Journal of Functional Foods最新文献

英文中文

Corrigendum to “In-depth genomic identification and safety evaluation of Lactobacillus acidophilus LA85” [J. Funct. Foods 123 (2024) 106604] 嗜酸乳杆菌LA85的深度基因组鉴定和安全性评价[J]。功能。食品123 (2024)106604]

IF 3.9 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-07-01 Epub Date: 2026-05-15 DOI: 10.1016/j.jff.2026.107334

Yongmei Qi, Yao Dong, Jiayue Gu, Yihui Cai, Yanyan Zhang, Zhonghui Gai, Mei Han

引用次数: 0

Corrigendum to “Nutraceutical potential of a novel phytonutrients formula in managing hyperuricemia: In silico, in vitro, and in vivo investigations” [J. Funct. Foods 129 (2025) 106849] “一种新型植物营养素配方在治疗高尿酸血症中的营养潜力：硅，体外和体内研究”的更正[J]。功能。食品129 (2025)106849]

IF 3.9 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-07-01 Epub Date: 2026-05-08 DOI: 10.1016/j.jff.2026.107309

Yuting Jian, Xiaoqun Zhong, Junjing Wang, Feijie Wang, Shaokun Yu, Jiannan Guo, Xiaona Gan, Juntao Kan, Wei Guo

引用次数: 0

Corrigendum to “Effects of high-protein rice bran fiber on intestinal microbiota composition in healthy older Chinese adults based on in vitro fermentation and a pilot intervention study” [J. Func. Food 139 (2026) 107242] “基于体外发酵和试点干预研究的高蛋白米糠纤维对中国健康老年人肠道菌群组成的影响”[J]。函数。食品139 (2026)107242]

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-05-01 Epub Date: 2026-03-23 DOI: 10.1016/j.jff.2026.107260

Jianqiang Li , Xinyi Lian , Zhaojun Liu , Ge Zhang , Jie Gu , Xin Wang , Jinjun Li , Xiuli Yu , Xiangyu Bian , Jian Kuang , Fangshu Shi , Yuling Li , Zhengxiang Hu , Xiaoqiong Li

引用次数: 0

Molecular docking-guided caffeic acid phenethyl ester/hydroxypropyl-β-cyclodextrin host-guest complexes: Alleviating of colonic inflammation and insights into their synergistic mechanism 分子对接引导的咖啡酸苯乙酯/羟丙基-β-环糊精主客体复合物：减轻结肠炎症及其协同机制的见解

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.jff.2026.107200

Jiayu Li , Qin Huang , Can Li , Dan Wu , Miao Li , Yukun Huang , Xiao Yang , Xianggui Chen , Pengfei Chen , Guangping Luo

Caffeic acid phenethyl ester (CAPE), a prominent polyphenolic compound in propolis, faces limited nutritional application due to its hydrophobicity and low bioavailability. By molecular docking, CAPE/hydroxypropyl-β-cyclodextrin (HP-β-CD) host-guest complexes exhibiting the lowest binding energy were identified and synthesized using saturated aqueous solution-freeze-drying methods, achieving an inclusion efficiency of 96.13% and enhanced storage stability. In vivo studies demonstrated that CAPE/HP-β-CD complexes effectively alleviated colonic inflammation by suppressing NF-κB pathway, restoring mucosal integrity and levels of short-chain fatty acids (SCFAs). Imaging flow cytometry revealed that HP-β-CD enhances cellular uptake of CAPE through an endocytosis-mediated mechanism, surpassing passive diffusion, thereby increasing intracellular CAPE accumulation in Caco-2 cells from 4.63 mg/g to 44.54 mg/g. Bioinformatic analyses further indicated that these complexes exhibited superior efficacy compared to CAPE in ameliorating gut microbial dysbiosis and promoting the proliferation of several bacterial genera within the Lachnospiraceae family, which contribute to maintaining intestinal homeostasis and producing SCFAs. Additionally, the majority of microbiota exhibited negative correlations with key inflammatory markers, including the beneficial genus Bifidobacterium, which is associated with butyric acid production. This study highlights the utility of molecular docking in the rational high-throughput screening of cyclodextrin-based carriers and elucidates the multifaceted mechanisms by which CAPE/HP-β-CD complexation enhances the efficacy of nutritional interventions against colonic inflammation.

咖啡酸苯乙酯（CAPE）是蜂胶中一种重要的多酚类化合物，由于其疏水性和低生物利用度，在营养方面的应用受到限制。通过分子对接，采用饱和水溶液-冷冻干燥的方法，鉴定并合成了结合能最低的CAPE/羟丙基-β-环糊精（HP-β-CD）主客体配合物，包合效率达96.13%，并提高了储存稳定性。体内研究表明，CAPE/HP-β-CD复合物通过抑制NF-κB通路，恢复粘膜完整性和短链脂肪酸（SCFAs）水平，有效缓解结肠炎症。成像流式细胞术显示，HP-β-CD通过内吞介导的机制增强细胞对CAPE的摄取，超越被动扩散，从而使Caco-2细胞内CAPE的积累从4.63 mg/g增加到44.54 mg/g。生物信息学分析进一步表明，与CAPE相比，这些复合物在改善肠道微生物生态失调和促进毛螺科几种细菌属的增殖方面表现出优越的功效，这些细菌属有助于维持肠道内稳态和产生scfa。此外，大多数微生物群与关键炎症标志物呈负相关，包括有益的双歧杆菌属，它与丁酸产生有关。本研究强调了分子对接在环糊精载体的合理高通量筛选中的作用，并阐明了CAPE/HP-β-CD络合增强营养干预抗结肠炎症效果的多方面机制。

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引用次数: 0

Citrus polyphenols for bone health: A systematic review of experimental and human studies 柑橘多酚对骨骼健康：实验和人体研究的系统综述

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.jff.2026.107177

Simone Perna , Nora Cornelli , Asmita Acharya , Eleonora Patta , Giuseppe Mazzola , Mariangela Rondanelli , Patrizia Riso

Citrus fruits are rich in flavanones hesperidin, naringenin, neohesperidin, and neoeriocitrin with emerging osteoprotective potential. This PRISMA-compliant systematic review integrated evidence from in vitro, in vivo, and human studies identified across PubMed, Scopus, and Google Scholar (2014–2025). Fifteen studies met eligibility (8 in vitro, 6 in vivo, 1 randomized human trial). Preclinical findings indicate enhanced osteoblastogenesis via ERK/Smad and Wnt/β-catenin signalling and suppression of osteoclastogenesis through RANKL–NF-κB/NFATc1, alongside reduced oxidative and inflammatory stress. Animal models demonstrated improved trabecular microarchitecture and accelerated fracture healing. In the only human trial found, hesperidin plus calcium improved calcium retention by ∼5.5% versus calcium alone. Overall citrus flavanones seem to exhibit convergent anabolic and anti-resorptive effects; however, long-duration, well-powered clinical trials with standardized formulations are required to establish efficacy for osteoporosis prevention.

柑橘类水果含有丰富的黄酮橙皮苷、柚皮苷、新橙皮苷和新橙皮苷，具有保护骨的潜力。这项符合prisma标准的系统评价综合了PubMed、Scopus和谷歌Scholar（2014-2025）中体外、体内和人体研究的证据。15项研究符合资格（8项体外，6项体内，1项随机人体试验）。临床前研究结果表明，通过ERK/Smad和Wnt/β-catenin信号传导增强了成骨细胞的形成，通过RANKL-NF -κB/NFATc1抑制了破骨细胞的形成，同时减少了氧化和炎症应激。动物模型显示骨小梁微结构得到改善，骨折愈合加快。在唯一发现的人体试验中，橙皮苷加钙比单独加钙可提高钙潴留约5.5%。总的来说，柑橘类黄酮似乎表现出趋同的合成代谢和抗吸收作用；然而，需要长期的、强有力的标准化配方临床试验来确定预防骨质疏松症的疗效。

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引用次数: 0

A novel antitumor peptide from silkworm pupae (Bombyx mori): Purification, characterization, and mechanism 一种从家蚕蛹中提取的新型抗肿瘤肽：纯化、表征及作用机制

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.jff.2026.107176

Guanyu Jiang, Yingfei Su, Liqing Tang, Yue Zhang, Xueping Jiang, Jianglong He, Ping Wu, Sitong Chen, Hao Li, Ran Zhang, Zhongzheng Gui

Bioactive peptide Tyr-Ala-Ser-Pro-Val-His (YASPVH) was purified from silkworm pupa protein enzymatic hydrolysates, and exhibited potent antiproliferative activity against breast cancer HCC-1937 cells. Besides, YASPVH induced G1 phase cell cycle arrest and suppressed HCC-1937 cell migration and invasion. YASPVH also triggered mitochondrial dysfunction, characterized by membrane potential depolarization and reactive oxygen species (ROS) accumulation, ultimately inducing mitochondrial apoptosis via the Bcl-2/Bax/caspase-3 pathway. Additionally, YASPVH promoted excessive intracellular ROS accumulation, leading to endoplasmic reticulum (ER) stress. This was evidenced by significantly elevated cytosolic Ca²⁺ levels and upregulation of ER stress markers PERK, ATF4, and CHOP. YASPVH furthermore inhibited the epithelial-mesenchymal transition process (EMT) by promoting E-cadherin expression while suppressing Vimentin and N-cadherin expression. Collectively, these results demonstrate that YASPVH exerts its antitumor effect by inhibiting proliferation and metastasis, and inducing apoptosis in HCC-1937 cells. This study identifies YASPVH as a promising candidate and provides a novel strategy for breast cancer treatment.

从蚕蛹蛋白酶解物中纯化得到生物活性肽Tyr-Ala-Ser-Pro-Val-His (YASPVH)，对乳腺癌HCC-1937细胞具有较强的抗增殖活性。YASPVH诱导G1期细胞周期阻滞，抑制HCC-1937细胞迁移和侵袭。YASPVH还引发线粒体功能障碍，其特征是膜电位去极化和活性氧（ROS）积累，最终通过Bcl-2/Bax/caspase-3途径诱导线粒体凋亡。此外，YASPVH促进细胞内ROS过度积累，导致内质网（ER）应激。这可以通过胞质Ca2+水平的显著升高和内质网应激标志物PERK、ATF4和CHOP的上调来证明。YASPVH通过促进E-cadherin表达，抑制Vimentin和N-cadherin表达，进而抑制上皮-间质转化过程（EMT）。综上所述，YASPVH通过抑制HCC-1937细胞的增殖转移和诱导细胞凋亡来发挥其抗肿瘤作用。本研究确定YASPVH是一个有希望的候选药物，并为乳腺癌治疗提供了新的策略。

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引用次数: 0

Structural characterization and hypolipidemic activity of polysaccharides from finger citron 佛手柑多糖的结构表征及降血脂活性

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.jff.2026.107185

Juan-Juan Ma , Xi Xie , Lu-Kai Ma , Qin Wang , Geng-Sheng Xiao , Hui-Fan Liu

In this study, the structural characterization and hypolipidemic activity in vivo of finger citron polysaccharide (FCP) were investigated. The FCP consisted of [→t)-Ara(f)-(1→], [→5)-Ara(f)-(1→], and [→4)-Gal(p)-UA-(1→] with the molecular weight of 46.35 KDa. FCP significantly decreased the levels of total cholesterol (TC), triglyceride (TG), low density cholesterol (LDL-C), phenylpropionate aminotransferase (ALT), and aspartate aminotransferase (AST) and increased the level of high density cholesterol (HDLC) in the serum of mice (P < 0.05). Besides, FCP could significantly improve the antioxidant enzymes activities and decreased the liver lipid metabolism indexes (P < 0.05). AMPK/ACC and PPARα/LXRα were used to investigate the hypolipidemic mechanism of FCP, which indicated that FCP could up-regulate the protein and gene levels of AMPK, acetyl-CoA carboxylase(ACC), PPARα and LXRα. This study provides an important basis of FCP for inhibiting the occurrence of metabolic disorders such as hyperlipemia and complications.

本文研究了指香橼多糖（FCP）的结构特征和体内降血脂活性。FCP由[→t)- ara (f)-(1→]、[→5)- ara (f)-(1→]和[→4)- gal (p)- ua -(1→]组成，分子量为46.35 KDa。FCP显著降低小鼠血清总胆固醇（TC）、甘油三酯（TG）、低密度胆固醇（LDL-C）、苯丙酸转氨酶（ALT）、天冬氨酸转氨酶（AST）水平，升高高密度胆固醇（HDLC）水平（P < 0.05）。此外，FCP还能显著提高抗氧化酶活性，降低肝脏脂质代谢指标（P < 0.05）。利用AMPK/ACC和PPARα/LXRα对FCP的降血脂机制进行了研究，结果表明FCP可以上调AMPK、乙酰辅酶a羧化酶（ACC）、PPARα和LXRα的蛋白和基因水平。本研究为FCP抑制高脂血症等代谢紊乱及并发症的发生提供了重要依据。

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引用次数: 0

Folate-producing Lactiplantibacillus plantarum TXZ 2–26 attenuates H-type hypertension by reshaping gut microbiota and metabolic profiles 产生叶酸的植物乳杆菌txz2 - 26通过重塑肠道微生物群和代谢谱来减轻h型高血压

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1016/j.jff.2026.107201

Pu Li , Luyao Liu , Dandan Han , Yuhan Liu , Buke Shi , Huan Liu , Yujie Chen , Yanglei Yi , Yali Cui

H-type hypertension, characterized by hyperhomocysteinemia and folate deficiency, is influenced by gut microbiota dysbiosis. Supplementation with folate-producing probiotics may offer a therapeutic strategy, but its mechanisms require clarification. Using a hypertensive mouse model induced by L-NAME/high-salt, we evaluated the effects of two Lactiplantibacillus plantarum strains: the high folate-producer TXZ 2–26 and a low-producer control, F4–1. Only TXZ 2–26 significantly attenuated elevations in systolic and diastolic blood pressure, reduced renal inflammation and fibrosis, and improved metabolic parameters. This was accompanied by a reversal of hypertension-associated gut dysbiosis—specifically, a decrease in pro-inflammatory taxa (e.g., Porphyromonadaceae) and an increase in beneficial microbes (e.g., Muribaculaceae).Metabolomic analysis revealed that TXZ 2–26 restored host metabolic pathways related to amino acid and lipid metabolism. Crucially, TXZ 2–26 treatment significantly increased folate levels and decreased homocysteine (HCY) in both feces and serum, establishing a strong inverse correlation between them. HCY levels were, in turn, positively correlated with blood pressure. Our findings demonstrate that the antihypertensive effect of L. plantarum TXZ 2–26 is specifically dependent on its high folate-producing capacity, which modulates the gut microbiota, reprograms host metabolism, and corrects the folate-HCY axis imbalance.

以高同型半胱氨酸血症和叶酸缺乏为特征的h型高血压受肠道菌群失调的影响。补充产叶酸的益生菌可能提供一种治疗策略，但其机制需要澄清。利用L-NAME/高盐诱导的高血压小鼠模型，我们评估了两种植物乳杆菌菌株的作用：高产叶酸的txz2 - 26和低产叶酸的对照F4-1。只有txz2 - 26能显著降低收缩压和舒张压升高，减少肾脏炎症和纤维化，改善代谢参数。这伴随着与高血压相关的肠道生态失调的逆转，特别是，促炎类群（如卟啉单胞菌科）的减少和有益微生物（如Muribaculaceae）的增加。代谢组学分析显示，txz2 - 26恢复了宿主与氨基酸和脂质代谢相关的代谢途径。重要的是，txz2 - 26处理显著提高了粪便和血清中叶酸水平，降低了同型半胱氨酸（HCY），两者之间形成了强烈的负相关关系。反过来，HCY水平与血压呈正相关。我们的研究结果表明，植物乳杆菌txz2 - 26的降压作用特别依赖于其高叶酸生产能力，其调节肠道微生物群，重新编程宿主代谢，并纠正叶酸- hcy轴失衡。

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引用次数: 0

Siraitia grosvenorii extract (Sweet Mogrosides) alleviates LPS-induced depressive-like behaviors through modulating neuroinflammation-pyroptosis axis 罗汉果提取物（甜罗汉果苷）通过调节神经炎症-焦死轴减轻lps诱导的抑郁样行为

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.jff.2026.107170

Yuan-yu Yang , Li-guo Li , Shang Li , Ya Su , Li-ming Liu , Quan Tang , Rui Qiu , Yong-Biao Li , Yong Cheng , Hui Zhou

This study investigates the antidepressant effects of Sweet Mogrosides (SMG) derived from Siraitia grosvenorii (SG), focusing on the outcomes of its oral administration and its novel dual-axis modulation of the neuroinflammation-pyroptosis pathway in an LPS-induced depression model. Behaviorally, oral SMG treatment significantly alleviated depressive-like behaviors in mice. Mechanistically, our results demonstrate that orally administered SMG not only rebalanced hippocampal pro- and anti-inflammatory cytokines (suppressing TNF-α while upregulating IL-10) but also significantly inhibited the NLRP3 inflammasome-mediated pyroptotic pathway, as evidenced by reduced IL-1β expression and decreased expression of GSDMD and microglial activation markers (CD68/CD86). Immunofluorescence analysis confirmed that oral SMG suppressed IBA1+ microglial activation and attenuated pro-inflammatory phenotypic shifts. By systematically elucidating that oral SMG can concurrently target both neuroinflammatory and pyroptosis cascades, this study highlights a novel mechanism of action and provides strong evidence for developing SMG as a dietary-based or orally active neuroprotective agent for inflammation-related depression.

本研究探讨了从罗汉果（SG）中提取的甜地黄苷（SMG）的抗抑郁作用，重点研究了其口服给药的效果，以及其在lps诱导的抑郁模型中对神经炎症-焦解通路的新型双轴调节。行为学上，口服SMG治疗可显著减轻小鼠的抑郁样行为。从机制上讲，我们的研究结果表明，口服SMG不仅重新平衡了海马的促炎性和抗炎细胞因子（抑制TNF-α，上调IL-10），而且还显著抑制了NLRP3炎症小体介导的热凋亡途径，这一点可以通过IL-1β表达降低、GSDMD和小胶质细胞激活标志物（CD68/CD86）表达降低得到证明。免疫荧光分析证实，口服SMG抑制IBA1+小胶质细胞激活，减轻促炎表型转移。通过系统地阐明口服SMG可以同时靶向神经炎症和焦亡级联反应，本研究强调了一种新的作用机制，并为将SMG开发为基于饮食或口服的炎症相关抑郁症神经保护剂提供了强有力的证据。

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引用次数: 0

Molecular and microstructural cues for starch digestive heterogeneity in Indian pearl millet (Pennisetum Glaucum) 印度珍珠粟（Pennisetum Glaucum）淀粉消化异质性的分子和微观结构线索

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-17 DOI: 10.1016/j.jff.2026.107208

Sneha Pandey , Deepanyeta Goswami , T. Vinutha , Suneha Goswami , Ranjeet Ranjan Kumar , Sumer Pal Singh , Shalini Gaur Rudra , Manish Kumar Singh , Tara Satyavathi , Aiswarya Girija , Sijo Joseph Thandapilly , Veda Krishnan

Pearl millet (PM) is a nutrient-rich, climate-resilient cereal with potential for low-glycemic food applications. This study examined molecular and microstructural determinants of in vitro starch digestibility in 11 PM genotypes. Variation in starch composition (amylose: 18.27–27.68%; amylopectin: 30.62–51.12%) influenced the distribution of digestible fractions. Rapidly digestible starch ranged from 26.32% (HHB-67 Improved) to 44.74% (PC-701), while slowly digestible starch varied from 14.65% (Pusa-1803) to 27.44% (Chanana Bajri) and was negatively correlated with predicted glycemic index (pGI: 54.63–58.87; r = −0.633). Rheological analysis showed an inverse relationship between peak viscosity and pGI (r = −0.828), suggesting restricted starch gelatinization reduces enzymatic accessibility. X-ray diffraction revealed that higher crystallinity (18.44–26.97%) was also associated with lower pGI (r = −0.788). The Principal Component Analysis grouped Chanana Bajri, PC-701 and 86M94 as structurally compact, slowly digestible types, while Dhodsar Local and Pusa-1803 aligned with higher RDS and pGI, confirming microstructure-governed digestibility variation.

珍珠粟（PM）是一种营养丰富、适应气候变化的谷物，具有低血糖食品应用的潜力。本研究检测了11种PM基因型体外淀粉消化率的分子和微观结构决定因素。淀粉组成的变化（直链淀粉：18.27-27.68%；支链淀粉：30.62-51.12%）影响了可消化部分的分布。快速消化淀粉为26.32% (HHB-67 Improved) ~ 44.74% (PC-701)，慢消化淀粉为14.65% (Pusa-1803) ~ 27.44% (Chanana Bajri)，与预测血糖指数呈负相关（pGI: 54.63 ~ 58.87, r = - 0.633）。流变学分析表明，峰值粘度与pGI呈反比关系（r = - 0.828），表明限制淀粉糊化降低了酶的可及性。x射线衍射显示，结晶度较高（18.44 ~ 26.97%）的pGI也较低（r =−0.788）。主成分分析将Chanana Bajri、PC-701和86M94归为结构紧凑、消化缓慢的类型，而Dhodsar Local和Pusa-1803则具有较高的RDS和pGI，证实了微观结构对消化率的影响。

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