Carbohydrate Polymers最新文献_第4页

Microencapsulation of phase change materials via nanopolysaccharide complex-stabilized Pickering emulsions 纳米多糖络合物稳定皮克林乳液对相变材料的微胶囊化

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-02-05 DOI: 10.1016/j.carbpol.2026.125066

Wangfang Deng , Yidong Zhang , Martti Toivakka , Chunlin Xu

Microencapsulation of phase change materials (PCMs) within polymer shells is an effective approach to prevent leakage, improve thermal conductivity, and broaden their applications in thermal energy storage. Herein, the fully bio-based complex of lignin-containing cellulose nanofibrils (LCNF) and chitin nanofibers (ChNF) was tailored to stabilize Pickering emulsion for in-situ polymerization of PCM microcapsules with a melamine-formaldehyde (MF) resin shell. The droplet size and stability of the emulsions can be effectively controlled by adjusting the morphology difference and concentration of the oppositely charged LCNF (negatively charged) and ChNF (positively charged). An optimal LCNF/ChNF complex stabilization system (LCNF: ChNF = 0.25 wt%: 0.25 wt%) was identified and utilized to stabilize n-octadecane (C₁₈) Pickering emulsions, thereby forming the basis for high-performance PCM microcapsules. The resulting microcapsules exhibited excellent thermal properties, including outstanding thermal cycling stability and a high latent heat storage capacity exceeding 205 J/g. Furthermore, the MF polymer shell provided microcapsules with a high encapsulation rate and encapsulation efficiency of 84.5% and 99.8%, respectively, while ensuring no leakage under prolonged high-temperature conditions. These results highlight the potential of the LCNF/ChNF complex as a green and effective stabilizer for PCM microcapsules, offering a new insight into sustainable solutions for energy storage technologies.

将相变材料（PCMs）微胶囊化在聚合物壳内是防止泄漏、提高导热性和扩大其在热能储存领域应用的有效途径。本文设计了含木质素的纤维素纳米纤维（LCNF）和几丁质纳米纤维（ChNF）的全生物基配合物，用于稳定皮克林乳液，用于原位聚合具有三聚氰胺甲醛（MF）树脂外壳的PCM微胶囊。通过调节带负电荷的LCNF和带正电荷的ChNF的形态差异和浓度，可以有效地控制乳状液的大小和稳定性。确定了最佳的LCNF/ChNF复合稳定体系（LCNF: ChNF = 0.25 wt%: 0.25 wt%），并将其用于稳定正十八烷（C18）皮克林乳状液，从而为高性能PCM微胶囊的制备奠定了基础。制备的微胶囊具有优异的热性能，包括出色的热循环稳定性和超过205 J/g的高潜热储存容量。此外，MF聚合物外壳为微胶囊提供了较高的包封率和包封效率，分别为84.5%和99.8%，同时保证了长时间高温条件下不泄漏。这些结果突出了LCNF/ChNF复合物作为PCM微胶囊绿色有效稳定剂的潜力，为储能技术的可持续解决方案提供了新的见解。

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引用次数: 0

Natural small molecule-polysaccharide nanoparticles: Preparation, characteristics-efficacy modulation, and drug delivery applications 天然小分子多糖纳米颗粒：制备、特性、功效调节和药物传递应用

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-01-25 DOI: 10.1016/j.carbpol.2026.125010

Weiyi Zhao , Weiqiang Huang , Xipei Wu , Xia Li , Wenyuan Gao , Lanping Guo

The rapid advancement of nanotechnology is revolutionizing fields like biology and materials science. However, concerns over the environmental and health impacts of conventional nanomaterials have spurred interest in sustainable alternatives. Natural small molecule-polysaccharide nanoparticles (NSM-PSNPs), synthesized from biocompatible and biodegradable polysaccharides and bioactive natural small molecules (NSMs), present a promising solution. These composite nanoparticles exhibit significant synergistic effects, enhancing the delivery, oral absorption, bioavailability, and controlled release of NSMs for therapeutic and other applications. Despite considerable progress, challenges remain in precisely controlling their structure-property relationships and understanding their behavior in complex biological environments. This review aims to address these challenges by providing strategic design principles for ideal NSM-PSNPs. It systematically outlines the classifications and properties of polysaccharides and NSMs, discusses assembly techniques for NSM-PSNPs, and analyzes the critical correlation between their characteristics and efficacy. Furthermore, the review examines key parameters affecting NSM-PSNPs properties to guide accurate control and explores their diverse applications, with a focus on drug delivery. Finally, it concludes by summarizing current challenges and future prospects in the development and application of NSM-PSNPs.

纳米技术的迅速发展正在给生物学和材料科学等领域带来革命性的变化。然而，对传统纳米材料对环境和健康影响的担忧激发了人们对可持续替代品的兴趣。天然小分子多糖纳米粒子（NSM-PSNPs）是由生物相容性和可生物降解的多糖和具有生物活性的天然小分子（NSMs）合成的，是一种很有前景的解决方案。这些复合纳米颗粒表现出显著的协同效应，增强了nsm的递送、口服吸收、生物利用度和控释，用于治疗和其他应用。尽管取得了相当大的进展，但在精确控制它们的结构-性质关系和理解它们在复杂生物环境中的行为方面仍然存在挑战。本文旨在通过提供理想的nsm - psnp的战略设计原则来解决这些挑战。系统地概述了多糖和nsm的分类和性质，讨论了nsm - psnp的组装技术，并分析了它们的特性与功效之间的关键相关性。此外，本文还研究了影响nsm - psnp特性的关键参数，以指导精确控制，并探讨了它们在药物传递方面的不同应用。最后，总结了nsm - psnp在开发应用中面临的挑战和未来的发展前景。

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引用次数: 0

Construction of bilayer asymmetric humidity-regulating packaging using 2-hydroxypropyl trimethyl ammonium chloride chitosan for enhanced strawberry preservation 2-羟丙基三甲基氯化铵壳聚糖构建双层非对称调湿包装增强草莓保鲜

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-01-20 DOI: 10.1016/j.carbpol.2026.124973

Hao Dong , Xing Xu , Keqin Mi , Xin Peng , Frank Ratego , Liping Tong , Shifeng Hou

To ensure high-quality harvested fruits and vegetables, maintaining a stable, high relative humidity is crucial. This study concentrated on the development of an asymmetric double-layer film designed to address the limitations inherent in single-layer films. The film incorporates 2-hydroxypropyl trimethyl ammonium chloride chitosan (HACC) as an autonomous humidity control material. HACC has a water adsorption energy of −2.03 eV, higher than polyvinyl alcohol (PVA), indicating better water absorption. The PVA/HACC film evenly distributes water molecules and has a higher adsorption capacity. HACC enhances adsorption kinetics and equilibrium through a synergistic “hydrogen bond-electrostatic” mechanism and increased free volume. Increasing the HACC concentration to 1.0% elevates the active layer's water absorption capacity to 0.43 g/g. The double-layer film exhibits a remarkably low water vapor permeability of (1.66 ± 0.03) × 10⁻¹¹ g·m/(m²·s·Pa), effectively minimizing moisture exchange. When used for fresh strawberries, compared with the control group, it increased internal relative humidity by 126.54% and reduced the relative humidity variation to 1.62 × 10⁻², effectively extending freshness to 7 days at room temperature. This innovative packaging solution actively regulates humidity, prolonging the freshness of fruits and vegetables. To encourage practical use, it's essential to assess the main challenges of large-scale promotion.

为了保证收获的水果和蔬菜的质量，保持稳定、高的相对湿度是至关重要的。本研究集中于非对称双层薄膜的开发，旨在解决单层薄膜固有的局限性。该薄膜采用2-羟丙基三甲基氯化铵壳聚糖（HACC）作为自主湿度控制材料。HACC的吸水能为- 2.03 eV，高于聚乙烯醇（PVA），具有更好的吸水性。PVA/HACC膜使水分子分布均匀，具有较高的吸附能力。HACC通过协同的“氢键静电”机制和增加的自由体积增强吸附动力学和平衡。当HACC浓度增加到1.0%时，活性层的吸水量提高到0.43 g/g。双层膜的水蒸气渗透率为（1.66±0.03）× 10−11 g·m/(m2·s·Pa)，有效地减少了水分交换。用于草莓鲜时，与对照组相比，内部相对湿度提高了126.54%，相对湿度变化减小到1.62 × 10−2，在室温下有效延长新鲜度至7天。这种创新的包装解决方案积极调节湿度，延长水果和蔬菜的新鲜度。为了鼓励实际应用，有必要评估大规模推广的主要挑战。

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引用次数: 0

Microcrystalline cellulose modified with ethylenediamine disuccinate via ring-opening grafting reaction: A novel and efficient biosorbent for heavy metal ions 开环接枝改性二磺酸乙二胺微晶纤维素：一种新型高效重金属离子生物吸附剂

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-02-09 DOI: 10.1016/j.carbpol.2026.125078

Ziyi Wang, Wenqi Wang, Lang Zhao, Min He, Rong Li

The development of efficient adsorbents is crucial for wastewater treatment given the severe threats posed by heavy metal pollution. This study reports a high-performance biosorbent synthesized by modifying ethylenediamine disuccinate onto microcrystalline cellulose via a 'ring-opening grafting' strategy. The successful modification was verified by comprehensive material characterization. The adsorption performance toward heavy metal ions was systematically evaluated. Under optimal conditions, the adsorption capacities of the biosorbent for Cr(VI), Al(III), and Pb(II) reached 484.84, 472.84, and 477.84 mg/g, respectively, within 30 min. After six adsorption-desorption cycles, the biosorbent retains all about 90% of its initial capacities for three metals, demonstrating excellent structural stability and reusability. Density functional theory calculations, encompassing surface electrostatic potential, Fukui function, binding energy, and differential charge density analyses, elucidate a coordination-dominated adsorption mechanism primarily at the -NH and -COOH sites. The calculated binding energies become less negative in the order Cr(VI) < Pb(II) < Al(III), which, alongside significant electron transfer/sharing, confirms the corresponding trend in adsorption strength. With its integrated advantages of high performance, low cost, and excellent recyclability, the biosorbent demonstrates strong competitiveness and application potential for treating heavy metal pollution.

考虑到重金属污染对废水的严重威胁，开发高效吸附剂对废水处理至关重要。本研究报告了通过“开环接枝”策略将二磺酸乙二胺修饰在微晶纤维素上合成的高性能生物吸附剂。通过材料的综合表征，验证了改性的成功。系统评价了其对重金属离子的吸附性能。在最佳条件下，该生物吸附剂对Cr（VI）、Al（III）和Pb（II）的吸附量在30 min内分别达到484.84、472.84和477.84 mg/g。经过六次吸附-解吸循环后，该生物吸附剂对三种金属的吸附能力仍保持90%左右，具有良好的结构稳定性和可重复使用性。密度泛函理论计算，包括表面静电势、福井函数、结合能和差分电荷密度分析，阐明了主要在-NH和-COOH位点上以配位为主的吸附机制。计算出的结合能在Cr(VI) < Pb(II) < Al（III）的顺序上变得更小，这与显著的电子转移/共享一起证实了吸附强度的相应趋势。该生物吸附剂具有高性能、低成本和良好的可回收性等综合优势，在重金属污染治理中具有很强的竞争力和应用潜力。

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引用次数: 0

HATU Coupling for Fast, Efficient, and Selective N-acylation of chitosan: DoE-optimized synthesis of cationic antibacterial derivatives 壳聚糖快速、高效、选择性n -酰化的HATU偶联：阳离子抗菌衍生物的doe优化合成

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-01-26 DOI: 10.1016/j.carbpol.2026.125012

Luca Protti , Vivien Nagy , Daniel Amani , Sankar Rathinam , Elvar Örn Viktorsson , Már Másson

Chitosan is a cationic polysaccharide valued in biomedicine for its biodegradability, biocompatibility, non-toxicity, and antimicrobial activity. However, its poor solubility and aggregation tendency limit its applications. These issues can be addressed through chemical modification, which also enhances biological properties. Common acylation and alkylation methods often lack efficiency and control over the degree of substitution (DS).

Here, a new N-acylation procedure using hexafluorophosphate azabenzotriazole tetramethyl uronium (HATU) as coupling agent in dimethyl sulfoxide (DMSO) is reported. The study focused on synthesizing a cationic betaine N-acyl chitosan derivative, N-(2-(N,N,N-trimethylammoniumyl)acetyl) chitosan (TAC), optimized through a Design of Experiments (DoE) approach to achieve full DS control.

Two 12-experiment full factorial DoE optimizations were conducted, varying equivalent ratios of betaine, HATU, 1-hydroxybenzotriazole (HOBt), and triethylamine (TEA). The DS of the TAC products was determined by NMR. The optimized procedure allowed for the quantitative conjugation of betaine, using a slight excess of HATU, requiring only 3 h to complete the synthesis of the TAC derivative from chitosan starting material. The procedure was successfully used for the synthesis of mixed phenylpropionyl-, cinnamoyl- and feruloyl-TAC chitosan derivatives, but further development may be needed for more general applicability. Antibacterial assay confirmed of TAC antibacterial activity, tested against Staphylococcus aureus.

壳聚糖是一种具有生物可降解性、生物相容性、无毒性和抗菌活性的阳离子多糖，在生物医学上具有重要的应用价值。但其溶解度差、易聚集等缺点限制了其应用。这些问题可以通过化学改性来解决，这也提高了生物性能。常见的酰化和烷基化方法往往缺乏效率和对取代度（DS）的控制。本文报道了以六氟磷酸氮杂苯并三唑四甲基脲铵（HATU）为偶联剂在二甲亚砜（DMSO）中进行n -酰化反应的新工艺。研究合成了阳离子甜菜碱N-酰基壳聚糖衍生物N-（2-（N，N，N-三甲基铵基）乙酰基）壳聚糖（TAC），并通过实验设计（DoE）方法对其进行了优化，以实现全DS控制。对甜菜碱、HATU、1-羟基苯并三唑（HOBt）和三乙胺（TEA）的等效比例进行了2个12个试验的全因子DoE优化。用核磁共振法测定了TAC产物的DS。优化后的程序允许甜菜碱的定量偶联，使用少量过量的HATU，仅需要3小时就可以完成壳聚糖起始材料TAC衍生物的合成。该方法已成功地用于合成混合苯基丙酰壳聚糖、肉桂酰壳聚糖和阿魏酰壳聚糖衍生物，但需要进一步发展以获得更广泛的适用性。抗菌实验证实了TAC对金黄色葡萄球菌的抑菌活性。

{"title":"HATU Coupling for Fast, Efficient, and Selective N-acylation of chitosan: DoE-optimized synthesis of cationic antibacterial derivatives","authors":"Luca Protti , Vivien Nagy , Daniel Amani , Sankar Rathinam , Elvar Örn Viktorsson , Már Másson","doi":"10.1016/j.carbpol.2026.125012","DOIUrl":"10.1016/j.carbpol.2026.125012","url":null,"abstract":"<div><div>Chitosan is a cationic polysaccharide valued in biomedicine for its biodegradability, biocompatibility, non-toxicity, and antimicrobial activity. However, its poor solubility and aggregation tendency limit its applications. These issues can be addressed through chemical modification, which also enhances biological properties. Common acylation and alkylation methods often lack efficiency and control over the degree of substitution (DS).</div><div>Here, a new <em>N</em>-acylation procedure using hexafluorophosphate azabenzotriazole tetramethyl uronium (HATU) as coupling agent in dimethyl sulfoxide (DMSO) is reported. The study focused on synthesizing a cationic betaine <em>N</em>-acyl chitosan derivative, <em>N</em>-(2-(<em>N,N,N</em>-trimethylammoniumyl)acetyl) chitosan (TAC), optimized through a Design of Experiments (DoE) approach to achieve full DS control.</div><div>Two 12-experiment full factorial DoE optimizations were conducted, varying equivalent ratios of betaine, HATU, 1-hydroxybenzotriazole (HOBt), and triethylamine (TEA). The DS of the TAC products was determined by NMR. The optimized procedure allowed for the quantitative conjugation of betaine, using a slight excess of HATU, requiring only 3 h to complete the synthesis of the TAC derivative from chitosan starting material. The procedure was successfully used for the synthesis of mixed phenylpropionyl-, cinnamoyl- and feruloyl-TAC chitosan derivatives, but further development may be needed for more general applicability. Antibacterial assay confirmed of TAC antibacterial activity, tested against <em>Staphylococcus aureus</em>.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125012"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-HMF-driven microporous N, O-dual doped carbon materials based on chitosan for syngas purification and CO2 capture 5-羟甲基糠醛驱动的壳聚糖微孔N， o双掺杂碳材料用于合成气净化和CO2捕集

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-02-07 DOI: 10.1016/j.carbpol.2026.125072

Jinpeng Zhai , Chao Liu , Lijuan Sun , Beichen Xue , Yongxin Wu , Rui Xiao

Biomass-derived carbohydrates, as abundant and renewable feedstocks, hold great promise for producing porous carbon materials (PCMs) applicable in CO₂ capture and syngas purification. This study presents a novel strategy for synthesizing N, O-dual doped carbon (NOC) materials through co-pyrolysis using 5-hydroxymethylfurfural (5-HMF) and chitosan (CTS) as precursors, wherein 5-HMF acts as a structural modulator. Combining experimental characterization with density functional theory (DFT) calculations, this work systematically investigated the synergistic mechanism between functional group evolution and carbon framework construction during co-pyrolysis, and elucidated the influence of N, O doping configurations on CO₂ adsorption selectivity. The results indicate that the incorporation of 5-HMF promotes a three-step reaction pathway introducing N, O-containing functional groups such as imine group (C=N) and carbonyl (C=O). The NOC prepared at 800 °C exhibited a CO₂/H₂ selectivity of 43.4 and a CO₂/(CO + H₂) multicomponent selectivity of 24.4 in a continuous flow (CO₂/CO/H₂, 25 °C, 1 bar). Theoretical calculations further revealed that the synergistic coupling of pyridinic N and carbonyl groups on the carbon surface significantly enhances surface polarity and Lewis basicity, thereby strengthening the selective adsorption of polar CO₂ molecules via Lewis acid-base interactions and electrostatic induction.

生物质衍生的碳水化合物作为一种丰富的可再生原料，在生产多孔碳材料（PCMs）方面具有很大的前景，可用于二氧化碳捕获和合成气净化。本研究提出了以5-羟甲基糠醛（5-HMF）和壳聚糖（CTS）为前体，以5-羟甲基糠醛作为结构调节剂，共热解合成N， o双掺杂碳（NOC）材料的新策略。结合实验表征和密度泛函理论（DFT）计算，系统研究了共热解过程中官能团演化与碳骨架构建之间的协同机制，并阐明了N， O掺杂构型对CO2吸附选择性的影响。结果表明，5-HMF的加入促进了含N， O的官能团如亚胺基（C=N）和羰基（C=O）的三步反应途径。在连续流动条件下（CO2/CO/H2, 25℃，1 bar）， 800℃条件下制备的NOC的CO2/H2选择性为43.4,CO2/(CO + H2)多组分选择性为24.4。理论计算进一步表明，吡啶N和羰基在碳表面的协同耦合显著增强了表面极性和Lewis碱度，从而通过Lewis酸碱相互作用和静电感应加强了极性CO2分子的选择性吸附。

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引用次数: 0

Understanding the formation of hemicellulose-polyphenol assemblies: case study of the xyloglucan-tannic acid system 了解半纤维素-多酚组合物的形成：以木葡聚糖-单宁酸体系为例

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-02-07 DOI: 10.1016/j.carbpol.2026.125077

Sarah Mamdouh, Isabelle Capron, Hugo Voisin

Hemicellulose and polyphenols present attractive functional potential for the elaboration of biobased materials but their interaction remains scarcely studied. In this study, the interaction behavior of xyloglucan (XG) and tannic acid (TA) was systematically studied over XG concentration ranging from 0.25 g/L to 3 g/L and TA:XG weight ratio from 0.1 to 10. Three distinct types of assemblies identified as swollen coils, dense beads or aggregated beads were described using a combination of QCM-D, light scattering and thermodynamic characterizations. They differed in size and colloidal behavior, and their formation was primarily governed by hydrophobic interactions and steric repulsions. These findings provide new insights into the molecular mechanisms driving hemicellulose–polyphenol association and highlight their potential in the design of functional, plant-inspired materials.

半纤维素和多酚在制备生物基材料方面具有很好的功能潜力，但它们之间的相互作用还很少被研究。本研究系统研究了木葡聚糖（XG）与单宁酸（TA）在XG浓度为0.25 g/L ~ 3g /L， TA:XG质量比为0.1 ~ 10时的相互作用行为。利用QCM-D、光散射和热力学表征的结合，描述了三种不同类型的组件，即膨胀线圈、密集珠状或聚集珠状。它们的大小和胶体行为不同，它们的形成主要受疏水相互作用和位阻排斥的支配。这些发现为半纤维素-多酚结合的分子机制提供了新的见解，并突出了它们在设计功能性植物灵感材料方面的潜力。

引用次数: 0

Injectable nanocellulose-based polylipoic acid hydrogels with tunable rheology, strong adhesion and multifunctional bioactivity 可注射的纳米纤维素基聚硫辛酸水凝胶，具有可调的流变性，强附着力和多功能生物活性

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-02-09 DOI: 10.1016/j.carbpol.2026.125084

Yuting Zhang , Mingyue Sun , Penghao Sun , He Liu , Zhanqian Song , Xu Xu , Zhaolan Zhai , Fuhao Dong

The development of injectable hydrogels that combine strong tissue adhesion, suitable rheological properties and effective antibacterial/antioxidant activities remains a major challenge for biomedical applications. Herein, we design nanocellulose-based dynamic hydrogels by integrating dopamine-grafted cellulose nanofibers (DCNF) with polylipoic acid (PTA). The DCNF not only constructs a percolated nanofibrous network that precisely regulates viscosity, shear-thinning behavior and structural recovery after injection, but also stabilizes PTA by quenching terminal sulfur radicals, thereby suppressing depolymerization. As a result, the obtained hydrogels exhibit excellent injectability, robust and repeatable adhesion on various substrates, and rapid network recovery, together with effective antibacterial activity against S. aureus and E. coli and pronounced antioxidant capacity. In vitro hemolysis and cytocompatibility assays confirm the good biocompatibility of the DCNF/PTA hydrogels. This work provided a simple nanocellulose-centered strategy to construct injectable, adhesive and bioactive hydrogels as promising handling performance in vitro for transdermal drug delivery and other biomedical applications.

开发具有强组织粘附性、合适的流变特性和有效的抗菌/抗氧化活性的可注射水凝胶仍然是生物医学应用的主要挑战。在此，我们通过整合多巴胺接枝的纤维素纳米纤维（DCNF）和聚硫辛酸（PTA）来设计基于纳米纤维素的动态水凝胶。DCNF不仅构建了一个渗透的纳米纤维网络，精确调节粘度、剪切减薄行为和注入后的结构恢复，而且通过淬灭末端硫自由基来稳定PTA，从而抑制解聚。结果表明，获得的水凝胶具有良好的可注射性，在各种底物上具有牢固且可重复的粘附性，并且具有快速的网络恢复，同时具有对金黄色葡萄球菌和大肠杆菌的有效抗菌活性和明显的抗氧化能力。体外溶血和细胞相容性实验证实DCNF/PTA水凝胶具有良好的生物相容性。这项工作提供了一种简单的以纳米纤维素为中心的策略来构建可注射、可粘附和具有生物活性的水凝胶，作为体外处理性能良好的经皮给药和其他生物医学应用。

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引用次数: 0

Precise structural characterization and therapeutic potential of a glucomannan polysaccharide from dried rhizome of plant Bletilla striata against ulcerative colitis 植物白芨干根茎葡甘露聚糖多糖的精确结构表征和治疗溃疡性结肠炎的潜力

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-01-30 DOI: 10.1016/j.carbpol.2026.125038

Huidan Hou , Lifeng Li , Tahidul Islam , Jingchun Shi , Mengyang Hou , Siliang Jiang , Xiaohan Zhao , Chengyuan Lin , Quanbin Han , Lin Zhu , Zhaoxiang Bian

Bletillae Rhizoma (Baiji), the dried tuber of Bletilla striata (Thunb.) Reichb.f. (BS), a traditional medicinal plant widely used in Chinese medicine. While polysaccharides from BS tuber (BSP) have attracted attention for their broad industrial applications, their detailed structural features and biological functions remain limited. In this study, a neutral polysaccharide (BSPN, 178 kDa), constituting about 80% of BSP, was extracted and purified. Structural analysis elucidated BSPN as a glucomannan (mannose: glucose = 4: 1), featuring a backbone of →4)-β-D-Manp-(1 → and →4)-β-D-Glcp-(1 → linkages with branching at →4, 6)-β-D-Manp-(1 → positions. Targeted enzymatic hydrolysis, with specific endoglycosidases to cleave characteristic glycosidic bonds, not only verified the purity of BSPN, but also generated diagnostic oligosaccharide fragments that revealed the native glycosidic linkage patterns as well as the precise position of acetyl substitution. Furthermore, BSPN significantly alleviated ulcerative colitis in mice in a dose-dependent manner, improving colon histology, enriching beneficial gut microbiota (Faecalibaculum spp., Bacteroides spp., and Bifidobacterium spp.), restoration of short-chain fatty acids levels (including a 69% increase in valeric acid), and upregulating glycoside hydrolase genes (GH1/GH2). Together, our findings provide the first comprehensive structural characterization and anti-colitis evaluation of BSPN, highlighting its potential as a therapeutic agent for ulcerative colitis.

白芨（Baiji），白芨（Bletilla striata）的干块茎。Reichb.f。中药中广泛使用的传统药用植物。虽然BS块茎多糖（BSP）因其广泛的工业应用而备受关注，但其详细的结构特征和生物学功能仍然有限。本研究提取并纯化了一种中性多糖（BSPN, 178 kDa），约占BSP的80%。结构分析表明BSPN为一种葡甘露聚糖（甘露糖：葡萄糖= 4:1），其主链为→4)-β- d - manp -(1→和→4)-β- d - glcp -(1→键，在→4,6)-β- d - manp -(1→位上有分支。利用特异性内糖苷酶进行特异性糖苷键的酶解，不仅验证了BSPN的纯度，而且产生了诊断性低聚糖片段，揭示了天然糖苷键模式以及乙酰基取代的精确位置。此外，BSPN以剂量依赖的方式显著缓解小鼠溃疡性结肠炎，改善结肠组织学，丰富有益肠道微生物群（Faecalibaculum spp., Bacteroides spp.和Bifidobacterium spp.），恢复短链脂肪酸水平（包括增加69%的戊酸），上调糖苷水解酶基因（GH1/GH2）。总之，我们的研究结果首次提供了BSPN的全面结构表征和抗结肠炎评估，突出了其作为溃疡性结肠炎治疗剂的潜力。

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引用次数: 0

Precision assembly of ethyl cellulose–zein Janus nanoparticles with lock-and-key structures for controlled release of quercetin and curcumin 用于槲皮素和姜黄素控释的具有锁-钥匙结构的乙基纤维素-玉米蛋白纳米颗粒的精密组装

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-15 Epub Date: 2026-02-02 DOI: 10.1016/j.carbpol.2026.125047

Tianqi Cao, Changhu Xue, Zihao Wei

Janus nanoparticles have attracted widespread attention in co-delivery and controlled release of nutraceuticals due to their anisotropic composition and properties. This study reported a novel method for preparing ethyl cellulose–zein Janus nanoparticles loaded with quercetin and curcumin. Morphological observations indicated that the Maillard reaction-mediated nanoprecipitation method successfully prepared Janus nanoparticles with lock-and-key structures. Multispectral technology and three-phase interfacial tension principle further confirmed the formation of Janus nanoparticles. Notably, the glycosylated bridge generated in the Maillard reaction played a crucial role in the formation of Janus nanoparticles. It enhanced the interface coupling between ethyl cellulose and zein, thus promoting the formation of Janus nanoparticles. Compared with single nanoparticles, Janus nanoparticles exhibited better thermal, storage, and physical stability, which was beneficial for their application in the food industry. It was found that Janus NPs could regionally encapsulate quercetin and curcumin in the EC hemisphere and zein sphere. In vitro digestion experiments indicated that Que/Cur-loaded Janus NPs could achieve the controlled release of quercetin and curcumin in the small intestine and colon, respectively. This study not only offers an idea for synthesizing food-grade Janus nanoparticles but also provides new insights into co-delivery and controlled release of nutraceuticals.

Janus纳米颗粒由于其各向异性的组成和性质，在保健品的共给药和控释方面引起了广泛的关注。本研究报道了一种制备含有槲皮素和姜黄素的乙基纤维素-玉米蛋白纳米颗粒的新方法。形态学观察表明，Maillard反应介导的纳米沉淀法成功制备了具有锁-钥匙结构的Janus纳米颗粒。多光谱技术和三相界面张力原理进一步证实了Janus纳米颗粒的形成。值得注意的是，在美拉德反应中产生的糖基化桥在Janus纳米颗粒的形成中起着至关重要的作用。它增强了乙基纤维素与玉米蛋白之间的界面偶联，从而促进了Janus纳米颗粒的形成。与单一纳米颗粒相比，Janus纳米颗粒具有更好的热稳定性、存储稳定性和物理稳定性，这有利于其在食品工业中的应用。发现Janus NPs可以在EC半球和玉米蛋白球中局部包封槲皮素和姜黄素。体外消化实验表明，Que/ cu -负载的Janus NPs可以分别在小肠和结肠中实现槲皮素和姜黄素的控释。该研究不仅为食品级Janus纳米颗粒的合成提供了思路，而且为营养保健品的共递送和控释提供了新的见解。

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引用次数: 0