Cancer and clinical oncology最新文献_第6页

Angiomatoid Fibrous Histiocytoma in the Forearm: A Case Report 前臂血管瘤样纤维组织细胞瘤1例报告

Cancer and clinical oncology

Pub Date : 2016-01-07 DOI: 10.5539/CCO.V6N1P36

H. M. Alshareef, Ahmed H Alhasan, Mohammed G. Felemban, A. Almalki, Amer Mohammed A Alshareef

Background: Angiomatoid fibrous histiocytoma [AFH] is a rare soft tissue tumor most commonly occurring in children, adolescents, and young adults. It is considered to be a tumor of intermediate malignancy because of its less aggressive course. The extremities are the most common site of involvement, followed by the trunk and head and neck. Case presentation: A 28-Year-old male presented with a right forearm mass that has been present for 2 years. There was no associated fever, no trauma, no night pain and no constitutional symptoms. On examination he had a forearm mass dorsally measuring 2x3 cm, firm, rounded, mobile with no skin changes and full range motion joint above and joint below. Lab and imaging studies done which showed soft tissue mass, multilobulated complex heterogeneous with increased vascularity. Patient underwent biopsy and surgical excision. Conclusion: Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential. Most often, the extremities are the most common site of involvement, followed by the trunk and head and neck of children and young adults. Its rarity may lead to misdiagnosis as either a reactive lesion or a benign or higher-grade tumor. This tumor has a relatively rare metastasis and its overall clinical outcome is excellent. It is clinically important to accurately diagnose this tumor so that wide local excision may be performed and patients may be appropriately monitored and followed up.

背景:血管瘤样纤维组织细胞瘤[AFH]是一种罕见的软组织肿瘤，最常见于儿童、青少年和年轻人。由于其侵袭性较弱，被认为是一种中度恶性肿瘤。四肢是最常见的受累部位，其次是躯干、头部和颈部。病例介绍:一名28岁男性，右前臂肿块已出现2年。无相关发热，无创伤，无夜间疼痛，无体质症状。检查时，患者前臂背侧肿块2x3 cm，结实、圆润，活动自如，无皮肤变化，上下关节全范围活动。实验室和影像学检查显示软组织肿块，多分叶复杂，不均匀，血管增多。患者接受活检和手术切除。结论:血管瘤样纤维组织细胞瘤是一种具有中等生物学潜能的肿瘤。大多数情况下，四肢是最常见的受累部位，其次是躯干、儿童和年轻人的头部和颈部。它的罕见性可能导致误诊为反应性病变或良性或更高级别肿瘤。这种肿瘤有一个相对罕见的转移和它的整体临床结果是很好的。准确诊断这种肿瘤具有重要的临床意义，因此可以进行大面积局部切除，并对患者进行适当的监测和随访。

{"title":"Angiomatoid Fibrous Histiocytoma in the Forearm: A Case Report","authors":"H. M. Alshareef, Ahmed H Alhasan, Mohammed G. Felemban, A. Almalki, Amer Mohammed A Alshareef","doi":"10.5539/CCO.V6N1P36","DOIUrl":"https://doi.org/10.5539/CCO.V6N1P36","url":null,"abstract":"Background: Angiomatoid fibrous histiocytoma [AFH] is a rare soft tissue tumor most commonly occurring in children, adolescents, and young adults. It is considered to be a tumor of intermediate malignancy because of its less aggressive course. The extremities are the most common site of involvement, followed by the trunk and head and neck. Case presentation: A 28-Year-old male presented with a right forearm mass that has been present for 2 years. There was no associated fever, no trauma, no night pain and no constitutional symptoms. On examination he had a forearm mass dorsally measuring 2x3 cm, firm, rounded, mobile with no skin changes and full range motion joint above and joint below. Lab and imaging studies done which showed soft tissue mass, multilobulated complex heterogeneous with increased vascularity. Patient underwent biopsy and surgical excision. Conclusion: Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential. Most often, the extremities are the most common site of involvement, followed by the trunk and head and neck of children and young adults. Its rarity may lead to misdiagnosis as either a reactive lesion or a benign or higher-grade tumor. This tumor has a relatively rare metastasis and its overall clinical outcome is excellent. It is clinically important to accurately diagnose this tumor so that wide local excision may be performed and patients may be appropriately monitored and followed up.","PeriodicalId":89904,"journal":{"name":"Cancer and clinical oncology","volume":"35 1","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2016-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70723484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Colorectal Cancer Survival Disparities among Puerto Rican Hispanics: A Comparison to Racial/Ethnic Groups in the United States. 波多黎各拉美裔人结直肠癌癌症生存率差异：与美国种族/民族群体的比较。

Cancer and clinical oncology

Pub Date : 2016-01-01 Epub Date: 2016-08-24 DOI: 10.5539/cco.v5n2p29

Maria Gonzalez-Pons, Mariela Torres, Javier Perez, Anneliese Velez, Jean Pierre Betancourt, Lorena Marcano, Marievelisse Soto-Salgado, Marcia Cruz-Correa

Purpose: Ethnic/racial disparities in colorectal cancer (CRC) survival have been well documented. However, there is limited information regarding CRC survival among Hispanic subgroups. This study reports the 5-year relative survival of Puerto Rican Hispanic (PRH) CRC patients and the relative risk of death compared to other racial/ethnic groups in the US.

Methods: CRC incidence data from subjects ≥50 years was obtained from the Puerto Rico Central Cancer Registry and the Surveillance, Epidemiology and End Results (SEER) database from January 1, 2001 to December 31, 2003. Relative survival rates were calculated using the life tables from the population of PR and SEER. A Poisson regression model was used to assess relative risk of death by stage, sex, and age.

Results: A total of 76,444 subjects with incident CRC were analyzed (non-Hispanic White (NHW) n=59,686; non-Hispanic black (NHB) n=7,700; US Hispanics (USH) n=5,699; PRH n=3,359). Overall and stage-specific five-year survival rates differed by race/ethnicity. When comparing PRH to the other racial/ethnic groups, PRH had the lowest survival rates in regional cancers and were the only racial/ethnic group where a marked 5-year survival advantage was observed among females (66.0%) compared to males (60.3%). A comparable and significantly higher relative risk of death of CRC was observed for PRH and NHB compared to NHW.

Conclusions: Our findings establish baseline CRC survival data for PRH living in Puerto Rico. The gender and racial/ethnic disparities observed in PRH compared to US mainland racial/ethnic groups warrant further investigation of the risk factors affecting this Hispanic subgroup.

目的：癌症（CRC）生存率的种族/民族差异已得到充分记录。然而，关于西班牙裔亚组CRC生存率的信息有限。本研究报告了波多黎各西班牙裔（PRH）CRC患者的5年相对生存率以及与美国其他种族/民族相比的相对死亡风险。方法：从波多黎各中央癌症登记处和监测、流行病学和最终结果（SEER）数据库获得2001年1月1日至2003年12月31日期间≥50岁受试者的CRC发病率数据。使用PR和SEER人群的生命表计算相对生存率。泊松回归模型用于评估阶段、性别和年龄的相对死亡风险。结果：共分析了76444名CRC患者（非西班牙裔白人（NHW）n=59686；非西班牙裔黑人（NHB）n=7700；美国西班牙裔（USH）n=5699；PRH n=3359）。总体和特定阶段的五年生存率因种族/民族而异。当将PRH与其他种族/民族群体进行比较时，PRH在区域癌症中的存活率最低，并且是唯一一个女性（66.0%）与男性（60.3%）相比具有显著5年生存优势的种族/民族。与NHW相比，PRH和NHB的CRC死亡相对风险相当且显著更高。结论：我们的研究结果为居住在波多黎各的PRH建立了基线CRC生存数据。与美国大陆种族/民族相比，在PRH中观察到的性别和种族/民族差异值得进一步调查影响这一西班牙裔亚组的风险因素。

{"title":"Colorectal Cancer Survival Disparities among Puerto Rican Hispanics: A Comparison to Racial/Ethnic Groups in the United States.","authors":"Maria Gonzalez-Pons, Mariela Torres, Javier Perez, Anneliese Velez, Jean Pierre Betancourt, Lorena Marcano, Marievelisse Soto-Salgado, Marcia Cruz-Correa","doi":"10.5539/cco.v5n2p29","DOIUrl":"10.5539/cco.v5n2p29","url":null,"abstract":"Purpose: Ethnic/racial disparities in colorectal cancer (CRC) survival have been well documented. However, there is limited information regarding CRC survival among Hispanic subgroups. This study reports the 5-year relative survival of Puerto Rican Hispanic (PRH) CRC patients and the relative risk of death compared to other racial/ethnic groups in the US.Methods: CRC incidence data from subjects ≥50 years was obtained from the Puerto Rico Central Cancer Registry and the Surveillance, Epidemiology and End Results (SEER) database from January 1, 2001 to December 31, 2003. Relative survival rates were calculated using the life tables from the population of PR and SEER. A Poisson regression model was used to assess relative risk of death by stage, sex, and age.Results: A total of 76,444 subjects with incident CRC were analyzed (non-Hispanic White (NHW) n=59,686; non-Hispanic black (NHB) n=7,700; US Hispanics (USH) n=5,699; PRH n=3,359). Overall and stage-specific five-year survival rates differed by race/ethnicity. When comparing PRH to the other racial/ethnic groups, PRH had the lowest survival rates in regional cancers and were the only racial/ethnic group where a marked 5-year survival advantage was observed among females (66.0%) compared to males (60.3%). A comparable and significantly higher relative risk of death of CRC was observed for PRH and NHB compared to NHW.Conclusions: Our findings establish baseline CRC survival data for PRH living in Puerto Rico. The gender and racial/ethnic disparities observed in PRH compared to US mainland racial/ethnic groups warrant further investigation of the risk factors affecting this Hispanic subgroup.","PeriodicalId":89904,"journal":{"name":"Cancer and clinical oncology","volume":"5 2","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342562/pdf/nihms-997584.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36895194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges of Preoperative Diagnosis and Management of Scalene Intramuscular Angioma 斜角肌内血管瘤术前诊断与治疗的挑战

Cancer and clinical oncology

Pub Date : 2015-12-18 DOI: 10.5539/CCO.V5N1P20

Lei Zhang, B. Wang, J. Goddard

Intramuscular angioma of scalene muscle is rare with only five cases reported so far. Four of them have not been suspected before surgery; one was diagnosed preoperatively by core biopsy. Preoperative diagnosis is important for management. Awareness of cytologic features could help preoperative diagnosis when need of ruling out malignancy and coagulopathy make fine needle aspiration a choice. We herein demonstrate a new case of a 27 year old male with history of hepatocellular carcinoma, who presented with a 6 cm left supraclavicular mass. The fine needle aspiration was paucicellular; however, the bland ovoid to spindle cells with a whirling and luminal arrangement in the background of blood, fatty drops and degenerate muscle are suggestive of intramuscular angioma. The magnetic resonance imagines (MRI) demonstrate a T1 isointense and T2 hyperintense ill-defined lesion splaying anterior and mid scalene muscles with subtle vascular voids at periphery. These features in combination with cytology findings indicate intramuscular angioma. The pre-operative findings are correlated to the histologic picture of mixed capillaries and varying sized venues intervening with fatty tissue and atrophic muscle. Intraoperatively, the mass is adjacent to the brachial plexus rootlets, interdigitating with the scalene muscle and pushing the carotid sheath, left subclavicular artery and vein aside. Following embolization, the mass is resected with minimal bleeding. Our case suggests that scalene intramuscular angioma can be successfully managed by surgery after embolization; preoperative diagnosis rendered by cytologic features and imaging characters would aid the planning of surgery.

斜角肌肌内血管瘤是一种罕见的疾病，目前仅报道5例。其中4人在手术前未被怀疑;1例术前通过核心活检确诊。术前诊断对治疗很重要。当需要排除恶性肿瘤和凝血功能障碍时，了解细胞学特征有助于术前诊断，因此可以选择细针穿刺。我们在此报告一个27岁男性肝癌病史的新病例，他表现为左侧锁骨上6厘米肿块。细针穿刺呈少细胞性;然而，在血液、脂肪滴和退化的肌肉背景下，平淡无奇的卵形到梭形细胞呈旋转和管状排列，提示肌内血管瘤。磁共振成像(MRI)显示T1等强度和T2高强度不明确的病变，呈前斜角肌和中斜角肌，周围有细微的血管空洞。这些特征结合细胞学结果提示肌内血管瘤。术前发现与混合毛细血管和不同大小的血管介入脂肪组织和萎缩肌肉的组织学图像相关。术中，肿块靠近臂丛神经根，与斜角肌交叉，推颈动脉鞘，左侧锁骨下动脉和静脉。栓塞后，以少量出血切除肿块。我们的病例表明斜角肌内血管瘤可以通过栓塞手术成功治疗;术前根据细胞学特征和影像学特征进行诊断有助于手术计划。

{"title":"Challenges of Preoperative Diagnosis and Management of Scalene Intramuscular Angioma","authors":"Lei Zhang, B. Wang, J. Goddard","doi":"10.5539/CCO.V5N1P20","DOIUrl":"https://doi.org/10.5539/CCO.V5N1P20","url":null,"abstract":"Intramuscular angioma of scalene muscle is rare with only five cases reported so far. Four of them have not been suspected before surgery; one was diagnosed preoperatively by core biopsy. Preoperative diagnosis is important for management. Awareness of cytologic features could help preoperative diagnosis when need of ruling out malignancy and coagulopathy make fine needle aspiration a choice. We herein demonstrate a new case of a 27 year old male with history of hepatocellular carcinoma, who presented with a 6 cm left supraclavicular mass. The fine needle aspiration was paucicellular; however, the bland ovoid to spindle cells with a whirling and luminal arrangement in the background of blood, fatty drops and degenerate muscle are suggestive of intramuscular angioma. The magnetic resonance imagines (MRI) demonstrate a T1 isointense and T2 hyperintense ill-defined lesion splaying anterior and mid scalene muscles with subtle vascular voids at periphery. These features in combination with cytology findings indicate intramuscular angioma. The pre-operative findings are correlated to the histologic picture of mixed capillaries and varying sized venues intervening with fatty tissue and atrophic muscle. Intraoperatively, the mass is adjacent to the brachial plexus rootlets, interdigitating with the scalene muscle and pushing the carotid sheath, left subclavicular artery and vein aside. Following embolization, the mass is resected with minimal bleeding. Our case suggests that scalene intramuscular angioma can be successfully managed by surgery after embolization; preoperative diagnosis rendered by cytologic features and imaging characters would aid the planning of surgery.","PeriodicalId":89904,"journal":{"name":"Cancer and clinical oncology","volume":"5 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2015-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5539/CCO.V5N1P20","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70722963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Cancer and Its Correlates: A Study of Knowledge and Preventive Behavior in Riyadh 皮肤癌及其相关因素:利雅得居民的知识和预防行为研究

Cancer and clinical oncology

Pub Date : 2015-12-08 DOI: 10.5539/CCO.V5N1P11

Fahad Alamri, M. Y. Saeedi, Muslet H. Alharbi, A. Ali, A. Ibrahim, K. Kassim

Background: Worldwide, the incidence of skin cancer has increased due to increased UV exposure to solar and artificial sources. In Saudi Arabia, skin cancer ranked the 9 th most common cancer for both sexes. However, it is considered to be a preventable disease. WHO has proposed several preventive methods to avoid the damaging effects of excessive exposure to UV rays including; social education and adopting positive behavioral changes. The present study aimed to evaluate the level of knowledge, attitudes and behaviors of people in Riyadh city towards skin cancer. Results: The mean respondent's age was 35 years (12-65 years). Females represented about two-thirds of the 341 respondent. A statistically significant associations were detected between awareness about skin cancer with the age (Beta =0.03, p =0.047), educational level (Beta =0.63, p =0.042) and skin color (Beta =-2.14, p<0.001) being significant predictors for disease. Conclusions: To our knowledge, this was the first study to assess the level of knowledge, attitudes, and practices regarding skin cancer in Saudi Arabia. Despite the limitations, the present study’s findings suggested that Saudis lack the sufficient knowledge to understand and assess the importance of skin cancer risk. In addition, the level of knowledge, attitude and behaviors are influenced by several factors as age, education level and skin color.

背景:在世界范围内，由于太阳和人造光源的紫外线照射增加，皮肤癌的发病率增加。在沙特阿拉伯，皮肤癌在男女最常见的癌症中排名第九。然而，它被认为是一种可预防的疾病。世卫组织提出了若干预防方法，以避免过度暴露于紫外线的破坏性影响，包括;社会教育和采取积极的行为改变。本研究旨在评估利雅得市人们对皮肤癌的知识水平、态度和行为。结果:平均年龄为35岁(12 ~ 65岁)。在341名受访者中，女性约占三分之二。年龄(Beta值=0.03,p =0.047)、教育程度(Beta值=0.63,p =0.042)和肤色(Beta值=-2.14,p<0.001)是皮肤癌认知的显著预测因子。结论:据我们所知，这是第一项评估沙特阿拉伯关于皮肤癌的知识、态度和实践水平的研究。尽管存在局限性，但本研究的发现表明，沙特人缺乏足够的知识来理解和评估皮肤癌风险的重要性。此外，知识水平、态度和行为还受到年龄、受教育程度和肤色等因素的影响。

{"title":"Skin Cancer and Its Correlates: A Study of Knowledge and Preventive Behavior in Riyadh","authors":"Fahad Alamri, M. Y. Saeedi, Muslet H. Alharbi, A. Ali, A. Ibrahim, K. Kassim","doi":"10.5539/CCO.V5N1P11","DOIUrl":"https://doi.org/10.5539/CCO.V5N1P11","url":null,"abstract":"Background: Worldwide, the incidence of skin cancer has increased due to increased UV exposure to solar and artificial sources. In Saudi Arabia, skin cancer ranked the 9 th most common cancer for both sexes. However, it is considered to be a preventable disease. WHO has proposed several preventive methods to avoid the damaging effects of excessive exposure to UV rays including; social education and adopting positive behavioral changes. The present study aimed to evaluate the level of knowledge, attitudes and behaviors of people in Riyadh city towards skin cancer. Results: The mean respondent's age was 35 years (12-65 years). Females represented about two-thirds of the 341 respondent. A statistically significant associations were detected between awareness about skin cancer with the age (Beta =0.03, p =0.047), educational level (Beta =0.63, p =0.042) and skin color (Beta =-2.14, p<0.001) being significant predictors for disease. Conclusions: To our knowledge, this was the first study to assess the level of knowledge, attitudes, and practices regarding skin cancer in Saudi Arabia. Despite the limitations, the present study’s findings suggested that Saudis lack the sufficient knowledge to understand and assess the importance of skin cancer risk. In addition, the level of knowledge, attitude and behaviors are influenced by several factors as age, education level and skin color.","PeriodicalId":89904,"journal":{"name":"Cancer and clinical oncology","volume":"5 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2015-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5539/CCO.V5N1P11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70722403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Non–Hodgkin’s Lymphoma of the Appendix 阑尾非霍奇金淋巴瘤

Cancer and clinical oncology

Pub Date : 2015-12-07 DOI: 10.5539/CCO.V5N1P1

G. Watson, J. Gleeson, D. Kelly, D. Byrne, P. D. L. Harpe-Golden, J. Mulsow, A. Fortune, D. Carney

Abstract Infiltration of the appendix as a manifestation of non-hodgkins lymphoma (NHL) at diagnosis or at relapse is a rare finding. We report the history of a patient with gastrointestinal non-hodgkin's lymphoma treated 8 years earlier who presented with symptoms suggestive of acute appendicitis secondary to relapsed NHL. Keywords: Non Hodgkins Lymphoma, Diffuse Large B Cell Lymphoma, appendix, PET CT

阑尾浸润作为非霍奇金淋巴瘤(NHL)在诊断或复发时的表现是一种罕见的发现。我们报告了8年前治疗的胃肠道非霍奇金淋巴瘤患者的病史，该患者表现出复发性NHL继发急性阑尾炎的症状。关键词:非霍奇金淋巴瘤，弥漫性大B细胞淋巴瘤，阑尾，PET CT

引用次数: 2

Methylation Markers for Early Detection and Differentiation of Follicular Thyroid Cancer Subtypes. 甲基化标记在滤泡性甲状腺癌亚型早期检测和分化中的应用。

Cancer and clinical oncology

Pub Date : 2015-11-01 Epub Date: 2015-06-15 DOI: 10.5539/cco.v4n2p1

Josena K Stephen, Kang Mei Chen, Jason Merritt, Dhananjay Chitale, George Divine, Maria J Worsham

Thyroid cancer has the fastest rising incidence rates and is the fifth most common cancer in women. There are four main types of which the papillary and follicular types together account for >90%, followed by medullary cancers (3%-5%) and anaplastic carcinomas (<3%). For individuals who present with early stage disease of papillary and follicular cancers, there are no accurate markers to predict whether they will develop metastatic or recurrent disease. Our immediate goal is to molecularly differentiate follicular cancer subtypes for enhanced classification. Promoter methylation status of genes with reported associations in thyroid cancer (CASP8, CDKN2A, DAPK1, ESR1, NIS, RASSF1 and TIMP3) were examined in a cohort of follicular thyroid cancers comprising of 26 Hurthle and 27 Classic subtypes utilizing quantitative methylation-specific PCR. RASSF1 was differentially methylated in Classic tumor tissue compared to Hurthle (p<0.001). Methylation of RASSF1 pointed to racial group differences between African Americans and Caucasian Americans (p=0.05). Extra thyroidal extension was found to be associated with DAPK1 (p=0.014) and ESR1 (p=0.036) methylation. Late stage disease was associated with older age (p<0.001) and methylation of DAPK1 (p=0.034) and ESR1 (p=0.035). The methylation status of RASSF1, DAPK1 and ESR1 suggests the utility of methylation markers to molecularly differentiate thyroid cancer subtypes for enhanced classification and early detection of thyroid cancer.

甲状腺癌发病率上升最快，是女性中第五大常见癌症。在一组包括26个Hurthle亚型和27个Classic亚型的滤泡性甲状腺癌中，利用定量甲基化特异性PCR检测了四种主要类型，其中乳头状和滤泡型加起来占90%以上，其次是髓样癌(3%-5%)和间变性癌(CASP8、CDKN2A、DAPK1、ESR1、NIS、RASSF1和TIMP3)。与Hurthle相比，RASSF1在经典肿瘤组织中的甲基化存在差异(pRASSF1指出非裔美国人和白种人美国人之间的种族差异(p=0.05)。发现甲状腺外展与DAPK1 (p=0.014)和ESR1 (p=0.036)甲基化有关。晚期疾病与年龄相关(pDAPK1 (p=0.034)和ESR1 (p=0.035)。RASSF1、DAPK1和ESR1的甲基化状态表明，甲基化标记物可用于甲状腺癌亚型的分子分化，以增强甲状腺癌的分类和早期发现。

{"title":"Methylation Markers for Early Detection and Differentiation of Follicular Thyroid Cancer Subtypes.","authors":"Josena K Stephen, Kang Mei Chen, Jason Merritt, Dhananjay Chitale, George Divine, Maria J Worsham","doi":"10.5539/cco.v4n2p1","DOIUrl":"https://doi.org/10.5539/cco.v4n2p1","url":null,"abstract":"Thyroid cancer has the fastest rising incidence rates and is the fifth most common cancer in women. There are four main types of which the papillary and follicular types together account for >90%, followed by medullary cancers (3%-5%) and anaplastic carcinomas (<3%). For individuals who present with early stage disease of papillary and follicular cancers, there are no accurate markers to predict whether they will develop metastatic or recurrent disease. Our immediate goal is to molecularly differentiate follicular cancer subtypes for enhanced classification. Promoter methylation status of genes with reported associations in thyroid cancer (CASP8, CDKN2A, DAPK1, ESR1, NIS, RASSF1 and TIMP3) were examined in a cohort of follicular thyroid cancers comprising of 26 Hurthle and 27 Classic subtypes utilizing quantitative methylation-specific PCR. RASSF1 was differentially methylated in Classic tumor tissue compared to Hurthle (p<0.001). Methylation of RASSF1 pointed to racial group differences between African Americans and Caucasian Americans (p=0.05). Extra thyroidal extension was found to be associated with DAPK1 (p=0.014) and ESR1 (p=0.036) methylation. Late stage disease was associated with older age (p<0.001) and methylation of DAPK1 (p=0.034) and ESR1 (p=0.035). The methylation status of RASSF1, DAPK1 and ESR1 suggests the utility of methylation markers to molecularly differentiate thyroid cancer subtypes for enhanced classification and early detection of thyroid cancer.","PeriodicalId":89904,"journal":{"name":"Cancer and clinical oncology","volume":"4 2","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5539/cco.v4n2p1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34380117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Exacerbation of Migraines Following Robotic Surgery for Endometrial Carcinoma 子宫内膜癌机器人手术后偏头痛加重

Cancer and clinical oncology

Pub Date : 2015-10-22 DOI: 10.5539/CCO.V4N2P53

J. P. Geisler, K. Manahan

Objective: Robotic hysterectomies are becoming increasingly common in the United States. Although benefits exist, risks are also present. The purpose of this study was to see what percentage of women with migraine headaches had a post-operative exacerbation. Study design: Records were examined for the diagnosis of migraine headaches as well as post-operative diagnosis of a headache. Records were also examined for age, estimated blood loss, total skin to skin operative time and body mass index. Results: Surgeries and records for 100 women were examined. Only 6% of women complained of post-operative headaches. However, 45% of women with history of migraines complained of post-operative headaches (p <0.001). Age was the only significant factor with women having post-operative headaches being significantly younger (p = 0.009). Conclusion: Post-operative headaches were more common in women with a pre-operative history of migraine headaches than in those without a history. Patients with a history of migraines should be warned of this risk.

目的:机器人子宫切除术在美国越来越普遍。虽然有好处，但风险也存在。这项研究的目的是观察女性偏头痛患者术后病情加重的比例。研究设计:检查偏头痛的诊断记录以及术后头痛的诊断记录。记录还检查了年龄，估计失血量，皮肤到皮肤的总手术时间和体重指数。结果:对100例妇女的手术和记录进行了分析。只有6%的女性抱怨术后头痛。然而，有偏头痛病史的女性中有45%抱怨术后头痛(p <0.001)。年龄是唯一的显著因素，术后头痛的女性明显年轻化(p = 0.009)。结论:术前有偏头痛病史的女性术后头痛比无偏头痛病史的女性更常见。有偏头痛病史的患者应注意这种风险。

引用次数: 0

Comprehensive Genomic Profiling of Recurrent Classic Glioblastoma in a Patient Surviving Eleven Years Following Antineoplaston Therapy 抗肿瘤药物治疗后存活11年的复发性典型胶质母细胞瘤患者的综合基因组分析

Cancer and clinical oncology

Pub Date : 2015-10-22 DOI: 10.5539/CCO.V4N2P41

S. Burzynski, T. Janicki, Gregory S. Burzynski

Most patients with recurrent glioblastoma (RGBM) die within 6 months regardless of treatment. In phase II studies of Antineoplaston A10 and AS2-1 injections (ANP), our investigators have reported objective responses and long-term survival in RGBM. Using a next-generation sequencing (NGS) based assay of 343 cancer-related genes and introns, comprehensive genomic profiling of tumor tissue obtained from a RGBM patient (who remains alive and well) was performed 11 years after diagnosis and permitted assignment of the patient’s RGBM to the classical subgroup. The most important genomic alterations included amplification of epidermal growth factor receptor (EGFR), cyclin-dependent kinase inhibitor 2A and 2B (CDKN2A/B), loss of phosphatase and tensin homolog (PTEN) and telomerase reverse transcriptase (TERT) mutation. An analysis of the signaling networks and other targets of ANP therapy was recently performed and presented in this publication. Based on our findings, patients with classical RGBM have a reasonable possibility of responding to ANP therapy and experiencing long-term survival. It is proposed that this subgroup of RGBM patients be enrolled in a genomics-driven clinical trial of ANP therapy.

大多数复发性胶质母细胞瘤(RGBM)患者在6个月内死亡，无论治疗如何。在抗肿瘤素A10和AS2-1注射(ANP)的II期研究中，我们的研究人员报告了RGBM的客观反应和长期生存。使用基于下一代测序(NGS)的343个癌症相关基因和内含子的分析，在诊断后11年对从RGBM患者(仍然存活且健康)获得的肿瘤组织进行了全面的基因组分析，并允许将患者的RGBM分配到经典亚组。最重要的基因组改变包括表皮生长因子受体(EGFR)、细胞周期蛋白依赖性激酶抑制剂2A和2B (CDKN2A/B)的扩增、磷酸酶和紧张素同源物(PTEN)的缺失以及端粒酶逆转录酶(TERT)的突变。对信号网络和ANP治疗的其他靶点的分析最近进行并发表在本出版物中。根据我们的研究结果，经典RGBM患者有合理的可能性对ANP治疗有反应并经历长期生存。建议将RGBM患者纳入基因组学驱动的ANP治疗临床试验。

{"title":"Comprehensive Genomic Profiling of Recurrent Classic Glioblastoma in a Patient Surviving Eleven Years Following Antineoplaston Therapy","authors":"S. Burzynski, T. Janicki, Gregory S. Burzynski","doi":"10.5539/CCO.V4N2P41","DOIUrl":"https://doi.org/10.5539/CCO.V4N2P41","url":null,"abstract":"Most patients with recurrent glioblastoma (RGBM) die within 6 months regardless of treatment. In phase II studies of Antineoplaston A10 and AS2-1 injections (ANP), our investigators have reported objective responses and long-term survival in RGBM. Using a next-generation sequencing (NGS) based assay of 343 cancer-related genes and introns, comprehensive genomic profiling of tumor tissue obtained from a RGBM patient (who remains alive and well) was performed 11 years after diagnosis and permitted assignment of the patient’s RGBM to the classical subgroup. The most important genomic alterations included amplification of epidermal growth factor receptor (EGFR), cyclin-dependent kinase inhibitor 2A and 2B (CDKN2A/B), loss of phosphatase and tensin homolog (PTEN) and telomerase reverse transcriptase (TERT) mutation. An analysis of the signaling networks and other targets of ANP therapy was recently performed and presented in this publication. Based on our findings, patients with classical RGBM have a reasonable possibility of responding to ANP therapy and experiencing long-term survival. It is proposed that this subgroup of RGBM patients be enrolled in a genomics-driven clinical trial of ANP therapy.","PeriodicalId":89904,"journal":{"name":"Cancer and clinical oncology","volume":"4 1","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2015-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5539/CCO.V4N2P41","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70722620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Anal Cancer Patients in a Metropolitan Hospital Present Infection with Multiple Oncogenic Viruses 某都市医院肛门癌患者存在多种致瘤病毒感染

Cancer and clinical oncology

Pub Date : 2015-08-03 DOI: 10.5539/CCO.V4N2P32

Kenneth O. Simbiri, H. Jha, D. Henry, E. Robertson

Background: Oncoviruses such as HPV, KSHV, and EBV have been reported in patients with HIV/AIDS. Exactly how oncovirus-associated cancers rise in AIDS patients is not fully established. We highlight results from anal cancer samples that were screened for certain known oncoviruses in HIV/AIDS patients. Methods : Tissues were obtained from 14 anal cancer patients. DNA was extracted from the tissues and used in PCR assays to identify the oncoviruses. Immunohistochemical assays were performed on slides using specific antibodies. Results: Using PCR we detected HPV-16 (P<0.0001), HPV-45 (P<0.0001), HPV-31 (P<0.0001), HPV-33 (P<0.0001), and EBV (P<0.0001) which were statistically significantly different, and KSHV (P=0.090). Utilizing immunohistochemistry, the samples were statistically significantly different in HPV-16 E6 (P<0.0001), HPV-16 E7 (P<0.0001), EBV (P<0.0001), and KSHV (P<0.0001). Conclusion: The findings indicate that oncogenic human papilloma and herpesviruses are present in anal cancer tissues. Their causal role to the cancer may have implications for long-term pathogenesis.

背景:HPV、KSHV和EBV等肿瘤病毒在HIV/AIDS患者中有报道。艾滋病患者中与癌病毒相关的癌症究竟是如何上升的还没有完全确定。我们强调从肛门癌样本中筛选某些已知的艾滋病毒/艾滋病患者的结果。方法:选取14例肛门癌患者的组织。从组织中提取DNA，用PCR方法鉴定癌病毒。使用特异性抗体在载玻片上进行免疫组织化学检测。结果:PCR检测HPV-16 (P<0.0001)、HPV-45 (P<0.0001)、HPV-31 (P<0.0001)、HPV-33 (P<0.0001)、EBV (P<0.0001)及KSHV (P=0.090)，差异有统计学意义。免疫组化分析结果显示，HPV-16 E6 (P<0.0001)、HPV-16 E7 (P<0.0001)、EBV (P<0.0001)、KSHV (P<0.0001)的表达差异有统计学意义。结论:肛门癌组织中存在致瘤性人乳头状瘤和疱疹病毒。它们对癌症的因果作用可能对长期发病机制有影响。

引用次数: 1

A Phase II Study of Antineoplastons A10 and AS2-1 Injections in Adult Patients With Recurrent Anaplastic Astrocytoma—Final report (Protocol BT-15) 抗瘤质体A10和AS2-1注射治疗复发性间变性星形细胞瘤的II期研究——最终报告(方案BT-15)

Cancer and clinical oncology

Pub Date : 2015-06-17 DOI: 10.5539/CCO.V4N2P13

S. Burzynski, T. Janicki, Gregory S. Burzynski

The recommended treatment for recurrent anaplastic astrocytoma (AA) consists of chemotherapy with temozolomide. There is an urgent need for new therapies for such patients. This phase II study evaluates efficacy and safety of a different form of cancer therapy that consists of antineoplastons A10 and AS2-1 (ANP). 27 patients, ages 19 to 57 years (median, 41) with recurrent AA were treated. All patients previously underwent surgery, all received radiation therapy, and 16 underwent chemotherapy. The patients received treatment with ANP administered daily every four hours (median dose of A10 6.0 g/kg/d and AS2-1 0.25 g/kg/d). All patients were included in efficacy and safety analysis. The median duration of ANP was 23.1 weeks. A complete response was documented in 7%, partial response in 11%, and stable disease in 22% of patients. Progression-free survival and overall survival at 12 months was 26% and 41% respectively. The only serious toxicity was Grade 3 reversible hypokalemia in 7% of patients. There was no chronic toxicity and there was a high quality of life. ANP shows efficacy with very good toxicity profile in this cohort of patients with recurrent AA.

复发性间变性星形细胞瘤(AA)的推荐治疗包括替莫唑胺化疗。对于这类患者，迫切需要新的治疗方法。这项II期研究评估了由抗瘤素A10和AS2-1 (ANP)组成的不同形式的癌症治疗的有效性和安全性。27例复发性AA患者，年龄19 ~ 57岁(中位41岁)。所有患者之前都接受过手术，所有患者都接受过放射治疗，16名患者接受过化疗。患者接受ANP治疗，每日每4小时给药一次(中位剂量A10 6.0 g/kg/d, AS2-1 0.25 g/kg/d)。所有患者均纳入疗效和安全性分析。ANP的中位持续时间为23.1周。7%的患者完全缓解，11%的患者部分缓解，22%的患者病情稳定。12个月无进展生存率和总生存率分别为26%和41%。唯一严重的毒性是7%的患者出现3级可逆性低钾血症。没有慢性毒性，生活质量也很高。ANP在这组复发性AA患者中显示出很好的疗效和毒性。

{"title":"A Phase II Study of Antineoplastons A10 and AS2-1 Injections in Adult Patients With Recurrent Anaplastic Astrocytoma—Final report (Protocol BT-15)","authors":"S. Burzynski, T. Janicki, Gregory S. Burzynski","doi":"10.5539/CCO.V4N2P13","DOIUrl":"https://doi.org/10.5539/CCO.V4N2P13","url":null,"abstract":"The recommended treatment for recurrent anaplastic astrocytoma (AA) consists of chemotherapy with temozolomide. There is an urgent need for new therapies for such patients. This phase II study evaluates efficacy and safety of a different form of cancer therapy that consists of antineoplastons A10 and AS2-1 (ANP). 27 patients, ages 19 to 57 years (median, 41) with recurrent AA were treated. All patients previously underwent surgery, all received radiation therapy, and 16 underwent chemotherapy. The patients received treatment with ANP administered daily every four hours (median dose of A10 6.0 g/kg/d and AS2-1 0.25 g/kg/d). All patients were included in efficacy and safety analysis. The median duration of ANP was 23.1 weeks. A complete response was documented in 7%, partial response in 11%, and stable disease in 22% of patients. Progression-free survival and overall survival at 12 months was 26% and 41% respectively. The only serious toxicity was Grade 3 reversible hypokalemia in 7% of patients. There was no chronic toxicity and there was a high quality of life. ANP shows efficacy with very good toxicity profile in this cohort of patients with recurrent AA.","PeriodicalId":89904,"journal":{"name":"Cancer and clinical oncology","volume":"4 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2015-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5539/CCO.V4N2P13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70722663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8