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Acellular dermal matrices and radiotherapy in breast reconstruction: a systematic review and meta-analysis of the literature. 脱细胞真皮基质和乳房重建中的放疗:文献的系统回顾和荟萃分析。
Pub Date : 2014-01-01 Epub Date: 2014-05-21 DOI: 10.1155/2014/472604
Luigi Valdatta, Anna Giulia Cattaneo, Igor Pellegatta, Stefano Scamoni, Anna Minuti, Mario Cherubino

The increasing use of commercially available acellular dermis matrices for postmastectomy breast reconstruction seems to have simplified the surgical procedure and enhanced the outcome. These materials, generally considered to be highly safe or with only minor contraindications due to the necessary manipulation in preparatory phases, allow an easier one-phase surgical procedure, in comparison with autologous flaps, offering a high patient satisfaction. Unfortunately, the claim for a higher rate of complications associated with irradiation at the implant site, especially when the radiation therapy was given before the reconstructive surgery, suggested a careful behaviour when this technique is preferred. However, this hypothesis was never submitted to a crucial test, and data supporting it are often discordant or incomplete. To provide a comprehensive analysis of the field, we searched and systematically reviewed papers published after year 2005 and registered clinical trials. On the basis of a meta-analysis of data, we conclude that the negative effect of the radiotherapy on the breast reconstruction seems to be evident even in the case of acellular dermis matrices aided surgery. However, more trials are needed to make solid conclusions and clarify the poor comprehension of all the factors negatively influencing outcome.

越来越多的商业上可用的脱细胞真皮基质用于乳房切除术后乳房重建似乎简化了手术程序并提高了结果。这些材料通常被认为是高度安全的,由于在准备阶段需要进行必要的操作,只有轻微的禁忌症,与自体皮瓣相比,这些材料允许更容易的一期手术,提供了很高的患者满意度。不幸的是,关于植入部位放射治疗并发症发生率较高的说法,特别是在重建手术前进行放射治疗时,建议首选这种技术时要小心。然而,这一假设从未经过关键的检验,支持它的数据往往不一致或不完整。为了提供该领域的全面分析,我们检索并系统地回顾了2005年以后发表的论文和注册的临床试验。在数据荟萃分析的基础上,我们得出结论,即使在脱细胞真皮基质辅助手术的情况下,放疗对乳房重建的负面影响似乎也是明显的。然而,需要更多的试验来得出可靠的结论,并澄清对所有负面影响结果的因素的理解不足。
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引用次数: 42
Hypospadias repair: a single centre experience. 尿道下裂修补术:单个中心的经验。
Pub Date : 2014-01-01 Epub Date: 2014-01-20 DOI: 10.1155/2014/453039
Mansoor Khan, Abdul Majeed, Waqas Hayat, Hidayat Ullah, Shazia Naz, Syed Asif Shah, Tahmeedullah Tahmeed, Kanwal Yousaf, Muhammad Tahir

Objectives. To determine the demographics and analyze the management and factors influencing the postoperative complications of hypospadias repair. Settings. Hayatabad Medical Complex Peshawar, Pakistan, from January 2007 to December 2011. Material and Methods. All male patients presenting with hypospadias irrespective of their ages were included in the study. The data were acquired from the hospital's database and analyzed with Statistical Package for Social Sciences (SPSS). Results. A total of 428 patients with mean age of 8.12 ± 5.04 SD presented for hypospadias repair. Midpenile hypospadias were the most common. Chordee, meatal abnormalities, cryptorchidism, and inguinal hernias were observed in 74.3%, 9.6%, 2.8%, and 2.1% cases, respectively. Two-stage (Bracka) and TIP (tubularized incised urethral plate) repairs were performed in 76.2% and 20.8% of cases, respectively. The most common complications were edema and urethrocutaneous fistula (UCF). The complications were significantly lower in the hands of specialists than residents (P-value = 0.0086). The two-stage hypospadias repair resulted in higher complications frequency than single-stage repair (P value = 0.0001). Conclusion. Hypospadias surgery has a long learning curve because it requires a great deal of temperament, surgical skill and acquaintance with magnifications. Single-stage repair should be encouraged wherever applicable due to its lower postoperative complications.

目的确定尿道下裂修补术的人口统计学特征,并分析影响术后并发症的处理方法和因素。研究地点巴基斯坦白沙瓦Hayatabad医疗中心,2007年1月至2011年12月。材料和方法。研究对象包括所有尿道下裂男性患者,不分年龄。数据来自医院数据库,并使用社会科学统计软件包(SPSS)进行分析。研究结果共有 428 名患者接受尿道下裂修补术,平均年龄(8.12 ± 5.04 SD)。尿道下裂中段最为常见。脊索畸形、肉阜畸形、隐睾和腹股沟疝分别占 74.3%、9.6%、2.8% 和 2.1%。分别有76.2%和20.8%的病例进行了两阶段(Bracka)和TIP(管状切开尿道板)修复。最常见的并发症是水肿和尿道皮肤瘘(UCF)。专科医生的并发症明显低于住院医生(P值=0.0086)。两阶段尿道下裂修复术的并发症发生率高于单阶段修复术(P 值 = 0.0001)。结论尿道下裂手术的学习曲线较长,因为它需要大量的气质、手术技巧和对放大镜的熟悉。由于单期修复术的术后并发症较低,因此应尽可能鼓励采用单期修复术。
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引用次数: 0
Second generation self-inflating tissue expanders: a two-year experience. 第二代自我充气组织扩张器:两年的经验。
Pub Date : 2014-01-01 Epub Date: 2014-01-23 DOI: 10.1155/2014/457205
Jamal Omran Al Madani

Background. Tissue expansion is a well-established surgical technique that produces an additional amount of normal skin to cover a defect. This technique is appealing because the skin quality and color are from the patient's own. The widely used injectable expanders are of great reliability but carry the disadvantage of being painful during injection and most of the time require multiple clinic visits. So the idea of self-inflation became attractive and hydrogel expanders were developed and became widely known for being painless during clinic visit and decrease number of visits. The first generation expanders were modified by adding an enclosing plastic shell to decrease the unopposed expansion that occurred in the first generation expanders, which lead to pressure necrosis of the skin flaps. This made it an attractive option for tissue expansion in children and some adult patients. Patients, Materials, and Methods. Charts of 17 patients were retrospectively reviewed, all of them had second generation self-inflating expanders implanted over a 2-year period for one of two purposes, the treatment of giant nevi or burn scars. Results. Fifteen patients were females and 2 were males. The indication was large burn scar in 14 cases (14/17), in which 47/55 expanders were implanted, and giant nevus in 3/17 cases in which 8/55 expanders were implanted. Extrusion of the expander occurred in 8/55 expanders (14.5%), which occurred in 6/14 patients. The highest percentage of extrusion occurred in the neck in which two out of three expanders extruded; otherwise this complication does not seem to be related to the indication, gender, nor age of the patients. It seems to be that it is technical in nature. The patients did not have to get any injections to fill the tissue expanders, which made the expansion process less painful and more convenient. Conclusion. This seems to be currently the largest published review in which second generation expanders were used. Those expanders seem to offer a desirable advantage of being painless for children, also they do not require repeated visits to the surgeon's clinic, which is of great value for patients living in the periphery.

背景。组织扩张是一种成熟的外科技术,可以产生额外的正常皮肤来覆盖缺陷。这种技术很有吸引力,因为皮肤的质量和颜色都来自病人自己。目前广泛使用的注射扩张器可靠性高,但注射过程中存在疼痛和多次就诊等缺点。因此,自我膨胀的想法变得很有吸引力,水凝胶膨胀器被开发出来,并因在诊所就诊时无痛和减少就诊次数而广为人知。第一代扩张器经过改进,增加了一个封闭的塑料外壳,以减少第一代扩张器中发生的无对抗膨胀,这种膨胀会导致皮瓣的压力坏死。这使得它成为儿童和一些成人患者组织扩张的一个有吸引力的选择。患者、材料和方法。回顾性分析了17例患者的图表,所有患者在2年内植入了第二代自充气式扩张器,用于治疗巨大痣或烧伤疤痕。结果。女性15例,男性2例。14例(14/17)的适应证为大面积烧伤瘢痕,其中47/55例植入扩张器;3/17例的适应证为巨大痣,其中8/55例植入扩张器。8/55例(14.5%)扩展器发生挤压,6/14例。挤压率最高的发生在颈部,其中三分之二的膨胀器挤压;除此之外,这种并发症似乎与患者的适应症、性别和年龄无关。从本质上看,这似乎是技术性的。患者不需要注射任何药物来填充组织扩张器,这使得扩张过程不那么痛苦,也更方便。结论。这似乎是目前发表的使用第二代扩展器的最大评论。这些扩张器似乎为儿童提供了无痛的理想优势,而且它们不需要反复访问外科医生的诊所,这对于生活在外围的患者来说是很有价值的。
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引用次数: 7
Aesthetic and functional outcomes of the innervated and thinned anterolateral thigh flap in reconstruction of upper limb defects. 神经支配薄股前外侧皮瓣重建上肢缺损的美学和功能效果。
Pub Date : 2014-01-01 Epub Date: 2014-11-16 DOI: 10.1155/2014/489012
Carlos Alberto Torres-Ortíz Zermeño, Javier López Mendoza

Background. The anterolateral thigh (ALT) flap has been widely described in reconstruction of the upper extremity. However, some details require refinement to improve both functional and aesthetic results. Methods. After reconstruction of upper extremity defects using thinned and innervated ALT flaps, functional and aesthetic outcomes were evaluated with the QuickDASH scale and a Likert scale for aesthetic assessment of free flaps, respectively. Results. Seven patients with a mean follow-up of 11.57 months and average flap thickness of 5 mm underwent innervation by an end-to-end neurorrhaphy. The average percentage of disability (QuickDASH) was 21.88% with tenderness, pain, temperature, and two-point discrimination present in 100% of cases, and the aesthetic result gave an overall result of 15.40 (good) with the best scores in color and texture. Conclusions. Simultaneous thinning and innervation of the ALT flap lead to a good cosmetic result and functional outcome with a low percentage of disability, which could result in minor surgical procedures and better recovery of motor and sensory function. Level of Evidence. IV.

背景。股骨前外侧皮瓣在上肢重建中有广泛的应用。然而,一些细节需要改进,以提高功能和美学效果。方法。使用薄化和神经支配的ALT皮瓣重建上肢缺损后,分别用QuickDASH量表和Likert量表对自由皮瓣的美学评价进行功能和美学评价。结果。7例患者平均随访11.57个月,皮瓣平均厚度5mm,行端到端神经吻合。平均残疾百分率(QuickDASH)为21.88%,压痛、疼痛、体温和两点辨别率100%存在,美学结果总体成绩为15.40分(良好),颜色和质地得分最高。结论。ALT皮瓣同时变薄和神经支配可获得良好的美容效果和功能结果,致残率低,可以进行小手术,更好地恢复运动和感觉功能。证据水平。4
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引用次数: 14
Use of vein conduit and isolated nerve graft in peripheral nerve repair: a comparative study. 静脉导管与离体神经移植修复周围神经的比较研究。
Pub Date : 2014-01-01 Epub Date: 2014-10-27 DOI: 10.1155/2014/587968
Imran Ahmad, Md Sohaib Akhtar

Aims and Objectives. The aim of this study was to evaluate the effectiveness of vein conduit in nerve repair compared with isolated nerve graft. Materials and Methods. This retrospective study was conducted at author's centre and included a total of 40 patients. All the patients had nerve defect of more than 3 cm and underwent nerve repair using nerve graft from sural nerve. In 20 cases, vein conduit (study group) was used whereas no conduit was used in other 20 cases. Patients were followed up for 2 years at the intervals of 3 months. Results. Patients had varying degree of recovery. Sensations reached to all the digits at 1 year in study groups compared to 18 months in control group. At the end of second year, 84% patients of the study group achieved 2-point discrimination of <10 mm compared to 60% only in control group. In terms of motor recovery, 82% patients achieved satisfactory hand function in study group compared to 56% in control group (P < .05). Conclusions. It was concluded that the use of vein conduit in peripheral nerve repair is more effective method than isolated nerve graft providing good sensory and motor recovery.

目的和目标。本研究的目的是评价静脉导管在神经修复中的效果,并与孤立的神经移植物进行比较。材料与方法。本回顾性研究在作者中心进行,共纳入40例患者。所有患者神经缺损均大于3cm,均采用腓肠神经移植修复。20例采用静脉导管(研究组),20例不采用静脉导管。每隔3个月随访2年。结果。患者有不同程度的恢复。实验组的感觉在1岁时到达所有的手指,而对照组为18个月。第二年末,研究组84%的患者达到了2点的辨析
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引用次数: 8
Funding for postbariatric body-contouring (bariplastic) surgery in England: a postcode lottery. 英国为减肥后的身体轮廓(减肥)手术提供资金:邮政编码彩票。
Pub Date : 2014-01-01 Epub Date: 2014-03-20 DOI: 10.1155/2014/153194
Samrat Mukherjee, Sachin Kamat, Samuel Adegbola, Sanjay Agrawal

Background. With the increase in bariatric surgery in the UK, there has been a substantial increase in patients undergoing massive weight loss (MWL) seeking postbariatric body-contouring (bariplastic) surgery. However, there is a wide variation of availability on the National Health Service (NHS). Aims. To (1) review the funding policies of Primary Care Trusts (PCTs) in England for bariplastic surgery and (2) analyse the number of procedures funded in two consecutive financial years. Methods. We sent out questionnaires to all PCTs in England regarding their funding policies for bariplastic surgery and requested the number of procedures funded in 2008-09 and 2009-10. Findings. 121/147 (82%) PCTs replied to our questionnaires. 73 (60%) excluded all bariplastic procedures. 106/121 (87.6%) PCTs had referral guidelines for plastic surgery. 46/121 (38%) PCTs provided the total number of funded abdominoplasty-apronectomy (A-A) in the two financial years: total number of A-A applicants rose from 393 to 531, but approval for funding fell from 24.2% to 19.6%. Only 3 (2%) PCTs indicated increase in their future spending on bariplastic procedures in the next 5 years, with 67% planning to decrease or unsure about future funding. Conclusion. There exists a postcode lottery for bariplastic surgery in England and we feel the need for guidelines on provision of bariplastic procedures following MWL.

背景。随着英国减肥手术的增加,寻求减肥后身体轮廓(减肥)手术的大量减肥(MWL)患者大幅增加。然而,国民保健服务(NHS)的可用性存在很大差异。目标(1)检讨英国初级保健信托基金(pct)在整形手术方面的资助政策;(2)分析连续两个财政年度获得资助的手术数量。方法。我们向英国所有的pct发放了问卷,询问他们对整形手术的资助政策,并询问了2008-09年和2009-10年获得资助的手术数量。结果:121/147(82%)的pct回答了我们的问卷。73%(60%)排除了所有整形手术。106/121(87.6%)的pct有整形手术转诊指南。在两个财政年度,46/121(38%)的pct提供了资助的腹整形-前列腺切除术(A-A)的总数量:A-A申请总数从393上升到531,但批准的资金从24.2%下降到19.6%。只有3家(2%)的pct表示未来5年在整形手术上的支出会增加,67%的pct计划减少或不确定未来的资金。结论。在英国,有一个邮政编码的整形手术抽奖,我们觉得有必要在MWL后提供整形手术的指导方针。
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引用次数: 20
Cleft Lip and Palate Treatment 唇腭裂治疗
Pub Date : 2013-05-25 DOI: 10.1007/978-3-319-63290-2
N. Alonso, D. Fisher, L. Bermúdez, R. da Silva Freitas
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引用次数: 12
Effect of abdominoplasty in the lipid profile of patients with dyslipidemia. 腹部成形术对血脂异常患者血脂的影响。
Pub Date : 2013-01-01 Epub Date: 2013-05-28 DOI: 10.1155/2013/861348
Guillermo Ramos-Gallardo, Ana Pérez Verdin, Miguel Fuentes, Sergio Godínez Gutiérrez, Ana Rosa Ambriz-Plascencia, Ignacio González-García, Sonia Mericia Gómez-Fonseca, Rosalio Madrigal, Luis Iván González-Reynoso, Sandra Figueroa, Xavier Toscano Igartua, Déctor Francisco Jiménez Gutierrez

Introduction. Dyslipidemia like other chronic degenerative diseases is pandemic in Latin America and around the world. A lot of patients asking for body contouring surgery can be sick without knowing it. Objective. Observe the lipid profile of patients with dyslipidemia, before and three months after an abdominoplasty. Methods. Patients candidate to an abdominoplasty without morbid obesity were followed before and three months after the surgery. We compared the lipid profile, glucose, insulin, and HOMA (cardiovascular risk marker) before and three months after the surgery. We used Student's t test to compare the results. A P value less than 0.05 was considered as significant. Results. Twenty-six patients were observed before and after the surgery. At the third month, we found only statistical differences in LDL and triglyceride values (P 0.04 and P 0.03). The rest of metabolic values did not reach statistical significance. Conclusion. In this group of patients with dyslipidemia, at the third month, only LDL and triglyceride values reached statistical significances. There is no significant change in glucose, insulin, HOMA, cholesterol, VLDL, or HDL.

介绍与其他慢性退行性疾病一样,血脂异常在拉丁美洲和世界各地流行。很多要求做身体塑形手术的病人可能会在不知情的情况下生病。观察血脂异常患者在腹部成形术前和术后三个月的血脂情况。方法。在手术前和手术后三个月,对无病态肥胖的腹部成形术候选患者进行随访。我们比较了手术前和手术后三个月的脂质状况、葡萄糖、胰岛素和HOMA(心血管风险标志物)。我们用学生t检验来比较结果。P值小于0.05被认为是显著的。后果26例患者在手术前后进行了观察。在第三个月,我们发现LDL和甘油三酯的值只有统计学差异(P 0.04和P 0.03)。其余代谢值没有达到统计学意义。结论在这组血脂异常患者中,第3个月时,只有LDL和甘油三酯值达到统计学意义。葡萄糖、胰岛素、HOMA、胆固醇、VLDL或HDL没有显著变化。
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引用次数: 13
Complex biological reconstruction after wide excision of osteogenic sarcoma in lower extremities. 下肢骨肉瘤广泛切除后复杂的生物重建。
Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1155/2013/538364
Kashif Abbas, Masood Umer, Haroon Ur Rashid

Wide margin resection of extremity tumor sometimes leaves a huge soft tissue and bony defects in limb salvage surgery. Adequate management of these defects is an absolute requirement when aiming for functional limb. Multidisciplinary management in such cases is an answer when complex biologic reconstruction is desired. We aim to present cases of osteogenic sarcoma of lower extremity requiring combined surgical approach to achieve effective musculoskeletal reconstruction. Patients and Methods. From 2006 to 2010 ten patients were operated on for osteogenic sarcoma of lower extremity requiring complex musculoskeletal reconstruction. Results. Six patients had pathology around knee joint, whereas one each with mid tibia, mid femur, proximal femur, and heel bone. Locking compression plate was used in 7 patients including six with periarticular disease. Eight out of ten patients underwent biologic reconstruction using autograft; endoprosthetic reconstruction and hindquarter amputation were done in the remaining two patients. Vascularized fibula was done in five patients, sural artery flap which was primarily done in three patients, spare part fillet flap, free iliac crest flap, and Gastrocnemius flap was done in one patient each. Secondary hemorrhage, infection, nonunion, wound dehiscence, and flap failure were notable complications in four patients. The Average Musculoskeletal Tumor Society score was 89%. Conclusion. Combined surgical approach results in cosmetically acceptable and functional limb.

在残肢手术中,大面积切除肢体肿瘤有时会留下巨大的软组织和骨缺损。当目标是肢体功能时,对这些缺陷进行适当的处理是绝对必要的。在这种情况下,多学科管理是一个答案,当需要复杂的生物重建。我们的目的是提出的情况下,成骨肉瘤的下肢需要联合手术途径,以实现有效的肌肉骨骼重建。患者和方法。从2006年到2010年,我们对10例下肢成骨肉瘤进行了手术治疗,需要进行复杂的肌肉骨骼重建。结果。膝关节周围病变6例,胫骨中部、股骨中部、股骨近端和跟骨各1例。锁定加压钢板用于7例患者,其中6例伴有关节周围疾病。10例患者中有8例采用自体移植物进行生物重建;其余2例患者行假体内重建和后腿截肢。带血管腓骨5例,腓肠动脉皮瓣3例,部分腓骨瓣、游离髂骨瓣、腓肠肌瓣各1例。继发性出血、感染、伤口不愈合、伤口裂开和皮瓣失效是4例患者的显著并发症。肌肉骨骼肿瘤协会的平均评分是89%。结论。联合手术可获得美观、功能良好的肢体。
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引用次数: 6
Skin-sparing mastectomy with immediate breast and nipple reconstruction: a new technique of nipple reconstruction. 保皮乳房切除术及即时乳房乳头重建:乳头重建新技术。
Pub Date : 2013-01-01 Epub Date: 2013-01-02 DOI: 10.1155/2013/406375
Raffaele Serra, Anna Maria Miglietta, Sergio Abonante, Vincent Giordano, Gianluca Buffone, Stefano de Franciscis

Background. Most women with breast cancer today can be managed with breast conservation; however, some women still require mastectomy for treatment of their disease. Skin-sparing mastectomy (SSM) with immediate reconstruction has emerged as a favorable option for many of these patients. The authors combined the SSM technique with the preservation of a small part of the areola with immediate nipple together with with breast reconstruction. Methods. In an 8-year-period 155 female patients (age: 20-52 years old; mean age: 37.5 years) with extensive ductal intraepithelial neoplasia (DIN) or invasive breast cancer were treated with areola skin sparing mastectomy with immediate nipple and breast reconstruction. Patients were followed up prospectively by the breast surgeon, the plastic surgeon, and the oncologist for complications and recurrence. Results. After treatment, only 2 cases (1.29%) had a local recurrence. 8 out of 155 (5.5%) patients developed early complications (infections, seroma, haematoma), and 5 out of 155 patients (3.22%) developed delayed complications (implant rotation, aestethic deterioration) in the post operative time period. The final aesthetic outcome was judged as positive in 150 out of 155 patients (96.78%). Conclusion. In our experience, immediate nipple reconstruction after skin-sparing mastectomy is a technically feasible procedure which can give excellent cosmetic results.

背景。如今,大多数患有乳腺癌的女性都可以通过乳房保护来治疗;然而,一些妇女仍然需要乳房切除术来治疗她们的疾病。保留皮肤乳房切除术(SSM)立即重建已成为许多这些患者的有利选择。作者将SSM技术与保留一小部分乳晕和直接乳头相结合,并与乳房重建相结合。方法。在8年的时间里155例女性患者(年龄:20-52岁;平均年龄:37.5岁)患有广泛导管上皮内瘤变(DIN)或浸润性乳腺癌的患者行乳晕保留皮肤乳房切除术并立即乳头和乳房重建术。乳房外科医生、整形外科医生和肿瘤科医生对患者进行前瞻性随访,观察并发症和复发情况。结果。经治疗后,仅有2例(1.29%)局部复发。155例患者中有8例(5.5%)出现早期并发症(感染、血肿、血肿),155例患者中有5例(3.22%)出现术后延迟并发症(种植体旋转、美学恶化)。155例患者中有150例(96.78%)的最终美学结果为阳性。结论。根据我们的经验,保留皮肤的乳房切除术后立即乳头重建是一种技术上可行的手术,可以获得良好的美容效果。
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引用次数: 6
期刊
Plastic Surgery International
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