L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma最新文献

The Authors have subjected 14 migraine patients to Doppler ultrasonic technique. Examinations have been performed on both common carotid arteries, either in headache phase or in pain-free periods. Results in each case suggest variable hemodynamic patterns during migraine attacks. Possible pathogenic mechanisms are discussed.

The Authors have studied the clinical employment of cimetidine. After the discussion of data is demonstrated the rapidity and helpfulness of this therapy in order to the other specific drugs.

The effect of SITS (6 . 10(-4)M on transepithelial potential (E) and short circuit current (I) of isolated frog skin has been studied either using Ringer or Cl- -depleted Ringer in the outside bathing solution. SITS affects the transepithelial potential (E) and the short-circuit current (I) only if normal Ringer is used and SITS is added in the outside bathing medium. The existence of a negative exchanging-charge carrier on the external membrane of the epithelial cells is postulated. This mechanism could be a step of the actively transported Cl- ions.

The Authors review 86 cases, aged over 70, needing surgical treatment because of atherosclerotic obstructive disease of the lower limb, stage III-IV. 35 patients underwent thigh amputation with 14% mortality in the early post-operative period (30 days) and 32% in the late post-operative period, considered up to 6 months. For 38 patients who underwent a revascularisation procedure mortality resulted 8% in the 30 post-operative days and 10% at 6 months. Escluding the aorto-iliac reconstructions through a trans-peritoneal approach, the overall mortality is limited to 3,2%. A major amputation was avoided in 76% of patients who underwent a revascularisation. On the base of their results the Authors discuss the indications of direct surgery in treatment of advanced ischemic lesions in elderly patients concluding that a surgical correction should be always considered in the aim of avoiding or limiting the amputation. In these high-risk elderly patients the extra-peritoneal aorto-iliac reconstructive technique must be preferred together with extraanatomical femoro-femoral or axillo-femoral by-passes.

The Authors using a experimental model on various groups of treated rabbits have studied the pharmakinet of 3GS. After the discussion of data they conclude for an absence of injury rivelable by morphometabolic areas integrity. Further more is evident an improvement of a few hematochemical parameters.

The authors analyze vascular liver modifications after porta-caval shunt in the rat. The examination of the portal vascular bed obtained by neoprene latex injection allows the definition of different morphologic phases, throughout these liver reaches new structural balance, with an efficacious lobular perfusion. In the same periods histological findings show a cell damage, without necrosis, followed by a recovery after 8 months. In distance, in normal rat porta-caval shunts induce a reduction of the liver volume, both the lobular structures have normal functions and morphology.

76 patients (prepuberal, puberal and adults) who had undergone surgery for monolateral (35) or bilateral (41) cryptorchidism in childhood were studied. Testicular volume (76 cases), seminiferal function (18 cases) and pituitary gonadotropin reserve (51 cases) were evaluated. We obtained the following results: 1) the prepuberal patients had a normal testicular volume, while 70% of the puberal and adult patients had a mean testicular volume below normal levels. 2) 55.6% of the adults who underwent spermiogram had a pathological seminiferal function. 3) The number of patients whith exagerated gonadotropin response to GnRH-test increases with increasing puberal stage and reaches its highest significance after complete puberal development. These data confirm that: 1) the long permanence of one or both testis out of their natural position has a negative influence on their trophism; 2) the long-term prognosis of the tubular function of the testis after orchidopessis is poor in a high percentage of cases. 3) the endocrine anomalies which follow the early morphologic and functional changes of the cryptorchid testis are more easily detected during puberty as a reduced hypothalamic feedback of the gonadotropin secretion.

The distribution of Mn2+-dependent poly(A) polymerase activity between chromatin and nucleoplasmic fractions in rat liver nuclei strongly depends on the method followed for the chromatin preparation. Currently used methods containing high salt cause a loss in bound activity not accompanied by a correspondent increase in the "free" one.

Thyrotropin-releasing hormone (TRH) was studied for its effects on some strips of the gastrointestinal tract in vitro. TRH showed to possess a certain stimulatory activity on proximal segments of the g.i. tract being approximately as effective as histamine. This motor activity of TRH is discussed taking into account a possible physiological role outside the brain.

The authors describe a few cases of "real anodontia" treated with removable, removable-irremovable or fixed prosthesis in which a preprosthetic orthodontal treatment was needed. Various aspects of this are examined: indications, counter indications, treatment plan and coordination of orthodontics and prosthesis.