Archives of Physiology and Biochemistry最新文献

Chronic sinusitis with nasal polyps (CRSwNP) has a relatively high recurrence rate, seriously affecting the quality of life of patients. Neuroinflammation interacts with the persistent inflammatory state of the nasal mucosa. This study aims to explore the application value of medical thermal imaging technology in predicting postoperative recurrence of nECRSwNP, and to evaluate potential biomarkers and efficacy assessment methods for neuroinflammation treatment, with the expectation of providing new strategies for reducing postoperative recurrence rates and improving the quality of life. Medical thermal imaging technology can monitor the temperature changes of nasal mucosa in real time and promptly detect alterations in inflammatory activity. The levels of EOS and cytokines in peripheral blood can serve as potential biomarkers for evaluating the status of neuroinflammation, which is helpful for identifying patients with a higher risk of recurrence, thereby enabling timely adjustment of treatment plans and improving the pertinence and effectiveness of neuroinflammation treatment.

Lipoprotein metabolic regulation plays a vital role in human health and disease, with its abnormalities closely associated with the onset and progression of various disorders. In cases of lymphadenopathy, this study aimed to develop a linear model based on multimodal ultrasound parameters and lipoprotein metabolic regulation, predicting changes in intraluminal and perilymphatic tissue stiffness during cervical lymphadenopathy to provide clinical guidance for assessing lymph node characteristics. All patients underwent multimodal ultrasound examinations including conventional 2D ultrasound, colour Doppler ultrasound, and elastography. The linear model developed based on these factors demonstrated high predictive power, indicating that changes in lipoprotein metabolism are closely linked to the pathophysiological processes of lymph nodes. In lymphadenopathy, lipoprotein metabolic regulation affects local inflammatory responses and extracellular matrix remodelling, thereby influencing lymph node stiffness and function. Additionally, lipoprotein regulation indirectly impacts lymph node hardness by modulating angiogenesis and extracellular matrix remodelling.

Background: The cardioprotective properties of resistance training (RT) in infarcted rats have been poorly investigated. This study aimed to evaluate the effects of eight weeks of RT prior myocardial infarction (MI) in rats. Method: Groups: SSh: sedentary sham surgery; SMI: sedentary MI; TMI: trained MI. At the end of the eighth week, the animals underwent either MI or sham surgery and were analysed four weeks later. Results: The TMI presented MI sizes, scar areas, masses of the atria, right ventricle, heart, left atrial area, E wave, and E/A ratio, smaller than the SMI. The protein expression related to Ca²⁺ handling were not affected by the RE. The maximal load (ML) of the TMI was greater than that of the SMI group. The VO₂ peak and maximum speed (Vmax) were lower in the infarcted groups. Conclusion: Prior RT confers cardioprotection against cardiac remodelling by attenuating infarct size progression, myocardial hypertrophy, and diastolic dysfunction.

Background: Post-stroke cognitive impairment (PSCI), a common complication following stroke, significantly impacts patients' quality of life and prognosis. Research indicates that neuroregulation and protein metabolic disorders play crucial roles in the development of PSCI.

Purpose: This study aimed to evaluate the reliability of the Regional Meningoarterial Score (rLMC) in determining collateral circulation status in acute ischaemic stroke patients.

Method: Participants were selected based on specific criteria including MRI-detected recent cerebral infarction, absence of prior large-scale subcortical infarction or haemorrhage, and no history of Alzheimer's disease or cognitive impairment.

Results: The results showed that cognitive impairment group (CI group) exhibited significantly lower serum acetylcholine levels compared to normal control group (CN group), while β-amyloid protein levels were markedly higher. CI group also demonstrated reduced expression of neuroregulatory factors.

Conclusion: These findings demonstrate that neuroregulatory factors and protein metabolites can serve as potential biomarkers for early diagnosis and intervention, effectively predicting post-stroke cognitive impairment.

Traditional cancer diagnosis methods include imaging examinations, biopsy, etc., but these methods are often invasive, time-consuming, and costly. This study aims to explore the application effect of infra-red thermography technology in cancer diagnosis and analyse the coping experience of primary caregivers during patient diagnosis and treatment. The data collection methods include semi-structured interviews, observations, and questionnaire surveys. The research results show that infra-red thermography technology has high sensitivity and specificity in cancer diagnosis, which can assist doctors in detecting early signs of tumours. Therefore, cancer diagnosis technology based on infra-red thermography has shown great potential in early detection and is expected to become a beneficial supplement to traditional diagnostic methods. At the same time, caregivers' coping experiences during cancer diagnosis and treatment are complex and diverse, requiring the healthcare system to provide more support and resources to help them better adapt and cope.

Context: Lipid peroxidation (LPO) causes oxidative stress and neuroinflammation in eye diseases. Malondialdehyde and 4-hydroxy-2-nonenal are produced in the eye via polyunsaturated fatty acid oxidation. Objective: Electrophiles damage biological components. LPO damages the retina and optic nerve, causing age-related macular degeneration, diabetic retinopathy, and glaucoma. Materials and Methods: LPO also causes cataracts and dry eye in the anterior area. It also stimulates NLRP3 and NF-κB pathways, causing inflammation. Results: Electrophiles damage biological components. LPO damages the retina and optic nerve, causing age-related macular degeneration, diabetic retinopathy, and glaucoma. LPO also causes cataracts and dry eye in the anterior area. It also stimulates NLRP3 and NF-κB pathways, causing inflammation. Conclusion: Understanding how lipid peroxidation, oxidative stress, and neuroinflammation interact is crucial to developing effective eye health and vision loss therapies.

Critical limb ischaemia (CLI), a severe peripheral artery disease, reduces blood flow, disrupting lipid metabolism and mitochondrial function. This leads to muscle loss, impaired repair, and greater limb loss risk. Standard diagnostics emphasise imaging and perfusion, often missing metabolic changes. The LIPID-CLI framework uses high-resolution mass spectrometry to analyse lipid shifts under mitochondrial stress. Biopsy limits shifted focus to blood markers reflecting tissue lipids. Altered ceramides and phospholipids indicate lipid-mitochondrial dysfunction and may serve as non-invasive biomarkers for early CLI detection and treatment. The method improves ceramides (400 mL), phospholipid ratio (1.5), acylcarnitines (6 L), OxPLs (300 mL), index score (<0.4), and mediator levels (200 mL). The reduction denotes decreased ceramide concentration (µmol/mL or ng/mL), normalised to total lipid content in affected tissues. This measure reflects how ceramide alterations disrupt lipid homeostasis and mitochondrial function in critical limb ischaemia (CLI).

Background: Hierarchical medical treatment is the core system of China's medical reform. The medical alliance model, as an important carrier, has been promoted nationwide. Purpose: This study aims to comprehensively assess the current status of pharmaceutical services in the medical alliance of Shaoxing City, with a focus on the application of metabolic abnormality tests, providing a basis for improving service homogeneity. Methods: The study adopted the cross-sectional survey method. Questionnaires were distributed to the heads of the pharmacy departments of 4 general hospitals of the medical alliance and 23 branch hospitals in Shaoxing from April to May 2021. Discussion: Measures such as optimising the allocation of testing resources, improving unified standards and mutual recognition mechanisms, and strengthening the collaboration between testing and pharmaceutical services should be taken to enhance the homogenisation level of metabolic abnormality tests, thereby comprehensively improving the pharmaceutical service capabilities of the medical alliance and promoting implementation of hierarchical medical treatment.

Lipid mediators control intestinal motility, epithelial signalling, and neuronal function by integrating metabolic, hormonal, and neurological interactions throughout the brain-gut axis. Recurrent loose stools without structural abnormalities are the hallmark of Functional Diarrhoea (FD), a condition marked by high oxidative stress and disruptions in this axis. The main aim of this work is to further understand the role of lipid profiles in oxidative stress and neurological abnormalities in FD using the proposed Lipid-Mediated Brain-Gut Axis (LIMBRA) model. The LIMBRA system analyzes lipid abnormalities using targeted blood and faecal lipidomics with oxidative stress and cognitive assessment. FD showed mild cognitive impairment, high oxidative stress, increased lipid peroxidation, and reduced omega-3 anti-inflammatory mediators. These findings support a lipid-based mechanism linking gastrointestinal dysregulation to brain oxidative stress and neurodegeneration, providing a foundation for future studies on lipid biomarkers and therapies for FD and related cognitive disorders.

Schwannoma of the ulnar nerve is often closely related to cubital tunnel syndrome. Neuroinflammation plays a significant role in the pathogenesis of ulnar schwannoma and cubital tunnel syndrome. This study aims to explore the application value of thermal radiation imaging technology in the diagnosis of ulnar schwannoma combined. After neuroinflammatory intervention, the patient's pain and numbness symptoms were significantly alleviated. Thermal radiation images show that the state of neuroinflammation is closely related to the improvement of neurological function. Thermal radiation imaging technology holds significant clinical importance in the diagnosis and treatment evaluation of ulnar schwannoma combined with cubital tunnel syndrome. It can provide real-time monitoring data of neuroinflammation and assist doctors in formulating more effective treatment plans. Neuroinflammatory intervention has shown good effects in alleviating patients' symptoms and promoting the recovery of neurological function, providing new ideas and methods for the treatment of ulnar schwannoma combined with cubital tunnel syndrome.