently functionalized gate electrodes which enabling parallel sensing through a shared two-dimensional electron gas (2DEG) channel. The gates are laterally positioned and electrically separated by a 50 nm Al2O3 isolation gap which facilitates selective and multiplexed biomarker detection on a single platform. A bilayer dielectric stack of HfO2 and Al2O3 is utilized to minimize gate leakage current and enhance sensing capability. The device performance is analysed using Silvaco ATLAS TCAD simulations with appropriate polarization based physical models. The simulation results show that the CEA-functionalized gate exhibits a sensitivity of 1.06 × 10–6 A/µm per unit concentration. The biosensor achieves a sensitivity of 2.95 × 10–7 A/µm per unit concentration at a drain voltage of 10 V during simultaneous detection of HER2 and CEA. The proposed structure enables efficient multiplexed biomarker sensing on a single chip and demonstrates improved performance over traditional single gate HEMT biosensors.

本研究提出了一种双栅Al0.23Ga0.77N/GaN MOSHEMT生物传感器,用于同时检测两种重要的CEA和HER2癌症生物标志物。该器件采用两个独立功能化栅极,通过共享二维电子气(2DEG)通道实现并行传感。这些门是横向定位的,并通过50 nm的Al2O3隔离间隙电分隔,这有助于在单个平台上进行选择性和多路生物标志物检测。利用HfO2和Al2O3的双层介电层来减小栅极泄漏电流,提高传感能力。利用Silvaco ATLAS TCAD仿真分析了该器件的性能,并建立了适当的极化物理模型。仿真结果表明,cea功能化栅极的灵敏度为1.06 × 10-6 a /µm /单位浓度。同时检测HER2和CEA时,在漏极电压为10 V时,生物传感器的灵敏度为2.95 × 10 - 7 a /µm /单位浓度。所提出的结构能够在单芯片上实现高效的多路生物标志物传感,并且比传统的单门HEMT生物传感器表现出更高的性能。
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引用次数: 0
Mixed-Phase Fe3O4/FeO Nanoclusters Derived from Jojoba Oil: Structural Insights and Electrical Performance for Sustainable Electronic Applications 荷荷巴油衍生的混合相Fe3O4/FeO纳米团簇:结构洞察和可持续电子应用的电气性能
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-09-09 DOI: 10.1134/S1028335826600756
Abdulaziz Almalki

The development of sustainable nanomaterials with tunable electrical and dielectric properties is essential for next-generation electronic and functional device applications. In this work, mixed-phase iron oxide nanoclusters (Fe3O4/FeO) were synthesized via a green co-precipitation route using jojoba oil as a natural reducing and stabilizing agent under mild and environmentally friendly conditions. Structural characterization by FTIR, XRD, and SEM/EDX confirmed the formation of Fe–O bonds, organic surface capping, and the coexistence of magnetite (Fe3O4) and wüstite (FeO) phases. The synthesized nanoclusters exhibited nanoscale crystallinity and aggregated spherical morphology. Electrical investigations revealed two distinct frequency-dependent conduction mechanisms: localized hopping conduction at low frequencies and thermally activated variable-range hopping at higher frequencies. The activation energy increased progressively with frequency, indicating enhanced charge transport barriers at elevated frequencies. Dielectric measurements demonstrated pronounced temperature- and frequency-dependent behavior, with enhanced polarization and increased capacitance at higher temperatures. The observed electrical transport and dielectric characteristics highlight the suitability of the synthesized Fe3O4/FeO nanoclusters for dielectric, electronic, and charge-storage-related applications. These findings demonstrate that jojoba oil provides an effective and sustainable route for producing functional iron oxide nanomaterials with promising electrical performance.

具有可调电性能和介电性能的可持续纳米材料的开发对于下一代电子和功能器件的应用至关重要。本研究以霍霍巴油为天然还原剂和稳定剂,在温和环保的条件下,通过绿色共沉淀法合成了混合相氧化铁纳米团簇(Fe3O4/FeO)。通过FTIR、XRD、SEM/EDX等结构表征,证实了Fe-O键的形成、有机表面盖层以及磁铁矿(Fe3O4)和钨钛矿(FeO)相的共存。合成的纳米团簇具有纳米级结晶度和球状聚集形态。电学研究揭示了两种不同的频率相关传导机制:低频的局部跳频传导和高频的热激活可变范围跳频。随着频率的增加,激活能逐渐增加,表明在高频率下电荷输运势垒增强。介电测量显示出明显的温度和频率依赖行为,在较高温度下具有增强的极化和增加的电容。观察到的电输运和介电特性突出了合成的Fe3O4/FeO纳米团簇在介电、电子和电荷存储相关应用中的适用性。这些发现表明,荷荷巴油为生产具有良好电性能的功能性氧化铁纳米材料提供了一条有效和可持续的途径。
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引用次数: 0
Impact of Lateral Scaling on the High-Frequency Performance of β-Ga2O3 Back-Barrier GaN HEMTs with a Graded InAlN Buffer 横向结垢对梯度InAlN缓冲层β-Ga2O3后垒GaN hemt高频性能的影响
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-09-09 DOI: 10.1134/S102833582660080X
P. Muthu Subramanian, T. Subhashini, Jackson Daniel, Veeranki Srinivasa Rao

This work investigates the impact of lateral scaling on the high-frequency characteristics of a β-Ga2O3 back-barrier (BB) HEMT incorporating a compositionally graded InAlN buffer. The proposed device structure consists of a sapphire substrate, graded InAlN buffer, β-Ga2O3 BB, GaN channel, and AlGaN barrier layer. The influence of LG and LGS on carrier confinement, electrical performance, and RF characteristics is systematically analysed. Energy band analysis reveals the formation of a deep quantum well at the heterointerface, facilitating strong 2DEG. The β-Ga2O3 BB effectively suppresses electron leakage toward the buffer region, while the graded InAlN buffer improves carrier transport through reduced scattering. The device exhibits a maximum drain current of approximately 2.4 A/mm at ({{V}_{{GS}}} = 2) V for LG = 20 nm and a peak transconductance of about 1.55 S/mm. High-frequency analysis demonstrates a maximum fT of nearly 300 GHz for optimized LGS and 250 GHz for LG = 20 nm. Furthermore, reduced gate length significantly lowers parasitic capacitances, leading to enhanced RF performance. The results indicate that lateral scaling strongly influences carrier transport, electrostatic control, and frequency response, with gate-length scaling exhibiting a more pronounced effect than source-to-gate spacing variation. The proposed β-Ga2O3 back-barrier architecture with a graded InAlN buffer demonstrates considerable potential for microwave, millimeter-wave, and advanced RF applications.

这项工作研究了横向结垢对含有分级InAlN缓冲液的β-Ga2O3背垒(BB) HEMT高频特性的影响。该器件结构由蓝宝石衬底、梯度InAlN缓冲层、β-Ga2O3 BB、GaN通道和AlGaN势垒层组成。系统分析了LG和LGS对载流子约束、电学性能和射频特性的影响。能带分析表明,在异质界面处形成了深量子阱,促进了强2DEG的形成。β-Ga2O3 BB有效地抑制了电子向缓冲区域的泄漏,而梯度InAlN缓冲层通过减少散射改善了载流子输运。当LG = 20 nm时,该器件在({{V}_{{GS}}} = 2) V下的最大漏极电流约为2.4 a /mm,峰值跨导约为1.55 S/mm。高频分析表明,优化后的LGS的最大fT接近300 GHz, LG = 20 nm的最大fT接近250 GHz。此外,栅极长度的减小显著降低了寄生电容,从而提高了射频性能。结果表明,横向标度对载流子输运、静电控制和频率响应有强烈影响,其中栅极长度标度的影响比源栅极间距变化更明显。所提出的β-Ga2O3背垒结构与梯度InAlN缓冲器在微波、毫米波和高级射频应用中具有相当大的潜力。
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引用次数: 0
Enhancing Prostate-Specific Antigen (PSA) Density Analysis Using Advanced OTFT Biosensor Technology 利用先进的OTFT生物传感器技术增强前列腺特异性抗原(PSA)密度分析
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-09-09 DOI: 10.1134/S1028335826600859
Rajesh Kumar Tiwari, Rajesh Mishra, Sanjay Kumar Sharma, Sandeep Kumar Ojha, Anushka Ojha

This paper explores the application of Organic Thin-Film Transistors (OTFTs) sensors in their detection of tumor cells, with a specific focus on measuring Prostate-Specific Antigen (PSA) concentration, a critical biomarker for diagnose of prostate-cancer. The study emphasizes the importance of sensitivity and specificity in the OTFT sensor’s compare to digital rectal examination (DRE) performance, as these parameters are essential for accurate cancer diagnostics. Sensitivity ensures that the sensor can detect low PSA concentrations, which is crucial for early-stage detection, while specificity minimizes false positives, distinguishing between malignant and benign conditions effectively.

The input characteristics of the OTFT sensor, particularly the gate voltage, play a significant role in its ability to detect PSA. Proper calibration of the gate voltage enhances the sensor’s sensitivity, enabling the detection of subtle changes in PSA levels. The output-characteristics, represented by the drain current, provide a quantifiable measure of PSA concentration, which is essential for assessing the presence and progression of tumour cells. This study demonstrates the potential of OTFT sensors as a non-invasive, precise, and reliable method for early cancer detection. By optimizing sensitivity, specificity, and the sensor’s input–output characteristics, OTFT technology could significantly improve diagnostic accuracy and patient outcomes in cancer care.

本文探讨了有机薄膜晶体管(OTFTs)传感器在肿瘤细胞检测中的应用,重点研究了前列腺特异性抗原(PSA)浓度的测量,这是诊断前列腺癌的重要生物标志物。该研究强调了OTFT传感器与直肠指检(DRE)性能相比的敏感性和特异性的重要性,因为这些参数对于准确的癌症诊断至关重要。灵敏度确保传感器可以检测到低PSA浓度,这对早期检测至关重要,而特异性可以最大限度地减少假阳性,有效区分恶性和良性疾病。OTFT传感器的输入特性,特别是栅极电压,对其检测PSA的能力起着重要的作用。正确校准栅极电压可以提高传感器的灵敏度,从而能够检测到PSA水平的细微变化。输出特性,由漏极电流表示,提供了PSA浓度的可量化测量,这对于评估肿瘤细胞的存在和进展至关重要。这项研究证明了OTFT传感器作为一种非侵入性、精确和可靠的早期癌症检测方法的潜力。通过优化灵敏度、特异性和传感器的输入输出特性,OTFT技术可以显著提高癌症治疗的诊断准确性和患者预后。
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引用次数: 0
High Sensitivity Dielectric-Modulated Negative Capacitance Gate-All-Around TFET (DM-NC-GAA-TFET) Biosensor with Nanocavity for Label-Free Biomolecule Detection 用于无标记生物分子检测的高灵敏度介质调制负电容栅极全能TFET (dm - nm - gaa -TFET)纳米腔生物传感器
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-08-21 DOI: 10.1134/S1028335826600641
Ravi Rastogi, Devendra Kumar Tripathi, Sarvesh Dubey

This study presents a high-performance dielectric-modulated Negative Capacitance Gate-All-Around Tunnel Field-Effect Transistor (DM-NC-GAA-TFET) biosensor for label-free biomolecule detection. The proposed device employs a nanocavity structure with varying dielectric constants (K) of biomolecules to improve sensing performance through enhanced gate-to-channel coupling and electrostatic control. The electrical and sensing characteristics of the biosensor are analyzed for different dielectric constants and cavity lengths. The transfer characteristics exhibit excellent switching behavior with an ON-state current of approximately 6.2 × 10−6 A and an OFF-state current of nearly 10−14 A, resulting in a high ION/IOFF ratio. The output characteristics demonstrate stable current saturation and improved channel controllability, while the transconductance reaches approximately 13.5 × 10−6 S, indicating efficient carrier transport. The effect of dielectric modulation is investigated for dielectric constants ranging from 1 to 10. The drain current increases from 5.8 × 10−6 to 6.7 × 10−6 A with increasing dielectric constant, confirming enhanced sensing capability. The proposed biosensor achieves a maximum drain current sensitivity of 8.1 × 10−7 A at K = 10. Furthermore, the subthreshold swing improves from 0.066 to 0.049 V/dec, while drain induced barrier lowering (DIBL) decreases from 0.038 to 0.021. The threshold voltage sensitivity increases from 0.085 to 0.148 for a 25 nm cavity length. These results demonstrate that the proposed DM-NC-GAA-TFET biosensor provides high sensitivity, excellent switching performance, and improved electrostatic characteristics for future low-power biosensing applications.

本研究提出了一种用于无标记生物分子检测的高性能介电调制负电容栅-全能隧道场效应晶体管(dm - nm - gaa - tfet)生物传感器。该器件采用具有不同生物分子介电常数(K)的纳米腔结构,通过增强门通道耦合和静电控制来提高传感性能。分析了不同介电常数和腔长下生物传感器的电学和传感特性。转移特性表现出优异的开关特性,其on -状态电流约为6.2 × 10−6 A, off -状态电流约为10−14 A,从而产生高离子/IOFF比。输出特性显示稳定的电流饱和和改进的通道可控性,而跨导达到约13.5 × 10−6 S,表明有效的载流子传输。研究了介电常数在1 ~ 10范围内介电调制的影响。随着介电常数的增加,漏极电流从5.8 × 10−6增加到6.7 × 10−6 A,证实了传感能力的增强。该生物传感器在K = 10时的最大漏极电流灵敏度为8.1 × 10−7 a。亚阈值摆幅从0.066 V/dec提高到0.049 V/dec,漏极诱导势垒降低(DIBL)从0.038 V/dec降低到0.021 V/dec。当腔长为25 nm时,阈值电压灵敏度从0.085提高到0.148。这些结果表明,所提出的DM-NC-GAA-TFET生物传感器具有高灵敏度、优异的开关性能和改进的静电特性,可用于未来的低功耗生物传感应用。
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引用次数: 0
Statistical Analysis of Cosh Gaussian Breathers in Cubic Quintic Media Possessing Hump Shaped Quintic Nonlinearity 具有驼峰型五次非线性的三次五次介质中Cosh -高斯呼吸的统计分析
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-08-21 DOI: 10.1134/S1028335826600707
Naveen Gupta, A. K. Alex, Deepak Kumar

Statistical investigation of the dynamics of cosh Gaussian (ChG) breather propagating in a cubic quintic (CQ) nonlinear medium possessing an axial hump shaped profile of quintic nonlinearity has been presented. Using moment theory approach the propagation dynamics of the breather has been reduced to an ordinary differential equation governing the evolution of the beam width of the laser beam. This allows a detailed analysis of how the beam shape parameter affects the stability and dynamical structure of the propagation dynamics of the breather. A variety of statistical and geometrical diagnostic techniques including probability density distributions, covariance matrices, recurrence structures and autocorrelation analysis are employed to investigate the underlying dynamics of the breather states. The analysis reveals that variations in the beam shape parameter of the ChG laser beam significantly modify dynamics of the breather. In particular, the transition from weak to strong nonlinear dynamics accompanied by enhanced statistical correlations and recurrence patterns has been observed.

本文研究了cosh - Gaussian (ChG)呼吸机在具有五次非线性轴向驼峰型的三次五次非线性介质中的传播动力学。利用矩量理论方法,将呼吸机的传播动力学简化为控制光束宽度演变的常微分方程。这样可以详细分析光束形状参数如何影响呼吸器传播动力学的稳定性和动态结构。采用各种统计和几何诊断技术,包括概率密度分布、协方差矩阵、递归结构和自相关分析来研究呼吸状态的潜在动力学。分析表明,ChG激光束的光束形状参数的变化显著地改变了呼吸器的动力学特性。特别是,从弱到强的非线性动力学转变伴随着增强的统计相关性和递归模式已被观察到。
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引用次数: 0
Relativistic Dilation and Superposition Projection of Time (State) 时间(态)的相对论膨胀与叠加投影
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-08-21 DOI: 10.1134/S1028335826600379
Fenghua Liu

This paper present a unified theoretical framework connecting relativistic time dilation, time–state correlation, and quantum superposition. The physical state of an object is modeled as an objective, continuous time-series function s = f(t). In the unobserved regime, the proper timeline of an object is independent of the observer’s reference frame; during observation, relativistic time dilation induces a corresponding state dilation effect, and the observed value represents the projection of the intrinsic state onto the observer’s timeline. Under elementary observation, classical behavior corresponds to a one-to-one state mapping (1 ≤ n < 2), while quantum behavior arises from a many-to-one relation (n ≥ 2) accompanied by state superposition, probabilistic outcomes, and the loss of temporal order. This paper derive formal superposition-projection formulas for time and state and apply the framework to interpret the double-slit interference experiment. The observed randomness of photon detection originates from unit-time projective sampling rather than fundamental indeterminacy, while the photon maintains a deterministic intrinsic wave function along its proper timeline. This paper predict a stepwise increase in discrete observable states as particle velocity approaches critical relativistic thresholds, supporting a continuous transition from classical to quantum behavior. This framework establishes a consistent bridge between special relativity, classical mechanics, probability theory, and quantum mechanics.

本文提出了相对论性时间膨胀、时间态相关和量子叠加的统一理论框架。物体的物理状态被建模为一个客观的、连续的时间序列函数s = f(t)。在未观测状态下,物体的固有时间轴与观察者的参考系无关;在观测过程中,相对论性时间膨胀引起相应的状态膨胀效应,观测值代表了内在状态在观察者时间线上的投影。在初等观测下,经典行为对应于一个一对一的状态映射(1≤n < 2),而量子行为则是一个多对一的关系(n≥2),伴随着状态叠加、概率结果和时间顺序的丧失。本文导出了时间和状态的形式化叠加投影公式,并应用该框架解释了双缝干涉实验。观察到的光子探测的随机性来源于单位时间的射影采样,而不是基本的不确定性,而光子沿着其适当的时间保持确定性的本征波函数。本文预测,随着粒子速度接近临界相对论阈值,离散可观测状态将逐步增加,支持从经典行为到量子行为的连续过渡。这个框架在狭义相对论、经典力学、概率论和量子力学之间建立了一个一致的桥梁。
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引用次数: 0
Investigation of Periodic Chirp Effects on Electron Acceleration in Vacuum by Hermite–Sinh–Gaussian Laser 厄米-辛-高斯激光对真空中电子加速的周期性啁啾效应研究
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-08-21 DOI: 10.1134/S1028335826600537
Vivek Sharma, Vishal Thakur

In this work, vacuum electron acceleration driven by a periodic chirped Hermite–Sinh–Gaussian (HSG) laser pulse is theoretically investigated, with particular emphasis on the influence of frequency chirp parameters and beam waist on relativistic energy gain. The study demonstrates that frequency chirping significantly modifies the phase evolution of the electromagnetic field, thereby improving phase synchronism between the electron and the accelerating field. In the unchirped case, energy saturation occurs at 3.38 GeV due to rapid electron–laser dephasing. Introduction of a positive chirp enhances phase matching and prolongs the effective interaction time, leading to systematic energy enhancement. The saturation energy increases from 3.84 GeV (α = 0.002) to 4.18 GeV (α = 0.005). Similarly, the chirp modulation constant Ω plays a crucial role in dynamic frequency compensation, increasing the maximum energy to 4.18 GeV for Ω = 0.002. Furthermore, the beam waist is found to strongly influence acceleration efficiency. Larger beam waists reduce transverse ponderomotive effects, extend the interaction length, and enhance longitudinal confinement, resulting in a monotonic rise in energy up to 5.26 GeV. The results establish chirp parameters and beam waist as effective control parameters for optimizing vacuum electron acceleration.

本文从理论上研究了周期啁啾赫米-辛-高斯(HSG)激光脉冲驱动的真空电子加速,重点研究了频率啁啾参数和束腰对相对论能量增益的影响。研究表明,频率啁啾显著地改变了电磁场的相位演化,从而改善了电子与加速场之间的相位同步性。在非啁啾情况下,由于快速的电子激光减相,能量饱和发生在3.38 GeV。引入正啁啾增强了相位匹配,延长了有效相互作用时间,使系统能量增强。饱和能由3.84 GeV (α = 0.002)增加到4.18 GeV (α = 0.005)。同样,啁啾调制常数Ω在动态频率补偿中起着至关重要的作用,当Ω = 0.002时,最大能量增加到4.18 GeV。此外,还发现梁腰对加速度效率有很大影响。更大的束腰减小了横向质心效应,延长了相互作用长度,增强了纵向约束,导致能量单调上升,最高可达5.26 GeV。结果表明,啁啾参数和束腰是优化真空电子加速度的有效控制参数。
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引用次数: 0
Structural, Optical, Electrical, Thermoelectric and Photoelectrochemical Properties of Nanoscale Silver Bismuth Selenide Thin Films 纳米级硒化铋银薄膜的结构、光学、电学、热电和光电化学性质
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-08-10 DOI: 10.1134/S1028335826600227
P. A. Chate, D. J. Sathe

Silver bismuth selenide thin films were prepared and examined to understand their structural, optical, compositional, electrical, and thermoelectric behavior. X-ray diffraction analysis verified the formation of a phase pure hexagonal structure with good crystallinity and preferred orientation. The scanning electron images reveal a dense and continuous film composed of uniformly distributed nanoscale crystallites, with sizes ranging approximately 18–25 nm. Optical characterization showed strong absorption across the visible to near-infrared spectral region, and the optical band gap determined from Tauc plots lies within a range favorable for optoelectronic and energy-conversion applications. Electrical transport measurements revealed temperature dependent semiconducting behavior. Thermoelectric investigations conducted over the temperature range of 300–525 K exhibited a negative Seebeck coefficient throughout, indicating n-type charge transport. The Seebeck coefficient increased from 80.46 μV K–1 at 300 K to 105.49 μV K–1 at 525 K. With increasing temperature, the carrier concentration rose from 1.1 × 1019 to 1.9 × 1019 cm–3, while the carrier mobility improved from 0.3 to 0.9 cm2 V–1 s–1. The enhancement in mobility is attributed to the weakening of grain-boundary potential barriers at elevated temperatures. The corresponding fill factor was 0.48, resulting in a photoelectrochemical conversion efficiency of approximately 1.02%.

制备并检测了硒化铋银薄膜,以了解其结构、光学、成分、电学和热电行为。x射线衍射分析证实形成了具有良好结晶度和择优取向的相纯六边形结构。扫描电子图像显示由均匀分布的纳米级晶体组成的致密连续薄膜,尺寸约为18-25 nm。光学特性显示在可见光到近红外光谱区域有很强的吸收,并且从Tauc图确定的光学带隙处于有利于光电和能量转换应用的范围内。电输运测量揭示了温度依赖性半导体行为。在300-525 K温度范围内进行的热电研究显示,整个塞贝克系数为负,表明n型电荷输运。塞贝克系数从300 K时的80.46 μV K - 1增加到525 K时的105.49 μV K - 1。随着温度的升高,载流子浓度从1.1 × 1019 cm-3增加到1.9 × 1019 cm-3,载流子迁移率从0.3 cm2 V-1 s-1提高到0.9 cm2 V-1 s-1。迁移率的增强是由于在高温下晶界势垒的减弱。相应的填充因子为0.48,光电转换效率约为1.02%。
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引用次数: 0
Electrostatic, Linearity and Sensitivity Analysis of Neutral Biomolecules Using NC-JL-GAA MOSFET-Based Biosensor 基于NC-JL-GAA mosfet生物传感器的中性生物分子静电、线性和灵敏度分析
IF 0.3 4区 物理与天体物理 Q4 MECHANICS Pub Date : 2026-08-10 DOI: 10.1134/S102833582660046X
Ravi Rastogi, Devendra Kumar Tripathi, Sarvesh Dubey, Alok Kumar, Abhinav Gupta

This study focuses on the intricate design and comprehensive investigation of electrostatic properties, analog analysis, and linearity characteristics associated with various neutral biomolecules. These investigations were conducted under varying dielectric constants, utilizing a novel device designated as the Negative Capacitance Junctionless Gate-All-Around (NC-JL-GAA) MOSFET. To evaluate the device’s sensing behavior, the analysis incorporated several neutral biomolecules, including Deoxyribonucleic Acid (DNA), Amino-propyl-tri-ethoxysilane (APTES), Streptavidin, Biotin, and air. The sensitivity of the electrostatic characteristics was thoroughly examined to ascertain the extent of their responsiveness. The simulated results demonstrate that the Subthreshold Swing (SS), Drain-Induced Barrier Lowering (DIBL), and OFF-state current (IOFF) consistently exhibit optimal performance across all investigated conditions. Notably, DNA yielded the highest ON-current (ION) and ION/IOFF ratio, thereby highlighting its superior interaction with the channel potential. These simulations were performed using the ATLAS™ 3D device simulator (SILVACO), which was calibrated against a device previously reported by other research groups. For validation purposes, the electrical and sensing characteristics of the device were benchmarked against those of other reported FET-based biosensors.

本研究的重点是复杂的设计和全面的研究静电特性,模拟分析,线性特性与各种中性生物分子相关。这些研究是在不同的介电常数下进行的,使用了一种名为负电容无结栅-全能(NC-JL-GAA) MOSFET的新型器件。为了评估该装置的传感行为,分析纳入了几种中性生物分子,包括脱氧核糖核酸(DNA)、氨基丙基三乙氧基硅烷(APTES)、链霉亲和素、生物素和空气。对静电特性的灵敏度进行了彻底的检查,以确定其响应的程度。模拟结果表明,在所有研究条件下,亚阈值摆幅(SS)、漏极诱导势垒降低(DIBL)和关闭状态电流(IOFF)始终表现出最佳性能。值得注意的是,DNA产生了最高的ON-current (ION)和ION/IOFF比率,从而突出了其与通道电位的优越相互作用。这些模拟是使用ATLAS™3D设备模拟器(SILVACO)进行的,该模拟器是根据其他研究小组先前报道的设备进行校准的。为了验证目的,该装置的电学和传感特性与其他报道的基于fet的生物传感器进行了基准测试。
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Doklady Physics
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