Journal of Functional Foods最新文献_第3页

Sanghuangporus vaninii-fermented green tea targets FoxO1/SIRT1 to alleviate obesity via integrated network pharmacology and multi-omics 三黄茯蓣发酵绿茶通过网络药理学和多组学研究，靶向FoxO1/SIRT1减轻肥胖

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-17 DOI: 10.1016/j.jff.2026.107214

Xuzhou Liu , Ying Ju , Liangliang Qi , Chao Wang , Bingchuan Tian , Mingguo Jiang , Preecha Prathepha , Jianan Huang , Zhonghua Liu

Building on prior evidence of enhanced in vitro lipid-lowering activity of Sanghuangporus vaninii-fermented green tea, this study evaluated its anti-obesity mechanisms in high-fat diet-induced obese mice. Components of the fermented tea were characterized, and network pharmacology predicted potential lipid-modulating targets. Seventy male C57BL/6 J mice were allocated to seven groups: a normal diet group, a high-fat diet group, a high-fat diet group treated with orlistat (positive control), and high-fat diet groups treated with either non-fermented tea or the fermented tea product at two dosages (200 or 400 mg/kg/day). After a four-week intervention, the fermented tea product significantly reduced body weight, serum total cholesterol, and hepatic lipid accumulation compared to the high-fat diet controls. Treatment also enhanced gut microbial diversity, reduced the Firmicutes/Bacteroidetes ratio, and increased fecal triglyceride excretion. Hepatic transcriptomics revealed upregulation of genes including Gadd45a and Bcl6, with pathway analysis confirming involvement in FoxO signaling. Mechanistically, the fermented tea product suppressed hepatic lipogenic genes while upregulating markers of fatty acid oxidation and lipolysis, consistent with network pharmacology predictions. These findings demonstrate that the fermented tea product alleviates diet-induced obesity through coordinated modulation of hepatic lipid metabolism and gut microbiota, outperforming non-fermented tea and providing novel insights into fermented tea as a dietary intervention.

本研究在已有证据表明桑黄茯苓发酵绿茶具有体外降脂活性的基础上，探讨了其对高脂饮食诱导的肥胖小鼠的抗肥胖机制。对发酵茶的成分进行了表征，并用网络药理学预测了潜在的脂质调节靶点。将70只雄性C57BL/6 J小鼠分为7组：正常饮食组、高脂饮食组、奥利司他高脂饮食组（阳性对照）和高脂饮食组（200或400 mg/kg/d）分别饲喂未发酵茶或发酵茶制品。经过四周的干预，与高脂肪饮食对照组相比，发酵茶产品显著降低了体重、血清总胆固醇和肝脏脂质积累。治疗还增强了肠道微生物的多样性，降低了厚壁菌门/拟杆菌门的比例，并增加了粪便甘油三酯的排泄。肝脏转录组学显示Gadd45a和Bcl6等基因上调，途径分析证实参与FoxO信号传导。从机制上讲，发酵茶产品抑制肝脏脂肪生成基因，同时上调脂肪酸氧化和脂肪分解标志物，与网络药理学预测一致。这些发现表明，发酵茶产品通过协调调节肝脏脂质代谢和肠道微生物群来减轻饮食引起的肥胖，优于非发酵茶，并为发酵茶作为饮食干预提供了新的见解。

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引用次数: 0

Ergogenic and cardiometabolic benefits of policosanol in male taekwondo athletes: a double-blind trial 对男性跆拳道运动员的有氧和心脏代谢益处：一项双盲试验

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-17 DOI: 10.1016/j.jff.2026.107190

Hamidreza Razmi , Aliakbar Alizadeh , Ahmad Zare Javid , Bijan Helli

High-intensity combat sports such as taekwondo impose considerable oxidative and metabolic stress, potentially impairing recovery and performance. Policosanol has demonstrated antioxidant and metabolic effects in non-athletic populations; however, evidence in trained athletes, particularly regarding performance outcomes, remains limited. In this 12-week randomized, double-blind, placebo-controlled trial, 44 male taekwondo athletes received either policosanol (25 mg/day) or placebo under standardized training conditions. Body composition, lipid profile, oxidative stress markers, aerobic capacity (Cooper test), and anaerobic power (RAST) were assessed before and after intervention. Compared with placebo, policosanol supplementation resulted in a significant reduction in lipid peroxidation (malondialdehyde, MDA). Improvements were also observed in anaerobic performance, VO₂max and Cooper test distance (p < 0.05). Although favorable within-group changes occurred in some antioxidant and lipid parameters, most cardiometabolic variables did not differ significantly between groups after baseline adjustment. Policosanol supplementation may support oxidative stress modulation and selected aspects of athletic performance in trained taekwondo athletes, while cardiometabolic effects appear modest.

像跆拳道这样的高强度格斗运动施加了相当大的氧化和代谢压力，潜在地损害了恢复和表现。在非运动人群中，多酚已被证明具有抗氧化和代谢作用；然而，训练有素的运动员的证据，特别是关于表现结果的证据仍然有限。在这项为期12周的随机、双盲、安慰剂对照试验中，44名男性跆拳道运动员在标准化训练条件下接受了政策甾醇（25毫克/天）或安慰剂。在干预前后评估体成分、血脂、氧化应激标志物、有氧能力（Cooper试验）和无氧能力（RAST）。与安慰剂相比，补充多酚可显著降低脂质过氧化（丙二醛，MDA）。无氧性能、vo2max和Cooper试验距离也有改善（p < 0.05）。虽然一些抗氧化和脂质参数在组内发生了有利的变化，但在基线调整后，大多数心脏代谢变量在组间没有显着差异。补充胆甾醇可能支持氧化应激调节和训练有素的跆拳道运动员的运动表现的某些方面，而心脏代谢的影响似乎不大。

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引用次数: 0

Combination of L-alanine and erythritol synergistically enhances water transport in an in vitro system using human-induced pluripotent stem cell-derived small intestinal epithelial cells l-丙氨酸和赤藓糖醇联合使用人诱导的多能干细胞来源的小肠上皮细胞在体外系统中协同增强水运输

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jff.2026.107202

Tsubasa Mizokami, Shintaro Ono

Glucose-containing beverages enhance water absorption from the lumen of the small intestine into capillaries via Na⁺-dependent glucose transporters. However, considering the harmful effects of excessive sugar, water absorption-promoting substances that do not worsen calorie intake and glucose metabolism are desirable. Alternative tools that avoid animal studies and clinical trials are required to quantitatively evaluate such substances. Here, we employed an in vitro system using human induced pluripotent stem (iPS) cell-derived small intestinal epithelial cells (hiPSC-SIECs) to evaluate the effects of glucose, amino acids, erythritol, and allose on water transport. Among the 15 amino acids, L-alanine had the greatest effect. Significant increases in water transport were also observed with erythritol and allose, which are promising sugar substitutes. Furthermore, L-alanine and erythritol showed synergistic effects. Overall, we demonstrate the efficacy of hiPSC-SIECs as an alternative tool for quantitation of water absorption and propose that L-alanine and erythritol can synergistically promote water absorption.

含葡萄糖的饮料通过Na+依赖性葡萄糖转运体促进小肠腔内的水分吸收进入毛细血管。然而，考虑到过多的糖的有害影响，促进水分吸收的物质，不增加热量摄入和葡萄糖代谢是可取的。需要避免动物研究和临床试验的替代工具来定量评估这些物质。本研究采用人诱导多能干细胞（iPS）衍生的小肠上皮细胞（hiPSC-SIECs）体外系统来评估葡萄糖、氨基酸、赤糖醇和醛对水转运的影响。15种氨基酸中，l -丙氨酸的影响最大。赤藓糖醇和醛糖的水转运也显著增加，这是很有前途的糖替代品。此外，l -丙氨酸和赤藓糖醇具有协同作用。总之，我们证明了hiPSC-SIECs作为定量水分吸收的替代工具的有效性，并提出l -丙氨酸和赤藓糖醇可以协同促进水分吸收。

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引用次数: 0

Sea anemone-derived bioactive peptides alleviate ulcerative colitis via remodeling the gut microbiota-metabolite-immune axis 海葵衍生的生物活性肽通过重塑肠道微生物-代谢-免疫轴来缓解溃疡性结肠炎

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jff.2026.107206

Jieqiong Lin , Ting Lu , Dahua Chen , Zhonghua Wang , Jun Zhou , Jiaojiao Han

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. This study investigates the protective effects of bioactive peptides derived from sea anemone (ACPs), prepared by enzymatic hydrolysis, in a dextran sulfate sodium (DSS)-induced murine model of UC. Notably, the peptide ERRK was identified as a dominant component of the ACPs mixture. Remarkably, low-dose ACPs (200 mg/kg) demonstrated superior efficacy over higher doses in ameliorating disease severity, as evidenced by reduced disease activity index (DAI) scores, increased colon length, and improved histopathology. ACPs significantly downregulated pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and upregulated anti-inflammatory cytokines (TGF-β, IL-10), while restoring intestinal barrier integrity via increased expression of tight junction proteins (ZO-1, Occludin, Claudin-1). Multi-omics analyses revealed that ACPs remodeled gut microbiota composition, enriched beneficial genera (Muribaculum, Prevotella), and modulated host serum metabolites, particularly pathways related to butyrate and tryptophan metabolism. These findings underscore the potential of ACPs, especially at low doses, as a novel functional food for UC management through integrated modulation of the gut microbiota-metabolite-immune axis.

溃疡性结肠炎（UC）是一种慢性炎症性肠病，治疗选择有限。本研究探讨了酶法制备海葵生物活性肽（ACPs）对葡聚糖硫酸钠（DSS）诱导的UC小鼠模型的保护作用。值得注意的是，肽ERRK被确定为ACPs混合物的主要成分。值得注意的是，低剂量ACPs （200 mg/kg）在改善疾病严重程度方面表现出优于高剂量的疗效，这可以通过降低疾病活动指数（DAI）评分、增加结肠长度和改善组织病理学来证明。ACPs显著下调促炎细胞因子（TNF-α、IL-1β、IL-6）和上调抗炎细胞因子（TGF-β、IL-10），同时通过增加紧密连接蛋白（ZO-1、Occludin、Claudin-1）的表达来恢复肠屏障的完整性。多组学分析显示，ACPs重塑了肠道微生物群组成，丰富了有益菌（Muribaculum, Prevotella），并调节了宿主血清代谢物，特别是与丁酸盐和色氨酸代谢相关的途径。这些发现强调了acp的潜力，特别是在低剂量下，作为一种新的功能性食品，通过肠道微生物群-代谢物-免疫轴的综合调节来治疗UC。

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引用次数: 0

Transcriptomic insights into the antidiabetic effects of mulberry leaf Fu brick tea in GK rats 桑叶茯砖茶对GK大鼠抗糖尿病作用的转录组学研究

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.jff.2026.107212

Fang Zhou , Ji-ming Jia , Ying Liu , Xuan-yu Liu , Xiang-yang Tang , Jie Qin , Peng-yun Fu , Meng-yao Ma , Hua Fu , Bao-de Zhu , Chang-wei Liu

Mulberry leaves and Fu brick tea are renowned for their exceptional hypoglycemic effects. This study used mulberry leaves and fu brick tea as raw materials to develop mulberry leaf Fu brick tea (MFT) as a dietary regulator that can assist in the prevention and alleviation of diabetes. The results demonstrate that administration of MFT at a dose of 210 mg/kg/day for a consecutive 4-week period significantly reduces fasting and random blood glucose levels in GK rats. Notably, levels of glycosylated hemoglobin and glycosylated serum protein return to the normal range, while insulin and glucagon levels are significantly increased, accompanied by substantial improvement in glucose tolerance. Moreover, MFT proves effective in regulating dyslipidemia and reducing liver damage. Transcriptomic analysis reveals that MFT enhances insulin sensitivity and promotes glycogen synthesis by up-regulating key genes in the PI3K-Akt and PPAR signaling pathways, including Insr, Ins1, Gys2, Pi3k, Akt, and Pparα. These findings highlight MFT as a potential dietary intervention for glucose regulation, warranting further evaluation in clinical studies.

桑叶和茯砖茶以其特殊的降糖作用而闻名。本研究以桑叶和茯砖茶为原料，开发了桑叶茯砖茶（MFT）作为饮食调节剂，有助于预防和缓解糖尿病。结果表明，连续4周以210 mg/kg/天的剂量给药MFT可显著降低GK大鼠的空腹和随机血糖水平。值得注意的是，糖化血红蛋白和糖化血清蛋白水平恢复到正常范围，而胰岛素和胰高血糖素水平显著升高，并伴有糖耐量的显著改善。此外，MFT被证明对调节血脂异常和减轻肝损害有效。转录组学分析显示，MFT通过上调Pi3k -Akt和PPAR信号通路中的关键基因，包括Insr、Ins1、Gys2、Pi3k、Akt和PPAR α，增强胰岛素敏感性，促进糖原合成。这些发现强调了MFT作为血糖调节的潜在饮食干预，值得在临床研究中进一步评估。

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引用次数: 0

Lactiplantibacillus plantarum Ln4 attenuates streptozotocin and high-fat diet-induced Type-2 diabetes 植物乳杆菌Ln4减轻链脲佐菌素和高脂肪饮食诱导的2型糖尿病

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-18 DOI: 10.1016/j.jff.2026.107219

Rachit Sood , Kritika , Sanjay , Hae-Jeung Lee

Type-2 diabetes mellitus (T2DM) is an expanding global concern with limited efficacy of conventional therapies. Probiotics have gained attention for their ability to modulate gut microbiota and glucose homeostasis. This study evaluated the therapeutic potential of Lactiplantibacillus plantarum Ln4 at LOW (5 × 10⁸ CFU/day) and HIGH (5 × 10⁹ CFU/day) doses in an STZ/HFD-induced diabetic mouse model, compared with metformin (200 mg/kg). STZ/HFD induction resulted in reduced body and muscle weight, increased food and water intake, elevated fasting blood glucose, OGTT, AUC, HOMA-IR, liver weight, and dysregulated metabolic biomarkers. Ln4 administration significantly reversed these alterations, normalized serum adiponectin, insulin, GLP-1, and HbA1c levels, and improved lipid profile, oxidative stress markers, and histopathological changes in liver and skeletal muscle. Mechanistically, Ln4 restored GLUT-2, GLUT-4, GCK, IRS/PI3K/Akt, AMPK, and GSK3β signaling while suppressing PEPCK and PTP1B expression. Overall, L. plantarum Ln4 effectively ameliorated hyperglycemia and dyslipidemia, showing efficacy comparable to metformin.

2型糖尿病（T2DM）是一个不断扩大的全球性问题，常规治疗的疗效有限。益生菌因其调节肠道微生物群和葡萄糖稳态的能力而受到关注。本研究评估了植物乳杆菌Ln4在低（5 × 108 CFU/天）和高（5 × 109 CFU/天）剂量下对STZ/ hfd诱导的糖尿病小鼠模型的治疗潜力，并与二甲双胍（200 mg/kg）进行了比较。STZ/HFD诱导导致身体和肌肉重量降低，食物和水摄入量增加，空腹血糖、OGTT、AUC、HOMA-IR、肝脏重量升高，代谢生物标志物失调。Ln4显著逆转了这些改变，使血清脂联素、胰岛素、GLP-1和HbA1c水平正常化，并改善了肝脏和骨骼肌的脂质谱、氧化应激标志物和组织病理学变化。在机制上，Ln4恢复GLUT-2、GLUT-4、GCK、IRS/PI3K/Akt、AMPK和GSK3β信号，同时抑制PEPCK和PTP1B的表达。总体而言，植物乳杆菌Ln4有效改善高血糖和血脂异常，其疗效与二甲双胍相当。

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引用次数: 0

Cirsium setidens attenuates doxorubicin-induced cardiotoxicity by modulating oxidative stress and inflammatory pathways 鸢尾草通过调节氧化应激和炎症途径减轻阿霉素诱导的心脏毒性

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.jff.2026.107197

Ji-Hye Song, Jangho Lee, Min-Sun Kim, Seung-U Son, Hyo-Kyoung Choi

Doxorubicin (DOX) is a widely used chemotherapeutic agent, but its clinical application is limited by cardiotoxicity associated with oxidative stress, inflammation, and apoptosis. Cirsium setidens (C. setidens), a traditional Korean edible plant, is known for its antioxidant and anti-inflammatory properties. This study investigated the cardioprotective potential of C. setidens aqueous extract (CSA) against DOX-induced cardiotoxicity (DICT). Metabolite profiling used UPLC-QTOF/MS revealed that CSA contains diverse bioactive compounds, predominantly amino acids and phenolic constituents, including flavonoids, coumarins, cinnamic acid derivatives, and higenamine. Cardiotoxic H9c2 cardiomyocytes and DOX-induced mouse model were used to investigate the in vitro and in vivo effects of CSA, respectively. CSA protected H9c2 cells against DICT while further enhancing DOX's anticancer effect in MDA-MB-231 cells. Moreover, CSA markedly attenuated DOX-induced cardiac dysfunction and myocardial injury, including electrocardiographic abnormalities and myocardial fibrosis. Mechanistically, CSA exerted its cardioprotective effects through coordinated regulation of the ROS-inflammation signaling axis. CSA suppressed inflammatory gene expression, including Il-1β, Il-6, Tnf-α, Ifn-γ, and Mcp-1. Concurrently, it activated the Nrf1/Nrf2 antioxidant signaling pathways, restoring the expression of downstream antioxidant genes such as Sod1, Sod2, and Ho-1. In addition, CSA modulated apoptosis-related genes by downregulating Bax, Casp9, Casp3, and Parp2, while upregulating anti-apoptotic genes Bcl2 and Bcl-xl. CSA demonstrates cardioprotective efficacy against DOX-induced cardiotoxicity by modulating ROS-inflammation-related oxidative and inflammatory pathways, supporting its potential for functional food applications.

阿霉素（DOX）是一种广泛使用的化疗药物，但其临床应用受到氧化应激、炎症和细胞凋亡相关的心脏毒性的限制。鸢尾草（C. setidens）是韩国传统食用植物，具有抗氧化和抗炎作用。本研究探讨了毛草水提物（CSA）对dox诱导的心脏毒性（DICT）的保护作用。UPLC-QTOF/MS代谢物分析显示，CSA含有多种生物活性化合物，主要是氨基酸和酚类成分，包括类黄酮、香豆素、肉桂酸衍生物和高铁胺。采用心脏毒性H9c2心肌细胞和dox诱导小鼠模型，分别研究CSA的体外和体内作用。CSA保护H9c2细胞抗DICT，同时进一步增强DOX对MDA-MB-231细胞的抗癌作用。此外，CSA显著减轻dox诱导的心功能障碍和心肌损伤，包括心电图异常和心肌纤维化。在机制上，CSA通过协调调节ros -炎症信号轴发挥其心脏保护作用。CSA抑制炎症基因表达，包括Il-1β、Il-6、Tnf-α、Ifn-γ和Mcp-1。同时，它激活Nrf1/Nrf2抗氧化信号通路，恢复下游抗氧化基因Sod1、Sod2、Ho-1的表达。此外，CSA通过下调Bax、Casp9、Casp3和Parp2调控凋亡相关基因，上调抗凋亡基因Bcl2和Bcl-xl。CSA通过调节ros炎症相关的氧化和炎症途径，对dox诱导的心脏毒性具有心脏保护作用，支持其在功能性食品中的应用潜力。

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引用次数: 0

Effects of GABA-enriched rice germ extract fermented by Lactobacillus brevis BJ20 on stress symptoms and related biomarkers in adults: a randomized, double-blind, placebo-controlled trial 由短乳杆菌BJ20发酵的富含gaba的大米胚芽提取物对成人应激症状和相关生物标志物的影响：一项随机、双盲、安慰剂对照试验

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jff.2026.107183

Ye Li Lee , Kyoung-min Rheu , Sang Yeoup Lee

Stress is a growing public health concern, and nutritional approaches have gained increasing attention for improving mental well-being. Fermentation enhances the bioactive γ-aminobutyric acid (GABA) content of agric ultural materials. This 8-week, randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of a novel GABA-enriched rice germ extract (RG30), produced by Lactobacillus brevis BJ20 fermentation, in 80 adults with mild-to-moderate perceived stress. Participants received 500 mg/day RG30 (120 mg GABA) or placebo. RG30 supplementation significantly reduced Stress Response Inventory scores compared with placebo (adjusted mean difference: −5.39; 95% CI: −10.25, −0.54; p = 0.035) and improved quality of life (EuroQol VAS, p ≤ 0.002) after 8 weeks. Among secondary outcomes, plasma serotonin levels showed relative preservation in the RG30 group with placebo (p = 0.036). No serious adverse events occurred. RG30 represents a safe, fermented, plant-derived functional ingredient that alleviates stress symptoms and enhances quality of life.

压力是一个日益严重的公共卫生问题，营养方法因改善心理健康而受到越来越多的关注。发酵提高了农产品中生物活性γ-氨基丁酸（GABA）的含量。这项为期8周的随机、双盲、安慰剂对照试验评估了一种由短乳杆菌BJ20发酵生产的新型富含gaba的水稻胚芽提取物（RG30）在80名轻度至中度感知应激的成年人中的疗效和安全性。参与者每天服用500毫克RG30（120毫克GABA）或安慰剂。与安慰剂相比，补充RG30显著降低了应激反应量表评分（校正平均差：- 5.39;95% CI: - 10.25, - 0.54; p = 0.035），并在8周后改善了生活质量（EuroQol VAS, p≤0.002）。在次要结果中，安慰剂组血浆血清素水平相对保持（p = 0.036）。未发生严重不良事件。RG30是一种安全、发酵的植物性功能性成分，可缓解应激症状，提高生活质量。

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引用次数: 0

Short-chain fatty acids attenuate obesity-induced oxidative stress by regulating the MUFA/PUFA ratio in phospholipids 短链脂肪酸通过调节磷脂中MUFA/PUFA比例来减轻肥胖诱导的氧化应激

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-18 DOI: 10.1016/j.jff.2026.107223

Yubin Li , Jia Zhang , Yuqiang Li , Yuming Su , Nan Li

Obesity-induced oxidative stress contributes to metabolic disorders, and its suppression may prevent disease. While gut microbiota-derived short-chain fatty acids (SCFAs) modulate lipid metabolism, their role in oxidative stress remains unclear. Using C57BL/6 J mice and cell models (HepG2 and 3 T3-L1), this study demonstrates that SCFAs alleviate obesity-related oxidative damage in liver and adipose tissues. Mechanistically, SCFAs activate AMPKα and PPARγ, which not only inhibit lipogenesis but also interact with SCD1 to increase the monounsaturated-to-polyunsaturated fatty acid ratio (MUFA/PUFA) in phospholipids, thereby reducing lipid peroxidation in both in vivo and in vitro models. Specifically, propionate and butyrate upregulated monounsaturated phospholipids PHDdiA-Pe and PKOHA-PS. Additionally, SCFAs restore the gut microbial balance disrupted by obesity in C57BL/6 J mice. These findings provide a theoretical basis for SCFA-based dietary interventions against obesity-related diseases.

肥胖引起的氧化应激有助于代谢紊乱，抑制其可预防疾病。虽然肠道微生物衍生的短链脂肪酸（SCFAs）调节脂质代谢，但它们在氧化应激中的作用尚不清楚。通过C57BL/6 J小鼠和细胞模型（HepG2和3t3 - l1），本研究表明SCFAs减轻了肝脏和脂肪组织中与肥胖相关的氧化损伤。机制上，scfa激活AMPKα和PPARγ，不仅抑制脂肪生成，而且与SCD1相互作用，增加磷脂中的单不饱和与多不饱和脂肪酸比率（MUFA/PUFA），从而减少体内和体外模型中的脂质过氧化。具体来说，丙酸盐和丁酸盐上调了单不饱和磷脂PHDdiA-Pe和PKOHA-PS。此外，SCFAs可以恢复C57BL/6 J小鼠因肥胖而破坏的肠道微生物平衡。这些发现为基于scfa的饮食干预对抗肥胖相关疾病提供了理论基础。

引用次数: 0

Probiotic mixture enhances spatial memory via gut-brain axis modulation in mice 益生菌混合物通过肠-脑轴调节增强小鼠空间记忆

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.jff.2026.107211

Bao-Hong Lee , I-Hong Pan , Kuei-Chang Li , Shu-Chi Cho , Cheng-Hao Huang , Wei-Hsuan Hsu

Probiotics modulate gut-brain communication and influence cognitive function. This study investigated the effects of a probiotic mixture, Pro-neuron, on spatial memory and gut microbiota in healthy mice. Male C57BL/6 mice were divided into three groups: blank control, positive control (PC, gamma-aminobutyric acid), and Pro-neuron. After four weeks of oral administration, spatial memory was assessed using the Y-maze test, and gut microbiota composition was analyzed via 16S rRNA sequencing. Pro-neuron significantly enhanced memory performance, as indicated by increased alternation behavior. Immunohistochemistry showed elevated hippocampal expression of brain-derived neurotrophic factor (BDNF), while acetylcholinesterase (AChE) levels remained unchanged. Pro-neuron also enriched beneficial microbiota taxa, including Bifidobacterium, Lactobacillus, and Muribaculum, which are associated with neuroactive metabolite production, including short-chain fatty acids. These findings suggest that Pro-neuron may enhance spatial memory by modulating gut microbiota and promoting hippocampal BDNF expression, supporting its potential as a cognitive health supplement.

益生菌调节肠-脑通讯，影响认知功能。本研究探讨了益生菌混合物Pro-neuron对健康小鼠空间记忆和肠道微生物群的影响。雄性C57BL/6小鼠分为空白对照组、阳性对照组（PC、γ -氨基丁酸）和Pro-neuron组。口服给药4周后，使用y迷宫测试评估空间记忆，并通过16S rRNA测序分析肠道微生物群组成。亲神经元显著提高了记忆性能，如增加交替行为所示。免疫组化显示海马脑源性神经营养因子（BDNF）表达升高，而乙酰胆碱酯酶（AChE）水平保持不变。Pro-neuron还丰富了有益的微生物群，包括双歧杆菌、乳酸杆菌和Muribaculum，它们与神经活性代谢物（包括短链脂肪酸）的产生有关。这些发现表明，Pro-neuron可能通过调节肠道微生物群和促进海马BDNF表达来增强空间记忆，支持其作为认知健康补充剂的潜力。

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引用次数: 0