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Open reduction internal fixation poststernotomy mediastinitis. 胸骨切开后纵隔炎切开复位内固定。
Pub Date : 2013-01-01 Epub Date: 2013-07-17 DOI: 10.1155/2013/571685
Hani Sinno, Tassos Dionisopoulos

Introduction. Mediastinitis has been reported to complicate 5% of sternotomy surgery. We have adopted an open reduction and rigid internal fixation (ORIF) approach during the conventional rescue surgery in the treatment of mediastinitis. Methods. A retrospective review was performed to compare the outcomes of patients that had an ORIF to correct postoperative mediastinitis following median sternotomy. These were compared with the outcome of the patients that did not undergo ORIF. Results. In the 5-year study period, we reviewed 35 mediastinitis patient charts. Postoperatively, the ORIF patient group remained in the Intensive Care Unit (ICU) and on a ventilator for a mean of 1.5 and 0.75 days, respectively. Patients treated without ORIF spent significantly more days in the ICU (mean of 7.5 days, P < 0.05) and on a ventilator (mean of 2.15 days, P = 0.1). Furthermore, it was found that none of the patients (0%) who underwent ORIF complained of any postoperative sternal instability or pain. Preoperatively, however, these rates were as high as 72%. Conclusions. In the select patient, ORIF can be a safe option in the management of mediastinitis, which we have shown to significantly decrease morbidity and mortality by providing anatomic reduction as well as physiologic stabilization. We have shown that ORIF will improve the quality of life of the patient by minimizing abnormal sternal mobility and pain and will also decrease inpatient costs by decreasing days spent in the ICU and ventilator dependence.

介绍。据报道,纵隔炎使5%的胸骨切开手术复杂化。我们在治疗纵隔炎的常规抢救手术中采用切开复位刚性内固定(ORIF)入路。方法。回顾性分析了胸骨正中切开行ORIF矫正术后纵隔炎患者的预后。将这些结果与未接受ORIF的患者的结果进行比较。结果。在5年的研究期间,我们回顾了35例纵隔炎患者的病历。术后,ORIF患者组在重症监护病房(ICU)和呼吸机上的平均时间分别为1.5天和0.75天。未使用ORIF的患者在ICU(平均7.5天,P < 0.05)和使用呼吸机(平均2.15天,P = 0.1)的天数明显增加。此外,我们发现接受ORIF的患者(0%)均无术后胸骨不稳或疼痛。然而,术前这些比率高达72%。结论。在选择的患者中,ORIF是治疗纵隔炎的安全选择,我们已经证明,通过提供解剖复位和生理稳定,ORIF可以显著降低发病率和死亡率。我们已经证明,ORIF将通过减少异常胸骨活动和疼痛来改善患者的生活质量,并通过减少在ICU的住院天数和对呼吸机的依赖来降低住院费用。
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引用次数: 1
Cleft lip and palate treatment. 唇腭裂治疗。
Pub Date : 2013-01-01 Epub Date: 2013-05-25 DOI: 10.1155/2013/372751
Nivaldo Alonso, David M Fisher, Luiz Bermudez, Renato da Silva Freitas
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引用次数: 0
Surgical Treatment of 55 Patients with Pressure Ulcers at the Department of Plastic and Reconstructive Surgery Kosovo during the Period 2000-2010: A Retrospective Study. 2000-2010年科索沃整形重建外科手术治疗55例压疮患者的回顾性研究
Pub Date : 2013-01-01 Epub Date: 2013-02-20 DOI: 10.1155/2013/129692
Shkelzen B Duci, Hysni M Arifi, Mimoza E Selmani, Agon Y Mekaj, Musli M Gashi, Zejn A Buja, Vildane H Ismajli, Adem N Kllokoqi, Enver T Hoxha

Objective. The objective of this study is to determine the incidence of PUs, the distribution of PUs, common injuries contributing to the occurrence of PUs in patients admitted to the Department of Plastic and Reconstructive Surgery Kosovo for surgical interventions of PUs, localization of PUs in body, the topical treatment of pressure ulcers before surgical intervention, the methods of surgical interventions, number of surgical interventions, duration of treatment, complications, and mortality. Materials and Methods. This study includes 55 patients with PUs treated surgically in 2000-2010 period in the Department of Plastic and Reconstructive Surgery Kosovo. The data were collected and analyzed from the archives and protocols of the University Clinical Center of Kosovo. Data processing was done with the statistical package In Stat 3. From statistical parameters arithmetic median and standard deviation were calculated. Data testing is done with χ (2)-test and the difference is significant if P < 0.05. Conclusion. Despite preventive measures against PUs, the incidence of Pus remains high.

目标。本研究的目的是确定科索沃整形重建外科手术治疗脓肿患者的脓肿发生率、脓肿分布、导致脓肿发生的常见损伤、脓肿在体内的定位、手术前对压疮的局部治疗、手术干预方法、手术干预次数、治疗时间、并发症和死亡率。材料与方法。本研究包括2000-2010年在科索沃整形重建外科手术治疗的55例脓肿患者。数据是从科索沃大学临床中心的档案和协议中收集和分析的。数据处理使用Stat 3中的统计包完成。根据统计参数计算算术中位数和标准差。数据采用χ(2)检验,P < 0.05为差异有统计学意义。结论。尽管有预防脓肿的措施,脓肿的发病率仍然很高。
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引用次数: 5
Implementing the brazilian database on orofacial clefts. 实施巴西面部唇腭裂数据库。
Pub Date : 2013-01-01 Epub Date: 2013-03-12 DOI: 10.1155/2013/641570
Isabella Lopes Monlleó, Marshall Ítalo Barros Fontes, Erlane Marques Ribeiro, Josiane de Souza, Gabriela Ferraz Leal, Têmis Maria Félix, Agnes Cristina Fett-Conte, Bruna Henrique Bueno, Luis Alberto Magna, Peter Anthony Mossey, Vera Gil-da Silva-Lopes

Background. High-quality clinical and genetic descriptions are crucial to improve knowledge of orofacial clefts and support specific healthcare polices. The objective of this study is to discuss the potential and perspectives of the Brazilian Database on Orofacial Clefts. Methods. From 2008 to 2010, clinical and familial information on 370 subjects was collected by geneticists in eight different services. Data was centrally processed using an international system for case classification and coding. Results. Cleft lip with cleft palate amounted to 198 (53.5%), cleft palate to 99 (26.8%), and cleft lip to 73 (19.7%) cases. Parental consanguinity was present in 5.7% and familial history of cleft was present in 26.3% subjects. Rate of associated major plus minor defects was 48% and syndromic cases amounted to 25% of the samples. Conclusions. Overall results corroborate the literature. Adopted tools are user friendly and could be incorporated into routine patient care. The BDOC exemplifies a network for clinical and genetic research. The data may be useful to develop and improve personalized treatment, family planning, and healthcare policies. This experience should be of interest for geneticists, laboratory-based researchers, and clinicians entrusted with OC worldwide.

背景。高质量的临床和遗传描述对于提高对口面部唇裂的认识和支持特定的医疗保健政策至关重要。本研究的目的是讨论巴西口腔面部裂数据库的潜力和前景。方法。从2008年到2010年,来自8个不同服务机构的遗传学家收集了370名受试者的临床和家族信息。使用国际病例分类和编码系统对数据进行集中处理。结果。唇裂合并腭裂198例(53.5%),腭裂99例(26.8%),唇裂73例(19.7%)。有血缘关系者占5.7%,有唇裂家族史者占26.3%。相关的主要和次要缺陷率为48%,综合征病例占样本的25%。结论。总体结果证实了文献。所采用的工具是用户友好的,可以纳入日常的病人护理。BDOC是临床和基因研究网络的典范。这些数据可能有助于制定和改进个性化治疗、计划生育和医疗保健政策。这一经验应该引起遗传学家、实验室研究人员和临床医生的兴趣。
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引用次数: 13
Prevalence of oral habits in children with cleft lip and palate. 唇腭裂儿童口腔习惯的患病率。
Pub Date : 2013-01-01 Epub Date: 2013-02-27 DOI: 10.1155/2013/247908
Paula Caroline Barsi, Thaieny Ribeiro da Silva, Beatriz Costa, Gisele da Silva Dalben

This study investigated the prevalence of oral habits in children with clefts aged three to six years, compared to a control group of children without clefts in the same age range, and compared the oral habits between children with clefts with and without palatal fistulae. The sample was composed of 110 children aged 3 to 6 years with complete unilateral cleft lip and palate and 110 children without alterations. The prevalence of oral habits and the correlation between habits and presence of fistulae (for children with clefts) were analyzed by questionnaires applied to the children caretakers. The cleft influenced the prevalence of oral habits, with lower prevalence of pacifier sucking for children with cleft lip and palate and higher prevalence for all other habits, with significant association (P < 0.05). There was no significant association between oral habits and presence of fistulae (P > 0.05). The lower prevalence of pacifier sucking and higher prevalence of other oral habits agreed with the postoperative counseling to remove the pacifier sucking habit when the child is submitted to palatoplasty, possibly representing a substitution of habits. There was no causal relationship between habits and presence of palatal fistulae.

本研究调查了3 ~ 6岁唇裂儿童的口腔习惯,并与同龄无唇裂儿童的对照组进行了比较,并比较了伴有和不伴有腭裂的唇裂儿童的口腔习惯。研究对象为110例3 ~ 6岁完全性单侧唇腭裂患儿和110例无唇腭裂患儿。通过对儿童看护人员进行问卷调查,分析唇腭裂儿童口腔习惯的流行情况以及口腔习惯与瘘管存在的关系。唇腭裂对口腔习惯的患病率有影响,唇腭裂患儿吮吸奶嘴的患病率较低,其他习惯的患病率较高,差异有统计学意义(P < 0.05)。口腔习惯与瘘管发生率无显著相关性(P > 0.05)。吮吸安抚奶嘴的患病率较低,其他口腔习惯的患病率较高,这与患儿术后接受腭成形术时去除吮吸安抚奶嘴习惯的咨询一致,可能代表习惯的替代。习惯与腭瘘的存在之间没有因果关系。
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引用次数: 10
Investing in a surgical outcomes auditing system. 投资于手术结果审计系统。
Pub Date : 2013-01-01 Epub Date: 2013-01-16 DOI: 10.1155/2013/671786
Luis Bermudez, Kristen Trost, Ruben Ayala

Background. Humanitarian surgical organizations consider both quantity of patients receiving care and quality of the care provided as a measure of success. However, organizational efficacy is often judged by the percent of resources spent towards direct intervention/surgery, which may discourage investment in an outcomes monitoring system. Operation Smile's established Global Standards of Care mandate minimum patient followup and quality of care. Purpose. To determine whether investment of resources in an outcomes monitoring system is necessary and effectively measures success. Methods. This paper analyzes the quantity and completeness of data collected over the past four years and compares it against changes in personnel and resources assigned to the program. Operation Smile began investing in multiple resources to obtain the missing data necessary to potentially implement a global Surgical Outcomes Auditing System. Existing personnel resources were restructured to focus on postoperative program implementation, data acquisition and compilation, and training materials used to educate local foundation and international employees. Results. An increase in the number of postoperative forms and amount of data being submitted to headquarters occurred. Conclusions. Humanitarian surgical organizations would benefit from investment in a surgical outcomes monitoring system in order to demonstrate success and to ameliorate quality of care.

背景。人道主义外科组织将接受治疗的病人数量和提供的治疗质量作为衡量成功的标准。然而,组织效能通常由用于直接干预/手术的资源百分比来判断,这可能会阻碍对结果监测系统的投资。“微笑行动”建立的全球护理标准要求最低限度的患者随访和护理质量。目的。确定是否有必要在结果监测系统中投入资源,并有效地衡量成功。方法。本文分析了过去四年收集的数据的数量和完整性,并将其与分配给该计划的人员和资源的变化进行了比较。“微笑手术”开始投入多种资源,以获得可能实施全球手术结果审计系统所需的缺失数据。现有的人力资源进行了重组,重点放在术后项目的实施、数据的获取和汇编以及用于教育当地基金会和国际雇员的培训材料上。结果。提交给总部的术后表格数量和数据量有所增加。结论。人道主义外科组织将受益于对手术结果监测系统的投资,以展示成功并改善护理质量。
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引用次数: 7
Complements c3 and c5 individually and in combination increase early wound strength in a rat model of experimental wound healing. 补体c3和c5单独或联合使用可增加实验性伤口愈合大鼠模型的早期伤口强度。
Pub Date : 2013-01-01 Epub Date: 2013-05-23 DOI: 10.1155/2013/243853
Hani Sinno, Meenakshi Malhotra, Justyn Lutfy, Barbara Jardin, Sebastian Winocour, Fadi Brimo, Lorne Beckman, Kevin Watters, Anie Philip, Bruce Williams, Satya Prakash

Background. Complements C3 and C5 have independently been shown to augment and increase wound healing and strength. Our goal was to investigate the combinatorial effect of complements C3 and C5 on wound healing. Methods. Each rat served as its own control where topical collagen was applied to one incision and 100 nM of C3 and C5 in collagen vehicle was applied to the other incision (n = 6). To compare between systemic effects, a sham group of rats (n = 6) was treated with collagen alone on one wound and saline on the other. At day 3, the tissue was examined for maximal breaking strength (MBS) and sectioned for histological examination. Results. There was a statistically significant 88% increase in MBS with the topical application of C3C5 when compared to sham wounds (n < 0.05). This was correlated with increased fibroblast and collagen deposition in the treated wounds. Furthermore, there appeared to be an additive hemostatic effect with the C3C5 combination. Conclusions. The combination of complements C3 and C5 as a topical application drug to skin wounds significantly increased wound healing maximum breaking strength as early as 3 days.

背景。补体C3和C5已被独立证明可以增强和增加伤口愈合和强度。我们的目的是研究补体C3和C5对伤口愈合的联合作用。方法。每只大鼠作为自己的对照,在一个切口上涂抹局部胶原蛋白,在另一个切口上涂抹100 nM胶原蛋白载体中的C3和C5 (n = 6)。为了比较全身效应,假组大鼠(n = 6)在一个伤口上单独使用胶原蛋白,在另一个伤口上使用生理盐水。第3天,检查组织的最大断裂强度(MBS),并切片进行组织学检查。结果。与假创面相比,外用C3C5的MBS增加了88%,差异有统计学意义(n < 0.05)。这与治疗伤口中成纤维细胞和胶原沉积的增加有关。此外,C3C5联合用药似乎有加性止血作用。结论。补体C3和C5作为外用药物联合应用于皮肤创面,可显著提高创面愈合,最大断裂强度最早可达3天。
{"title":"Complements c3 and c5 individually and in combination increase early wound strength in a rat model of experimental wound healing.","authors":"Hani Sinno,&nbsp;Meenakshi Malhotra,&nbsp;Justyn Lutfy,&nbsp;Barbara Jardin,&nbsp;Sebastian Winocour,&nbsp;Fadi Brimo,&nbsp;Lorne Beckman,&nbsp;Kevin Watters,&nbsp;Anie Philip,&nbsp;Bruce Williams,&nbsp;Satya Prakash","doi":"10.1155/2013/243853","DOIUrl":"https://doi.org/10.1155/2013/243853","url":null,"abstract":"<p><p>Background. Complements C3 and C5 have independently been shown to augment and increase wound healing and strength. Our goal was to investigate the combinatorial effect of complements C3 and C5 on wound healing. Methods. Each rat served as its own control where topical collagen was applied to one incision and 100 nM of C3 and C5 in collagen vehicle was applied to the other incision (n = 6). To compare between systemic effects, a sham group of rats (n = 6) was treated with collagen alone on one wound and saline on the other. At day 3, the tissue was examined for maximal breaking strength (MBS) and sectioned for histological examination. Results. There was a statistically significant 88% increase in MBS with the topical application of C3C5 when compared to sham wounds (n < 0.05). This was correlated with increased fibroblast and collagen deposition in the treated wounds. Furthermore, there appeared to be an additive hemostatic effect with the C3C5 combination. Conclusions. The combination of complements C3 and C5 as a topical application drug to skin wounds significantly increased wound healing maximum breaking strength as early as 3 days.</p>","PeriodicalId":20105,"journal":{"name":"Plastic Surgery International","volume":"2013 ","pages":"243853"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/243853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31599192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Sensory recovery outcome after digital nerve repair in relation to different reconstructive techniques: meta-analysis and systematic review. 不同重建技术对指神经修复后感觉恢复效果的影响:meta分析和系统评价。
Pub Date : 2013-01-01 Epub Date: 2013-07-30 DOI: 10.1155/2013/704589
Felix J Paprottka, Petra Wolf, Yves Harder, Yasmin Kern, Philipp M Paprottka, Hans-Günther Machens, Jörn A Lohmeyer

Good clinical outcome after digital nerve repair is highly relevant for proper hand function and has a significant socioeconomic impact. However, level of evidence for competing surgical techniques is low. The aim is to summarize and compare the outcomes of digital nerve repair with different methods (end-to-end and end-to-side coaptations, nerve grafts, artificial conduit-, vein-, muscle, and muscle-in-vein reconstructions, and replantations) to provide an aid for choosing an individual technique of nerve reconstruction and to create reference values of standard repair for nonrandomized clinical studies. 87 publications including 2,997 nerve repairs were suitable for a precise evaluation. For digital nerve repairs there was practically no particular technique superior to another. Only end-to-side coaptation had an inferior two-point discrimination in comparison to end-to-end coaptation or nerve grafting. Furthermore, this meta-analysis showed that youth was associated with an improved sensory recovery outcome in patients who underwent digital replantation. For end-to-end coaptations, recent publications had significantly better sensory recovery outcomes than older ones. Given minor differences in outcome, the main criteria in choosing an adequate surgical technique should be gap length and donor site morbidity caused by graft material harvesting. Our clinical experience was used to provide a decision tree for digital nerve repair.

指神经修复术后良好的临床效果与正常的手功能高度相关,并具有显著的社会经济影响。然而,竞争手术技术的证据水平很低。目的是总结和比较不同方法(端到端和端侧吻合、神经移植、人工导管、静脉、肌肉和静脉内肌肉重建和再植)的指神经修复的结果,为选择一种单独的神经重建技术提供帮助,并为非随机临床研究创建标准修复的参考值。87份出版物包括2997份神经修复适合于精确评估。对于指神经修复,实际上并没有什么特别的技术优于其他技术。与端到端接合或神经移植相比,只有端侧接合的两点辨别能力较差。此外,该荟萃分析显示,在接受数字再植的患者中,年轻与改善的感觉恢复结果相关。对于端到端匹配,最近的出版物有明显更好的感官恢复结果比旧的。考虑到结果的微小差异,选择合适的手术技术的主要标准应该是间隙长度和移植材料收获引起的供体部位发病率。我们的临床经验为指神经修复提供了决策树。
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引用次数: 78
Complements and the wound healing cascade: an updated review. 补品和伤口愈合级联:最新综述。
Pub Date : 2013-01-01 Epub Date: 2013-07-24 DOI: 10.1155/2013/146764
Hani Sinno, Satya Prakash

Wound healing is a complex pathway of regulated reactions and cellular infiltrates. The mechanisms at play have been thoroughly studied but there is much still to learn. The health care system in the USA alone spends on average 9 billion dollars annually on treating of wounds. To help reduce patient morbidity and mortality related to abnormal or prolonged skin healing, an updated review and understanding of wound healing is essential. Recent works have helped shape the multistep process in wound healing and introduced various growth factors that can augment this process. The complement cascade has been shown to have a role in inflammation and has only recently been shown to augment wound healing. In this review, we have outlined the biology of wound healing and discussed the use of growth factors and the role of complements in this intricate pathway.

伤口愈合是一个复杂的调控反应和细胞浸润的途径。其中的机制已被彻底研究,但仍有许多东西需要学习。仅美国的医疗保健系统每年平均花费90亿美元用于治疗伤口。为了帮助减少患者的发病率和死亡率相关的异常或延长皮肤愈合,一个更新的审查和了解伤口愈合是必不可少的。最近的工作帮助塑造了伤口愈合的多步骤过程,并引入了各种生长因子来增强这一过程。补体级联已被证明在炎症中起作用,直到最近才被证明可以促进伤口愈合。在这篇综述中,我们概述了伤口愈合的生物学,并讨论了生长因子的使用和补体在这一复杂途径中的作用。
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引用次数: 222
Philtral columns and nostril shapes in nigerian children: a morphometric and aesthetic analysis. 尼日利亚儿童的中耳柱和鼻孔形状:形态计量学和美学分析。
Pub Date : 2013-01-01 Epub Date: 2013-06-11 DOI: 10.1155/2013/382754
Ibrahim Abdulrasheed, Asuku Malachy Eneye

Background. The upper lip-nose complex contributes significantly to the concept of symmetry and proportion of the face. A study of the morphology and aesthetic preferences of the lip-nose complex will provide a database that will serve as a guide for reconstruction. Subjects and Methods. Hundred Nigerian children participated in this study. Demographic data and standard photographs of the philtral column and nostrils were obtained. Sixty volunteers were recruited to evaluate the photographs. Each volunteer was asked to rank the photographs based on their aesthetic preference. Results. The morphology of the philtral columns was classified into four groups: (1) triangular, (2) concave, (3) flat, and (4) parallel. The nostril shape was also classified into four groups: (1) triangular, (2) round, (3) teardrop, and (4) rectangular. In both genders, the triangular shape of philtral column was the most common. There are significant age differences in the aesthetic rankings of philtral columns and nostril shapes. Conclusion. Our study establishes the basal values for the morphometric and aesthetic parameters of the lip-nose complex of 5- and 6-year-old children in Nigeria. We hope our results and reconstructive surgery will intersect at a point to treat disfigurements of the philtrum and nostrils successfully.

背景。上唇鼻综合体对面部对称和比例的概念有重要贡献。对唇鼻复合体形态和审美偏好的研究将提供一个数据库,作为重建的指导。研究对象和方法。100名尼日利亚儿童参加了这项研究。获得了人口统计学数据和中耳柱和鼻孔的标准照片。60名志愿者被招募来评估这些照片。每位志愿者被要求根据自己的审美偏好对照片进行排名。结果。中心柱的形态分为四组:(1)三角形,(2)凹形,(3)扁平,(4)平行。鼻孔形状也分为四组:(1)三角形,(2)圆形,(3)泪滴状,(4)矩形。在两性中,中柱的三角形形状最为常见。中柱和鼻孔形状的审美排名存在显著的年龄差异。结论。我们的研究建立了尼日利亚5- 6岁儿童的唇鼻综合体的形态计量学和美学参数的基础值。我们希望我们的结果和重建手术能在某一点上交叉,成功地治疗中鼻孔和鼻孔的畸形。
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引用次数: 14
期刊
Plastic Surgery International
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