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Interleukin-6: possible implications in human diseases. 白细胞介素-6:对人类疾病的可能影响。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01 DOI: 10.1007/BF02871787
T Hirano, T Kishimoto

It has been demonstrated that interleukin-6 (IL-6) is a cytokine regulating immune response, acute-phase reaction and hematopoiesis. The deregulated expression of IL-6 was suggested to be actually involved in the pathogenesis of polyclonal B cell activation and autoimmune diseases such as rheumatoid arthritis. It could be hypothesized that continuous polyclonal B cell activation may be eventually leading to the generation of plasmacytoma/myeloma, possibly with additional expression of oncogene(s) such as c-myc gene. Therefore, future studies on the gene regulation of IL-6 would provide critical informations on the molecular pathogenesis of these diseases. Furthermore, IL-6 could be used as anti-cancer drug in certain tumors. Moreover, inhibitors of IL-6 such as anti-IL-6 monoclonal antibodies or soluble forms of IL-6 receptors could be useful in the treatment of such polyclonal/monoclonal B cell abnormalities.

研究表明，白细胞介素-6 (IL-6)是调节免疫反应、急性期反应和造血的细胞因子。IL-6的失调控表达实际上参与了多克隆B细胞活化和自身免疫性疾病如类风湿关节炎的发病机制。我们可以假设，持续的多克隆B细胞活化可能最终导致浆细胞瘤/骨髓瘤的产生，可能伴随着癌基因如c-myc基因的额外表达。因此，今后对IL-6基因调控的研究将为这些疾病的分子发病机制提供重要信息。此外，IL-6还可作为某些肿瘤的抗癌药物。此外，IL-6抑制剂如抗IL-6单克隆抗体或IL-6受体的可溶性形式可用于治疗此类多克隆/单克隆B细胞异常。
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引用次数: 29
[Immunoreactive methods and their importance for the diagnosis of clinical forms of toxoplasmosis]. [免疫反应方法及其在弓形虫病临床诊断中的重要性]。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01
E Mannweiler
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引用次数: 0
Diagnosis of hemophilia A in a female subject by using restriction fragment length polymorphisms linked to the factor VIII gene. 利用与因子VIII基因相关的限制性片段长度多态性诊断女性血友病A。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01 DOI: 10.1007/BF02871795
A M Randi, E Sacchi, M Sampietro, G Papaleo, G Muleo, P M Mannucci

A 6-year-old girl, daughter of a male patient with moderate hemophilia A (factor VIII 3%), was referred to our Center because she also had very low levels of factor VIII (4%). The proband's brother has mild hemophilia A (7%); the mother (29%) is a possible carrier, no other case of hemophilia A being reported in her family. Hence, the factor VIII deficiency found in the girl is consistent either with a carrier state with extreme lyonization in favour of the hemophilic gene or with homozygosity for the hemophilia gene. To distinguish these possibilities, we studied the segregation of three restriction fragment length polymorphisms (RFLPs) linked to the factor VIII gene in the 4 members of the family. Employing one intragenic (FVIII-BclI) and two extragenic (St14-TaqI and Dx13-BglII) RFLPs, we showed that the proband has inherited from both parents the defective gene, being therefore homozygous for the hemophilia gene.

一名6岁女孩，是一名患有中度血友病A(因子VIII 3%)的男性患者的女儿，因为她的因子VIII水平也很低(4%)而被转介到我们中心。先证者的兄弟患有轻度A型血友病(7%);母亲(29%)为可能的携带者，其家族中未报告其他a型血友病病例。因此，在女孩身上发现的因子VIII缺乏要么与血友病基因的极端电离的载体状态一致，要么与血友病基因的纯合性一致。为了区分这些可能性，我们研究了该家族4个成员中与因子VIII基因相关的三个限制性内切片段长度多态性(RFLPs)的分离。利用一个基因内RFLPs (FVIII-BclI)和两个基因外RFLPs (St14-TaqI和Dx13-BglII)，我们发现先证从父母双方遗传了缺陷基因，因此是血友病基因的纯合子。
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引用次数: 2
[Rheographic effects of timolol maleate in a collyrium on the ocular microcirculation in diabetic patients]. [马来酸替马洛尔对糖尿病患者眼球微循环流变学的影响]。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01
S Colombati, L Monti, M Baggiani, F Filippini
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引用次数: 0
[Hemorheological factors and platelet activation]. [血液流变学因素与血小板活化]。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01
G G Nenci
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引用次数: 0
[Hemorheological alterations in patients with chronic cerebral ischemia]. 慢性脑缺血患者的血液流变学改变。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01
P B Carrieri, T Liguori, A Lombardo, C Ciliberti, A Boccuzzi, R Patitucci, G Orefice
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引用次数: 0
Immunochemical and structural characterization of an IgG1 heavy chain disease. IgG1重链病的免疫化学和结构特征。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01 DOI: 10.1007/BF02871793
P Sala, E Tonutti, S Pizzolitto, S Noda, F W Putnam, G De Lange, C Boccazzi, A Bottaro, A O Carbonara

The immunochemical and structural analysis of an IgG1 heavy chain disease is reported. The abnormal component is characterized by extensive deletion including the CH1 domain and most or all of the VH region.

报道了一种IgG1重链病的免疫化学和结构分析。异常成分的特征是广泛的缺失，包括CH1结构域和大部分或全部VH区域。
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引用次数: 1
[Correlation between hemorheological and blood gas analytical indices in hypoxic-hypercapnic respiratory insufficiency]. [低氧-高碳酸血症性呼吸功能不全血液流变学和血气分析指标的相关性]。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01
F Porro, G Figini, L Curti, M Fanelli
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引用次数: 0
[Correlation between hemorheological and blood coagulation parameters in patients with arteriosclerosis of supraaortic vessels and/or recent cerebral ischemic attacks]. [主动脉上血管硬化和/或近期脑缺血发作患者血液流变学和凝血参数的相关性]
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01
G Avellone, V Di Garbo, R Cordova, G Alletto, G Abruzzese, A Strano
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引用次数: 0
[Determination of serum angiotensin II in proliferative diabetic retinopathy]. [增生性糖尿病视网膜病变血清血管紧张素II的测定]。
La Ricerca in clinica e in laboratorio
Pub Date : 1989-01-01
S Volanti, R Puglioli, F Rubbi, P Tabacchi, L Pensabeni, A M Martelli, R Caramazza
{"title":"[Determination of serum angiotensin II in proliferative diabetic retinopathy].","authors":"S Volanti,&nbsp;R Puglioli,&nbsp;F Rubbi,&nbsp;P Tabacchi,&nbsp;L Pensabeni,&nbsp;A M Martelli,&nbsp;R Caramazza","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"177-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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