首页 > 最新文献
paperpass

The Internet journal of mental health最新文献

英文 中文
Awareness Of Risk Factors And Aspects of Breast Cancer Among North Indian Women 北印度妇女对乳腺癌危险因素和各方面的认识
Pub Date : 2008-12-31 DOI: 10.5580/11d4
S. Puri, C. Mangat, V. Bhatia, M. Kalia, A. Sehgal, A. Kaur
Objectives: To determine the knowledge of women about breast cancer and its risk factors. Study design: Community based descriptive cross sectional analysis. Setting: Field practice and adjoining areas of urban health training center of Department of community medicine, Government medical college and hospital, Chandigarh. Study subjects: Women more than 30 yrs of age of Chandigarh, North India. Main outcome measures: Women's demographics, knowledge about breast cancer, risk factors, treatment, detection and preventive modalities. Results: All the respondents had heard of breast cancer. Awareness about breast mass/lump to be cardinal symptom of breast cancer was known to 47.2% (463) of respondents. The two main causes of breast cancer according to respondents were late initiation of breast feeding (150, 15.3%) or not practicing breast feeding (166, 16.9%).Late marriage being a risk factor was known only to 55(5.9%) respondents and relation of obesity with breast cancer was known to only 89(9.1%) subjects. The main preventive modality, breast self exam was known by only (324, 33%) subjects. Of those who knew about breast self examination correct methodology was known only to 1/4th of respondents (255, 25.9%).Conclusions: Women do have knowledge deficits about breast cancer and various factors related to it.
目的:了解妇女对乳腺癌及其危险因素的认知情况。研究设计:基于社区的描述性横断面分析。地点:昌迪加尔政府医学院和医院社区医学系城市卫生培训中心的实习和毗邻地区。研究对象:印度北部昌迪加尔30岁以上的女性。主要结果衡量指标:妇女人口统计、乳腺癌知识、风险因素、治疗、检测和预防方式。结果:所有受访者都听说过乳腺癌。47.2%(463)的受访者知道乳房肿块/肿块是乳腺癌的主要症状。据应答者称,乳腺癌的两个主要原因是开始母乳喂养较晚(150,15.3%)或不进行母乳喂养(166,16.9%)。只有55人(5.9%)知道晚婚是一个危险因素,只有89人(9.1%)知道肥胖与乳腺癌的关系。只有324,33 %的受试者知道主要的预防方式是乳房自我检查。在了解乳房自我检查正确方法的受访者中,只有1/4的人(255人,25.9%)知道正确方法。结论:女性对乳腺癌及其相关因素的认识存在缺陷。
{"title":"Awareness Of Risk Factors And Aspects of Breast Cancer Among North Indian Women","authors":"S. Puri, C. Mangat, V. Bhatia, M. Kalia, A. Sehgal, A. Kaur","doi":"10.5580/11d4","DOIUrl":"https://doi.org/10.5580/11d4","url":null,"abstract":"Objectives: To determine the knowledge of women about breast cancer and its risk factors. Study design: Community based descriptive cross sectional analysis. Setting: Field practice and adjoining areas of urban health training center of Department of community medicine, Government medical college and hospital, Chandigarh. Study subjects: Women more than 30 yrs of age of Chandigarh, North India. Main outcome measures: Women's demographics, knowledge about breast cancer, risk factors, treatment, detection and preventive modalities. Results: All the respondents had heard of breast cancer. Awareness about breast mass/lump to be cardinal symptom of breast cancer was known to 47.2% (463) of respondents. The two main causes of breast cancer according to respondents were late initiation of breast feeding (150, 15.3%) or not practicing breast feeding (166, 16.9%).Late marriage being a risk factor was known only to 55(5.9%) respondents and relation of obesity with breast cancer was known to only 89(9.1%) subjects. The main preventive modality, breast self exam was known by only (324, 33%) subjects. Of those who knew about breast self examination correct methodology was known only to 1/4th of respondents (255, 25.9%).Conclusions: Women do have knowledge deficits about breast cancer and various factors related to it.","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83745614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Health Care Access For Migrant Farmworkers: A Paradigm For Better Health 农民工获得医疗保健:改善健康的典范
Pub Date : 2008-12-31 DOI: 10.5580/cd5
P. Clark, L. Surry, K. Contino
It is estimated that 9.3 million undocumented individuals are currently living in the United States. More than 15% of the United States' Gross Domestic Product (GDP) is spent in health care each year, more than any other developed nation worldwide; however, the benefits of the health care system are not uniformly felt by everyone living within our borders as more than 47 million Americans have no health care insurance coverage. For this reason, many utilize the emergency room for all of their health needs. Only 1 in 5 farm workers is able to obtain health insurance through either their employer or through the state or federal governments. The lack of health insurance makes it increasingly difficult for the uninsured and undocumented populations to obtain health care, as more than two-thirds of this population is living in poverty. To assist in delivering health care to these individuals and to help ensure necessary public health measures, the paradigm of a “Health Promoter” is being put forth to serve as a potential solution to cost-effective managed health care. The Health Promoter paradigm brings a third world concept to the first world. It is hoped that this paradigm can serve other hospitals and health care facilities to bring medical attention to other undocumented populations nationwide.
据估计,目前有930万非法移民居住在美国。美国每年超过15%的国内生产总值(GDP)用于医疗保健,比世界上任何其他发达国家都要多;然而,并不是每个居住在我们境内的人都能享受到医疗保健系统的好处,因为超过4700万美国人没有医疗保险。出于这个原因,许多人利用急诊室来满足他们所有的健康需求。只有五分之一的农场工人能够通过雇主或州或联邦政府获得医疗保险。由于缺乏医疗保险,无保险和无证件人口越来越难以获得医疗保健,因为这些人口中有三分之二以上生活在贫困之中。为了协助向这些人提供保健并帮助确保必要的公共卫生措施,正在提出"健康促进者"的范例,作为具有成本效益的管理保健的潜在解决方案。健康促进者范例将第三世界的概念引入第一世界。希望这一范例可以为其他医院和卫生保健机构提供服务,使全国其他无证人口得到医疗关注。
{"title":"Health Care Access For Migrant Farmworkers: A Paradigm For Better Health","authors":"P. Clark, L. Surry, K. Contino","doi":"10.5580/cd5","DOIUrl":"https://doi.org/10.5580/cd5","url":null,"abstract":"It is estimated that 9.3 million undocumented individuals are currently living in the United States. More than 15% of the United States' Gross Domestic Product (GDP) is spent in health care each year, more than any other developed nation worldwide; however, the benefits of the health care system are not uniformly felt by everyone living within our borders as more than 47 million Americans have no health care insurance coverage. For this reason, many utilize the emergency room for all of their health needs. Only 1 in 5 farm workers is able to obtain health insurance through either their employer or through the state or federal governments. The lack of health insurance makes it increasingly difficult for the uninsured and undocumented populations to obtain health care, as more than two-thirds of this population is living in poverty. To assist in delivering health care to these individuals and to help ensure necessary public health measures, the paradigm of a “Health Promoter” is being put forth to serve as a potential solution to cost-effective managed health care. The Health Promoter paradigm brings a third world concept to the first world. It is hoped that this paradigm can serve other hospitals and health care facilities to bring medical attention to other undocumented populations nationwide.","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90084811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Determinants Of The Utilization Of The Tetanus Toxoid (TT) Vaccination Coverage In Bangladesh: Evidence From A Bangladesh Demographic Health Survey 2004 孟加拉国破伤风类毒素疫苗接种覆盖率的决定因素:2004年孟加拉国人口健康调查的证据
Pub Date : 2008-12-31 DOI: 10.5580/f60
M. M. Rahman
Objectives: This paper employs statistical methods to determine the complete vaccination rate and to identify the factors that influence vaccination of mothers during pregnancy. The principal objective of this paper is to suggest various policy options on the basis of study findings in order to provide guidelines to fulfill the complete vaccination coverage in Bangladesh. Methods: This study analyzes data extracted from Bangladesh Demographic and Health Survey 2004 (BDHS) considering only the case of the mothers of last five years preceding the survey. To meets the objectives this study considers bivariate and multivariate analysis Results: The analysis showed that, although maximum respondents received two or more doses of TT injection a significant portion of women did not receive the TT injection yet (18.6 percent). The immunization coverage of two/more doses was higher among mothers whose husbands are highly educated and non-manual workers. This study elucidates that the rate of immunizing increases with the increase of mother's education. Receiving two/more doses of TT injection shows highest prevalence (58.3 percent) among mothers whose mobility status is unrestricted. The logistic analysis showed that receiving two or more doses of TT injection is almost 3 times higher among respondents using modern toilet facility. The model also shows that higher proportion of respondents belonging to upper category regarding household asset and quality index received two/more doses TT injection than their congruent parts. The other contributing factors for tetanus toxoid vaccination coverage were found to be mother's age at last birth, told about pregnancy complications, place of residences, mother's earning status, sources of drinking water. Conclusion: The results indicate several policy options: (1) improve the monitoring and supervision of vaccination activities especially in the rural area (2) mass media campaign to create awareness among both urban and rural women, their husbands and families about the importance of TT vaccination and the consequences of not being vaccinated (3) education for husband's and wife needs to be given very high priority (4)enable women to exercise their rights to control their concerning freedom of movement, own health acre and access to economic resources
目的:采用统计学方法确定全接种率,并找出影响孕期母亲接种率的因素。本文的主要目的是在研究结果的基础上提出各种政策选择,以便为实现孟加拉国疫苗接种的完全覆盖提供指导。方法:本研究分析了2004年孟加拉国人口与健康调查(BDHS)中提取的数据,仅考虑了调查前5年的母亲的情况。为了达到目的,本研究考虑了双变量和多变量分析结果:分析表明,尽管最大应答者接受了两次或更多剂量的TT注射,但很大一部分妇女尚未接受TT注射(18.6%)。在丈夫受过高等教育和从事非体力劳动的母亲中,两剂以上的免疫接种率较高。本研究说明免疫接种率随母亲受教育程度的增加而增加。在行动能力不受限制的母亲中,接受两次或更多剂量TT注射的流行率最高(58.3%)。逻辑分析显示,在使用现代化厕所设施的应答者中,接受两剂或两剂以上TT注射的比例几乎高出3倍。该模型还显示,在家庭资产和质量指数方面属于较高类别的受访者中,接受两次/更多剂量TT注射的比例高于其相同部分。其他影响破伤风类毒素疫苗接种率的因素包括母亲的最后一次分娩年龄、妊娠并发症情况、居住地、母亲的收入状况、饮用水来源。结论:结果提示了几种政策选择:(1)加强对疫苗接种活动的监测和监督,特别是在农村地区;(2)开展大众媒体运动,使城乡妇女、她们的丈夫和家庭认识到破伤风疫苗接种的重要性和未接种疫苗的后果;(3)必须高度重视对夫妻的教育;(4)使妇女能够行使其权利,控制其有关的行动自由、拥有健康土地和获得经济资源的机会
{"title":"Determinants Of The Utilization Of The Tetanus Toxoid (TT) Vaccination Coverage In Bangladesh: Evidence From A Bangladesh Demographic Health Survey 2004","authors":"M. M. Rahman","doi":"10.5580/f60","DOIUrl":"https://doi.org/10.5580/f60","url":null,"abstract":"Objectives: This paper employs statistical methods to determine the complete vaccination rate and to identify the factors that influence vaccination of mothers during pregnancy. The principal objective of this paper is to suggest various policy options on the basis of study findings in order to provide guidelines to fulfill the complete vaccination coverage in Bangladesh. Methods: This study analyzes data extracted from Bangladesh Demographic and Health Survey 2004 (BDHS) considering only the case of the mothers of last five years preceding the survey. To meets the objectives this study considers bivariate and multivariate analysis Results: The analysis showed that, although maximum respondents received two or more doses of TT injection a significant portion of women did not receive the TT injection yet (18.6 percent). The immunization coverage of two/more doses was higher among mothers whose husbands are highly educated and non-manual workers. This study elucidates that the rate of immunizing increases with the increase of mother's education. Receiving two/more doses of TT injection shows highest prevalence (58.3 percent) among mothers whose mobility status is unrestricted. The logistic analysis showed that receiving two or more doses of TT injection is almost 3 times higher among respondents using modern toilet facility. The model also shows that higher proportion of respondents belonging to upper category regarding household asset and quality index received two/more doses TT injection than their congruent parts. The other contributing factors for tetanus toxoid vaccination coverage were found to be mother's age at last birth, told about pregnancy complications, place of residences, mother's earning status, sources of drinking water. Conclusion: The results indicate several policy options: (1) improve the monitoring and supervision of vaccination activities especially in the rural area (2) mass media campaign to create awareness among both urban and rural women, their husbands and families about the importance of TT vaccination and the consequences of not being vaccinated (3) education for husband's and wife needs to be given very high priority (4)enable women to exercise their rights to control their concerning freedom of movement, own health acre and access to economic resources","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81951451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Maternal Mortality - A Legal Case Study 产妇死亡率——一个法律案例研究
Pub Date : 2008-12-31 DOI: 10.5580/46a
Tharwat Mohammed Halwani
These study legal case discuss a case of Maternal Mortality presented for litigation demonstrating the obstacles and shortcomings of instruments of justices and social constitutions to guarantee patient rights and safety. INTRODUCTION The Tenth of the International Classification of Diseases (ICD-10) defines a maternal death as the death of a woman pregnant or within 42 days of termination of pregnancy, irrespective of the duration and site of the pregnancy, from any cause related to or aggravated by the pregnancy or its management but not from accidental or incidental causes (1). Maternal Mortality during childbirth is one of the most concerned attention of health authority in the world because it is linked with economic situation of the mother health care standard in the society and the accessibility of the mother to proper health authority during pregnancy and birth. The mother who die during pregnancy is a healthy mother and her death is very tragic because it changes an occasion which is supposed to be a happy one into a tragic occasion affecting the child and the mother in one hand and the family member in the other because the family will be disrupted , the young child or children left by the mother would suffer from malnutrition, sickness and death. The father would lead unsettled life (2). Medical authorities classify the causes of maternal death according to the following classification: Direct causes: about (80%)
这些研究法律案例讨论了一个提出诉讼的孕产妇死亡率案例,表明了司法和社会宪法在保障患者权利和安全方面的障碍和缺陷。《国际疾病分类》(ICD-10)将产妇死亡定义为怀孕妇女或终止妊娠后42天内的死亡,无论怀孕的持续时间和地点如何。(1)分娩期间的产妇死亡率是世界卫生当局最关注的问题之一,因为它与社会的经济状况、母亲保健标准以及母亲在怀孕和分娩期间获得适当卫生当局的机会有关。在怀孕期间死亡的母亲是一个健康的母亲,她的死亡是非常悲惨的,因为它把一个应该是幸福的场合变成了一个悲惨的场合,一方面影响到孩子和母亲,另一方面影响到家庭成员,因为家庭将被破坏,母亲留下的年幼的孩子或孩子将遭受营养不良、疾病和死亡。父亲将过着不稳定的生活(2)。医疗当局根据以下分类对产妇死亡的原因进行分类:直接原因:约(80%)
{"title":"Maternal Mortality - A Legal Case Study","authors":"Tharwat Mohammed Halwani","doi":"10.5580/46a","DOIUrl":"https://doi.org/10.5580/46a","url":null,"abstract":"These study legal case discuss a case of Maternal Mortality presented for litigation demonstrating the obstacles and shortcomings of instruments of justices and social constitutions to guarantee patient rights and safety. INTRODUCTION The Tenth of the International Classification of Diseases (ICD-10) defines a maternal death as the death of a woman pregnant or within 42 days of termination of pregnancy, irrespective of the duration and site of the pregnancy, from any cause related to or aggravated by the pregnancy or its management but not from accidental or incidental causes (1). Maternal Mortality during childbirth is one of the most concerned attention of health authority in the world because it is linked with economic situation of the mother health care standard in the society and the accessibility of the mother to proper health authority during pregnancy and birth. The mother who die during pregnancy is a healthy mother and her death is very tragic because it changes an occasion which is supposed to be a happy one into a tragic occasion affecting the child and the mother in one hand and the family member in the other because the family will be disrupted , the young child or children left by the mother would suffer from malnutrition, sickness and death. The father would lead unsettled life (2). Medical authorities classify the causes of maternal death according to the following classification: Direct causes: about (80%)","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74975266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, Perception and Behaviour of Nigerian Youths on HIV/AIDS 尼日利亚青年对艾滋病毒/艾滋病的认识、认知和行为
Pub Date : 2008-12-31 DOI: 10.5580/1995
C. Durojaiye
Background: The pandemic of HIV remains on the increase with young people at increased risk of infection. This study assesses the knowledge of HIV/AIDS, perception and practices of youths in Lagos, Nigeria. Method: Descriptive cross-sectional survey conducted between May and June 2008 using structured pre-tested questionnaires among 315 randomly selected students enrolled at a tertiary institution in Lagos, Nigeria. Results: The knowledge of some aspects of the disease was quite high in the study group. The overall mean score to a ten HIV/AIDS knowledge questions was 8.3 of 10 points. 73.5% did not perceive themselves at risk of infection and 70.3% have multiple lifetime sexual partners. Those who perceived themselves at risk are significantly (p=0.019) more likely to always use condoms. Conclusion: The low risk-perception has hindered commitment to behaviour change. Strategies that focus on influencing risk-perception are recommended to prevent further transmission of the virus in young people. Institution where study is done: Yaba College of Technology, Lagos, Nigeria
背景:艾滋病毒的流行仍在增加,年轻人感染的风险增加。本研究评估了尼日利亚拉各斯青年对艾滋病毒/艾滋病的认识、认知和实践。方法:2008年5月至6月,在尼日利亚拉各斯一所高等院校随机抽取315名学生,采用结构化预测试问卷进行描述性横断面调查。结果:研究组对本病某些方面的了解程度较高。10个艾滋病知识问题的总体平均得分为8.3分(满分10分)。73.5%的人认为自己没有感染的风险,70.3%的人终生有多个性伴侣。那些认为自己有风险的人(p=0.019)更有可能一直使用避孕套。结论:低风险认知阻碍了行为改变的承诺。建议采取侧重于影响风险认知的战略,以防止病毒在年轻人中进一步传播。完成研究的机构:尼日利亚拉各斯的Yaba技术学院
{"title":"Knowledge, Perception and Behaviour of Nigerian Youths on HIV/AIDS","authors":"C. Durojaiye","doi":"10.5580/1995","DOIUrl":"https://doi.org/10.5580/1995","url":null,"abstract":"Background: The pandemic of HIV remains on the increase with young people at increased risk of infection. This study assesses the knowledge of HIV/AIDS, perception and practices of youths in Lagos, Nigeria. Method: Descriptive cross-sectional survey conducted between May and June 2008 using structured pre-tested questionnaires among 315 randomly selected students enrolled at a tertiary institution in Lagos, Nigeria. Results: The knowledge of some aspects of the disease was quite high in the study group. The overall mean score to a ten HIV/AIDS knowledge questions was 8.3 of 10 points. 73.5% did not perceive themselves at risk of infection and 70.3% have multiple lifetime sexual partners. Those who perceived themselves at risk are significantly (p=0.019) more likely to always use condoms. Conclusion: The low risk-perception has hindered commitment to behaviour change. Strategies that focus on influencing risk-perception are recommended to prevent further transmission of the virus in young people. Institution where study is done: Yaba College of Technology, Lagos, Nigeria","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75990775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Chitosan A Marine Medical Polymer And Its Lipid Lowering Capacity 壳聚糖一种海洋医用聚合物及其降脂能力
Pub Date : 2008-12-31 DOI: 10.5580/1045
B. Prajapati
The present report is the collection of information on chitosan; a natural biodegradable copolymer; which is extensively researched the improvement of drug delivery like topical, ocular, implantation and injection (micro and Nanoparticles). However there are many other areas where chitosan is widely used like industrial work, nutrient supply and health care. The present review is focused on its fat binding and lipid lowering capacity as a nutrient or health care product.
本报告是对壳聚糖的资料收集;一种天然的可生物降解共聚物;广泛研究改善药物传递,如局部,眼,植入和注射(微粒子和纳米粒子)。然而,壳聚糖在其他许多领域也有广泛的应用,如工业工作、营养供应和保健。本文综述了其作为一种营养或保健产品的脂肪结合和降脂能力。
{"title":"Chitosan A Marine Medical Polymer And Its Lipid Lowering Capacity","authors":"B. Prajapati","doi":"10.5580/1045","DOIUrl":"https://doi.org/10.5580/1045","url":null,"abstract":"The present report is the collection of information on chitosan; a natural biodegradable copolymer; which is extensively researched the improvement of drug delivery like topical, ocular, implantation and injection (micro and Nanoparticles). However there are many other areas where chitosan is widely used like industrial work, nutrient supply and health care. The present review is focused on its fat binding and lipid lowering capacity as a nutrient or health care product.","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90566696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Milestones In Development Of Good Clinical Practice 良好临床实践发展的里程碑
Pub Date : 2008-12-31 DOI: 10.5580/2193
S. Abraham, Della Grace, Thomas Parambi, S.a Pahuja
Good Clinical Practice (GCP) is a standard for design, conduct, performance, monitoring, auditing, recording, analysis and reporting of clinical trials that provides assurance that the data and reported results are credible and accurate, and that the rights, integrity and confidentiality of trial subjects are protected. The present day guidelines on GCP have evolved through a series of regulations and policy formulations. This is increasingly considered as an essential part of drug regulation. These guidelines have been evolved with consideration of WHO, ICH, USFDA and European GCP guidelines as well as the Ethical guidelines for Biomedical Research on Human Subjects issued by the Indian Council of Medical Research. They should be followed for carrying out all biomedical research in India at all stages of drug development, whether prior or subsequent to product registration in India. This article describes the major milestones in the evolution of Good Clinical Practices. Good clinical practice (GCP) is an international ethical scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects. It also ensures that the rights, welfare and safety of subjects involved in trials are maintained and are consistent with the principles stated in the World Medical Association Declaration of Helsinki, entitled ‘ethical principles for medical research involving human subjects1. ‘Guideline CPMP/ICH/135/95 entitled good clinical practice’ was developed under the subject of International Conference on the Harmonisation of the technical requirements for the registration of human pharmaceuticals (ICH process) and is applicable in the European union of the United States and Japan. Clinical trial data that have developed according to the guideline should therefore be acceptable by regulatory authorities in each of the three regions, together with Australia, Canada, Nordic countries and the World Health Organisation which was also involved in its development2. The definition of GCP given in the guideline is ‘a standard for the design, conduct, performance monitoring, auditing, recording, analysing and reporting of clinical trials that provides assurance that the data and reported results are credible and accurate, and that the rights, integrity and confidentiality of trial subjects are protected.’ The present day guideline on GCP has evolved through a series of regulation and policy formulations. The major milestones in the evolution of GCP are as follows. 1. FEDERAL FOOD AND DRUGS ACT OF 1906 The purpose of the FDA is to prohibit adulterated/ misbranded food or drugs from interstate commerce. The act is originally enacted in 1906 brought “truth in labelling”. This act was emerged in consequences of a most dramatic report of Sinclair’s book, the Jungle, which graphically illustrated problems in the nation’s meat processing industry. Samuel Haukin’s, Adams magazine article concerning what he called
公众对磺胺灾难的愤怒最终导致了对安全的立法要求,因为如果违反常识或制造商的利益使用,所有药物都在一定程度上有害,安全意味着按照标签上列出的条件使用无毒。标签这个词是一个艺术术语。它的意思是“在任何物品的直接容器上展示书面、印刷或图形材料”。法律要求,如果某些信息被要求在药品标签上,这些信息也必须在外部或内部标签上,通过这种外包装清晰可见。例如,法律可以要求某些信息作为药品标签(包装说明书)的一部分随附,而不要求信息出现在药品标签上。这个新的标签,除了要求安全证明,扩大了掺假和错误标签的含义,以前是由法律严格执行的。现在要求标签向消费者提供充分的使用说明。4. 1951年DURHAM - HUMPHREY修正案免除了某些药物的标签必须包含足够的使用说明的要求。该法案经过修订,正式区分了处方药和非处方药。在那之前,所有的药品都可以由消费者在柜台上购买。处方药必须附有警告语,说明只有在卫生专业人员的授权下才能合法配药。5. 纽伦堡法典1946年纽伦堡法典包括十项原则,以指导医师调查员在涉及人体受试者的实验。这些原则,特别是关于自愿同意的第一原则,主要是以法律概念为基础的,因为在纳粹暴行发生时存在的医学道德守则没有涉及同意和对人类受试者的其他保障。二战期间和后来的冷战期间,美国也曾出现过保护士兵和平民免受战时状况破坏的“社会必要性”,纳粹医生提出这种必要性,作为进行实验以立即找到解决新闻问题的答案的理由,但他们没有为进行研究的残酷方式提供任何理由。确定进行人体研究的基本原则的必要性侧重于病人保护,对病人受试者和健康的人(无论是囚犯还是志愿者)进行的研究不作区分。在德国,纽伦堡法典被视为医学研究的准则。其中的许多原则至今仍然有效。这就是知情同意的必要性,病人可以在任何时候退出实验的规则,以及禁止以任何方式可能导致实验对象重大伤害或死亡的实验。纽伦堡十项原则现在很少应用了。这主要是由于他们没有区分治疗性实验和纯科学实验,而且世界医学协会修订的《赫尔辛基宣言》对这些实验进行了修订。1962年的灾难1962年,沙利度胺,一种在国外开发并广泛使用的安眠药,正在美国研究使用。辛辛那提的William S Merrell公司在使用这种药物进行调查时,发现孕妇在怀孕的前三个月服用这种药物会对胎儿造成伤害。这些母亲所生的孩子通常没有手臂或其他严重的畸形。很明显,人们在服药,但开处方的人和药品制造商都不清楚药物的效果。良好临床实践发展的里程碑3 / 5在这种情况下1951年的Durham Humfrey修正案根本不足以保护公众。这一系列的法律诉讼表明,大型开处方者依赖生产商提供有关药品的信息,而在某些情况下,这些信息是基于不充分的测试。这就产生了1962年的凯弗弗-哈里斯修正案,该修正案解决了药物的有效性和安全性问题。7. 1962年KEFAUVER - HARRIS修正案这些修正案通常被称为药物功效修正案。它们规定了制造商的注册和对生产场所的检查,并要求制造商承担前所未有的责任。在上市之前,任何新药制造商都必须提供有效性和安全性的证明。建立了良好的生产规范,即所谓的GMP,如果制造商不遵守这些规范生产药物,则该药物被认为是掺假的。
{"title":"Milestones In Development Of Good Clinical Practice","authors":"S. Abraham, Della Grace, Thomas Parambi, S.a Pahuja","doi":"10.5580/2193","DOIUrl":"https://doi.org/10.5580/2193","url":null,"abstract":"Good Clinical Practice (GCP) is a standard for design, conduct, performance, monitoring, auditing, recording, analysis and reporting of clinical trials that provides assurance that the data and reported results are credible and accurate, and that the rights, integrity and confidentiality of trial subjects are protected. The present day guidelines on GCP have evolved through a series of regulations and policy formulations. This is increasingly considered as an essential part of drug regulation. These guidelines have been evolved with consideration of WHO, ICH, USFDA and European GCP guidelines as well as the Ethical guidelines for Biomedical Research on Human Subjects issued by the Indian Council of Medical Research. They should be followed for carrying out all biomedical research in India at all stages of drug development, whether prior or subsequent to product registration in India. This article describes the major milestones in the evolution of Good Clinical Practices. Good clinical practice (GCP) is an international ethical scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects. It also ensures that the rights, welfare and safety of subjects involved in trials are maintained and are consistent with the principles stated in the World Medical Association Declaration of Helsinki, entitled ‘ethical principles for medical research involving human subjects1. ‘Guideline CPMP/ICH/135/95 entitled good clinical practice’ was developed under the subject of International Conference on the Harmonisation of the technical requirements for the registration of human pharmaceuticals (ICH process) and is applicable in the European union of the United States and Japan. Clinical trial data that have developed according to the guideline should therefore be acceptable by regulatory authorities in each of the three regions, together with Australia, Canada, Nordic countries and the World Health Organisation which was also involved in its development2. The definition of GCP given in the guideline is ‘a standard for the design, conduct, performance monitoring, auditing, recording, analysing and reporting of clinical trials that provides assurance that the data and reported results are credible and accurate, and that the rights, integrity and confidentiality of trial subjects are protected.’ The present day guideline on GCP has evolved through a series of regulation and policy formulations. The major milestones in the evolution of GCP are as follows. 1. FEDERAL FOOD AND DRUGS ACT OF 1906 The purpose of the FDA is to prohibit adulterated/ misbranded food or drugs from interstate commerce. The act is originally enacted in 1906 brought “truth in labelling”. This act was emerged in consequences of a most dramatic report of Sinclair’s book, the Jungle, which graphically illustrated problems in the nation’s meat processing industry. Samuel Haukin’s, Adams magazine article concerning what he called ","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82348134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effects Of Demographic And Household Variables On Infant And Child Under-five Mortality: An Application Of Logistic Model 人口和家庭变量对婴儿和五岁以下儿童死亡率的影响:Logistic模型的应用
Pub Date : 2008-12-31 DOI: 10.5580/2395
M. Hossain, M. Islam
Infant and child are the assets of a country. Women are at the heart of development because they bear children and they are nearly half of the total population. Infant and child mortality is powerful indicators to assess overall health situation of a country. Demographic and household factors have strong influence on infant and child mortality. So, the aim of this study is to identify the effects of demographic and household variables on infant, child and under-five mortality of Charghat Thana in Rajshahi District, Bangladesh. For this, a number of 800 rural women have been interviewed through a structured questionnaire by purposive sampling technique. In this study, logistic regression model is employed to determine which factors effect on infant, child and under-five mortality. In this analysis, it is indicated that age at marriage, birth order, birth interval, household conditions, source of drinking water and breastfeeding practices have significant effects on infant, child and under-five mortality.
婴儿和儿童是国家的财富。妇女处于发展的核心,因为她们生育孩子,她们占总人口的近一半。婴儿和儿童死亡率是评估一个国家总体健康状况的有力指标。人口和家庭因素对婴儿和儿童死亡率有很大影响。因此,本研究的目的是确定人口统计和家庭变量对孟加拉国拉杰沙希区查格特塔那的婴儿、儿童和五岁以下儿童死亡率的影响。为此,采用有目的抽样技术,通过结构化问卷对800名农村妇女进行了访谈。本研究采用logistic回归模型确定影响婴儿、儿童和五岁以下儿童死亡率的因素。这项分析表明,结婚年龄、出生顺序、生育间隔、家庭条件、饮用水来源和母乳喂养做法对婴儿、儿童和五岁以下儿童的死亡率有重大影响。
{"title":"Effects Of Demographic And Household Variables On Infant And Child Under-five Mortality: An Application Of Logistic Model","authors":"M. Hossain, M. Islam","doi":"10.5580/2395","DOIUrl":"https://doi.org/10.5580/2395","url":null,"abstract":"Infant and child are the assets of a country. Women are at the heart of development because they bear children and they are nearly half of the total population. Infant and child mortality is powerful indicators to assess overall health situation of a country. Demographic and household factors have strong influence on infant and child mortality. So, the aim of this study is to identify the effects of demographic and household variables on infant, child and under-five mortality of Charghat Thana in Rajshahi District, Bangladesh. For this, a number of 800 rural women have been interviewed through a structured questionnaire by purposive sampling technique. In this study, logistic regression model is employed to determine which factors effect on infant, child and under-five mortality. In this analysis, it is indicated that age at marriage, birth order, birth interval, household conditions, source of drinking water and breastfeeding practices have significant effects on infant, child and under-five mortality.","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89348818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Levels And Patterns Of Child Mortality: Application Of Indirect Techniques 儿童死亡率的水平和模式:间接技术的应用
Pub Date : 2008-12-31 DOI: 10.5580/d0d
Q. Chowdhury, R. Islam, K. Hossain
The child mortality has been recognized as an excellent summary index of the standard of living and socio-economic development as well as community health system of a country. And it has been considered as a frantic topic to population research in Bangladesh. The purpose of this study is to estimate the general levels and patterns of child mortality in Natore Sadar upazila. The results show the probabilities of dying (nq0) by Brass, Trussel and Sullivan indicate that are higher for early age group of mother then decline in middle age group and again start to increase with the age of mother increases. The result implies upward patterns of male child mortality over female child but male child mortality patterns for Trussel technique stretch out upward to the patterns of other two techniques. The estimated probability of dying in case of duration of marriage, the male child mortality is higher over female child mortality of all marriage duration groups and the shorter as well as the longer duration, the probability of dying both for male and female are always shown upward patterns. In the study it can be observed baby born to mother below aged 19 years as well as above aged 35 or to mother whose duration of marriage year is less than 4 years as well as greater than 20 years has highest mortality risk.
儿童死亡率被认为是一个国家生活水平和社会经济发展以及社区卫生系统的一个极好的综合指标。它一直被认为是孟加拉国人口研究的一个疯狂话题。本研究的目的是估计纳托雷·萨达尔·乌帕齐拉儿童死亡率的一般水平和模式。Brass, Trussel和Sullivan的研究结果表明,母亲的死亡概率(nq0)在母亲的早期年龄组较高,在中年组下降,随着母亲年龄的增加又开始增加。结果表明,男婴死亡率高于女婴,但Trussel技术的男婴死亡率向上延伸到其他两种技术的模式。就婚姻持续时间而言,所有婚姻持续时间组的估计死亡概率中,男童死亡率高于女童死亡率,而且婚姻持续时间越短和越长,男童和女童的死亡概率总是呈上升趋势。研究发现,年龄在19岁以下和35岁以上的母亲所生的婴儿,以及结婚时间在4年以下和20年以上的母亲所生的婴儿,死亡风险最高。
{"title":"Levels And Patterns Of Child Mortality: Application Of Indirect Techniques","authors":"Q. Chowdhury, R. Islam, K. Hossain","doi":"10.5580/d0d","DOIUrl":"https://doi.org/10.5580/d0d","url":null,"abstract":"The child mortality has been recognized as an excellent summary index of the standard of living and socio-economic development as well as community health system of a country. And it has been considered as a frantic topic to population research in Bangladesh. The purpose of this study is to estimate the general levels and patterns of child mortality in Natore Sadar upazila. The results show the probabilities of dying (nq0) by Brass, Trussel and Sullivan indicate that are higher for early age group of mother then decline in middle age group and again start to increase with the age of mother increases. The result implies upward patterns of male child mortality over female child but male child mortality patterns for Trussel technique stretch out upward to the patterns of other two techniques. The estimated probability of dying in case of duration of marriage, the male child mortality is higher over female child mortality of all marriage duration groups and the shorter as well as the longer duration, the probability of dying both for male and female are always shown upward patterns. In the study it can be observed baby born to mother below aged 19 years as well as above aged 35 or to mother whose duration of marriage year is less than 4 years as well as greater than 20 years has highest mortality risk.","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83338504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Maternal Risk Factors Of Low Birth Weight In Chandigarh India 印度昌迪加尔低出生体重产妇危险因素
Pub Date : 2008-12-31 DOI: 10.5580/10f1
M. Sharma, Dinesh Kumar, A. Huria, Pratiksha Gupta
Objectives: To investigate risk factors of Low Birth Weight. Setting: Govt. Medical College and Hospital, Chandigarh. Participants: 193neonates delivered in the health facility. Statistical Analysis: Normal test of proportions. Results: The overall proportion of LBW was 23.8%. Proportion of LBW was comparatively higher among babies born to mothers who were below 20 years of age (50.0%), poorly educated (32.6%), belonging to family with income less than Rs. 2000 per capita, (28.9%), poorly nourished with pre-pregnancy weight less than 45 kg (50.0%), as compared to others. Primi mothers were comparatively at lower risk (18.4%) of delivering LBW babies as compared to multi-gravida mothers (29.5%). Low literacy level, low per capita income, birth order two and above and maternal age above 30 years were found to be significant risk factors of LBW. Conclusions: Population based interventions in terms of improving maternal education and socio-economic status irrespective of parity should be adopted for reducing the prevalence of LBW.
目的:探讨低出生体重的危险因素。地点:昌迪加尔政府医学院和医院。参与者:在保健设施分娩的193名新生儿。统计分析:比例正态检验。结果:LBW总比例为23.8%。与其他人相比,低体重婴儿的比例在以下人群中相对较高:20岁以下(50.0%)、受教育程度较低(32.6%)、属于人均收入低于2000卢比的家庭(28.9%)、营养不良且孕前体重低于45公斤(50.0%)。与多胎母亲(29.5%)相比,第一胎母亲分娩LBW婴儿的风险相对较低(18.4%)。识字率低、人均收入低、出生顺序2及以上、产妇年龄大于30岁是LBW的显著危险因素。结论:应采取以人口为基础的干预措施,提高产妇教育水平和社会经济地位,而不考虑性别平等,以降低低生育率。
{"title":"Maternal Risk Factors Of Low Birth Weight In Chandigarh India","authors":"M. Sharma, Dinesh Kumar, A. Huria, Pratiksha Gupta","doi":"10.5580/10f1","DOIUrl":"https://doi.org/10.5580/10f1","url":null,"abstract":"Objectives: To investigate risk factors of Low Birth Weight. Setting: Govt. Medical College and Hospital, Chandigarh. Participants: 193neonates delivered in the health facility. Statistical Analysis: Normal test of proportions. Results: The overall proportion of LBW was 23.8%. Proportion of LBW was comparatively higher among babies born to mothers who were below 20 years of age (50.0%), poorly educated (32.6%), belonging to family with income less than Rs. 2000 per capita, (28.9%), poorly nourished with pre-pregnancy weight less than 45 kg (50.0%), as compared to others. Primi mothers were comparatively at lower risk (18.4%) of delivering LBW babies as compared to multi-gravida mothers (29.5%). Low literacy level, low per capita income, birth order two and above and maternal age above 30 years were found to be significant risk factors of LBW. Conclusions: Population based interventions in terms of improving maternal education and socio-economic status irrespective of parity should be adopted for reducing the prevalence of LBW.","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74808996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
期刊
The Internet journal of mental health
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
mjeditor
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1