Advances in Colloid and Interface Science最新文献_第3页

Supramolecular self-assembly of enzymatically hydrolyzed food protein polypeptides: Versatile architecture for enhancing the intestinal absorption of natural bioactive compounds 酶水解食物蛋白多肽的超分子自组装：增强肠道吸收天然生物活性化合物的多功能结构

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-01 DOI: 10.1016/j.cis.2025.103734

Jin Feng , Songbai Liu , Wuyang Huang , Ying Li

Nanotechnology has been widely utilized to enhance the intestinal absorption of natural bioactive compounds (BCs). However, the complicated and dynamic environment in the gastrointestinal tract (GIT) – characterized by digestive enzymes, mucus matrix, epithelial cell layer, and extensive metabolic activity – presents notable challenges to the oral delivery of BCs. To address these limitations, nanocarriers based on enzymatically hydrolyzed food protein polypeptides (EH-FPPs) have been developed, which exhibit high biocompatibility, loading capacity, and capacity to overcome different absorption barriers. This review provides a comprehensive summary of recent advancements in EH-FPP-assembled nanocarriers, including their self-assembly mechanisms, supramolecular structures, and loading approaches for natural BCs. Besides, it elucidates the how these nanocarriers enhance the intestinal absorption of BCs from the perspectives of controlled release, mucus penetration, transcytosis, and paracellular transport. Furthermore, it critically assesses the role of these nanocarriers in improving the overall bioavailability and therapeutic efficacy of encapsulated BCs, while also addressing their current limitations and future research directions. This review seeks to elucidate the complex relationships between the self-assembly process, multi-scale structure, and GIT fate of EH-FPP-based vehicles, which highlights their potential as advanced BC delivery systems for precision nutrition and individualized health.

纳米技术已被广泛应用于促进天然生物活性化合物（bc）的肠道吸收。然而，消化道（GIT）复杂而动态的环境——以消化酶、粘液基质、上皮细胞层和广泛的代谢活动为特征——给口服给药带来了显著的挑战。为了解决这些限制，基于酶水解食品蛋白多肽（EH-FPPs）的纳米载体被开发出来，它具有高的生物相容性、负载能力和克服不同吸收障碍的能力。本文综述了eh - fpp组装纳米载体的最新进展，包括其自组装机制、超分子结构和天然bc的装载方法。并从控释、黏液渗透、胞吞作用和细胞旁转运等方面阐述了这些纳米载体如何增强bc的肠道吸收。此外，它批判性地评估了这些纳米载体在提高包封bc的整体生物利用度和治疗效果方面的作用，同时也指出了它们目前的局限性和未来的研究方向。本文旨在阐明eh - fpp载体的自组装过程、多尺度结构和GIT命运之间的复杂关系，强调其作为精密营养和个性化健康的先进BC输送系统的潜力。

{"title":"Supramolecular self-assembly of enzymatically hydrolyzed food protein polypeptides: Versatile architecture for enhancing the intestinal absorption of natural bioactive compounds","authors":"Jin Feng , Songbai Liu , Wuyang Huang , Ying Li","doi":"10.1016/j.cis.2025.103734","DOIUrl":"10.1016/j.cis.2025.103734","url":null,"abstract":"<div><div>Nanotechnology has been widely utilized to enhance the intestinal absorption of natural bioactive compounds (BCs). However, the complicated and dynamic environment in the gastrointestinal tract (GIT) – characterized by digestive enzymes, mucus matrix, epithelial cell layer, and extensive metabolic activity – presents notable challenges to the oral delivery of BCs. To address these limitations, nanocarriers based on enzymatically hydrolyzed food protein polypeptides (EH-FPPs) have been developed, which exhibit high biocompatibility, loading capacity, and capacity to overcome different absorption barriers. This review provides a comprehensive summary of recent advancements in EH-FPP-assembled nanocarriers, including their self-assembly mechanisms, supramolecular structures, and loading approaches for natural BCs. Besides, it elucidates the how these nanocarriers enhance the intestinal absorption of BCs from the perspectives of controlled release, mucus penetration, transcytosis, and paracellular transport. Furthermore, it critically assesses the role of these nanocarriers in improving the overall bioavailability and therapeutic efficacy of encapsulated BCs, while also addressing their current limitations and future research directions. This review seeks to elucidate the complex relationships between the self-assembly process, multi-scale structure, and GIT fate of EH-FPP-based vehicles, which highlights their potential as advanced BC delivery systems for precision nutrition and individualized health.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103734"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in molecular simulations of clays: From slit pore to clay matrix nanopore 粘土分子模拟的新进展：从狭缝孔到粘土基质纳米孔

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-25 DOI: 10.1016/j.cis.2025.103767

Jiangtao Pang , Qi Li , Yunfeng Liang , Takeshi Tsuji

Clays play a critical role in natural and engineered systems due to their unique layered structures, surface reactivity, and capacity to regulate fluid and solute behavior. From carbon sequestration and contaminant containment to enhanced oil recovery and subsurface energy storage, understanding clay–fluid interactions is essential for predicting system performance of sediment complex. However, most atomistic studies have relied on idealized infinite-sheet models, which overlook critical features such as edge terminations, finite particle size, and morphological heterogeneity—elements that dominate in real clay aggregates. This review addresses this knowledge gap by synthesizing recent advances in finite-particle modeling, which capture edge chemistry, stacking disorder, and confinement-driven transport dynamics. We examine the structural construction of finite clay models, discuss key force field developments, and highlight how finite systems alter hydration, ion adsorption, and molecular diffusion. Particular focus is placed on the emergence of anisotropic pore geometries, dynamic confinement effects, and size-dependent mechanical behavior. By bridging infinite and finite modeling paradigms, this review aspires to contribute to on-going efforts in modeling, experimentation, and multiscale integration toward more representative depictions of clay behavior across diverse applications.

由于其独特的层状结构、表面反应性以及调节流体和溶质行为的能力，粘土在自然和工程系统中起着至关重要的作用。从固碳和污染物控制到提高采收率和地下能量储存，了解粘土-流体相互作用对于预测沉积物复体的系统性能至关重要。然而，大多数原子论研究都依赖于理想化的无限薄片模型，忽略了诸如边缘终止、有限粒径和形态异质性等关键特征——这些因素在实际粘土聚集体中占主导地位。这篇综述通过综合有限粒子模型的最新进展来解决这一知识差距，该模型捕获了边缘化学、堆叠无序和受限驱动的输运动力学。我们研究了有限粘土模型的结构结构，讨论了关键力场的发展，并强调了有限系统如何改变水合作用、离子吸附和分子扩散。特别关注的是各向异性孔隙几何形状的出现、动态约束效应和尺寸相关的力学行为。通过桥接无限和有限建模范式，本综述希望有助于在建模、实验和多尺度集成方面的持续努力，以便在不同的应用中对粘土行为进行更有代表性的描述。

{"title":"Recent advances in molecular simulations of clays: From slit pore to clay matrix nanopore","authors":"Jiangtao Pang , Qi Li , Yunfeng Liang , Takeshi Tsuji","doi":"10.1016/j.cis.2025.103767","DOIUrl":"10.1016/j.cis.2025.103767","url":null,"abstract":"<div><div>Clays play a critical role in natural and engineered systems due to their unique layered structures, surface reactivity, and capacity to regulate fluid and solute behavior. From carbon sequestration and contaminant containment to enhanced oil recovery and subsurface energy storage, understanding clay–fluid interactions is essential for predicting system performance of sediment complex. However, most atomistic studies have relied on idealized infinite-sheet models, which overlook critical features such as edge terminations, finite particle size, and morphological heterogeneity—elements that dominate in real clay aggregates. This review addresses this knowledge gap by synthesizing recent advances in finite-particle modeling, which capture edge chemistry, stacking disorder, and confinement-driven transport dynamics. We examine the structural construction of finite clay models, discuss key force field developments, and highlight how finite systems alter hydration, ion adsorption, and molecular diffusion. Particular focus is placed on the emergence of anisotropic pore geometries, dynamic confinement effects, and size-dependent mechanical behavior. By bridging infinite and finite modeling paradigms, this review aspires to contribute to on-going efforts in modeling, experimentation, and multiscale integration toward more representative depictions of clay behavior across diverse applications.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103767"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programming superlyophobic interfaces via fine-tuning surface chemistry: From controllable fabrication to intelligent manipulation 通过微调表面化学来编程超疏水界面：从可控制造到智能操作

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-26 DOI: 10.1016/j.cis.2025.103765

Lu Tie, Ran Lei, Dandan Xi

Recent advances have expanded superwetting system from single to multiple superlyophobicity, enabling diverse superlyophobic interfaces. However, current research lacks a comprehensive understanding of how surface chemistry governs superlyophobic properties-knowledge that is essential for rationally designing superwetting behaviors. This article highlights design principles of fine-tuning surface chemistry, fabrication strategies and multifunctional applications of diverse superlyophobic interfaces, emphasizing how lyophobic and lyophilic components of surface govern single and multiple superlyophobicity. Based on surface thermodynamics, the preparation methods, regulation strategies and underlying mechanism for various types of superlyophobic interfaces are systematically analyzed. Furthermore, the article distills representative applications that align with various single and multiple superlyophobic interfaces under complex environmental conditions and functional requirements, offering a foundational framework for their practical utilization. By establishing surface chemistry design criteria, we provide insights into the rational control of single or multiple superlyophobicity and the integration of additional functionalities, thereby enabling the exploration of novel wetting states and multifunctional interfaces. Finally, we outline future challenges and emerging trends, including advances in multiple superlyophobic mechanisms, innovative fabrication techniques, and next-generation performance enhancements for these interfaces.

最近的研究进展将超湿系统从单一的超疏水性扩展到多个超疏水性，从而实现了不同的超疏水性界面。然而，目前的研究缺乏对表面化学如何控制超疏水性的全面理解，而这种知识对于合理设计超润湿行为至关重要。本文重点介绍了各种超疏水界面的设计原理、制备策略和多功能应用，强调了表面的疏水和亲水组分如何影响单和多超疏水性。基于表面热力学，系统分析了各类超疏水界面的制备方法、调控策略和作用机理。此外，本文还提炼出在复杂环境条件和功能需求下，与各种单一和多个超疏水界面相匹配的代表性应用，为其实际应用提供了基础框架。通过建立表面化学设计标准，我们提供了对单个或多个超疏水性的合理控制以及附加功能的集成的见解，从而能够探索新的润湿状态和多功能界面。最后，我们概述了未来的挑战和新兴趋势，包括多种超疏水机制的进展，创新的制造技术，以及这些接口的下一代性能增强。

{"title":"Programming superlyophobic interfaces via fine-tuning surface chemistry: From controllable fabrication to intelligent manipulation","authors":"Lu Tie, Ran Lei, Dandan Xi","doi":"10.1016/j.cis.2025.103765","DOIUrl":"10.1016/j.cis.2025.103765","url":null,"abstract":"<div><div>Recent advances have expanded superwetting system from single to multiple superlyophobicity, enabling diverse superlyophobic interfaces. However, current research lacks a comprehensive understanding of how surface chemistry governs superlyophobic properties-knowledge that is essential for rationally designing superwetting behaviors. This article highlights design principles of fine-tuning surface chemistry, fabrication strategies and multifunctional applications of diverse superlyophobic interfaces, emphasizing how lyophobic and lyophilic components of surface govern single and multiple superlyophobicity. Based on surface thermodynamics, the preparation methods, regulation strategies and underlying mechanism for various types of superlyophobic interfaces are systematically analyzed. Furthermore, the article distills representative applications that align with various single and multiple superlyophobic interfaces under complex environmental conditions and functional requirements, offering a foundational framework for their practical utilization. By establishing surface chemistry design criteria, we provide insights into the rational control of single or multiple superlyophobicity and the integration of additional functionalities, thereby enabling the exploration of novel wetting states and multifunctional interfaces. Finally, we outline future challenges and emerging trends, including advances in multiple superlyophobic mechanisms, innovative fabrication techniques, and next-generation performance enhancements for these interfaces.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103765"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrokinetic transport in saturated and unsaturated porous media: A pore-scale view 饱和和非饱和多孔介质中的电动输运：孔隙尺度的观点。

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-12 DOI: 10.1016/j.cis.2025.103755

Yunfan Huang, Zhiguo Tian, Hangyu Chen, Wei Liu, Moran Wang

Electrokinetic transports in porous media play a crucial role in diverse applications such as geophysical exploration, nuclear waste disposal, water desalination, soil and groundwater remediation, low-salinity waterflooding, and ionic battery operation. This review systematically examines electrokinetic mechanisms in single-phase and multiphase flows in porous media, with a special focus on multiscale and multiphysico-chemical coupling effects. After briefly introducing fundamental theories on microscale electrokinetic transports, we highlight the impact of nanoscale confinement and geometric regulation at first on single-phase electrokinetic flows and ion transport. Next, we discuss the influences of non-uniform ionic concentration and temperature fields on electrokinetic transports, encompassing the impact of surface chemical reactions via charge regulation and reactive transports, and thermodiffusion effects. Furthermore, we provide a concise overview of the current understanding of electrokinetics in multiphase flows, including interfacial charging, wettability alteration, and electrokinetic multiphase dynamics. Finally, we try to outline future research directions, addressing statistics-based theories, multiscale simulations, and advanced experimental designs for electrokinetic transports in porous media.

多孔介质中的电动输运在地球物理勘探、核废料处理、海水淡化、土壤和地下水修复、低盐度水驱和离子电池操作等多种应用中发挥着至关重要的作用。本文系统地研究了多孔介质中单相和多相流动的电动力学机制，特别关注了多尺度和多物理化学耦合效应。在简要介绍了微尺度电动力学输运的基本理论之后，我们首先强调了纳米尺度约束和几何调控对单相电动力学流动和离子输运的影响。接下来，我们讨论了不均匀离子浓度和温度场对电动力学输运的影响，包括通过电荷调节和反应性输运进行的表面化学反应的影响，以及热扩散效应。此外，我们简要概述了目前对多相流中电动力学的理解，包括界面充电、润湿性改变和电动力学多相动力学。最后，我们试图概述未来的研究方向，解决基于统计的理论，多尺度模拟，以及先进的实验设计在多孔介质中的电动输运。

{"title":"Electrokinetic transport in saturated and unsaturated porous media: A pore-scale view","authors":"Yunfan Huang, Zhiguo Tian, Hangyu Chen, Wei Liu, Moran Wang","doi":"10.1016/j.cis.2025.103755","DOIUrl":"10.1016/j.cis.2025.103755","url":null,"abstract":"<div><div>Electrokinetic transports in porous media play a crucial role in diverse applications such as geophysical exploration, nuclear waste disposal, water desalination, soil and groundwater remediation, low-salinity waterflooding, and ionic battery operation. This review systematically examines electrokinetic mechanisms in single-phase and multiphase flows in porous media, with a special focus on multiscale and multiphysico-chemical coupling effects. After briefly introducing fundamental theories on microscale electrokinetic transports, we highlight the impact of nanoscale confinement and geometric regulation at first on single-phase electrokinetic flows and ion transport. Next, we discuss the influences of non-uniform ionic concentration and temperature fields on electrokinetic transports, encompassing the impact of surface chemical reactions via charge regulation and reactive transports, and thermodiffusion effects. Furthermore, we provide a concise overview of the current understanding of electrokinetics in multiphase flows, including interfacial charging, wettability alteration, and electrokinetic multiphase dynamics. Finally, we try to outline future research directions, addressing statistics-based theories, multiscale simulations, and advanced experimental designs for electrokinetic transports in porous media.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103755"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lignin nanoparticles as Pickering stabilizers: Emulsion engineering through physicochemical design and meta-analysis 木质素纳米颗粒作为皮克林稳定剂：通过物理化学设计和荟萃分析的乳液工程。

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-15 DOI: 10.1016/j.cis.2025.103752

Ronald Marquez , Roberto J. Aguado , Quim Tarrés , Laura Tolosa , Blaise L. Tardy , Orlando J. Rojas , Martin A. Hubbe , Marc Delgado-Aguilar

This review systematically examines the principal physicochemical parameters that govern the formation, stability, and properties of Pickering emulsions stabilized by lignin nanoparticles (LNPs). We consider the role of particle size, charge and concentration, oil volume fraction, as well as emulsification variables (pH and shearing method). We demonstrate the broad applicability of fundamental physical chemistry principles in explaining the long-term stability of LNP-stabilized Pickering emulsions. LNPs with diameters of 25–50 nm, at concentrations between 0.2 and 2 wt%, generally yield emulsions stable for over six months. This suggests that rapid interfacial coverage by smaller particles, facilitated by high-energy emulsification, is critical for preventing initial coalescence. Such emulsions are generally more stable at acidic to neutral pH (pH 3–7). In addition, more negative LNP zeta potentials (up to −64 mV) correlate with enhanced colloidal stability due to the electrostatic repulsion between oil droplets. Furthermore, LNP modification such as acetylation and polymer grafting can significantly enhance emulsion stability by balancing surface wettability (hydrophilicity/hydrophobicity) and interfacial activity. A meta-analysis and support vector regressor with Bayesian optimization and eXplainable artificial intelligence (AI) analysis confirmed high-energy emulsification (ultrasonication, high-shear mixing), pH, and packing parameter (LNP_size/LNP_conc ratio) as the main features that can influence the formulation of emulsions and lead to smaller droplets and larger lifetimes. Finally, we propose heuristics to tailor LNP-stabilized Pickering emulsions that require stability and functionality, including those used in agriculture and crop protection, food, nutraceuticals, stimuli-responsive and energy systems, as well as coatings.

本文系统地研究了影响木质素纳米颗粒（LNPs）稳定皮克林乳液形成、稳定性和性能的主要物理化学参数。我们考虑了粒径、电荷和浓度、油体积分数以及乳化变量（pH和剪切方法）的作用。我们证明了基本物理化学原理在解释lnp稳定皮克林乳剂的长期稳定性方面的广泛适用性。直径为25-50纳米的LNPs，浓度在0.2 - 2%之间，通常可以产生稳定超过6个月的乳剂。这表明，在高能乳化作用下，小颗粒快速覆盖界面对于防止初始聚结至关重要。这种乳剂通常在酸性到中性pH （pH 3-7）下更稳定。此外，由于油滴之间的静电斥力，更多的负LNP zeta电位（高达-64 mV）与增强的胶体稳定性相关。此外，LNP改性（如乙酰化和聚合物接枝）可以通过平衡表面润湿性（亲水性/疏水性）和界面活性来显著提高乳液稳定性。一项基于贝叶斯优化和可解释人工智能（AI）分析的荟萃分析和支持向量回归分析证实，高能乳化（超声、高剪切混合）、pH和填料参数（LNPsize/LNPconc比）是影响乳液配方的主要特征，可以导致更小的液滴和更长的寿命。最后，我们提出了启发式方法来定制需要稳定性和功能性的lnp稳定皮克林乳剂，包括用于农业和作物保护、食品、营养药品、刺激响应和能源系统以及涂料的乳剂。

{"title":"Lignin nanoparticles as Pickering stabilizers: Emulsion engineering through physicochemical design and meta-analysis","authors":"Ronald Marquez , Roberto J. Aguado , Quim Tarrés , Laura Tolosa , Blaise L. Tardy , Orlando J. Rojas , Martin A. Hubbe , Marc Delgado-Aguilar","doi":"10.1016/j.cis.2025.103752","DOIUrl":"10.1016/j.cis.2025.103752","url":null,"abstract":"<div><div>This review systematically examines the principal physicochemical parameters that govern the formation, stability, and properties of Pickering emulsions stabilized by lignin nanoparticles (LNPs). We consider the role of particle size, charge and concentration, oil volume fraction, as well as emulsification variables (pH and shearing method). We demonstrate the broad applicability of fundamental physical chemistry principles in explaining the long-term stability of LNP-stabilized Pickering emulsions. LNPs with diameters of 25–50 nm, at concentrations between 0.2 and 2 wt%, generally yield emulsions stable for over six months. This suggests that rapid interfacial coverage by smaller particles, facilitated by high-energy emulsification, is critical for preventing initial coalescence. Such emulsions are generally more stable at acidic to neutral pH (pH 3–7). In addition, more negative LNP zeta potentials (up to −64 mV) correlate with enhanced colloidal stability due to the electrostatic repulsion between oil droplets. Furthermore, LNP modification such as acetylation and polymer grafting can significantly enhance emulsion stability by balancing surface wettability (hydrophilicity/hydrophobicity) and interfacial activity. A meta-analysis and support vector regressor with Bayesian optimization and eXplainable artificial intelligence (AI) analysis confirmed high-energy emulsification (ultrasonication, high-shear mixing), pH, and packing parameter (LNP<sub>size</sub>/LNP<sub>conc</sub> ratio) as the main features that can influence the formulation of emulsions and lead to smaller droplets and larger lifetimes. Finally, we propose heuristics to tailor LNP-stabilized Pickering emulsions that require stability and functionality, including those used in agriculture and crop protection, food, nutraceuticals, stimuli-responsive and energy systems, as well as coatings.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103752"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications and advances in characterizing pore-interface structures in coal using small angle scattering technology: A review 小角散射技术在煤中孔界面结构表征中的应用与进展

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-26 DOI: 10.1016/j.cis.2025.103769

Yixin Zhao , Chengxi Wang , Xiaodong Guo , Shuaipeng Zhu , Yingfeng Sun

The multiscale pore-fracture interface in coal forms the fundamental physical basis governing both coalbed methane (CBM) storage-transport behavior and CO₂ geological storage efficiency. This review systematically discusses the principle of small angle scattering (SAS) technology in the analysis of coal matrix pore interface, and focuses on the frontier application of coal-fluid interface in terms of geometry, physicochemical properties and dynamic evolution. Results indicate that SAS can nondestructively quantify the entire pore system, including closed pores. Moreover, the predominance of closed pores in quantity and distribution is strongly affected by coal type and tectonic stress. The unique advantages of in-situ SAS technology in real-time tracking of interface dynamics and complex response mechanisms (such as expansion/contraction, pore damage and structural rearrangement of coal matrix under external fields such as gas adsorption, stress loading and pyrolysis) are analyzed. Through the interface fractal, SAS provides key parameters for quantitative description of interface complexity and its internal correlation with coal chemical composition. The application of “contrast-matching small-angle neutron scattering” (CM-SANS) in visualization of fluid accessibility, the key role of time-resolved small angle scattering technology in capturing instantaneous dynamic structural response of rock mass, and the cutting-edge technology of multi-scale and multi-dimensional data fusion are systematically discussed. The purpose of this review is to provide robust micromechanical support for understanding the coal-fluid interaction, thereby promoting innovation in energy and environmental engineering technologies such as CBM efficient development and carbon capture, utilization, and storage (CCUS).

煤中多尺度孔隙-破裂界面是控制煤层气储输行为和CO2地质封存效率的基本物理基础。本文系统论述了小角散射（SAS）技术在煤基质孔隙界面分析中的原理，重点介绍了煤-流体界面在几何、理化性质和动态演化等方面的前沿应用。结果表明，SAS可以无损地量化包括封闭孔隙在内的整个孔隙系统。封闭孔隙在数量和分布上的优势性受煤型和构造应力的强烈影响。分析了原位SAS技术在气体吸附、应力加载、热解等外场作用下煤基体膨胀收缩、孔隙损伤、结构重排等复杂响应机制的实时跟踪方面的独特优势。通过界面分形，SAS为定量描述界面复杂性及其与煤化学成分的内在关联提供了关键参数。系统讨论了“对比匹配小角中子散射”（CM-SANS）技术在流体可达性可视化中的应用、时间分辨小角散射技术在捕捉岩体瞬时动力结构响应中的关键作用以及多尺度、多维数据融合的前沿技术。本文综述的目的是为理解煤流相互作用提供强有力的微观力学支持，从而促进能源和环境工程技术的创新，如煤层气高效开发和碳捕集、利用和封存（CCUS）。

{"title":"Applications and advances in characterizing pore-interface structures in coal using small angle scattering technology: A review","authors":"Yixin Zhao , Chengxi Wang , Xiaodong Guo , Shuaipeng Zhu , Yingfeng Sun","doi":"10.1016/j.cis.2025.103769","DOIUrl":"10.1016/j.cis.2025.103769","url":null,"abstract":"<div><div>The multiscale pore-fracture interface in coal forms the fundamental physical basis governing both coalbed methane (CBM) storage-transport behavior and CO<sub>2</sub> geological storage efficiency. This review systematically discusses the principle of small angle scattering (SAS) technology in the analysis of coal matrix pore interface, and focuses on the frontier application of coal-fluid interface in terms of geometry, physicochemical properties and dynamic evolution. Results indicate that SAS can nondestructively quantify the entire pore system, including closed pores. Moreover, the predominance of closed pores in quantity and distribution is strongly affected by coal type and tectonic stress. The unique advantages of in-situ SAS technology in real-time tracking of interface dynamics and complex response mechanisms (such as expansion/contraction, pore damage and structural rearrangement of coal matrix under external fields such as gas adsorption, stress loading and pyrolysis) are analyzed. Through the interface fractal, SAS provides key parameters for quantitative description of interface complexity and its internal correlation with coal chemical composition. The application of “contrast-matching small-angle neutron scattering” (CM-SANS) in visualization of fluid accessibility, the key role of time-resolved small angle scattering technology in capturing instantaneous dynamic structural response of rock mass, and the cutting-edge technology of multi-scale and multi-dimensional data fusion are systematically discussed. The purpose of this review is to provide robust micromechanical support for understanding the coal-fluid interaction, thereby promoting innovation in energy and environmental engineering technologies such as CBM efficient development and carbon capture, utilization, and storage (CCUS).</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103769"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From non-porous to highly porous homogeneous and heterogeneous structures: The evolving role of deep eutectic solvents in customizing chitosan-based materials – A review 从无孔到高孔均质和非均质结构：深度共晶溶剂在定制壳聚糖基材料中的演变作用综述。

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-16 DOI: 10.1016/j.cis.2025.103756

Roberto Castro-Muñoz , Rene Cabezas

To date, chitosan (CS) is the most investigated biopolymer due to its interesting physicochemical features and versatility in several applications. Due to its multiple chemical functionalities and adaptable ability toward several shapes, structures, materials and networks, CS is still explored by the research community and extends it to new applications. In this regard, deep eutectic solvents (DESs), a new generation of green solvents and additives, have recently been investigated in tuning the properties of CS derived materials and structures. In starting pioneering works, the use of DES was mainly focused on their complete blending with CS phases to generate fully miscible non-porous structured materials. However, the versatility of DES systems, depending on their nature, has turned into tailoring CS networks into highly porous structures with adjusted porosities according to the target application. The role of the DES in customizing CS structures has evolved from producing non-porous to the design of highly porous structures. Therefore, this review paper lays out the core successful applications of implementing distinct types of DESs into CS networks to improve specific properties (such as encapsulation capacity, drug delivery ability, mechanical and thermal stability, water absorption, porosity, tuned hydrophobicity, adhesive and self-healable properties, among others) in the resulting customized structures, including flat non-porous structures, eutectogels, aerogels, beads, monoliths, among other derivative structures. Apart from elucidating the modification protocols of CS networks assisted by DESs, we also pinpoint the key interactions between the polymer and the DES system, resulting in the desired structure. In addition, we also provide key findings on the role of DES in the chemical functionalization, quaternization, methylation and polymerization reaction of specific CS derivatives. After revising the current literature, we finally declare perspectives and future scopes of research in the field.

壳聚糖（CS）是迄今为止研究最多的生物聚合物，因为它具有有趣的物理化学特性和多种用途。由于其多种化学功能和对多种形状、结构、材料和网络的适应能力，CS仍在不断被研究界探索并扩展到新的应用领域。在这方面，深共晶溶剂（DESs）作为新一代绿色溶剂和添加剂，最近被研究用于调整CS衍生材料和结构的性能。在开始开创性工作时，DES的使用主要集中在与CS相完全共混以生成完全可混相的无孔结构材料。然而，根据其性质，DES系统的多功能性已经将CS网络定制为具有根据目标应用调整孔隙度的高多孔结构。DES在定制CS结构中的作用已经从生产无孔结构发展到设计高孔结构。因此，本文概述了在CS网络中实施不同类型的DESs的核心成功应用，以改善所得到的定制结构中的特定性能（如封装能力、药物输送能力、机械和热稳定性、吸水率、孔隙率、调节疏水性、粘接和自愈性能等），包括平面无孔结构、共凝胶、气凝胶、珠状、单体、在其他衍生结构中。除了阐明由DES辅助的CS网络的修饰协议外，我们还确定了聚合物和DES系统之间的关键相互作用，从而产生所需的结构。此外，我们还提供了DES在特定CS衍生物的化学功能化、季铵化、甲基化和聚合反应中的作用的关键发现。在对现有文献进行修订后，我们最后提出了该领域的研究前景和未来的研究范围。

{"title":"From non-porous to highly porous homogeneous and heterogeneous structures: The evolving role of deep eutectic solvents in customizing chitosan-based materials – A review","authors":"Roberto Castro-Muñoz , Rene Cabezas","doi":"10.1016/j.cis.2025.103756","DOIUrl":"10.1016/j.cis.2025.103756","url":null,"abstract":"<div><div>To date, chitosan (CS) is the most investigated biopolymer due to its interesting physicochemical features and versatility in several applications. Due to its multiple chemical functionalities and adaptable ability toward several shapes, structures, materials and networks, CS is still explored by the research community and extends it to new applications. In this regard, deep eutectic solvents (DESs), a new generation of green solvents and additives, have recently been investigated in tuning the properties of CS derived materials and structures. In starting pioneering works, the use of DES was mainly focused on their complete blending with CS phases to generate fully miscible non-porous structured materials. However, the versatility of DES systems, depending on their nature, has turned into tailoring CS networks into highly porous structures with adjusted porosities according to the target application. The role of the DES in customizing CS structures has evolved from producing non-porous to the design of highly porous structures. Therefore, this review paper lays out the core successful applications of implementing distinct types of DESs into CS networks to improve specific properties (such as encapsulation capacity, drug delivery ability, mechanical and thermal stability, water absorption, porosity, tuned hydrophobicity, adhesive and self-healable properties, among others) in the resulting customized structures, including flat non-porous structures, eutectogels, aerogels, beads, monoliths, among other derivative structures. Apart from elucidating the modification protocols of CS networks assisted by DESs, we also pinpoint the key interactions between the polymer and the DES system, resulting in the desired structure. In addition, we also provide key findings on the role of DES in the chemical functionalization, quaternization, methylation and polymerization reaction of specific CS derivatives. After revising the current literature, we finally declare perspectives and future scopes of research in the field.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103756"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial reactions at gas–liquid and solid–liquid interfaces in underground hydrogen storage 地下储氢气液界面和固液界面微生物反应。

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-20 DOI: 10.1016/j.cis.2025.103762

Gloire Imani , Lei Zhang , Eike Marie Thaysen , David A. Wood , Aliakbar Hassanpouryouzband , Dongyan Fan , Shuaishi Fu , Yongfei Yang , Jun Yao , Hai Sun

Underground hydrogen storage (UHS) in porous formations is a promising technology for large-scale energy systems, but microbial activity poses potential risks to hydrogen purity, injectivity and recovery. This review examines the interfacial processes that govern microbial behavior in UHS, focusing on interactions at gas–liquid and solid–liquid interfaces where hydrogenotrophic metabolism, biofilm formation, and colloidal adhesion occur. Microbial colonization at rock-water interfaces alters key physicochemical properties, including wettability, interfacial tension, and capillarity, which in turn affect hydrogen retention and multiphase flow dynamics. We synthesize current knowledge on microbial attachment mechanisms to rock, mass transfer limitations for hydrogen consumption, and biofilm-induced pore modifications. Special emphasis is given to the impact of microbial activity on interfacial phenomena, such as bubble disconnection, wettability shifts, and surface fouling, which are relevant to hydrogen loss and system performance. This review aims to bridge that gap by providing an interdisciplinary synthesis of microbial interfacial dynamics relevant to UHS.

在大型能源系统中，多孔地层地下储氢（UHS）是一项很有前途的技术，但微生物活动对氢的纯度、注入性和采收率构成了潜在风险。本文综述了在UHS中控制微生物行为的界面过程，重点研究了氢营养代谢、生物膜形成和胶体粘附发生的气液和固液界面的相互作用。微生物在岩石-水界面上的定植会改变关键的物理化学性质，包括润湿性、界面张力和毛细性，从而影响氢潴留和多相流动力学。我们综合了微生物对岩石的附着机制、氢消耗的传质限制以及生物膜诱导的孔隙修饰等方面的现有知识。特别强调了微生物活动对界面现象的影响，如气泡断开、润湿性转移和表面污垢，这些都与氢损失和系统性能有关。本综述旨在通过提供与UHS相关的微生物界面动力学的跨学科综合来弥合这一差距。

{"title":"Microbial reactions at gas–liquid and solid–liquid interfaces in underground hydrogen storage","authors":"Gloire Imani , Lei Zhang , Eike Marie Thaysen , David A. Wood , Aliakbar Hassanpouryouzband , Dongyan Fan , Shuaishi Fu , Yongfei Yang , Jun Yao , Hai Sun","doi":"10.1016/j.cis.2025.103762","DOIUrl":"10.1016/j.cis.2025.103762","url":null,"abstract":"<div><div>Underground hydrogen storage (UHS) in porous formations is a promising technology for large-scale energy systems, but microbial activity poses potential risks to hydrogen purity, injectivity and recovery. This review examines the interfacial processes that govern microbial behavior in UHS, focusing on interactions at gas–liquid and solid–liquid interfaces where hydrogenotrophic metabolism, biofilm formation, and colloidal adhesion occur. Microbial colonization at rock-water interfaces alters key physicochemical properties, including wettability, interfacial tension, and capillarity, which in turn affect hydrogen retention and multiphase flow dynamics. We synthesize current knowledge on microbial attachment mechanisms to rock, mass transfer limitations for hydrogen consumption, and biofilm-induced pore modifications. Special emphasis is given to the impact of microbial activity on interfacial phenomena, such as bubble disconnection, wettability shifts, and surface fouling, which are relevant to hydrogen loss and system performance. This review aims to bridge that gap by providing an interdisciplinary synthesis of microbial interfacial dynamics relevant to UHS.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103762"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning for nanoparticle-based imaging: From rational design to precision diagnosis 基于纳米粒子成像的机器学习：从合理设计到精确诊断

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-30 DOI: 10.1016/j.cis.2025.103773

Nan Kang , Zengyue Li , Fu Tan , Zimei Liu , Yao Yang , Xiaoqing Qian , Qian Zhang

Nanoparticles have become essential in nanomedicine due to their tunable physicochemical properties and multifunctional capabilities, particularly in biomedical imaging for early disease detection and real-time therapeutic monitoring. Nevertheless, the rational design of nanoparticles with predictable behavior in complex biological environments remains significant challenges. Recent advances in machine learning have created novel paradigms for the precise design and efficient application of nanoparticle-based imaging platforms. This review summarizes recent progress in this area, covering machine learning-guided nanoparticle design and fabrication, elucidating their dynamic behavior in biological systems, optimizing cellular uptake and intracellular delivery, and improving imaging sensitivity alongside quantitative analytical precision through intelligent signal processing methodologies. Overall, the integration of machine learning has accelerated the development of intelligent nanoparticulate systems by establishing critical correlations between material parameters and biological performance, thereby driving innovation in precision imaging technologies.

纳米粒子由于其可调节的物理化学性质和多功能能力，特别是在用于早期疾病检测和实时治疗监测的生物医学成像方面，已成为纳米医学中必不可少的材料。然而，在复杂的生物环境中合理设计具有可预测行为的纳米颗粒仍然是一个重大挑战。机器学习的最新进展为基于纳米粒子的成像平台的精确设计和有效应用创造了新的范例。本文综述了该领域的最新进展，包括机器学习引导的纳米颗粒设计和制造，阐明其在生物系统中的动态行为，优化细胞摄取和细胞内递送，以及通过智能信号处理方法提高成像灵敏度和定量分析精度。总的来说，通过建立材料参数和生物性能之间的关键相关性，机器学习的集成加速了智能纳米颗粒系统的发展，从而推动了精密成像技术的创新。

{"title":"Machine learning for nanoparticle-based imaging: From rational design to precision diagnosis","authors":"Nan Kang , Zengyue Li , Fu Tan , Zimei Liu , Yao Yang , Xiaoqing Qian , Qian Zhang","doi":"10.1016/j.cis.2025.103773","DOIUrl":"10.1016/j.cis.2025.103773","url":null,"abstract":"<div><div>Nanoparticles have become essential in nanomedicine due to their tunable physicochemical properties and multifunctional capabilities, particularly in biomedical imaging for early disease detection and real-time therapeutic monitoring. Nevertheless, the rational design of nanoparticles with predictable behavior in complex biological environments remains significant challenges. Recent advances in machine learning have created novel paradigms for the precise design and efficient application of nanoparticle-based imaging platforms. This review summarizes recent progress in this area, covering machine learning-guided nanoparticle design and fabrication, elucidating their dynamic behavior in biological systems, optimizing cellular uptake and intracellular delivery, and improving imaging sensitivity alongside quantitative analytical precision through intelligent signal processing methodologies. Overall, the integration of machine learning has accelerated the development of intelligent nanoparticulate systems by establishing critical correlations between material parameters and biological performance, thereby driving innovation in precision imaging technologies.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103773"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The surface-first paradigm: Engineering nanocarriers for infection-responsive drug delivery 表面优先范式：用于感染反应性药物递送的工程纳米载体。

IF 19.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science

Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1016/j.cis.2025.103761

Rohan M. Shah , Indu Pal Kaur , Snehal R. Jadhav

The surface of a nanocarrier is the frontline interface between its therapeutic cargo and the complex biological milieu it encounters. While traditional drug delivery research has focused on payload optimisation, emerging challenges, such as antimicrobial resistance, chronic inflammation, and site-specific pathology, demand a strategic pivot toward a surface-first paradigm. This review proposes a surface-first framework for nanocarrier engineering - prioritising dynamic, responsive, and selective surface interactions over conventional passive shielding. It critically evaluates the limitations of conventional surface modifications (e.g., PEGylation) and spotlights zwitterionic coatings and platelet-cloaked nanoparticles as flagship examples of next-generation stealth and targeting. Using infection-responsive systems as exemplars, we show how surface chemistry not only improves pharmacokinetics and biodistribution but also serves as a precision trigger (e.g., pH-activated charge reversal and MMP-cleavable linkers) for on-demand activation at the site of need. We highlight the need for standardised surface-characterisation protocols, modular manufacturing schemes, and integrated diagnostic–therapeutic interfaces to support clinical translation. Embracing a surface-first approach is both timely and essential to drive the future of targeted therapy. While interfacial principles are well established, we focus on an infection-centred, mechanism-first synthesis that links core–surface co-design to controlled release.

纳米载体的表面是其治疗货物与其遇到的复杂生物环境之间的前线界面。虽然传统的给药研究侧重于有效载荷优化，但新出现的挑战，如抗菌素耐药性、慢性炎症和部位特异性病理，要求将战略重心转向表面优先范式。这篇综述提出了纳米载体工程的表面优先框架-优先考虑动态、响应性和选择性表面相互作用，而不是传统的被动屏蔽。它批判性地评估了传统表面修饰（如聚乙二醇化）的局限性，并将两性离子涂层和血小板隐形纳米颗粒作为下一代隐身和瞄准的旗舰例子。以感染反应系统为例，我们展示了表面化学如何不仅改善药代动力学和生物分布，而且还作为精确触发器（例如，ph激活的电荷反转和mmp可切割连接物）在需要的部位按需激活。我们强调需要标准化的表面表征协议、模块化制造方案和集成的诊断-治疗接口来支持临床翻译。采用表面优先的方法对推动靶向治疗的未来既及时又必要。虽然界面原理已经很好地建立起来，但我们专注于以感染为中心、机制优先的综合，将岩心-表面协同设计与控制释放联系起来。

{"title":"The surface-first paradigm: Engineering nanocarriers for infection-responsive drug delivery","authors":"Rohan M. Shah , Indu Pal Kaur , Snehal R. Jadhav","doi":"10.1016/j.cis.2025.103761","DOIUrl":"10.1016/j.cis.2025.103761","url":null,"abstract":"<div><div>The surface of a nanocarrier is the frontline interface between its therapeutic cargo and the complex biological milieu it encounters. While traditional drug delivery research has focused on payload optimisation, emerging challenges, such as antimicrobial resistance, chronic inflammation, and site-specific pathology, demand a strategic pivot toward a surface-first paradigm. This review proposes a <em>surface-first</em> framework for nanocarrier engineering - prioritising dynamic, responsive, and selective surface interactions over conventional passive shielding. It critically evaluates the limitations of conventional surface modifications (e.g.<em>,</em> PEGylation) and spotlights zwitterionic coatings and platelet-cloaked nanoparticles as flagship examples of next-generation stealth and targeting. Using infection-responsive systems as exemplars, we show how surface chemistry not only improves pharmacokinetics and biodistribution but also serves as a precision trigger (e.g., pH-activated charge reversal and MMP-cleavable linkers) for on-demand activation at the site of need. We highlight the need for standardised surface-characterisation protocols, modular manufacturing schemes, and integrated diagnostic–therapeutic interfaces to support clinical translation. Embracing a surface-first approach is both timely and essential to drive the future of targeted therapy. While interfacial principles are well established, we focus on an infection-centred, mechanism-first synthesis that links core–surface co-design to controlled release.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"349 ","pages":"Article 103761"},"PeriodicalIF":19.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0