Carbohydrate Polymers最新文献_第7页

RGD-Alginate beads as scaffolds for culturing primary human dermal and pulmonary fibroblasts rgd -海藻酸酯微球作为培养原代人皮肤和肺成纤维细胞的支架

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-10 DOI: 10.1016/j.carbpol.2026.124913

M.C. Stahl , K.G. Bergendahl , D. Zaytseva-Zotova , K.R. Rytterager , C.T. Nordgård , J.S. Kjesbu , H. Haslene-Hox , Ø. Halaas , P. Sætrom , A.S. Chahal , B.L. Strand

The use of hydrogel microparticles as granular hydrogels is an emerging approach in tissue engineering, where microparticles offer printability, injectability, and serve as scaffolds for cell culture. While culturing dermal fibroblasts for tissue engineering applications is well reported, there is limited research on culturing primary human pulmonary fibroblasts on granular hydrogels. In this study, we grafted RGD-peptides to alginate, formed microbeads, and investigated the ability of granular hydrogels to support the adhesion and growth of primary normal human dermal fibroblasts (NHDFs) and human pulmonary fibroblasts (HPFa). NHDFs adhered to linear RGD (linRGD)-alginate microbeads and spread on the bead surfaces with increased adhesion with increased peptide concentration (0.3–1.3 mM). In contrast, HPFa did not adhere to the linRGD-alginate microbeads. However, HPFa adhered and spread on flat linRGD-alginate gels, indicating that HPFa do respond to linRGD as an adhesion ligand. Supplementation of

M n^{2 +}

resulted in cell adhesion to linRGD-alginate microbeads. Enhanced adhesion and spreading of HPFa to RGD-alginate microbeads were observed when using cyclic RGD. Hence, RGD-alginate microbeads is a promising material for structuring primary human dermal and pulmonary fibroblasts, showing the relevance of using alginate microbeads as scaffolds for 3D cultures with fibroblasts.

使用水凝胶微颗粒作为颗粒水凝胶是组织工程中的一种新兴方法，其中微颗粒具有可打印性，可注射性，并可作为细胞培养的支架。虽然培养真皮成纤维细胞用于组织工程的报道很多，但在颗粒状水凝胶上培养原代人肺成纤维细胞的研究有限。在这项研究中，我们将rgd -肽移植到海藻酸盐上，形成微球，并研究颗粒水凝胶支持原代正常人真皮成纤维细胞（NHDFs）和人肺成纤维细胞（HPFa）粘附和生长的能力。NHDFs粘附在线性RGD (linRGD)-海藻酸盐微球上，并随着肽浓度的增加而在微球表面扩散（0.3-1.3 mM）。相反，HPFa不粘附在linrgd -海藻酸微球上。然而，HPFa在扁平的linRGD-海藻酸凝胶上粘附和扩散，表明HPFa作为一种粘附配体确实对linRGD有反应。补充Mn2+导致细胞粘附到linrgd -海藻酸微球。当使用环状RGD时，观察到HPFa对RGD-海藻酸微球的粘附和扩散增强。因此，rgd -海藻酸微球是一种很有前途的材料，用于构建原代人皮肤和肺成纤维细胞，表明使用海藻酸微球作为成纤维细胞3D培养支架的相关性。

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引用次数: 0

Wine processing induced structural modification of Polygonati Rhizoma polysaccharide and their enhancement of Tc1 cell immunomodulatory activity via microbiota-mediated butyrate metabolism 葡萄酒加工诱导黄精多糖结构改变，并通过微生物介导的丁酸盐代谢增强Tc1细胞免疫调节活性

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-16 DOI: 10.1016/j.carbpol.2026.124935

Fenghe Yang , Chun Wang , Zhiqian Song , Shitao Peng , Ziqi Tian , Wenjie Lu , Tao Lin , Qiao He , Aiping Lyu , Zhangchi Ning

The herb Polygonati Rhizoma is highly esteemed for its immune regulatory therapeutic and nutritive properties, with polysaccharide identified as the principal components that play a pivotal role in immune response modifying. In China, the immunomodulatory effects of Polygonati Rhizoma polysaccharide (PRP) are believed to enhanced after wine processing. However, the structural changes and underlying mechanisms remain insufficiently elucidated. We isolated and purified PRP and wine processing PRP (WPRP) for structural and functional analysis. Structural analysis showed a processing-driven shift from a low-molecular-weight fructo-glucosyl fructan in PRP (1.85 kDa) to a higher-molecular-weight, pectin-type polysaccharide in WPRP (7.31 kDa) enriched in arabinose, galactose and galacturonic acid. The precise structural transition was from α-D-Glcp → [2)-β-D-Fruf-(1]₃ → 2)-β-D-Fruf-(1 → 6)-α-D-Glcp-(1 → 2)-β-D-Fruf → in PRP to → 4)-β-D-Galp-(1 → 4)-β-D-Galp-(1 → 4)-α-D-GalAp-(1 → 5)-α-L-Araf-(1 → [5)-α-L-Araf-(1]₃ → 4)-α-D-GalAp-(1 → 4)-α-D-GalAp-(1 → in WPRP. WPRP exhibited stronger immunomodulatory activity than PRP in immunosuppressed mice. Mechanistically, galacturonic acid-rich pectins and arabinan driven by wine processing are preferential fermentable substrates for butyrate-producing gut bacteria, which promoted Tc1 cell activation/differentiation, and preserved intestinal epithelial integrity. These findings reveal that PRP drives structural remodeling after wine processing, modulating microbial butyrate metabolism and promoting Tc1 activation, which provide novel insights into the modern medical value of traditional dietary resources.

中药黄精因其免疫调节治疗和营养特性而备受推崇，多糖被确定为在免疫反应调节中起关键作用的主要成分。在中国，黄精多糖（PRP）在葡萄酒加工后的免疫调节作用被认为是增强的。然而，结构变化和潜在的机制仍然没有充分阐明。我们分离纯化了PRP和葡萄酒加工PRP （WPRP）进行了结构和功能分析。结构分析表明，在加工过程中，PRP从低分子量的果糖-葡萄糖基果聚糖（1.85 kDa）转变为高分子量的果胶型多糖（7.31 kDa），富含阿拉伯糖、半乳糖和半乳糖醛酸。精确的结构转变是α-D-Glcp→(2),β-D-Fruf——(1)₃→2)-β-D-Fruf -(1→6)α-D-Glcp -(1→2)β-D-Fruf→PRP→4)-β-D-Galp -(1→4)-β-D-Galp -(1→4)-α-D-GalAp -(1→5)α-L-Araf -(1→[5)α-L-Araf——(1)₃→4)-α-D-GalAp -(1→4)-α-D-GalAp -(1→WPRP。WPRP在免疫抑制小鼠中表现出比PRP更强的免疫调节活性。从机制上讲，富含半乳糖醛酸的果胶和由葡萄酒加工驱动的阿拉伯糖是产生丁酸的肠道细菌的首选发酵底物，可以促进Tc1细胞的活化/分化，并保持肠道上皮的完整性。这些发现揭示了PRP驱动葡萄酒加工后的结构重塑，调节微生物丁酸盐代谢，促进Tc1活化，为传统膳食资源的现代医学价值提供了新的见解。

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引用次数: 0

Flame-retardant and electromagnetic-interference-shielding silver nanowire/silicon dioxide/aramid nanofiber/sodium alginate lightweight porous composite for wearable sensors 用于可穿戴传感器的阻燃和电磁干扰屏蔽银纳米线/二氧化硅/芳纶纳米纤维/海藻酸钠轻质多孔复合材料

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI: 10.1016/j.carbpol.2026.125034

Xinxin Cai , Hui Liu , Wen Li , Jiwen Hu , Xiaobin Li , Shudong Lin

With the rapid advancement of wearable electronics and smart devices, multifunctional wearable sensors have gained increasing attention. Therefore, a multifunctional silver nanowire/silicon dioxide/aramid nanofiber/sodium alginate (AgNWs/SiO₂/ANF/SA) porous composite was fabricated via liquid‑nitrogen freeze-drying, combining lightweight structure, electromagnetic interference (EMI) shielding, flame retardancy, and sensing. The porous composite was crosslinked through dual interactions of calcium ions (Ca²⁺) coordination and hydrogen bonding, forming a layered porous structure. The incorporation of AgNWs remarkably improved the electrical conductivity and EMI shielding capability of the porous composite. In particular, the AgNWs/SiO₂/ANF/SA composite containing 40% AgNWs (40Ag-A) achieved a low density of 44.01 kg/m³ together with outstanding EMI shielding effectiveness. Moreover, Ca²⁺ crosslinking with ANF and SA, combined with the synergistic reinforcement of SiO₂, enhanced the flame-retardant and smoke-suppression properties, lowering the heat release rate (PHRR), total heat release (THR), total smoke production (TSP), and carbon monoxide production rate (COP) of 40Ag-A to 41.64 kW/m², 2.98 MJ/m², 0.12 m², and 2.00 × 10⁻³ g/s. The wearable strain sensor fabricated using the 40Ag-A demonstrated outstanding sensitivity (S = 7.40, 19.45, and 40.23) and fast response/recovery characteristics (36 ms), allowing real-time detection of human joint movements. Therefore, the porous composite achieved synergistic enhancement in lightweight structure, electromagnetic shielding, flame retardancy, and sensing performance, showing great potential for wearable electronics, safety protection, and Smart Internet of Things applications.

随着可穿戴电子产品和智能设备的飞速发展，多功能可穿戴传感器越来越受到人们的关注。因此，通过液氮冷冻干燥制备了一种集轻量化、电磁干扰屏蔽、阻燃和传感于一体的多功能银纳米线/二氧化硅/芳纶纳米纤维/海藻酸钠（AgNWs/SiO2/ANF/SA）多孔复合材料。多孔复合材料通过钙离子（Ca2+）配位和氢键的双重相互作用交联，形成层状多孔结构。AgNWs的加入显著提高了多孔复合材料的导电性和电磁干扰屏蔽能力。特别是含有40% AgNWs （40Ag-A）的AgNWs/SiO2/ANF/SA复合材料，具有44.01 kg/m3的低密度，并具有出色的电磁干扰屏蔽效果。此外，Ca2+与ANF和SA交联，结合SiO2的协同增强，增强了阻燃和抑烟性能，使40ab - a的放热率（PHRR）、总放热率（THR）、总产烟率（TSP）和一氧化碳产率（COP）分别降至41.64 kW/m2、2.98 MJ/m2、0.12 m2和2.00 × 10−3 g/s。使用40Ag-A制成的可穿戴应变传感器具有出色的灵敏度（S = 7.40,19.45和40.23）和快速响应/恢复特性（36 ms），可以实时检测人体关节运动。因此，多孔复合材料在结构轻量化、电磁屏蔽、阻燃性、传感性能等方面实现了协同增强，在可穿戴电子、安全防护、智能物联网等领域应用潜力巨大。

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引用次数: 0

A starch from Spirulina subsalsa: structural characterization and anti-photoaging activity 螺旋藻淀粉的结构表征及抗光老化活性

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-26 DOI: 10.1016/j.carbpol.2026.125001

Yang Zhao , Qianchen Sun , Kexin Pei , Haiyan Pei

Spirulina subsalsa is a filamentous cyanobacterium with great potential as a source of functional polysaccharides, but the structural characteristics of these polysaccharides and their potential role in skin photoaging protection remain largely unexplored. In this study three polysaccharide fractions (SPS-1, SPS-2, & SPS-3) were isolated from the aqueous extract of Spirulina subsalsa, among which SPS-1 was further investigated due to its structural homogeneity and superior yield. SPS-1 was a homogeneous neutral polysaccharide composed mainly of glucose (98.9%), with a molecular mass of 2.89 × 10⁵ g/mol and a relatively low polydispersity index (PDI = 2.22). NMR and methylation analyses confirmed that it had a semi-rigid starch structure, characterized by a backbone of repeating →4)-α-d-Glcp-(1 → residues with limited branching. In UVB-irradiated HaCaT cells, SPS-1 exhibited anti-photoaging effects by attenuating oxidative stress, suppressing inflammation, and restoring extracellular matrix homeostasis through inhibition of the MAPK/NF-κB pathways. In vivo evaluation demonstrated its efficacy in enhancing skin barrier function, with limited skin permeation promoting surface retention and sustained activity that improved hydration and reduced water loss. These results indicate that SPS-1 has potential natural anti-photoaging activity and provide a theoretical basis for the structure–function study and skincare application of Spirulina subsalsa polysaccharides.

螺旋藻是一种极具潜力的丝状蓝藻多糖来源，但这些多糖的结构特征及其在皮肤光老化保护中的潜在作用仍未得到充分研究。本研究从螺旋藻的水提物中分离出三个多糖组分（SPS-1、SPS-2、SPS-3），其中SPS-1因其结构均匀且产率较高，对其进行了进一步研究。SPS-1是一种以葡萄糖为主要成分的均匀中性多糖（98.9%），分子量为2.89 × 105 g/mol，具有较低的多分散性指数（PDI = 2.22）。核磁共振和甲基化分析证实它具有半刚性淀粉结构，其特征是重复→4)-α-d- glcp -(1)→有限分支残基的主链。在uvb照射的HaCaT细胞中，SPS-1通过抑制MAPK/NF-κB通路，减轻氧化应激，抑制炎症，恢复细胞外基质稳态，表现出抗光老化作用。体内评价证明了其增强皮肤屏障功能的功效，有限的皮肤渗透促进表面保留和持续活性，从而改善水合作用并减少水分流失。这些结果表明，SPS-1具有潜在的天然抗光老化活性，为螺旋藻多糖的结构功能研究和护肤应用提供了理论依据。

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引用次数: 0

Re-engineering chitin: From poor processability to functional hydrogels via ketone modification and dynamic crosslinking 重组几丁质：通过酮修饰和动态交联，从较差的可加工性到功能性水凝胶

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.1016/j.carbpol.2026.125048

Rafael F.N. Quadrado , Chisom Friday , Atanur Satir , Charles E. Frazier , Kevin J. Edgar , André R. Fajardo

Chitin remains underutilized in hydrogel systems due to its low solubility and chemical inertness compared to its deacetylated derivative, chitosan. In this work, we report the design of a novel ketone-functionalized hydroxypropyl chitin (Ox-HPChit), obtained via selective oxidation using sodium hypochlorite, enabling dynamic covalent gelation through Schiff base formation with carboxymethyl chitosan (CMCs). This fully biopolymeric system forms injectable, self-healing hydrogels under mild conditions, without the need for synthetic crosslinkers or initiators. The optimized Ox-HPChit/CMCs hydrogel (Gel(1:2)) exhibited rapid gelation (24 min), high swelling capacity (2350%) and robust mechanical recovery, with over 85% of the storage modulus restored after high-strain cycles. Macroscopic injectability, as well as self-healing and adhesion to surfaces, were visually demonstrated. Furthermore, methotrexate-loaded hydrogels showed pH-responsive release, with 79.2% released at pH 5.5 after 24 h, due to the reversible nature of the imine crosslinks that form the hydrogel network. These findings demonstrate the successful development of a new functional chitin derivative and highlight its ability to act as a reactive precursor for dynamic, all-polysaccharide hydrogel networks formed via reversible imine chemistry. This work expands the chemical versatility of chitin and underscores its potential as a carbohydrate platform for the rational design of advanced polysaccharide-based materials, including drug delivery systems.

由于其低溶解度和化学惰性，甲壳素在水凝胶系统中仍未得到充分利用，与其去乙酰化衍生物壳聚糖相比。在这项工作中，我们报道了一种新型酮功能化羟丙基几丁质（oxh - hpchit）的设计，通过使用次氯酸钠选择性氧化获得，通过与羧甲基壳聚糖（cmc）形成希夫碱实现动态共价凝胶化。这种完全的生物聚合物系统在温和的条件下形成可注射的、自愈的水凝胶，不需要合成交联剂或引发剂。优化后的Ox-HPChit/ cmc水凝胶（Gel(1:2)）具有快速凝胶化（24 min）、高溶胀容量（2350%）和强大的机械恢复能力，在高应变循环后恢复了85%以上的存储模量。肉眼可见其可注射性、自愈性和表面粘附性。此外，由于形成水凝胶网络的亚胺交联的可逆性，负载甲氨蝶呤的水凝胶表现出pH响应性释放，24小时后在pH 5.5下释放79.2%。这些发现证明了一种新的功能性几丁质衍生物的成功开发，并突出了其作为通过可逆亚胺化学形成的动态全多糖水凝胶网络的活性前体的能力。这项工作扩展了几丁质的化学多样性，并强调了它作为合理设计高级多糖基材料（包括药物输送系统）的碳水化合物平台的潜力。

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引用次数: 0

Structural characterization of Taiwanofungus camphoratus polysaccharide and its ameliorative effects on myelosuppression and immunosuppression by regulating macrophage activation 樟脑多糖的结构表征及其通过调节巨噬细胞活化对骨髓抑制和免疫抑制的改善作用

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-28 DOI: 10.1016/j.carbpol.2026.125020

Yawen Wang , Jianbin Wang , Hang Lian , Xueting Liu , Jiahao Zheng , Leyi Wang , Juan Liang , Xinyue Wei , Yange Liu

Chemotherapy-induced myelosuppression and immunosuppression impair anticancer efficacy, while macrophages maintain hematopoietic and immune homeostasis. The potential of Taiwanofungus camphoratus polysaccharides to alleviate these two conditions through macrophage modulation remains unexplored. This study focuses on a bioactive polysaccharide from Taiwanofungus camphoratus mycelium, aiming to characterize it and explore its molecular mechanism in alleviating myelosuppression and immunosuppression. Using advanced purification and analytical techniques, we identified a Taiwanofungus camphoratus polysaccharide (ACPSA) which has two structural domains: a heteroglucan constructed with →4) -α-D-Glcp -(1→ and →6)-α-D-Galp-(1→ backbone linkages; and, β-glucan constituents featuring linear →6)-β-D-Glcp-(1→ and →3)-β-D-Glcp-(1→ polymeric frameworks. Using mouse models of myelosuppression and immunosuppression, along with macrophage models, we found that ACPSA alleviates damage to the bone marrow and immune organs, restores hematopoietic stem/progenitor cell differentiation, normalizes leukocyte depletion, and corrects macrophage abnormalities by upregulating classical activation markers. Morphometric and immunoblot analyses demonstrated that ACPSA enhances classical macrophage activation and phagocytic capacity in vitro. ACPSA promoted macrophage reconstitution and activation in vivo. This study employs proteomics to explore the molecular mechanisms of ACPSA's biological functions. It has been verified that ACPSA enhances classical macrophage activation and phagocytic function by suppressing macrophage autophagy. This mechanism highlights its therapeutic potential in addressing chemotherapy-induced complications.

化疗诱导的骨髓抑制和免疫抑制损害抗癌功效，而巨噬细胞维持造血和免疫稳态。樟树多糖通过巨噬细胞调节来缓解这两种情况的潜力尚未被探索。本研究以樟脑菌丝体中的一种生物活性多糖为研究对象，对其进行表征，探讨其缓解骨髓抑制和免疫抑制的分子机制。利用先进的纯化和分析技术，我们鉴定出了一个具有两个结构域的台湾樟树多糖（ACPSA）：一个是由→4)-α- d - glcp -(1→和→6)-α- d - glcp -(1→和→6)-α- d - glcp -(1→和→3)-β- d - glcp -(1→聚合框架构成的杂葡聚糖；通过小鼠骨髓抑制和免疫抑制模型以及巨噬细胞模型，我们发现ACPSA可以减轻对骨髓和免疫器官的损伤，恢复造血干细胞/祖细胞分化，使白细胞消耗正常化，并通过上调经典激活标记物来纠正巨噬细胞异常。形态计量学和免疫印迹分析表明，ACPSA增强体外巨噬细胞活化和吞噬能力。ACPSA在体内促进巨噬细胞的重建和活化。本研究采用蛋白质组学方法探讨ACPSA生物学功能的分子机制。已证实ACPSA通过抑制巨噬细胞自噬来增强经典巨噬细胞活化和吞噬功能。这一机制突出了其在解决化疗引起的并发症方面的治疗潜力。

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引用次数: 0

Chitosan-based advanced biomaterials and stimuli-responsive systems for diabetic ulcer management: From principles to translational potential 基于壳聚糖的先进生物材料和刺激反应系统用于糖尿病溃疡管理：从原理到转化潜力

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-27 DOI: 10.1016/j.carbpol.2026.125005

Girish Kumar , Tarun Virmani , Abhishek Sharma , Bhawna Goel , Nitin Chitranshi , Md Sayeed Akhtar , Khalid Orayj , Joana Galvão Duarte , Filipa Mascarenhas-Melo

Diabetic ulcers remain a significant clinical concern because of their poor healing, persistent inflammation, and increased infection risk. Chitosan and its derivatives have emerged as promising biomaterials for ulcer management due to their biocompatibility, biodegradability, mucoadhesiveness, pH responsiveness, and intrinsic properties, including hemostatic effects, antibacterial activity, anti-inflammatory properties, antioxidant capabilities, and self-healing capabilities. This review provides a comprehensive and current overview of chitosan-based approaches for diabetic ulcer management, focusing on both conventional and advanced biomaterials, including nanoparticles, hydrogels, nanofibers, microneedles, sponges, and 3D scaffolds. Special attention is given to stimuli-responsive chitosan systems designed to adjust drug release in response to specific cues, such as pH, reactive oxygen species, temperature, enzymes, or glucose levels. To underscore the translation potential, the review compiles commercialized products, recent patents, and clinical trials related to the management of diabetic ulcers based on chitosan formulations. Finally, the integration of AI-driven design with smart chitosan systems is proposed as a future direction towards personalized and predictive diabetic ulcer management.

糖尿病性溃疡由于其愈合不良、持续炎症和感染风险增加，仍然是一个重要的临床问题。壳聚糖及其衍生物由于其生物相容性、生物可降解性、黏附性、pH响应性和内在特性，包括止血作用、抗菌活性、抗炎特性、抗氧化能力和自愈能力，已成为治疗溃疡的有前途的生物材料。本文综述了目前以壳聚糖为基础的糖尿病溃疡治疗方法的全面概况，重点介绍了传统和先进的生物材料，包括纳米颗粒、水凝胶、纳米纤维、微针、海绵和3D支架。特别关注刺激反应性壳聚糖系统，该系统设计用于根据特定线索（如pH、活性氧、温度、酶或葡萄糖水平）调节药物释放。为了强调转化潜力，本综述汇编了基于壳聚糖配方的糖尿病溃疡管理相关的商业化产品、最新专利和临床试验。最后，提出了人工智能驱动设计与智能壳聚糖系统的集成，作为个性化和预测性糖尿病溃疡管理的未来方向。

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引用次数: 0

An ultra-expansible chitosan-silk fibroin miniaturized sponge loaded with tranexamic acid modified gelatin for coagulation abnormalities 一种载氨甲环酸改性明胶用于凝血异常的超膨胀壳聚糖-丝素微型海绵

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI: 10.1016/j.carbpol.2026.125032

Yuxiang Wang , Haizhou Qiu , Birui Yang , Yang Li , Wentao Wang , Yujiang Fan , Li Jiang , Yong Sun

The coagulation abnormalities, including complex and irregular bleeding surfaces and underlying coagulopathies in patients, are significant clinical cause of uncontrollable hemorrhage and death in accidental trauma. Herein, we have developed an ultra-expansible chitosan-silk fibroin miniaturized sponge (MS-GT) for delivering antifibrinolytic drug — tranexamic acid (TXA) to achieve in situ hemostasis of the first-aid wounds. TXA-modified gelatin was combined with the highly compressed functional chitosan-based sponge through strong hydrogen bonds, which stabilized sponge's compression state and made it easier to undergo thermosensitive dissolution to release its expansion potential. The MS-GT (∼ 3 mm³, thickness < 1 mm) could achieve a volume expansion of over 11 times within five seconds to seal complex and irregular deep wounds without the need for additional specialized instruments. In addition, the loaded TXA promoted the formation of fibrin to enhance hemostatic efficacy for overcoming the bleeding in coagulation disorders, including disseminated intravascular coagulation (DIC) and hemophilia B model, with significantly superior hemostatic effect comparing with bulk sponge and clinical collagen sponge. This chitosan-based MS-GT alleviated the formation of fibrous capsules in the liver during the post-hemostasis regeneration process, offering new insights for the development of emergency hemostatic materials.

凝血功能异常，包括复杂不规则的出血表面和潜在的凝血功能病变，是意外创伤中不可控制出血和死亡的重要临床原因。在此，我们开发了一种超膨胀壳聚糖-丝素蛋白微型海绵（MS-GT），用于输送抗纤溶药物氨甲环酸（TXA），以实现急救伤口的原位止血。txa改性明胶通过强氢键与高压缩功能壳聚糖基海绵结合，稳定了海绵的压缩状态，使其更容易进行热敏溶解，释放膨胀势。MS-GT （~ 3mm3，厚度<； 1mm）可以在5秒内实现超过11倍的体积膨胀，以密封复杂和不规则的深度伤口，而无需额外的专门仪器。此外，负载TXA促进纤维蛋白的形成，增强止血效果，克服凝血障碍（包括弥散性血管内凝血（DIC）和血友病B模型）的出血，止血效果明显优于散装海绵和临床胶原蛋白海绵。这种壳聚糖基MS-GT减轻了肝脏在止血后再生过程中纤维囊的形成，为急诊止血材料的开发提供了新的见解。

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引用次数: 0

Stretch-oriented chitosan/PVA-based anisotropic double network hydrogel curing by annealing and rehydration for wearable strain sensors 可穿戴应变传感器用拉伸取向壳聚糖/聚乙烯醇基各向异性双网水凝胶退火复水化固化

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-26 DOI: 10.1016/j.carbpol.2026.125014

Zijian Gao , Wenjun Kang , Xin Guan , Honglei Liu , Yihan Guo , Zichun Zhao , Yongqi Yang , Jian Sun , Hailun Ren , Zhaohui Jin

Conductive hydrogel is considered as ideal candidates for flexible electronic devices. However, the limited toughness, flexibility and swelling behavior of conductive hydrogel hinder their application in various environments. In this work, an anisotropic and swelling resistant hydrogel is developed by stretching and reorienting polymer chains by combining with annealing and rehydration process, which is inspired by hierarchical structure of natural tissues. As a result, this hydrogel exhibits significant variability in mechanical properties along and perpendicular to the orientation direction. The toughness along the orientation direction is 1018.5 ± 35.6 kJ·m⁻³ and the tearing energy is 0.56 ± 0.03 kJ·m⁻². The toughness perpendicular to the orientation direction is 483.4 ± 18.6 kJ·m⁻³ and the tearing energy is 2.24 ± 0.07 kJ·m⁻². The hydrophobic interactions of 2-hydroxyethyl methacrylate, in conjunction with the dense polymer network contribute to swelling resistant of the hydrogel. The anisotropic hydrogel is further integrated into flexible sensors, which could be capable of monitoring human motion in amphibious environments, providing distinctly different feedback signals in the directions parallel and perpendicular to the orientation. This work provides a promising strategy to prepare diverse anisotropic materials, offering new solutions for sensor technology.

导电水凝胶被认为是柔性电子器件的理想候选材料。然而，导电水凝胶有限的韧性、柔韧性和膨胀特性阻碍了其在各种环境中的应用。在本研究中，受自然组织分层结构的启发，通过拉伸和重定向聚合物链，结合退火和再水化过程，开发了一种各向异性和抗膨胀的水凝胶。因此，这种水凝胶在取向方向上和垂直方向上表现出显著的力学性能变化。取向方向韧性为1018.5±35.6 kJ·m−3，撕裂能为0.56±0.03 kJ·m−2。垂直于取向方向的韧性为483.4±18.6 kJ·m−3，撕裂能为2.24±0.07 kJ·m−2。2-羟乙基甲基丙烯酸酯的疏水相互作用与致密的聚合物网络相结合，有助于水凝胶的抗膨胀性。将各向异性水凝胶进一步集成到柔性传感器中，可以在两栖环境中监测人体运动，在平行和垂直方向上提供明显不同的反馈信号。这项工作为制备各种各向异性材料提供了一种有前途的策略，为传感器技术提供了新的解决方案。

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引用次数: 0

Deep eutectic hydrogel with polyphenol metal coordination and size reduced cellulose for high performance strain sensing 深共晶水凝胶与多酚金属配位和尺寸减小纤维素高性能应变传感

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-05-01 Epub Date: 2026-01-22 DOI: 10.1016/j.carbpol.2026.124998

Kunpeng Qian , Yu Sun , Wenya Ma , Xuliang Wang , Huanhuan Liu , Yijie Li , Li Li

Deep eutectic solvent (DES)-based hydrogels are environmentally friendly and structurally tunable, yet their applications are often limited by poor conductivity, weak resilience and rigidity. Herein, a multifunctional hydrogel (DC-TAZn) was developed by reinforcing a choline chloride-polyacrylic acid (ChCl-PAA) matrix with size-reduced cellulose nanofibers (CNF) and dynamic tannic acid-Zn²⁺ coordination. The hydrogel exhibits high ionic conductivity (0.34 S/m), excellent stretchability (up to 807%), remarkable resilience (>99.89%), and a reliable gauge factor (1.99) for strain sensing. Additionally, DC-TAZn hydrogel shows strong adhesion, self-healing ability and antibacterial activity, while maintaining functionality under extreme conditions. This multi-synergistic hydrogel provides a sustainable strategy for designing next-generation smart hydrogels with integrated mechanical, conductive, and sensing functionalities, advancing applications in wearable electronics and intelligent human-machine interfaces.

深度共晶溶剂（DES）为基础的水凝胶具有环保和结构可调的特点，但其应用往往受到导电性差、回弹性弱和刚性差的限制。本文通过还原纤维素纳米纤维（CNF）和动态单宁酸- zn2 +配位增强氯化胆碱-聚丙烯酸（ChCl-PAA）基质，制备了一种多功能水凝胶（DC-TAZn）。该水凝胶具有高离子电导率（0.34 S/m）、优异的拉伸性（高达807%）、卓越的回弹性（>99.89%）和可靠的应变传感测量因子（1.99）。此外，DC-TAZn水凝胶具有很强的粘附力、自愈能力和抗菌活性，在极端条件下也能保持功能。这种多协同水凝胶为设计具有综合机械、导电和传感功能的下一代智能水凝胶提供了可持续的策略，推动了可穿戴电子产品和智能人机界面的应用。

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引用次数: 0