Journal of Leather Science and Engineering最新文献_第2页

Soil burial evaluation of finished leather biodegradability: microbial community dynamics and biogeochemical cycles 成品皮革生物降解性的土壤掩埋评价：微生物群落动态和生物地球化学循环

Journal of Leather Science and Engineering

Pub Date : 2026-08-01 DOI: 10.1186/s42825-026-00268-3

Xia Li, Yuxin Zhang, Yue Yu, Yunhang Zeng, Bi Shi, Ya-nan Wang

Biodegradability of finished leather is crucial for the sustainable development of the leather industry. Herein, the biodegradability evaluation system of finished leather was engineered using soil burial degradation, microbial community dynamics, and biogeochemical cycles. The protein content of chrome grain leather (CGL), chrome-free grain leather (FGL) and chrome-free suede leather (FSL) exceeded 60%, indicating their inherent biodegradation potential during soil burial. After 6 months of soil burial, the biodegradation rate of FGL was around 2.16-fold that of CGL, demonstrating higher biodegradability of chrome-free finished leather. Besides, total nitrogen contents in FSL and CGL soils at 9 months were 2.45- and 1.07- fold those in the initial soil, respectively. These results suggested that organic matter from the finished leathers, particularly chrome-free finished leathers, was gradually released during soil burial degradation. Metagenome sequencing revealed that the diversity of the soil microbial community was considerably enhanced by the soil burial degradation of finished leather. Pseudomonadota, Actinomycetota, and Chloroflexota are the dominant bacteria phyla driving the soil burial biodegradation of finished leather. Accordingly, the degradation of finished leather can change the relative abundance of genes encoding enzymes involved in amino acid metabolism. The degradation of finished leather may continuously release nitrogen-containing substrates, supporting key nitrogen cycling processes including organic nitrogen metabolism, nitrification, assimilation, and nitrate reduction. These results diversify the evaluation systems for finished leather biodegradability, and demonstrate that chrome-free finished leather holds significant promise for the sustainable development of the leather industry.

Graphical abstract

成品皮革的生物降解性对皮革工业的可持续发展至关重要。在此基础上，利用土壤埋藏降解、微生物群落动态和生物地球化学循环，设计了成品皮革可生物降解性评价体系。铬粒革（CGL）、无铬粒革（FGL）和无铬绒面革（FSL）的蛋白质含量均超过60%，表明其在土壤埋藏过程中具有内在的生物降解潜力。土壤埋藏6个月后，FGL的生物降解率约为CGL的2.16倍，表明无铬成品革具有较高的生物降解性。此外，FSL和CGL土壤9个月的总氮含量分别是初始土壤的2.45倍和1.07倍。这些结果表明，在土壤埋藏降解过程中，整理革中的有机质，尤其是无铬整理革中的有机质逐渐释放。宏基因组测序结果显示，皮革制品的土壤埋藏降解显著提高了土壤微生物群落的多样性。假单胞菌门、放线菌门和氯氟菌门是驱动成品皮革土壤埋藏生物降解的优势菌门。因此，成品皮革的降解可以改变编码氨基酸代谢酶的基因的相对丰度。成品皮革的降解可以不断释放含氮底物，支持关键的氮循环过程，包括有机氮代谢、硝化、同化和硝酸盐还原。这些结果多样化了成品皮革生物降解性的评价体系，并表明无铬成品皮革对皮革工业的可持续发展具有重要的前景。图形抽象

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引用次数: 0

Advances in collagen-based materials for tissue-engineered meniscus 组织工程半月板胶原基材料的研究进展

Journal of Leather Science and Engineering

Pub Date : 2026-08-01 DOI: 10.1186/s42825-026-00253-w

Yang Sun, Jiaxing Li, Xinyue Zhang, Xue Zhan, Yizhe Wen, Xuran Li, Jie Liang, Yafang Chen, Yujiang Fan, Xingdong Zhang

Meniscus possesses weak self-repairability once getting hurt due to heterogeneity, particularly “white region” of avascular parts. However, the effect of conventional therapies in restoring structure and function of the meniscus isn’t ideal. Collagen, a key part of the extracellular matrix, is quite promising. Its excellent biocompatibility and biological activity enable collagen-based tissue-engineered meniscus scaffolds to be safely implanted in the body, effectively improving the pathological and physiological state of cells at the meniscus injury site and the surrounding microenvironment. This review describes the application of different implantable medical collagen-based materials used for meniscal regeneration and repair. Firstly, the structure and physiological function of meniscus are described briefly. Then, different collagen-based materials for meniscal repair are introduced emphatically. Last but not least, some current challenges and issues regarding collagen-based strategies on meniscus repair are analyzed so as to provide strategies for future studies.

Graphical Abstract

半月板由于其异质性，损伤后自我修复能力较弱，尤其是无血管部位的“白色区域”。然而，传统的治疗方法在恢复半月板结构和功能方面的效果并不理想。胶原蛋白是细胞外基质的重要组成部分，其前景十分广阔。其优异的生物相容性和生物活性使胶原基组织工程半月板支架能够安全植入体内，有效改善半月板损伤部位细胞的病理生理状态及周围微环境。本文综述了不同植入式医用胶原基材料在半月板再生和修复中的应用。首先简要介绍半月板的结构和生理功能。然后重点介绍了用于半月板修复的不同胶原基材料。最后分析了目前基于胶原蛋白的半月板修复策略所面临的挑战和存在的问题，为今后的研究提供策略。图形抽象

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引用次数: 0

Bioactive fish-derived collagen peptides enhance cutaneous repair by reprogramming the wound microenvironment toward antioxidant, anti-inflammatory and pro-remodeling status 生物活性鱼源性胶原蛋白肽通过将伤口微环境重新编程为抗氧化、抗炎和促重塑状态来增强皮肤修复

Journal of Leather Science and Engineering

Pub Date : 2026-07-16 DOI: 10.1186/s42825-026-00260-x

Marie Salon, Mouna Rahabi, Christelle Bonnet, Mélanie Gadelorge, Mathilde Lavernhe, Maylis Farno, Clément Blot, Mélissa Parny, Hélène Authier, Charlotte Peyrot, Isabelle Raymond-Letron, Pascale Jolimaitre, Lise Lefèvre, Agnès Coste

Chronic wounds are marked by persistent inflammation that disrupts normal tissue repair. Growing attention is being directed toward dietary supplements as non-pharmacological strategies to support wound healing. This study evaluated the therapeutic potential of a specific formulation of bioactive fish-derived collagen peptides, Naticol^®, in promoting cutaneous repair. The results demonstrated that oral supplementation with Naticol^® accelerated excisional wound closure in type 2 diabetic mice by restoring essential histological features of healthy skin and enhancing collagen production. This effect is achieved through the establishment of an antioxidant and anti-inflammatory wound microenvironment, the enhancement of scavenger-dependent efferocytosis, and the modulation of MMP9/TIMP1 ratio in favor of tissue remodeling. Notably, Naticol^® drove transcriptional reprogramming of human dermal fibroblasts and monocytes toward antioxidant, anti-inflammatory, and pro-repair phenotypes. In human keratinocytes, Naticol^® increased migratory capacity, further contributing to tissue regeneration. Consistent with in vivo findings, Naticol^® treatment improved wound healing in human skin explants by reinforcing an antioxidant, anti-inflammatory, and pro-reparative microenvironment. These results highlight Naticol^®, a fish-derived bioactive collagen peptide preparation, as a promising functional food component, providing an innovative complementary approach for the management of chronic wounds.

Graphical Abstract

慢性伤口的特征是持续的炎症，破坏正常的组织修复。越来越多的注意力被指向膳食补充剂作为支持伤口愈合的非药物策略。本研究评估了一种特殊配方的生物活性鱼源胶原蛋白肽Naticol®在促进皮肤修复方面的治疗潜力。结果表明，口服补充Naticol®通过恢复健康皮肤的基本组织学特征和促进胶原蛋白的产生，加速了2型糖尿病小鼠的切除伤口愈合。这种效果是通过建立抗氧化和抗炎的伤口微环境，增强清除剂依赖性的efferocytosis，以及调节MMP9/TIMP1比率以促进组织重塑来实现的。值得注意的是，Naticol®驱动人类真皮成纤维细胞和单核细胞向抗氧化、抗炎和促修复表型的转录重编程。在人角质形成细胞中，Naticol®增加迁移能力，进一步促进组织再生。与体内实验结果一致，Naticol®治疗通过增强抗氧化、抗炎和促进修复的微环境，改善了人体皮肤外植体的伤口愈合。这些结果突出了Naticol®，一种鱼类来源的生物活性胶原蛋白肽制剂，作为一种有前途的功能性食品成分，为慢性伤口的治疗提供了一种创新的补充方法。图形抽象

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引用次数: 0

Preparation, identification, and multi-target anti-photoaging mechanisms of bioactive collagen peptides 生物活性胶原肽的制备、鉴定及多靶点抗光老化机制研究

Journal of Leather Science and Engineering

Pub Date : 2026-07-02 DOI: 10.1186/s42825-026-00249-6

Zhenyu Liu, Yanli Yang, Yuanlong Chi, Zhenghong Xu

This study aimed to identify anti-photoaging peptides in porcine skin and to elucidate their bioactive mechanisms using physicochemical property prediction, molecular docking, cell experiments, and network pharmacology. Four collagen peptides were identified from porcine skin hydrolysates via ultrafiltration, gel chromatography, and multi-pathway molecular docking. Among them, FGPYGF and GPPSGGFG exhibited superior photoprotective efficacy which increased the viability of UVB-damaged HaCaT cells to 72.15% and 66.36% at 400 µM, respectively, while effectively suppressing cellular senescence at 200 µM. Molecular docking revealed that synergetic and stronger binding was mediated by hydrogen bonding, ionic interactions, and π-π stacking in forming complexes between both bioactive peptides and four target enzymes (MMP-1, MMP-9, NF-κB, and IL-1β), with binding energies ranging from − 8.34 to -18.37 kcal/mol. FGPYGF inhibited MMP-1 expression and promoted type I collagen synthesis, while GPPSGGFG significantly reduced ROS levels. FGPYGF blocked inflammation and matrix degradation by targeting the TNF signaling pathway and collagen catabolic processes (IL1B/MMP9/2), while GPPSGGFG delayed cell cycle progression and enhanced antioxidant capacity via the FoxO/PI3K-Akt pathway (CCND1/SIRT1). This study confirms that multi-target intervention through cross-pathway modulation significantly enhances photoprotection, providing a theoretical basis for the rational design and precision application of anti-photoaging peptides.

Graphical Abstract

本研究旨在通过理化性质预测、分子对接、细胞实验和网络药理学等方法，鉴定猪皮肤中抗光老化肽，并阐明其生物活性机制。通过超滤、凝胶层析和多途径分子对接，从猪皮水解物中鉴定出4种胶原蛋白肽。其中，FGPYGF和GPPSGGFG表现出较强的光保护作用，在400µM下可使uvb损伤的HaCaT细胞活力分别提高到72.15%和66.36%，在200µM下可有效抑制细胞衰老。分子对接发现，活性肽与4种靶酶（MMP-1、MMP-9、NF-κB和IL-1β）之间通过氢键、离子相互作用和π-π叠加形成配合物，结合能在−8.34 ~ -18.37 kcal/mol之间。FGPYGF抑制MMP-1表达，促进I型胶原合成，而GPPSGGFG显著降低ROS水平。FGPYGF通过靶向TNF信号通路和胶原分解代谢过程（IL1B/MMP9/2）阻断炎症和基质降解，而GPPSGGFG通过FoxO/PI3K-Akt通路（CCND1/SIRT1）延迟细胞周期进程并增强抗氧化能力。本研究证实了通过交叉通路调制的多靶点干预可显著增强光保护作用，为抗光老化肽的合理设计和精准应用提供了理论依据。图形抽象

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引用次数: 0

From waste to 3D printing material: upcycling leather shavings in thermoplastic polyurethane and determining the filament fabrication threshold 从废物到3D打印材料：在热塑性聚氨酯中升级回收皮革刨花并确定长丝制造阈值

Journal of Leather Science and Engineering

Pub Date : 2026-07-01 DOI: 10.1186/s42825-026-00255-8

R. Mascolo, G. Calvanese, M. U. Nazir, E. Bilotti, L. Giorleo

This study explores the potential of upcycling wet-white leather shavings as a filler in thermoplastic polyurethane (TPU) composites for fused filament fabrication (FFF). Leather waste was chemically analyzed to ensure compliance with environmental and safety regulations before being incorporated into TPU at varying concentrations (10 wt% to 40 wt%). Morphological, thermal, rheological, and mechanical characterizations were performed to assess the feasibility of composites for filament production and 3D printing. Results indicated that composites containing up to 30 wt% leather waste maintained good printability, with a speed of 50 mm/s at 220–225 °C identified as optimal printing parameters. Higher filler concentrations (40 wt%) caused severe embrittlement due to material breakage during spool preparation for printing and during filament handling in the FFF feeding system, rendering the material unusable. Despite these limitations, the material demonstrated a promising potential for sustainable additive manufacturing applications in fashion, automotive interiors, and design, offering an eco-friendly alternative for repurposing industrial leather waste.

Graphical Abstract

本研究探讨了升级回收湿白色皮革刨花作为热塑性聚氨酯（TPU）复合材料中用于熔丝制造（FFF）的填料的潜力。在以不同的浓度（10 wt%至40 wt%）加入TPU之前，对皮革废料进行化学分析，以确保符合环境和安全法规。通过形态学、热、流变学和力学表征来评估复合材料用于长丝生产和3D打印的可行性。结果表明，含30 wt%皮革废料的复合材料保持良好的印刷性能，在220 ~ 225℃下，打印速度为50 mm/s为最佳打印参数。较高的填料浓度（40 wt%）会导致严重的脆性，这是由于在印刷的线轴准备和FFF进料系统中的长丝处理过程中材料断裂，导致材料无法使用。尽管存在这些限制，但这种材料在时尚、汽车内饰和设计领域的可持续增材制造应用方面显示出了巨大的潜力，为工业皮革废料的再利用提供了一种环保的替代方案。图形抽象

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引用次数: 0

Enzymolysis behavior and safe collagenase management of porcine collagen fillers 猪胶原蛋白填料的酶解行为及安全胶原酶管理

Journal of Leather Science and Engineering

Pub Date : 2026-07-01 DOI: 10.1186/s42825-026-00244-x

Hang Wang, Rui Zhao, Chihchieh Lo, Donglei Yu, Hsien-Li Peter Peng, Jing Wang, He Qiu

Collagen-based fillers are increasingly recognized as versatile biomaterials for soft-tissue augmentation, yet evidence guiding the enzymatic management of collagen-associated complications remains limited. Here, we performed a systematic characterization of two National Medical Products Administration-approved porcine type I collagen fillers (PCFs), glutaraldehyde cross-linked PCF (CL-PCF) and uncross-linked PCF (UCL-PCF), using hyaluronic acid (HA) filler as a clinical benchmark. CL-PCF exhibited superior mechanical robustness and markedly enhanced resistance to collagenase degradation relative to UCL-PCF. In a rabbit ear embolization model, both PCFs induced significantly milder vascular ischemic manifestations than HA. In vivo enzymolysis assessment in SD rats demonstrated that collagenase concentrations ≤ 300 IU/mL effectively facilitated the controlled degradation of PCFs without inducing notable tissue injury, whereas higher concentrations resulted in extensive matrix loss, hemorrhage, and focal skeletal muscle lysis with inflammatory infiltration. This study provides the first integrated mechanistic and safety-oriented framework for understanding the enzymolysis of collagen fillers and optimizing collagenase-based interventions. These findings offer clinical guidance for complication management and inform evidence-based decision-making in collagen filler applications.

Graphical Abstract

胶原蛋白为基础的填充物越来越被认为是用于软组织增强的多功能生物材料，但指导胶原蛋白相关并发症的酶管理的证据仍然有限。在这里，我们以透明质酸（HA）填充剂作为临床基准，对两种国家药品监督管理局批准的猪I型胶原蛋白填充剂（PCF），戊二醛交联PCF （CL-PCF）和非交联PCF （UCL-PCF）进行了系统的表征。与UCL-PCF相比，CL-PCF具有更强的机械稳定性和抗胶原酶降解能力。在兔耳栓塞模型中，两种PCFs诱导的血管缺血表现均明显轻于HA。SD大鼠体内酶解实验表明，胶原酶浓度≤300 IU/mL可有效促进PCFs的可控降解，而不引起明显的组织损伤，而较高浓度可导致广泛的基质丢失、出血和局灶性骨骼肌溶解伴炎症浸润。这项研究为理解胶原蛋白填充物的酶解和优化胶原酶干预提供了第一个完整的机制和安全导向的框架。这些发现为并发症的处理提供了临床指导，并为胶原填料应用的循证决策提供了依据。图形抽象

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引用次数: 0

Controllable fabrication of a tannin-lignin-phenolic carbon foam with excellent smoke suppression and preferable mechanical properties 具有良好抑烟性能和良好力学性能的单宁-木质素-酚醛碳泡沫材料的可控制备

Journal of Leather Science and Engineering

Pub Date : 2026-06-22 DOI: 10.1186/s42825-026-00247-8

Qingmiao Jiang, Yuxin Zhou, Minghua Liu, Yuancai Lv, Hong Guo, Yifan Liu, Xiaoxia Ye, Yongqian Shi

With the depletion of petroleum resources, biomass has been widely applied as an alternative to petroleum-based feedstocks. In this work, a lightweight tannin-lignin-phenolic carbon foam (TLCF_5−ME) with excellent smoke suppression was developed. The foam precursor was prepared by substituting 30 wt% of phenol with modified lignin, and tannin was used as a framework filler to reinforce the samples. The effects of lignin, tannin type, including myrica extract (ME), wattle extract (WE), and tannic acid (TA), and addition amount of tannin on the mechanical behavior and smoke suppression of carbon foam were determined, and the mechanism was illustrated. Surprisingly, it was found that the total smoke release of TLCF_5−ME was only 0.39 m²/m², which was 97.62% lower than that of pure phenolic carbon foam (CF), and the compressive strength of TLCF_5−ME was 0.32 MPa, which was 33.33% higher than that of CF. In summary, adding modified lignin and ME not only reduced the use of phenol, but also increased the number of aromatic rings and improved the graphitization degree of carbon foam, thereby promoting the formation of compact char layers under combustion, and further effectively inhibiting the smoke production of samples.

Graphical Abstract

随着石油资源的日益枯竭，生物质作为石油基原料的替代品得到了广泛的应用。本文研制了一种轻质单宁-木质素-酚醛碳泡沫（TLCF5−ME），具有良好的抑烟性能。用改性木质素代替30%的苯酚制备泡沫前驱体，并用单宁作为骨架填料增强样品。研究了木质素、单宁类型（杨梅提取物（ME）、金合欢提取物（WE）和单宁酸（TA））以及单宁添加量对泡沫炭的力学性能和抑烟性能的影响，并对其机理进行了探讨。令人惊讶的是，TLCF5−ME的总烟雾释放量仅为0.39 m2/m2，比纯酚醛碳泡沫（CF）低97.62%，TLCF5−ME的抗压强度为0.32 MPa，比纯酚醛碳泡沫（CF）高33.33%。综上所示，添加改性木质素和ME不仅减少了苯酚的使用，还增加了芳香环的数量，提高了泡沫碳的石墨化程度。从而促进燃烧时致密炭层的形成，进一步有效抑制样品的产烟。图形抽象

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引用次数: 0

Collagen-derived electronic skins: from biomimetic principles to multifunctional sensing and applications 胶原蛋白衍生电子皮肤：从仿生原理到多功能传感和应用

Journal of Leather Science and Engineering

Pub Date : 2026-06-02 DOI: 10.1186/s42825-026-00251-y

Mengtao Zhao, Yuchong Ren, Yixiang Mao, Wanhong Wu, Xiaoyao Tan, Ling Bai, Yan Xu, Hao Yuan, Yanxia Wei, Guiqiang He, Aixia Lu, Jie Yu, Zhongxue Bai, Mengchen Huang, Jian Zhou

Electronic skin (e-skin) holds significant potential for applications in health monitoring and human-machine interaction. However, conventional materials are often limited by poor biocompatibility and mechanical mismatch with biological tissues. Collagen and its derivatives, as naturally derived biopolymers, have emerged as an ideal matrix for constructing high-performance e-skin due to their exceptional biocompatibility, tunable biodegradability, mechanical properties that closely match human skin, and bioactivity endowed by abundant cell-recognition motifs. This review systematically presents the biomimetic design principles and advanced fabrication strategies of collagen-derived e-skins (CDE-Skins), including structural biomimicry, diversified manufacturing techniques, and conductive functionalization. It further examines their performance and underlying mechanisms in multimodal sensing, such as tactile, thermal, humidity, and biochemical sensing, elucidating the origins of their high sensitivity and stable signal response. The article also highlights representative applications in personalized telehealth monitoring, wound protection and therapy, and human-machine teleoperation. Concurrently, it outlines current challenges and offers perspectives on future research directions. This work aims to provide a comprehensive theoretical foundation to advance technological innovation and accelerate the practical translation of biocompatible e-skin technologies.

Graphical Abstract

The alternative text for this image may have been generated using AI.

电子皮肤（e-skin）在健康监测和人机交互方面具有巨大的应用潜力。然而，传统材料往往受到生物相容性差和与生物组织机械不匹配的限制。胶原蛋白及其衍生物作为天然衍生的生物聚合物，由于其卓越的生物相容性、可调节的生物降解性、与人类皮肤密切匹配的机械性能以及丰富的细胞识别基序所赋予的生物活性，已成为构建高性能电子皮肤的理想基质。本文系统地介绍了胶原衍生电子皮肤的仿生设计原理和先进的制造策略，包括结构仿生、多样化制造技术和导电功能化。它进一步研究了它们在多模态传感中的性能和潜在机制，如触觉、热、湿度和生化传感，阐明了它们高灵敏度和稳定信号响应的起源。本文还重点介绍了个性化远程医疗监测、伤口保护和治疗、人机远程操作等方面的代表性应用。同时，概述了当前面临的挑战，并对未来的研究方向提出了展望。本研究旨在为推进生物相容性电子皮肤技术的技术创新和加速实际转化提供全面的理论基础。此图像的替代文本可能是使用AI生成的。

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引用次数: 0

Investigating the elution mechanism and efficiency of 2,4,5-trichlorophenol removal from pickled hide using β-cyclodextrin 研究了β-环糊精对腌皮中2,4,5-三氯酚的去除机理和效果

Journal of Leather Science and Engineering

Pub Date : 2026-06-01 DOI: 10.1186/s42825-026-00240-1

Qinyang Li, Yanni Cao, Liming Zhao, Yuling Tang, Jianfei Zhou

The residual issue of 2,4,5-trichlorophenol (2,4,5-TriCP) affects the leather industry because excessive 2,4,5-TriCP levels are detected in several finished leather products. This study reports the feasibility of using ecofriendly cyclodextrins (CDs) for 2,4,5-TriCP removal from pickled hide via host-guest interactions. Molecular docking, fluorescence spectroscopy, and quartz crystal microbalance with dissipation monitoring results confirmed that β-CD was suitable for 2,4,5-TriCP removal owing to its appropriate cavity structure. Batch elution experiments were performed to evaluate the influence of key parameters on the removal efficiency of β-CD, including time, temperature, sodium chloride (NaCl), β-CD concentrations, and the number of elution cycles. The mentioned optimal elution conditions were identified: 8% (w/v) NaCl, 120 min duration, 5 g·L^− 1 β-CD, 298.15 K, and five elution cycles. 2,4,5-TriCP (40.55–116.39 mg·kg^− 1) was completely removed, meeting the international ecotextile standard limit for chlorophenol (0.05 mg·kg^− 1). Finally, the physical properties of the β-CD eluted pickled hide samples were barely affected compared to the samples treated using the conventional process, confirming that β-CD could be used as a green eluting agent for sustainable leather production.

Graphical abstract

The alternative text for this image may have been generated using AI.

2,4,5-三氯苯酚（2,4,5- tricp）的残留问题影响了皮革工业，因为在几种成品皮革中检测到过量的2,4,5- tricp。本研究报道了利用生态友好型环糊精（CDs）通过主-客体相互作用从腌制皮中去除2,4,5-三聚氰胺的可行性。分子对接、荧光光谱和石英晶体微平衡耗散监测结果证实，β-CD具有合适的腔体结构，适合去除2,4,5- tricp。通过间歇洗脱实验，考察时间、温度、氯化钠（NaCl）、β-CD浓度、洗脱次数等关键参数对β-CD去除率的影响。确定了最佳洗脱条件：8% (w/v) NaCl，持续时间120 min， 5 g·L−1 β-CD, 298.15 K， 5个洗脱周期。2,4,5- tricp （40.55-116.39 mg·kg−1）被完全去除，符合国际生态纺织品标准氯酚限量（0.05 mg·kg−1）。最后，与传统工艺处理的样品相比，β-CD洗脱的酸洗皮革样品的物理性能几乎没有受到影响，证实了β-CD可以作为可持续皮革生产的绿色洗脱剂。图形抽象此图像的替代文本可能是使用AI生成的。

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引用次数: 0

Triple-helical recombinant humanized type I collagen promotes photodamaged skin repair via ECM remodeling and anti-inflammatory mechanisms 三螺旋重组人源I型胶原蛋白通过ECM重塑和抗炎机制促进光损伤皮肤修复

Journal of Leather Science and Engineering

Pub Date : 2026-06-01 DOI: 10.1186/s42825-026-00245-w

Nannan Wei, Yuchen Zhang, Wenjie Huang, Xinyu Tian, Linyan Yao, Jianxi Xiao

Ultraviolet (UV) irradiation is a major cause of photoaging, driving oxidative stress, inflammation, and extracellular matrix (ECM) degradation. Collagen is central to dermal integrity, yet animal-derived sources pose immunogenic and pathogen risks, while recombinant collagens reported to date often lack the stable triple-helical architecture required for bioactivity. Here, we present a triple-helical recombinant humanized type I collagen (THRCI) that combines native-like conformation with excellent biosafety and regenerative efficacy. THRCI supported fibroblast adhesion, proliferation, migration, and collagen synthesis, while suppressing intracellular reactive oxygen species and pro-inflammatory cytokines. In zebrafish, THRCI reduced oxidative stress and alleviated UV-induced caudal fin atrophy. In a murine model of acute UV photodamage, topical THRCI accelerated epidermal recovery, restored hydration and barrier function, increased dermal density, and promoted collagen fiber remodeling, while downregulating IL-6, IL-1β, MMP-1, and MMP-9. Collectively, these findings indicate that THRCI exhibits effective photodamage-repair properties in our established models and represents a promising animal-free collagen biomaterial for skin regeneration.

Graphical Abstract

The alternative text for this image may have been generated using AI.

紫外线（UV）照射是光老化的主要原因，驱动氧化应激、炎症和细胞外基质（ECM）降解。胶原蛋白是真皮完整性的核心，但动物源性胶原存在免疫原性和病原体风险，而迄今为止报道的重组胶原往往缺乏生物活性所需的稳定的三螺旋结构。在这里，我们提出了一种三螺旋重组人源化I型胶原（THRCI），它结合了天然的类似构象，具有良好的生物安全性和再生功效。THRCI支持成纤维细胞粘附、增殖、迁移和胶原合成，同时抑制细胞内活性氧和促炎细胞因子。在斑马鱼中，THRCI降低氧化应激，减轻紫外线诱导的尾鳍萎缩。在小鼠急性紫外线光损伤模型中，外用THRCI可加速表皮恢复，恢复水合和屏障功能，增加真皮密度，促进胶原纤维重塑，同时下调IL-6、IL-1β、MMP-1和MMP-9。总的来说，这些发现表明，在我们建立的模型中，THRCI具有有效的光损伤修复特性，代表了一种有前途的用于皮肤再生的无动物胶原生物材料。此图像的替代文本可能是使用AI生成的。

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引用次数: 0