Biosensors and Bioelectronics: X最新文献_第9页

Molecular imprinting and nanomaterial synergy for lactate detection 乳酸检测的分子印迹和纳米材料协同作用

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-07-25 DOI: 10.1016/j.biosx.2025.100659

Christopher Animashaun , Gymama Slaughter

Molecularly imprinted polymer (MIP)-based electrochemical sensors have emerged as promising non-enzymatic platforms for the selective and stable detection of clinically and environmentally relevant biomarkers. This review provides a critical, comprehensive analysis of recent advances in MIP-based lactate sensing, with particular emphasis on hybrid systems that integrate conductive nanomaterials including gold and silver nanoparticles, laser-induced graphene, and reduced graphene oxide. These synergistic combinations leverage enhanced surface area, electrical conductivity, and molecular recognition to improve sensor sensitivity, selectivity, and long-term operational stability. Key fabrication strategies, such as electropolymerization, green nanomaterial synthesis, and surface imprinting, are critically examined for their roles in optimizing imprinting sensitivity and electron transfer efficiency. Application areas span real-time lactate monitoring in wearable health devices to environmental surveillance in complex matrices. Despite significant progress, challenges related to reproducibility, template removal efficiency, fouling resistance, and scalable manufacturing persist. The review concludes by outlining future directions, including integration into flexible and paper-based platforms, and the development of smart, implantable systems. With continued innovation, MIP-based lactate sensors are poised to become essential components in next-generation point-of-care diagnostics and environmental monitoring technologies.

基于分子印迹聚合物（MIP）的电化学传感器已经成为有前途的非酶平台，用于选择性和稳定地检测临床和环境相关的生物标志物。这篇综述对基于mip的乳酸传感技术的最新进展进行了批判性的全面分析，特别强调了将导电纳米材料（包括金纳米颗粒和银纳米颗粒）、激光诱导石墨烯和还原氧化石墨烯集成在一起的混合系统。这些协同组合利用增强的表面积、电导率和分子识别来提高传感器的灵敏度、选择性和长期运行稳定性。关键的制造策略，如电聚合，绿色纳米材料合成和表面印迹，严格审查其在优化印迹灵敏度和电子转移效率方面的作用。应用领域涵盖可穿戴健康设备的实时乳酸监测到复杂矩阵的环境监测。尽管取得了重大进展，但与可重复性、模板去除效率、抗结垢性和可扩展制造相关的挑战仍然存在。该综述最后概述了未来的发展方向，包括集成到灵活的纸质平台，以及开发智能的可植入系统。随着不断创新，基于mip的乳酸传感器将成为下一代即时诊断和环境监测技术的重要组成部分。

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引用次数: 0

Smartphone-based colorimetric detection of urinary glucose using a novel green and red/green approach 基于智能手机的尿葡萄糖比色检测，采用一种新颖的绿色和红/绿方法

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-06-24 DOI: 10.1016/j.biosx.2025.100650

Tileshwar Sahare, Simran Rana, Badri Narayana Sahoo, Milan Khanda, Abhijeet Joshi

Urine dipsticks are commonly used to detect pathological changes in urine due to their low cost and easy operation, having glucose parameter to detect glucosuria. Despite their advantages, the urine dipstick is ineffective in the early detection of diabetes due to its limitations in the detection of glucose below 100 mg/dl. Here, we present a novel, cost-effective ambient ring light-based smartphone platform to accurately estimate urinary glucose concentrations in lower points utilizing glucose sensors obtained from commercially available urine dipsticks (Mission® and Recombigen™). Glucose sensors changed color from green to brown with the increasing glucose concentration, resulting in a response time of 5 min. In this study, smartphone was used to capture images and analyze Red-Green-Blue (RGB) profiles, extracted with the help of an open-source smartphone-android-based Color Picker app. G intensity was determined to be inversely proportional and R/G intensity to be directly proportional to the increasing glucose concentration. LOD was found to be 6.2 and 24 mg/dl for Mission® glucose sensors with G and R/G respectively. On the other hand, Recombigen™ dipstick glucose sensors, LOD was evaluated as 5.8 and 16 mg/dl with G and R/G respectively. This smartphone-based assessment of glucose using dipsticks can be beneficial in the current screening and diagnostics sector of earlier detection of glucose in urine.

尿试纸成本低，操作方便，具有葡萄糖参数，可检测血糖，常用于检测尿液病理变化。尽管尿试纸有其优点，但由于其在检测葡萄糖低于100 mg/dl时的局限性，在糖尿病的早期检测中是无效的。在这里，我们提出了一种新颖的、具有成本效益的基于环境环光的智能手机平台，该平台利用从市售尿试纸（Mission®和Recombigen™）获得的葡萄糖传感器，准确估计低处的尿葡萄糖浓度。葡萄糖传感器的颜色随着葡萄糖浓度的增加从绿色变为棕色，导致响应时间为5分钟。在本研究中，使用智能手机捕获图像并分析红绿蓝（RGB）配置文件，并借助开源的基于智能手机android的color Picker应用程序提取。G强度被确定为反比，R/G强度与葡萄糖浓度的增加成正比。Mission®葡萄糖传感器的LOD分别为6.2和24 mg/dl，分别为G和R/G。另一方面，Recombigen™试纸式葡萄糖传感器的LOD分别以G和R/G计算为5.8和16 mg/dl。这种基于智能手机的葡萄糖评估使用试纸可以在当前的筛查和诊断领域早期检测尿液中的葡萄糖有益。

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引用次数: 0

A smart hip implant with embedded multidirectional sensing and wireless load monitoring for enhanced orthopedic care 一种内置多向传感和无线负荷监测的智能髋关节植入物，用于增强骨科护理

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-06-30 DOI: 10.1016/j.biosx.2025.100648

Leila Donyaparastlivari, Alwathiqbellah Ibrahim

This study presents the development, integration, and experimental validation of a smart total hip replacement (THR) system that combines piezoelectric load sensing, energy harvesting, and wireless data transmission. The implant incorporates seven piezoelectric sensors embedded within the femoral head, strategically positioned using Finite Element Analysis (FEA) to identify high-strain contact zones during gait. A customized cam-driven benchtop setup simulated cyclic loading at walking (2 Hz), jogging (3 Hz), and running (4 Hz) frequencies to evaluate the sensor system under physiologically relevant conditions. The results confirmed the implant’s ability to capture localized load variations with high spatial fidelity and repeatability, as sensor output correlated strongly with applied force across dynamic trials. RMS voltage-load profiles and calibration curves were established, enabling accurate quantification of transmitted joint forces. Additionally, the harvested signals demonstrated sufficient power output for wireless communication and potential onboard functionality, positioning the device as a self-sustained biomechanical monitor. This multifunctional platform represents a significant advancement in orthopedic implant technology, offering real-time, in vivo assessment of implant loading to support personalized rehabilitation strategies, early failure detection, and long-term postoperative care.

本研究介绍了一种智能全髋关节置换术（THR）系统的开发、集成和实验验证，该系统结合了压电负载传感、能量收集和无线数据传输。该植入物在股骨头中嵌入了7个压电传感器，利用有限元分析（FEA）进行战略性定位，以识别步态中的高应变接触区。定制的凸轮驱动台式装置模拟了步行（2hz）、慢跑（3hz）和跑步（4hz）频率下的循环载荷，以评估传感器系统在生理相关条件下的性能。结果证实，植入物能够捕捉局部载荷变化，具有高空间保真度和可重复性，因为传感器输出与动态试验中的施加力密切相关。建立了均方根电压负载曲线和校准曲线，实现了传递关节力的精确量化。此外，收集到的信号显示出足够的功率输出用于无线通信和潜在的机载功能，将该设备定位为一个自我维持的生物力学监测仪。这个多功能平台代表了骨科种植体技术的重大进步，提供实时的、体内的种植体负荷评估，以支持个性化的康复策略、早期失效检测和长期的术后护理。

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引用次数: 0

β-Cyclodextrin-conjugated butein as a selective electrochemical molecular trafficking system for bilastine β-环糊精共轭丁蛋白作为胆碱的选择性电化学分子运输系统

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1016/j.biosx.2025.100647

Ramya Kanagaraj , Shanmugam SenthilKumar , Gururaja Perumal Pazhani , Murugan Veerapandian

Simple method for monitoring the therapeutic efficient concentration of anti-histamine drug, bilastine (BIL), is essential for rationalizing allergy and respiratory therapy. Herein, an external redox-mediator free molecular trafficking approach was developed using conjugated oligosaccharide-polyphenol system, β-cyclodextrin-butein (BCD-Bt). Mechanism behind the molecular loading of BIL within the hydrophobic cavity of BCD simultaneously enabling the redox-active signal transduction from the conjugated Bt are explored using cyclic and differential pulse voltammetric analyses. BCD-Bt sensor platform exemplified the selective loading of analyte BIL with a reliable detection linearity (nm to μM, R² = 0.981) and limit feasible for salivary therapeutic drug monitoring. Synergistic optical absorbance and emission-based molecular trafficking test further complements the multi-modal functionality of the demonstrated BCD-Bt in other similar molecular assays.

监测抗组胺药物bilastine （BIL）治疗有效浓度的简单方法，对变态反应和呼吸治疗的合理化至关重要。本研究利用偶联低聚糖-多酚体系β-环糊精-丁蛋白（BCD-Bt）建立了一种无氧化还原介质的外部分子运输方法。利用循环和差分脉冲伏安分析探讨了BCD疏水腔内BIL分子负载的机制，同时使共轭Bt的氧化还原活性信号转导成为可能。BCD-Bt传感器平台可选择性负载分析物BIL，具有可靠的检测线性（nm ~ μM, R2 = 0.981）和可行的唾液治疗药物监测限。协同光学吸收和基于发射的分子运输测试进一步补充了BCD-Bt在其他类似分子分析中的多模态功能。

引用次数: 0

Digital sensing technologies in cancer care: A new era in early detection and personalized diagnosis 数字传感技术在癌症治疗：早期检测和个性化诊断的新时代

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-06-25 DOI: 10.1016/j.biosx.2025.100651

Muge Yucel , Ahmet Önder , Tolunay Kurt , Berfin Keles , Merve Beyaz , Yaren Karadağ , İrem Yaşyerli , A. Irem Celik , Fatih Sema , Senem Tetik , Sanem Dinçkal , Soner Karabacak , Palaniappan Alagappan , Bo Liedberg , Umit Hakan Yildiz

Digital sensor platforms are systems that integrate sensors with digital technology, which revolutionize data collection, processing, and transmission for enabling real-time, high-precision and automated diagnostics. These platforms often serve as the backbone of modern monitoring systems, enabling real-time data acquisition and analysis for a wide range of applications. Recent advancements in digital sensor platforms have paved the way for transformative innovations in cancer diagnosis. These cutting-edge technologies offer unprecedented opportunities to facilitate early detection, improve diagnostic accuracy, and personalize treatment methods. This review explores the landscape of digital sensor platforms in the context of cancer diagnosis, providing an overview of their principles, functionalities, and clinical applications. The review further illustrates that biosensors, lab-on-a-chip (LOC) devices and wearable sensors have leveraged on nanotechnology, biorecognition materials and artificial intelligence (AI) for revolutionizing cancer diagnosis. It consolidates the recent advances in digital sensor platforms for cancer diagnosis and the associated critical challenges, such as regulatory concerns, standardization, and ethical considerations. Further, the review summarizes the feasibility for the integration of digital sensor platforms with routine clinical practices for the development of efficient cancer diagnosis and treatment methods.

数字传感器平台是将传感器与数字技术集成在一起的系统，它彻底改变了数据收集、处理和传输，实现了实时、高精度和自动化诊断。这些平台通常作为现代监控系统的支柱，为广泛的应用提供实时数据采集和分析。数字传感器平台的最新进展为癌症诊断的变革性创新铺平了道路。这些尖端技术为促进早期检测、提高诊断准确性和个性化治疗方法提供了前所未有的机会。这篇综述探讨了数字传感器平台在癌症诊断中的前景，概述了它们的原理、功能和临床应用。这篇综述进一步说明，生物传感器、芯片实验室（LOC）设备和可穿戴传感器已经利用纳米技术、生物识别材料和人工智能（AI）来彻底改变癌症诊断。它整合了用于癌症诊断的数字传感器平台的最新进展和相关的关键挑战，如监管问题、标准化和伦理考虑。此外，本文还总结了数字传感器平台与常规临床实践相结合的可行性，以开发高效的癌症诊断和治疗方法。

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引用次数: 0

Design and analysis of a magneto-resistance-based device to mitigate risks from high magnetic field exposure 设计和分析一种基于磁电阻的装置，以减轻高磁场暴露的风险

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-06-25 DOI: 10.1016/j.biosx.2025.100654

Kazi Mustafizur Rahman, Md Mushfiqur Rahman, Sadia Islam, Hasib Md Abid Bin Farid, Md Faysal Nayan

The motivation is to develop a device for pacemaker-implanted patients that would automatically alert them in an intense magnetic field. Moreover, the employees working near any strong magnetic environment would benefit by avoiding high exposure. This research delves into a comprehensive process for the implementation and characterization of such a wearable based on the magnetoresistance effect, which is a function of the magnetic field. The program executes on the Arduino IDE platform. Samples are taken for varying magnetic flux density along each axis, for changes in distance of 2.5 mm. The calculations take place accordingly and provide outputs in microtesla units. Subsequently, the device is analyzed by plotting the responses, and it also helps to understand the working procedure. For a certain axis, the magnetic field is generally stronger than others. The goal is to determine the highest absolute value at any instance, including the Earth's geomagnetic field of 22–67 μT. Regulatory standards are followed to divide the magnetic flux density into four states: power saver (below 150 μT), safe (150–500 μT), unsafe (500–750 μT), and danger (over 750 μT). These values consist of ±20 μT error, which is quite insignificant. Depending on the state, the novel device generates different warning signals to mitigate risk from magnetic fields. From the error bar plot, it is realized that the percentage of error decreases while calculating higher magnetic flux. The errors could be reduced remarkably by ensuring better calibration and compensation techniques in the future.

其动机是为植入心脏起搏器的患者开发一种装置，该装置可以在强磁场中自动提醒他们。此外，在任何强磁环境附近工作的员工都可以避免高暴露。本研究基于磁场的函数磁阻效应，对这种可穿戴设备的实现和表征进行了全面的研究。该程序在Arduino IDE平台上执行。沿着每条轴的不同磁通密度采集样品，距离变化为2.5 mm。计算相应地进行，并提供以微特斯拉为单位的输出。随后，通过绘制响应来分析设备，也有助于了解工作流程。对于某个轴，磁场通常比其他轴强。目标是确定在任何情况下的最高绝对值，包括22-67 μT的地球地磁场。根据法规标准，将磁通密度分为节能（低于150 μT）、安全（150 ~ 500 μT）、不安全（500 ~ 750 μT）和危险（超过750 μT）四种状态。这些值由±20 μT的误差组成，这是相当不显著的。根据不同的状态，这种新型装置会产生不同的警告信号，以减轻磁场带来的风险。从误差柱状图中可以看出，计算较高磁通时，误差百分比减小。通过确保未来更好的校准和补偿技术，可以显著减少误差。

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引用次数: 0

Face-wearable integrated bioelectronics for quantitative, automated diagnosis of blepharospasm 用于定量、自动诊断眼睑痉挛的可穿戴式集成生物电子学

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-08-23 DOI: 10.1016/j.biosx.2025.100677

Hojoong Kim , Hoodam Kim , Seungpyo Kang , Gamze Kilic-Berkmen , Kyoungmin Min , H.A. Jinnah , Woon-Hong Yeo

Blepharospasm (BSP) is a neuro-ophthalmologic disorder marked by excessive blinking and involuntary contractions of the muscles around the eyes. Current standard clinical evaluations rely mainly on subjective assessments, often resulting in inconsistencies and human errors in diagnosis and severity monitoring. Here, we introduce a wireless, face-wearable, all-in-one bioelectronic system designed to continuously capture high-fidelity electrooculograms and electromyograms as a quantitative tool for diagnosing BSP. This device features soft membrane sensors and integrated circuits that ensure skin conformity, allowing for highly accurate signal detection on the face. The wearable system has been optimized in both design and functionality to detect a wide range of BSP-related issues across multiple patients, such as increased blink rates, eyelid fluttering, and prolonged eye closures. Our study shows that the normal blink frequency is similar (p = 0.546); however, the BSP group exhibits longer durations and higher amplitudes (p < 0.005). Partial blinks are more frequent and have higher amplitudes, but similar durations (p < 0.005). Long blinks are different in both frequency and duration, but not amplitude (p < 0.01). Flutter events also show group differences in frequency (p < 0.01) and duration (p < 0.005), with no amplitude difference (p = 0.168). A machine learning-based prediction model demonstrates an accuracy of 81.5 % and an F1-score of 0.814 when validated against expert-annotated video data. Overall, the combination of wireless soft bioelectronics and advanced machine learning algorithms, presented in this work, shows a first-of-a-kind approach to effectively and accurately diagnosing BSP.

眼睑痉挛（BSP）是一种神经眼科疾病，其特征是过度眨眼和眼睛周围肌肉的不自主收缩。目前的标准临床评估主要依赖于主观评估，常常导致诊断和严重程度监测中的不一致和人为错误。在这里，我们介绍了一种无线的、可穿戴的、一体化的生物电子系统，该系统旨在连续捕获高保真的眼电图和肌电图，作为诊断BSP的定量工具。该设备具有软膜传感器和集成电路，确保皮肤一致性，允许对面部进行高精度信号检测。该可穿戴系统在设计和功能上都进行了优化，可以检测多个患者的各种bsp相关问题，例如眨眼频率增加、眼皮抖动和闭眼时间延长。我们的研究表明，正常眨眼频率相似（p = 0.546）；然而，BSP组表现出更长的持续时间和更高的振幅（p < 0.005）。部分眨眼更频繁，幅度更大，但持续时间相似（p < 0.005）。长时间眨眼的频率和持续时间不同，但幅度没有差异（p < 0.01）。颤振事件在频率（p < 0.01）和持续时间（p < 0.005）上也存在组间差异，但振幅无差异（p = 0.168）。基于机器学习的预测模型在针对专家注释的视频数据进行验证时显示准确率为81.5%，f1分数为0.814。总的来说，无线软生物电子学和先进的机器学习算法的结合，在这项工作中，展示了一种有效和准确诊断BSP的第一种方法。

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引用次数: 0

Nanostructure modified carbon thread as wearable patch for enzymatic and non-invasive monitoring of glucose from human samples 纳米结构修饰的碳线可穿戴贴片用于人体样品中葡萄糖的酶促和无创监测

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-06-25 DOI: 10.1016/j.biosx.2025.100653

Jithin Thomas Chacko , K. Niyas , Anson T. Mathew , P Abdul Rasheed

Traditional blood-based glucose detection methods are invasive, inconvenient, and unsuitable for continuous monitoring, highlighting the critical need for a non-invasive alternative. To address this urgent need, we developed a non-invasive and wearable electrochemical glucose sensor patch based on a platinum-copper (Pt-Cu) nanocomposite electrodeposited on carbon cloth thread (CCT) electrode after functionalizing with an electropolymerized polyphenol (Pphe)-glucose oxidase (GOx) film. The immobilization of GOx via the formation of a polyphenol film was done by electropolymerization of phenol in presence of GOx. The detection capability of the developed sensor was evaluated by chronoamperometry analysis and found that the sensor is able to detect glucose with wide linear detection range from 100 to 1500 μM with an ultra-low limit of detection (LOD) of 31.1 μM and 64.4 μM for artificial sweat and urine respectively. In addition, the developed sensor is found to be reproducible, repeatable and highly selective in presence of common interfering molecules present in the human samples. Furthermore, the developed sensor was seamlessly integrated into a wearable prototype device on a commercial bandage with custom made potentiostat circuit called Nanopot. The developed wearable prototype sensor system also exhibits a wide linear detection range from 300 to 1500 μM and a promising LOD of 25.8 μM. These results further validate the reliability, consistency, and practical applicability of the sensor system with a promising potential to address the urgent demand for non-invasive, painless and user-friendly diabetes management.

传统的血糖检测方法具有侵入性、不方便且不适合连续监测，因此迫切需要一种非侵入性的替代方法。为了解决这一迫切需求，我们开发了一种无创可穿戴的电化学葡萄糖传感器贴片，该贴片基于铂-铜（Pt-Cu）纳米复合材料，经电聚合多酚(Pphe)-葡萄糖氧化酶（GOx）膜功能化后电沉积在碳布线（CCT）电极上。利用苯酚在氧化石墨烯存在下的电聚合，通过形成多酚膜来固定氧化石墨烯。通过计时安培分析对传感器的检测能力进行了评价，发现传感器能够在100 ~ 1500 μM的宽线性检测范围内检测葡萄糖，对人工汗液和尿液的超低检测限（LOD）分别为31.1 μM和64.4 μM。此外，开发的传感器被发现是可重复的，可重复的，在人类样品中存在的常见干扰分子的高度选择性。此外，开发的传感器被无缝集成到商业绷带上的可穿戴原型设备中，该设备带有定制的定位器电路Nanopot。所开发的可穿戴原型传感器系统还具有300 ~ 1500 μM的宽线性检测范围和25.8 μM的有前途的LOD。这些结果进一步验证了传感器系统的可靠性、一致性和实用性，在解决非侵入性、无痛性和用户友好型糖尿病管理的迫切需求方面具有很大的潜力。

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引用次数: 0

Dry-printed carbon nanotube film based electrochemical immunosensor for total testosterone detection 基于干印碳纳米管薄膜的总睾酮检测电化学免疫传感器

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-07-25 DOI: 10.1016/j.biosx.2025.100660

Narender Kumar Joon, Jane Besong-Ndika, Elisa Mikkonen, Ville Rajala, Samuel Dulay, Ilkka Varjos

Testosterone (TST), a critical hormone for male health, requires precise monitoring due to the significant adverse effects of both deficiency and excess, including reproductive dysfunction, mood alterations, and metabolic imbalances. This study reports a novel electrochemical biosensor designed for rapid and sensitive point-of-care (POC) detection of total TST in serum samples. The sensing platform utilizes a cost-effective, roll-to-roll processed carbon nanotube (CNT) film as a scaffold. To create the biorecognition layer, bovine serum albumin-testosterone conjugate (BSA TST) was uniformly immobilized into the CNT film using an automated liquid dispensing system, enabling high-throughput and reproducible sensor fabrication. The biosensor employs a competitive immunoassay principle, where TST in the sample competes with immobilized BSA TST for the binding sites of antibody against TST horse-radish peroxidase conjugate (AbHRP). Amperometry at −0.2 V vs. Ag/AgCl ink was used to monitor affinity reaction upon addition of H₂O₂ with 3,3′,5,5′-Tetramethylbenzidine (TMB) redox mediator yielding a dynamic range of 82–1080 ng/dL. Limit of detection (LOD) and limit of quantification (LOQ) of 12.7 and 82 ng/dL were achieved respectively. Validation in spiked human serum demonstrated excellent performance, with quantifiable results aligning well with the established physiological range of TST in healthy males (186–1180 ng/dL), highlighting the potential of this biosensor for clinical applications.

睾酮（TST）是一种对男性健康至关重要的激素，由于缺乏和过量的显著不利影响，包括生殖功能障碍、情绪改变和代谢失衡，需要精确监测。本研究报道了一种新型电化学生物传感器，用于快速、灵敏的即时（POC）检测血清样本中的总TST。该传感平台采用了一种具有成本效益的、卷对卷加工的碳纳米管（CNT）薄膜作为支架。为了制造生物识别层，使用自动液体分配系统将牛血清白蛋白-睾酮偶联物（BSA TST）均匀固定在碳纳米管薄膜中，实现高通量和可重复的传感器制造。该生物传感器采用竞争性免疫测定原理，其中样品中的TST与固定化的BSA TST竞争抗TST马萝卜过氧化物酶偶联物（AbHRP）抗体的结合位点。采用−0.2 V对Ag/AgCl墨水的电流法监测H2O2与3,3 ',5,5 ' -四甲基联苯胺（TMB）氧化还原介质的亲和反应，动态范围为82-1080 ng/dL。检测限为12.7 ng/dL，定量限为82 ng/dL。在加标人血清中的验证显示出优异的性能，可量化的结果与健康男性TST的既定生理范围（186-1180 ng/dL）非常吻合，突出了该生物传感器在临床应用中的潜力。

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引用次数: 0

A self-powered photovoltaic colorimetric detector for sensing metal ions at ultralow concentrations 用于感应超低浓度金属离子的自供电光伏比色检测器

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X

Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1016/j.biosx.2025.100674

Wan-Jhen Wu , Chia-Yu Hsu , Shang-Yu Tsai , Po-Hsien Tseng , Yu-Ting Tai , Guan-Ling Hou , Yu-Sheng Lai , Fu-Hsiang Ko

The accumulation of toxic metal ions from industrial activities poses significant environmental and health risks, thus necessitating the development of portable, rapid, and highly sensitive detection systems. We report a self-powered photovoltaic colorimetric sensor that is capable of detecting Al³⁺, Fe³⁺, and Cu²⁺ ions at nanomolar concentrations. Traditional spectrometer-based platforms are bulky and unsuitable for onsite applications, whereas conventional colorimetric sensors often suffer from limited sensitivity and poor reproducibility. To address these limitations, we utilize a rhodamine derivative (R6GH) that undergoes a ring-opening reaction upon interaction with target metal ions, which results in a visible color change under green LED illumination. The portable sensor integrates a Schottky junction that is fabricated by depositing gallium-doped zinc oxide (GZO) onto an n-type silicon substrate via atomic layer deposition, which enables the efficient conversion of optical signals into electrical outputs. The device operates in dual detection mode. In voltage mode, the detection limits are 16 nM for Al³⁺, 22 nM for Fe³⁺, and 41 nM for Cu²⁺. In current mode, the respective detection limits are 26, 18, and 34 nM. Compared with conventional chemosensors, this system offers an improvement in sensitivity of up to two orders of magnitude. Additionally, the sensor demonstrates excellent signal reproducibility, with a relative standard deviation (RSD) of less than 1.14 % across 560 switching cycles. The combination of high sensitivity, rapid response (<30 s), and stable, self-powered operation makes this device a promising candidate for real-time metal ion monitoring for the future of bioelectronic devices in healthcare.

工业活动产生的有毒金属离子的积累构成重大的环境和健康风险，因此有必要开发便携式、快速和高灵敏度的检测系统。我们报道了一种自供电光伏比色传感器，能够检测纳米摩尔浓度的Al3+， Fe3+和Cu2+离子。传统的基于光谱仪的平台体积庞大，不适合现场应用，而传统的比色传感器往往存在灵敏度有限和再现性差的问题。为了解决这些限制，我们利用罗丹明衍生物（R6GH）在与目标金属离子相互作用时发生开环反应，从而在绿色LED照明下产生可见的颜色变化。该便携式传感器集成了一个肖特基结，该结是通过原子层沉积将掺镓氧化锌（GZO）沉积在n型硅衬底上制成的，从而实现了光信号到电输出的有效转换。该设备工作在双检测模式。电压模式下，Al3+的检测限为16 nM， Fe3+的检测限为22 nM， Cu2+的检测限为41 nM。在当前模式下，检测限分别为26、18和34 nM。与传统的化学传感器相比，该系统的灵敏度提高了两个数量级。此外，该传感器具有出色的信号再现性，在560个开关周期内相对标准偏差（RSD）小于1.14%。高灵敏度、快速响应（30秒）和稳定的自供电操作相结合，使该设备成为未来医疗保健中生物电子设备实时金属离子监测的有希望的候选者。

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