L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma最新文献

A further experimental study on changes produced in rabbits by low dosage contraceptives is presented. The administration has been continued for six months. Serum biochemical and hepatic ultrastructural findings are in agreements with literature data. On the contrary the early changes of cardiac microcirculation and chiefly renal glomerular tuft seem to be rather unusual. The weight to be attached to the knowledges descending from the presented data in assessing allowance of contraceptive treatments in human subjects and aiming preventive medicine purposes is emphasized.

Maternal and feto-neonatal pathology in pregnant women with Hb values less than 10 gr./100 ml. in the last ten weeks of pregnancy was estimated. WHO considers HB values (gr./100 ml.) a valid and sufficient parameter for a clinical classification of the different degrees of anaemia in pregnancy: the authors agree with this suggestion.

The authors, on personal experience, based on parathyroidectomies for secondary hyperparathyroidism, relate the surgical anatomic findings after a brief discussion on indications. They relate beside some atypical seats of parathyroid glands, observed in 11 glands of the 59 removed. Finally they emphasize the importance of accuracy of surgical exploration because that cannot be helped by instrumental methods or by gross pathologic observation.

Blood polyamines were evaluated in normal children of various ages (from infancy to adolescence). Polyamines show a distinctive pattern: maximal values were observed during infancy; they decrease during childhood and again increase at puberty. After i.m. injection of Human Growth Hormone (HGH), polyamine concentrations increase significantly in the first 60 minutes. Polyamines increase more in patients previously untreated or treated intermittently with HGH than in patients under continuous treatment. The results suggest that in humans as well as in animals, polyamines could be involved in the growth processes and that the effect of HGH probably consists in a stimulation of polyamine synthesis.

The difficulties in correct differential diagnosis between depression and early pre-senile dementia syndromes are pointed-out by the AA. They underline that, on the ground of literature reports and clinical experience, the instrumental methods (electroencephalography, cerebral blood flow examination, pneumoencephalography, evoked cerebral responses, etc...) appear of little use in differential diagnosis, if separately considered. A particular attention is called on psychometric tests, in order to worn the non-specialist against any too over-simplified and mechanistic acceptance of test results.

The Authors report a case of a congenital arteriovenous fistula between the subclavian artery and vein in a 42 years-old woman. The clinical examinations are discussed for the exact classification and the topographic localisation. The surgical treatment (extirpation of the fistula) is necessary especially because arteriovenous fistulas have a tendency to progress, which may lead to severe cardiac insufficiency, aneurismatic dilatations and risks of endocarditis.

The pharmacokinetics of 3GS has been studied monitoring various groups of treated rabbits. After discussion of data the Authors conclude that the compound has no toxicity. This is demonstrated by electron microscopy of morphometabolic areas. Further more an improvement of biochemical data are revealed.

The Authors describe an unusual motor preservation case, induced by right basal ganglia lesion and with not previously reported characteristics. Possible pathogenetic mechanisms are discussed.

Cortico-spongious autoplastic bone grafts have in reconstructive hand surgery several precise indications. Bone infusion is certain if the technique used is appropriated permitting the cosmetic and functional recovery of the corresponding digital ray. The indications are: post-traumatic non-union, great loss of bone, bone neoplasm. The authors basing their causistic on 28 cases discuss the indications, surgical technique and results.

The Authors describe one case of acute renal insufficiency in a patient treated with high doses of gentamicin over a period of three weeks. The documentation includes electron microscope observations of needle biopsy material revealing the presence of electron-dense masses (cytosegregosomes) in the epithelial cells of the proximal renal tubules, such as had previously been described only in animal experiments and human autopsy studies. The clinical course and favorable outcome of this case of gentamicin-induced renal failuse afford the opportunity for some interesting considerations concerning the kinetics and toxic proclivities of this aminoglycoside antibiotic.