Pub Date : 2023-07-13DOI: 10.25135/rnp.404.2304.2761
Ebrar Inal, Ebru ÖZDEMİR NATH, Mahmoud Abudayyak, Şeyma Ulusoy, Hatice Akbal İnan, M. Çiçek, M. Kartal
: The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plant Vitex agnus-castus L. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of the V. agnus-castus EO’s in-vitro cytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits of V. agnus-castus were analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of the V. agnus-castus . EOs extracted from Balıkesir region were defined as the “ α - pinene-1,8-cineole” chemotype, while EOs extracted from İstanbul region were defined as the “sabinene-1,8-cineole” chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze the in-vitro cytotoxic effects of flowers. This study is also the first to show the in-vitro cytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent -especially the purple flower’s IC 50 is about 4.68 µg/mL on the MCF7 cell line-than İstanbul regions, which might be attributed to the higher amount of α -pinene, caryophyllene, and limonene content. Our results indicated that the V. agnus-castus EOs, which contain α -pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.
{"title":"Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities","authors":"Ebrar Inal, Ebru ÖZDEMİR NATH, Mahmoud Abudayyak, Şeyma Ulusoy, Hatice Akbal İnan, M. Çiçek, M. Kartal","doi":"10.25135/rnp.404.2304.2761","DOIUrl":"https://doi.org/10.25135/rnp.404.2304.2761","url":null,"abstract":": The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plant Vitex agnus-castus L. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of the V. agnus-castus EO’s in-vitro cytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits of V. agnus-castus were analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of the V. agnus-castus . EOs extracted from Balıkesir region were defined as the “ α - pinene-1,8-cineole” chemotype, while EOs extracted from İstanbul region were defined as the “sabinene-1,8-cineole” chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze the in-vitro cytotoxic effects of flowers. This study is also the first to show the in-vitro cytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent -especially the purple flower’s IC 50 is about 4.68 µg/mL on the MCF7 cell line-than İstanbul regions, which might be attributed to the higher amount of α -pinene, caryophyllene, and limonene content. Our results indicated that the V. agnus-castus EOs, which contain α -pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43806231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-11DOI: 10.25135/rnp.405.2304.2763
Jiang Yongjun, Zi-jun Chen, Yuhong Tian, Mingzhu Ma
: A new pyran-2-one derivative, Nocardiopyrone C ( 1 ), and three known compounds, Nocardiopyrone B ( 2 ), 1-hydroxy-4-methoxy-2-naphthoic acid ( 3 ), and 2-(aminocarbonyl)-phenylcarbamate ( 4 ) were identified from the marine-derived Nocardiopsis aegyptia ZSN1. The chemical structure of the novel compound ( 1 ) was ascertained as (7 R )-5-(methoxymethyl)-3-methyl-6-(pentan-2-yl)-2 H -pyran-2-one using HRESIMS data, spectroscopic data, and ECD calculations. All four isolated compounds displayed antimicrobial activity, with the new compound 1 having the same MIC value of 50.0 µ M against E. coli , S. aureus , and C. albicans .
从海洋来源的埃及诺卡opsis aegyptia ZSN1中鉴定出新的吡喃-2- 1衍生物Nocardiopyrone C(1)和三个已知化合物Nocardiopyrone B(2)、1-羟基-4-甲氧基-2-萘酸(3)和2-(氨基羰基)-苯氨基甲酸酯(4)。新化合物(1)的化学结构为(7r)-5-(甲氧基甲基)-3-甲基-6-(戊烷-2-基)-2 H -吡喃-2- 1。4个化合物均具有抗菌活性，其中新化合物1对大肠杆菌、金黄色葡萄球菌和白色念珠菌的MIC值相同，均为50.0µM。
{"title":"Nocardiopyrone C, a New Antimicrobial Pyran-2-one Derivative from a Marine-derived Actinomycete Strain Nocardiopsis aegyptia ZSN1","authors":"Jiang Yongjun, Zi-jun Chen, Yuhong Tian, Mingzhu Ma","doi":"10.25135/rnp.405.2304.2763","DOIUrl":"https://doi.org/10.25135/rnp.405.2304.2763","url":null,"abstract":": A new pyran-2-one derivative, Nocardiopyrone C ( 1 ), and three known compounds, Nocardiopyrone B ( 2 ), 1-hydroxy-4-methoxy-2-naphthoic acid ( 3 ), and 2-(aminocarbonyl)-phenylcarbamate ( 4 ) were identified from the marine-derived Nocardiopsis aegyptia ZSN1. The chemical structure of the novel compound ( 1 ) was ascertained as (7 R )-5-(methoxymethyl)-3-methyl-6-(pentan-2-yl)-2 H -pyran-2-one using HRESIMS data, spectroscopic data, and ECD calculations. All four isolated compounds displayed antimicrobial activity, with the new compound 1 having the same MIC value of 50.0 µ M against E. coli , S. aureus , and C. albicans .","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":"5 S1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41265665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.25135/rnp.403.2304.2765
Dongdong Zhang, Haonan Xu, Wei Wang, Xinzhu Li, Yu-ze Li, Yi Jiang, Xiaomei Song, Chong Deng
The genus Kadsura is an important part of traditional Chinese medicine, it has the functions of promoting wind, eliminating dampness, activating blood circulation. Modern pharmacological studies have shown that lignans are one of the main components to possess these medicinal effects. This review aimed to provide a systematic summary on the traditional use, phytochemistry, pharmacology, toxicology and other aspects of lignans in genus Kadsura. In this paper, we collected the relevant literature on Kadsura lignans from 1973 to the present, and isolated more than 337 lignans from this genus, including dibenzocyclooctadienes, aryltetralins, tetrahydrofurans, diarylbutanes, 7,8-secolignans, bisepoxylignans, neolignans, seco-dibenzocyclooctadienes, sesquilignan and coumarin-containing lignan. Previous pharmacological studies have shown that lignans of the genus Kadsura have antitumor, anti-inflammatory, antibacterial, anti-HIV, anti-platelet aggregation, immunomodulatory and antioxidant effects. In clinical practice, it is commonly used to treat Alzheimer's disease, inflammation and insomnia. Kadsura is an important part of the field of Chinese medicine and is widely used in traditional medicine. However, further clarification of its active ingredients and mechanism of action and the establishment of a complete quality standard system are needed in order to provide a scientific basis for in-depth studies of this genus.
{"title":"Traditional Use, Pharmacology and Toxicology of the Lignans in Genus Kadsura: A Systematic Review","authors":"Dongdong Zhang, Haonan Xu, Wei Wang, Xinzhu Li, Yu-ze Li, Yi Jiang, Xiaomei Song, Chong Deng","doi":"10.25135/rnp.403.2304.2765","DOIUrl":"https://doi.org/10.25135/rnp.403.2304.2765","url":null,"abstract":"The genus Kadsura is an important part of traditional Chinese medicine, it has the functions of promoting wind, eliminating dampness, activating blood circulation. Modern pharmacological studies have shown that lignans are one of the main components to possess these medicinal effects. This review aimed to provide a systematic summary on the traditional use, phytochemistry, pharmacology, toxicology and other aspects of lignans in genus Kadsura. In this paper, we collected the relevant literature on Kadsura lignans from 1973 to the present, and isolated more than 337 lignans from this genus, including dibenzocyclooctadienes, aryltetralins, tetrahydrofurans, diarylbutanes, 7,8-secolignans, bisepoxylignans, neolignans, seco-dibenzocyclooctadienes, sesquilignan and coumarin-containing lignan. Previous pharmacological studies have shown that lignans of the genus Kadsura have antitumor, anti-inflammatory, antibacterial, anti-HIV, anti-platelet aggregation, immunomodulatory and antioxidant effects. In clinical practice, it is commonly used to treat Alzheimer's disease, inflammation and insomnia. Kadsura is an important part of the field of Chinese medicine and is widely used in traditional medicine. However, further clarification of its active ingredients and mechanism of action and the establishment of a complete quality standard system are needed in order to provide a scientific basis for in-depth studies of this genus.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49457344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Two new trienoic acid derivatives, namely penioxa acids A ( 1 ) and B ( 2 ), have been isolated from the marine-derived fungus strain Penicillium oxalicum BTBU20213011. Their structures were determined by extensive analysis of spectroscopic data, including 1D and 2D NMR, and HRESIMS
{"title":"Two New Trienoic Acid Derivatives from Marine-derived Fungus Penicillium oxalicum BTBU20213011","authors":"Fuhang Song, Xinyu Liu, Yifei Dong, Xinwan Zhang, Xinjun Zhang, Xiuli Xu, Caixia Chen","doi":"10.25135/rnp.400.2303.2737","DOIUrl":"https://doi.org/10.25135/rnp.400.2303.2737","url":null,"abstract":": Two new trienoic acid derivatives, namely penioxa acids A ( 1 ) and B ( 2 ), have been isolated from the marine-derived fungus strain Penicillium oxalicum BTBU20213011. Their structures were determined by extensive analysis of spectroscopic data, including 1D and 2D NMR, and HRESIMS","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49621717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-08DOI: 10.25135/rnp.391.2301.2683
Chuangfeng Zhang, Sun Yunbo, Tongxing Wang, Shuo Shen, Dan Bi, Feng-Jun He, B. Hou, Yifu Zhang, Ya Tian, Z. Jia
: Three new chromone glycosides, named 2-methyl-5-hydroxyl-4-chromone-7-O - β -D-glucuronide ( 1 ), 2-ethyl-5-hydroxyl-4-chromone-7-O - β -D-glucuronide ( 2 ) and 1-acetyl-3-C - β -D-glucopyranosyl-5-methyl- phloroglucinyl-6-O - β -D-glucopyranoside ( 6 ), together with eight known compounds were isolated from the water extract of Dryopteris crassirhizoma Nakai ， and the water extract preparation process is consistent with Lianhua Qingwen capsule. All the chemical structures of new compounds were characterized by 1D and 2D NMR spectra as well as high resolution mass and IR spectra. The chemical structures of known compounds were characterized by NMR spectra along with comparison of their spectroscopic data with those reported in the literature. The binding ability of these compounds to 3CL hydrolase of SARS-COV-2 was evaluated by molecular docking. The results showed that the chromone glycosides with glucuronic acid fragment had good docking effect with 3CL hydrolase and this indicated the chromone glucuronides could be further studied as potential antiviral compounds.
{"title":"Three New Chemical Constituents of Dryopteris crassirhizoma Nakai in Lianhua Qingwen Capsule and Investigation on Their Antiviral Potential Based on 3CL Hydrolase of SARS-CoV-2","authors":"Chuangfeng Zhang, Sun Yunbo, Tongxing Wang, Shuo Shen, Dan Bi, Feng-Jun He, B. Hou, Yifu Zhang, Ya Tian, Z. Jia","doi":"10.25135/rnp.391.2301.2683","DOIUrl":"https://doi.org/10.25135/rnp.391.2301.2683","url":null,"abstract":": Three new chromone glycosides, named 2-methyl-5-hydroxyl-4-chromone-7-O - β -D-glucuronide ( 1 ), 2-ethyl-5-hydroxyl-4-chromone-7-O - β -D-glucuronide ( 2 ) and 1-acetyl-3-C - β -D-glucopyranosyl-5-methyl- phloroglucinyl-6-O - β -D-glucopyranoside ( 6 ), together with eight known compounds were isolated from the water extract of Dryopteris crassirhizoma Nakai ， and the water extract preparation process is consistent with Lianhua Qingwen capsule. All the chemical structures of new compounds were characterized by 1D and 2D NMR spectra as well as high resolution mass and IR spectra. The chemical structures of known compounds were characterized by NMR spectra along with comparison of their spectroscopic data with those reported in the literature. The binding ability of these compounds to 3CL hydrolase of SARS-COV-2 was evaluated by molecular docking. The results showed that the chromone glycosides with glucuronic acid fragment had good docking effect with 3CL hydrolase and this indicated the chromone glucuronides could be further studied as potential antiviral compounds.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42686518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-17DOI: 10.25135/rnp.394.2304.2764
Guopeng Zhao, Chun-Li Jiao
{"title":"Bromophenols from the Marine Red Alga Symphyocladia latiuscula and Their Radical Scavenging Activity","authors":"Guopeng Zhao, Chun-Li Jiao","doi":"10.25135/rnp.394.2304.2764","DOIUrl":"https://doi.org/10.25135/rnp.394.2304.2764","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47672864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-17DOI: 10.25135/rnp.393.2303.2730
Thanh Q. C. Nguyen, Kim Yen Huynh, Trong Tuan Nguyen, Thanh Men Tran
{"title":"Protective Effect of Syzygium jambos (L.) Leaf Extract and Its Constituents Against LPS-induced Oxidative Stress","authors":"Thanh Q. C. Nguyen, Kim Yen Huynh, Trong Tuan Nguyen, Thanh Men Tran","doi":"10.25135/rnp.393.2303.2730","DOIUrl":"https://doi.org/10.25135/rnp.393.2303.2730","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42233012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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