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New Pharmacological Therapeutic Approaches for Depressive Disorders: A Systematic Review 抑郁症的新药物治疗方法:系统综述
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.32
Taysa Leite de Aquino, Jaiany Rodrigues Libório, Ana Luiza Menezes Santana Bezerra, Giovana Macêdo Egídio Cavalcante, Dara Fern, A. Duarte, A. Martin, J. D. A. D. Paula, M. L. Neto
Introduction: Depression, being the most disabling disease in the world and presenting high morbidity and mortality, requires an effective treatment to ensure the maintenance of the patients' quality of life. About a third of patients do not respond adequately to antidepressant treatment. New pharmacological therapies are being approached in order to reduce the unfavourable outcomes resulting from this pathology. Objective: To develop a systematic review of the literature on the new possibilities of pharmacological treatments for depression in the last four years. Method: A systematic review was carried out following the PRISMA protocol (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). We have included studies on the effectiveness of new pharmacological therapies in patients with major depressive disorder and treatment-resistant depression. Results: In the treatment of the Major Depressive Disorder (MDD), the use of brexpiprazole 1 mg/day in addition to the usual Antidepressant Treatment (ADT) resulted in significant improvement in the main symptoms. Already referring to treatments for treatment-resistant depression (TRD): nasal esketamine proved beneficial in the short term, Intravenous (IV) ketamine also appears as an effective therapy. Conclusion: The use of brexpiprazole 1 mg/day associated with an antidepressant, and the use of lactobacilli represent a new option for those with MDD. In addition, ketamine, riluzole, and cariprazine appear as new hopes for those who have not yet achieved remission of the depressive disorder with the use of more than two antidepressants.
引言:抑郁症是世界上致残性最强的疾病,发病率和死亡率都很高,需要有效的治疗才能保证患者生活质量的维持。大约三分之一的患者对抗抑郁药物治疗没有充分的反应。为了减少这种病理导致的不良结果,新的药物治疗方法正在被采用。目的:对近四年来有关抑郁症药物治疗新可能性的文献进行系统综述。方法:按照PRISMA方案(系统评价和荟萃分析的首选报告项目)进行系统评价。我们纳入了关于新药物治疗在重度抑郁症和治疗难治性抑郁症患者中的有效性的研究。结果:在治疗重度抑郁障碍(MDD)时,在常规抗抑郁药治疗(ADT)基础上加用brexpiprazole 1 mg/d,可显著改善主要症状。已经提到治疗难治性抑郁症(TRD)的方法:鼻用氯胺酮证明在短期内有益,静脉注射氯胺酮似乎也是一种有效的治疗方法。结论:brexpiprazole 1mg /day联合抗抑郁药和乳酸菌治疗是MDD患者的新选择。此外,氯胺酮、利鲁唑和卡吡嗪似乎是那些使用两种以上抗抑郁药仍未达到抑郁症缓解的人的新希望。
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引用次数: 0
The Major Factors Associated with Increased Dog Population Vis-a-Vis Spread of Rabies within Srinagar District of Kashmir Valley, India 与印度克什米尔谷地斯利那加地区犬类数量增加相对狂犬病传播相关的主要因素
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.11
Namera Thahaby, Afzal Hoque Ak, A. Bhat, Salha Hamdani
Background: Information regarding open garbage dumps may cause public health dilemma within the community and cause stray dog proliferation. Most wastes have a family origin and stray dogs are largely attracted by these foods. Methods: The information, besides as attitudes and perception on rabies, is thus vital for the prevention of human deaths. Two sources i.e., primary and secondary sources were utilized for identifying the probable factors responsible for increased dog population. Results: Regarding the major factors associated with increases dog population, the respondents (both the people 99.68% and commercial 100%) believed that open garbage dumps are a public health barrier in the area and commence to stray dog proliferation. Conclusion: Open garbage dumps are a public health problem in the Srinagar area. Till date only around 2,000 sterilizations were conducted and also around 2,000 stray dogs were administered the anti-rabies vaccine, however this is too less in comparison with the total population of dogs and still, the ballot of dogs from the particular zones of Srinagar is deficient.
背景:有关露天垃圾场的信息可能会在社区内造成公共卫生困境,并导致流浪狗的繁殖。大多数废物都有家庭来源,流浪狗很大程度上被这些食物吸引。方法:这些信息除了对狂犬病的态度和认识外,对预防人类死亡至关重要。两个来源,即,主要和次要来源,用于确定可能的因素负责增加狗的数量。结果:对于导致犬类数量增加的主要因素,受访者(99.68%的人)和商家(100%)认为露天垃圾场是该地区的公共卫生障碍,并开始导致流浪狗的繁殖。结论:露天垃圾场是斯利那加地区的一个公共卫生问题。到目前为止,只进行了大约2000次绝育手术,大约2000只流浪狗接种了抗狂犬病疫苗,但与狗的总数相比,这太少了,而且来自斯利那加特定地区的狗的投票仍然不足。
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引用次数: 0
Parkinson's Disease: Signs, Affect and Management Factors 帕金森病:体征、影响和管理因素
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.45
Dogan Zeytun
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引用次数: 0
Long-Term Outcomes in Women and Men Population Participating In Program of Managed Care after Acute MyocardialInfarction (MC-AMI): A 12-Months Follow-Up from a Single Cardiology Care Centre 急性心肌梗死(MC-AMI)后参与管理护理项目的女性和男性人群的长期结局:来自单一心脏病学护理中心的12个月随访
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.08
K. Wilkosz, K. Wita, M. Wybraniec, M. Wita, Joanna Fluder, Monika Malta, Jarosław Chmurawa, Andrzej Kubicjus
Background: The number of studies confirming the importance of Cardiac Rehabilitation (CR) towards the reduction of mortality and morbidity has increased. On the basis of scientific evidence, we developed a care program in Poland for patients with myocardial infarction I (MC-AMI (in Polish KOS-zawal). There is a lack of data on possible improvement in long-term prognosis among women after acute myocardial infarctions (AMI), who were also involved with CR. Aim: The aim of the study is to compare the male and female population who participate in MC-AMI, regarding major cardiovascular events (MACE), defined as a composite of death, recurrent myocardial infarction, and hospitalization for heart failure in a one-year follow-up. Methods: This is a prospective research study from a single cardiology care centre. The study compares two groups: women and men who have agreed to participate in the MC-AMI program. Results: As such, 529 patients were included in the study: 167 women and 362 men. In the 12-month follow-up, the incidence of MACE events was not statistically significantly, as observed in the study groups (11.38% vs. 11.33%; P=0.98). Cox multivariate regression analysis of the surveyed population also revealed that coronary heart disease, diabetes mellitus type II, and previous percutaneous coronary intervention was significantly related to the primary endpoint. Conclusion: Women who participate in the MC-AMI program do not exhibit a worse prognosis following MACE, compared to men in 12-month follow-up. Given the benefits of the program, the percentage of women participating in the program should definitely improve.
背景:越来越多的研究证实心脏康复(CR)对降低死亡率和发病率的重要性。在科学证据的基础上,我们在波兰为心肌梗死I (MC-AMI,波兰语为koszawal)患者制定了一个护理方案。缺乏关于急性心肌梗死(AMI)后参与CR的女性长期预后可能改善的数据。目的:本研究的目的是比较参与MC-AMI的男性和女性人群在主要心血管事件(MACE)方面的差异,MACE定义为死亡、复发性心肌梗死和心力衰竭住院的复合随访一年。方法:这是一项来自单一心脏病学护理中心的前瞻性研究。这项研究比较了两组同意参加MC-AMI项目的女性和男性。结果:因此,529名患者纳入研究:167名女性和362名男性。在12个月的随访中,MACE事件的发生率无统计学意义,在研究组中观察到(11.38% vs 11.33%;P = 0.98)。调查人群的Cox多因素回归分析也显示冠心病、糖尿病II型、既往经皮冠状动脉介入治疗与主要终点显著相关。结论:在12个月的随访中,与男性相比,参与MC-AMI计划的女性在MACE后的预后并不差。考虑到该计划的好处,参加该计划的女性比例肯定会提高。
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引用次数: 0
Mucormycosis: A Fungal Infection Affecting Coronavirus Patients 毛霉病:一种影响冠状病毒患者的真菌感染
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.23
Dogan Zeytun
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引用次数: 0
Prevalence of Iron Deficiency Anemia and Associated Factors among Pregnant Women Attending Antenatal Care Follow up at Dodola General Hospital West Arsi Zone Oromia Region South East Ethiopia 埃塞俄比亚东南部奥罗米亚地区西阿尔西区Dodola总医院接受产前保健随访的孕妇缺铁性贫血患病率及相关因素
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.40
Fikadu Nugusu Dessalegn, Tilahun Ermeko Wanamo, Debebe Wordofa
Background: Anemia is defined as reduction in red cell mass which, will decreases oxygen-carrying capacity of red blood cells to tissues that can be determined in the laboratory by reduction in haemoglobin concentration (haemoglobin level of less than 11 gm/dl) or haematocrit value is less than 33%. Anemia in pregnant women is often caused by iron deficiency, which is the most common nutrient deficiency in the world, affecting more than two billion people globally. Inadequate intake or absorption of iron conjunction with blood loss during pregnancy may contribute to anemia. Iron deficiency and consequent anemia during pregnancy could be associated with severe complication like increase risks of maternal mortality and morbidity, premature delivery and low birth weight. In pregnant women, an adequate iron status is important to ensure a complication related to pregnancy as well as a normal development of the embryo, foetus and maturity of the new born child. Objectives: To assess the prevalence of iron deficiency anemia and associated factors among pregnant women attending Antenatal care (ANC) follow up at Dodola General Hospital, West Arsi zone, Oromia Region, south East Ethiopia 2018 G.C. Methods: An institutional based cross-sectional study was conducted from February 5 to March 30, 2018 G.C. Systematic random sampling technique was employed to select each participant. Data was checked, coded and analyzed by using SPSS version 20 Software, Odds ratio with corresponding 95% confidence interval was used to determine the association between independent and dependent variables. Multivariate logistic regression analysis was performed to determine the independent factors associated with iron deficiency anemia in these pregnant women and finally presented by tables and chart. Results: The prevalence of iron deficiency anemia was 19.3%. Multivariate logistic regression analysis revealed that pregnant women who had monthly income less than or equal to one thousand birr, Antenatal care visit one times, History of vaginal bleeding, Women who ate only injera with shiro and women who drunks caffeine containing drinks with food during their pregnancy were factors significantly associated with iron deficiency anemia. Conclusion and Recommendations: The prevalence of iron deficiency anemia among pregnant women in this study was relatively low. The hospitals should give special attention for pregnant women to attend Ante natal care and health professionals should advice the pregnant women on nutrition as well as effects of taking caffeine containing drinks during their pregnancy.
背景:贫血被定义为红细胞数量减少,红细胞对组织的携氧能力降低,可在实验室通过血红蛋白浓度降低(血红蛋白水平低于11克/分升)或红细胞压积值低于33%来确定。孕妇贫血通常是由缺铁引起的,缺铁是世界上最常见的营养缺乏症,影响着全球20多亿人。怀孕期间铁的摄入或吸收不足以及失血可能导致贫血。怀孕期间缺铁和随之而来的贫血可能与严重并发症有关,如增加产妇死亡率和发病率、早产和低出生体重的风险。在孕妇中,足够的铁水平对于确保妊娠并发症以及胚胎、胎儿和新生儿的正常发育非常重要。目的:评估埃塞俄比亚东南部奥罗米亚地区西阿尔西区Dodola总医院2018年产前保健(ANC)随访孕妇缺铁性贫血的患病率及其相关因素。方法:2018年2月5日至3月30日,采用基于机构的横断面研究方法,采用系统随机抽样技术选择每个参与者。采用SPSS version 20软件对数据进行检验、编码和分析,采用相应95%置信区间的比值比来确定自变量与因变量之间的相关性。对这些孕妇进行多因素logistic回归分析,确定与缺铁性贫血相关的独立因素,最后以表格形式呈现。结果:缺铁性贫血患病率为19.3%。多因素logistic回归分析显示,月收入小于等于1000 birr的孕妇、产前检查1次、阴道出血史、孕期只吃含shiro的injera以及孕期在食物中饮用含咖啡因的饮料是缺铁性贫血的显著相关因素。结论和建议:本研究中孕妇缺铁性贫血的患病率相对较低。医院应特别注意孕妇参加产前护理,保健专业人员应就孕妇在怀孕期间服用含咖啡因饮料的营养和影响向孕妇提供建议。
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引用次数: 1
Lifestyle Factors as Risk Factors and Treatment Options in Tendinopathy . 生活方式因素是肌腱病变的危险因素和治疗选择。
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.22
Jaap Wonders
Physical therapists and other therapists often treat patients with tendinopathy, which is a condition that occurs frequently and has poor prognosis and long recovery time. Multiple lifestyle factors have found to be risk factors for tendinopathy. Lifestyle factors such as exercise and movement, nutrition, sleep and psychosocial factors are often interrelated and can create a vicious spiral for patients with tendinopathy. Unhealthy lifestyle factors can cause chronic pain, low-grade inflammation, elevated adiposity, higher waist-to-rib ratio, greater body mass index, overweight, obesity, high cholesterol, metabolic syndrome, diabetes type II, rheumatoid arthritis and inflammatory-related diseases, which are the main factors explaining the association between lifestyle factors and tendinopathy. Single or multiple lifestyle interventions are available for the treatment of patients with tendinopathy. Both exercise and movement and nutritional interventions tend to improve tendon health and recovery of tendinopathy indirectly by decreasing adiposity, weight, diabetic symptoms, low-grade inflammation and pain. They are also likely to improve blood levels, bone and muscle health, and collagen synthesis of tendons, tendon function and tendon-related pain. Sleep, psychological factors, smoking behaviour and alcohol use also affect tendon pain and tissue healing. Physical therapists and other therapists may incorporate interventions as part of the treatment of tendinopathy targeted at improving sleep and psychosocial factors. Smoking behaviour and alcohol use should be discouraged, for which multiple interventions are available. The purpose of this commentary article is to inform physical therapists and other therapists about lifestyle factors as risk factors and treatment options in tendinopathy.
物理治疗师和其他治疗师经常治疗肌腱病变患者,这是一种频繁发生,预后差,恢复时间长的疾病。多种生活方式因素已被发现是肌腱病变的危险因素。生活方式因素,如锻炼和运动、营养、睡眠和社会心理因素往往相互关联,并可能对腱鞘病患者造成恶性循环。不健康的生活方式因素可导致慢性疼痛、低度炎症、脂肪升高、腰肋比升高、体重指数升高、超重、肥胖、高胆固醇、代谢综合征、II型糖尿病、类风湿性关节炎和炎症相关疾病,这些是解释生活方式因素与肌腱病变之间关联的主要因素。单一或多种生活方式干预可用于治疗肌腱病变患者。运动和营养干预都倾向于通过减少肥胖、体重、糖尿病症状、低度炎症和疼痛间接改善肌腱健康和肌腱病变的恢复。它们还可能改善血液水平、骨骼和肌肉健康、肌腱胶原蛋白合成、肌腱功能和肌腱相关疼痛。睡眠、心理因素、吸烟行为和饮酒也会影响肌腱疼痛和组织愈合。物理治疗师和其他治疗师可能会将干预措施作为肌腱病治疗的一部分,以改善睡眠和社会心理因素。应劝阻吸烟行为和饮酒,对此可采取多种干预措施。这篇评论文章的目的是告知物理治疗师和其他治疗师关于生活方式因素作为肌腱病的风险因素和治疗选择。
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引用次数: 0
Assessing Factors Associated with Poor Community Based Health Insurance for Client Satisfaction Level with Public Health Care Services in Negele Arsi District Health Centers, West Arsi Zone Ethiopia 评估与不良社区医疗保险相关的因素,以提高客户对西阿尔西地区内格勒阿尔西地区卫生中心公共卫生保健服务的满意度
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.21
Girum Fufa, Tilahun Ermeko Wanamo, A. Mohammed, Abate Lette Wodera
Introduction: Community-Based Health Insurance (CBHI) schemes are emerging tool for providing financial protection for poor people living developing countries like Ethiopia. In Ethiopia, Community-Based Health Insurance (CBHI) was piloted in 13 districts and finally expanded to 427 districts, but satisfaction of community for the scheme and health service delivery is yet limited. Therefore, this study aimed to assess the satisfaction level of Community for health insurance. Methods: A facility based cross-sectional study design was conducted from March and April, 2019 in Arsi Nagele Woreda health centers. Three hundred ninety eight participants who visited the health care facility during the study period were included for the study. The data was entered to Epi-data version 3.1 and exported to Statistical Packages for Social Sciences (SPSS) version 21.0 for analysis Results: A total of 399 patients were participated in the study, yielding a response rate of 95%. 63.1% were male and 36.9% were females. The findings of the study showed that the overall client satisfaction level of CBHI with the health services received from the targeted health centers were 63.4%. Age, educational status, waiting time, drugs availability and knowledge were predictors for Clients satisfaction regarding service of community based health insurance. Qualitative dimension showed that the most unsatisfactory aspects for the Community Based Health Insurance (CBHI) health service were lack of skill personnel and availability of drugs at health facilities. Conclusion and recommendations: This study showed higher clients’ satisfaction level when compared to similar studies in the country. Young age, lack of drugs and supplies, poor information provision, long waiting time at consultation, were found to be the major predictors of dissatisfaction. Therefore, the district health offices should address and work on this predictor to regulate clients’ satisfaction for Community Based Health Insurance (CBHI).
前言:基于社区的健康保险计划是为生活在埃塞俄比亚等发展中国家的穷人提供财务保护的新兴工具。在埃塞俄比亚,以社区为基础的健康保险在13个县进行了试点,并最终扩大到427个县,但社区对该计划和提供的保健服务的满意程度仍然有限。因此,本研究旨在评估社区居民对健康保险的满意度。方法:2019年3月至4月在Arsi Nagele worreda卫生中心进行了基于设施的横断面研究设计。在研究期间访问过卫生保健机构的338名参与者被纳入研究。将数据输入Epi-data 3.1版本,导出到SPSS 21.0版本进行分析。结果:共有399例患者参与研究,有效率为95%。男性占63.1%,女性占36.9%。研究结果表明,CBHI客户对目标保健中心提供的保健服务的总体满意度为63.4%。年龄、文化程度、等待时间、药物可得性和知识是社区健康保险服务满意度的预测因子。质量方面表明,社区健康保险保健服务最不令人满意的方面是保健设施缺乏技术人员和药品供应。结论与建议:与国内同类研究相比,本研究显示出较高的客户满意度。年龄小,缺乏药物和用品,信息提供不良,咨询等待时间长,被发现是不满的主要预测因素。因此,地区卫生办公室应该解决和工作在这一预测因素,以调节客户对社区健康保险(chi)的满意度。
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引用次数: 0
Complications of a Heart Transplanted Patient with COVID-19 Infection 1例心脏移植患者感染COVID-19的并发症
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.16
G. Chatzis
Our knowledge of coronavirus disease-2019 (COVID-19) and its cardiovascular implications is growing every day. The pandemic has raised the question of whether to continue offering heart transplantations due to concerns regarding the risk for exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during hospitalization and challenges in curbing the infection with high levels of immunosuppression. We present the case of a 47-year-old woman who presented with COVID-19 on immunosuppression therapy due to recent heart transplantation four months before admission. The patient’s condition worsened, and despite monitoring and treatment updates, she died on day 19 of admission. Although most immunocompromised persons effectively clear a SARS-CoV-2 infection, this case highlights the potential for ongoing and accelerated viral evolution associated with an immunocompromised state. Patients can manifest acute rejection in the months following transplantation surgery, which can ultimately lead to death.
我们对2019冠状病毒病(COVID-19)及其心血管影响的了解每天都在增长。由于担心住院期间暴露于严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)的风险,以及在高水平的免疫抑制中遏制感染的挑战,大流行引发了是否继续提供心脏移植的问题。我们报告了一名47岁女性的病例,她在入院前4个月因最近的心脏移植而接受了免疫抑制治疗。患者病情恶化,尽管进行了监测和治疗更新,但她于入院第19天死亡。虽然大多数免疫功能低下的人都能有效清除SARS-CoV-2感染,但本病例强调了与免疫功能低下状态相关的病毒持续和加速进化的可能性。患者在移植手术后的几个月内可能出现急性排斥反应,最终可能导致死亡。
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引用次数: 0
Beyond The Lungs: SARS-CoV-2 Pathways to the Nervous System and Its Consequences 肺之外:SARS-CoV-2通往神经系统的途径及其后果
Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.28
Ana Luiza Menezes Santana Bezerra, A. Morgado, Esther Barbosa Gonçalves Felix, Francisco Marcos Bezerra Cunha, M. Neto, Ana Luíza de Aguiar Rocha Martin
Understanding the SARS-CoV-2 pathophysiology regarding neural system contamination and damage is necessary for clinical and therapeutic approaches, which may reduce the damage caused by the disease. In this regard, it is important to highlight that, besides the direct effect on neurons, the inflammatory state caused by a dysregulation of the immune system due to infection are both factors responsible for neurological phenomena of the disease. The presence of the virus in the bloodstream, its ability to directly penetrate the NS through peripheral nerves and the weakening of the blood-brain barrier are added to the tropism of SARS-CoV-2 by ACE-2 receptors, which favours the appearance of brain manifestations, associated with metabolic complications in the autoimmune processes induced by viral clinical condition. It is essential to remember that the cerebrovascular events have been increasingly reported in infected patients and are associated with the hypercoagulability caused by the disease. The activation of the coagulation cascade and deregulation of physiological anticoagulant mechanisms, such as protein C system and the disintegration of fibrin, are possible causes of this hypercoagulable state present in COVID-19. Even though it is still not evident whether the impairment of the nervous system is a result of direct infection by SARS-CoV-2 or of a diffuse inflammatory process affecting various organs and systems generating multiple manifestations, including those of the nervous system, we highlight that the quantity of drugs administered in intensive care units also can interfere with neurological conditions.
了解SARS-CoV-2在神经系统污染和损伤方面的病理生理机制对临床和治疗都是必要的,这可能会减少疾病造成的损害。在这方面,重要的是要强调,除了对神经元的直接影响外,由感染引起的免疫系统失调引起的炎症状态都是导致该疾病神经系统现象的因素。SARS-CoV-2在血液中的存在、其通过周围神经直接穿透NS的能力以及血脑屏障的减弱,都是ACE-2受体对SARS-CoV-2的趋向性的补充,这有利于出现与病毒临床状况诱导的自身免疫过程中代谢并发症相关的脑表现。重要的是要记住,越来越多的感染患者报告了脑血管事件,并与疾病引起的高凝性有关。凝血级联的激活和生理抗凝机制的解除,如蛋白C系统和纤维蛋白的解体,可能是COVID-19出现这种高凝状态的原因。尽管目前尚不清楚神经系统损伤是由SARS-CoV-2直接感染引起的,还是由影响各种器官和系统的弥漫性炎症过程引起的,产生多种表现,包括神经系统的表现,但我们强调,重症监护病房给药的数量也会干扰神经系统疾病。
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引用次数: 0
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