Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240896
Dingjiayi Zhai
Dementia has become a global crisis, numbering over 50 million people in the world, more than half of whom are Alzheimers disease (AD)s patients. AD is a heterogeneous disease that has complex pathobiologic properties. The exact AD mechanism is unclear at this point, but the pathological hallmarks constitute amyloid- (A) plaques and tau neurofibrillary tangles and most treatments are based on this. AD has a serious impact on society and on humanity, but drugs approved to treat AD are few and ineffective. The article analyzes the possible causes of pathological hallmarks and describes existing treatment options, as well as their shortcomings and potential future treatments. It also speculates on the direction of possible future therapeutic options providing reference for more new technologies and methods of treating AD in the future. However, there are still many unclear pathogenic mechanisms and more effective treatments are needed for further research on AD in the future.
痴呆症已成为全球性危机，全球痴呆症患者超过 5000 万，其中一半以上是阿尔茨海默病患者（AD）。阿尔茨海默病是一种异质性疾病，具有复杂的病理生物学特性。目前，阿尔茨海默病的确切发病机制尚不清楚，但其病理特征是淀粉样蛋白（A）斑块和 tau 神经纤维缠结，大多数治疗方法都是以此为基础的。注意力缺失症对社会和人类造成了严重影响，但获准用于治疗注意力缺失症的药物却很少且效果不佳。文章分析了病理特征的可能原因，介绍了现有的治疗方案及其不足和未来可能的治疗方法。文章还推测了未来可能的治疗方案方向，为未来更多治疗 AD 的新技术和新方法提供参考。然而，目前仍有许多不明确的致病机制，未来需要更有效的治疗方法来进一步研究 AD。
{"title":"Research progress and future development direction of Alzheimer's therapy","authors":"Dingjiayi Zhai","doi":"10.54254/2753-8818/33/20240896","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240896","url":null,"abstract":"Dementia has become a global crisis, numbering over 50 million people in the world, more than half of whom are Alzheimers disease (AD)s patients. AD is a heterogeneous disease that has complex pathobiologic properties. The exact AD mechanism is unclear at this point, but the pathological hallmarks constitute amyloid- (A) plaques and tau neurofibrillary tangles and most treatments are based on this. AD has a serious impact on society and on humanity, but drugs approved to treat AD are few and ineffective. The article analyzes the possible causes of pathological hallmarks and describes existing treatment options, as well as their shortcomings and potential future treatments. It also speculates on the direction of possible future therapeutic options providing reference for more new technologies and methods of treating AD in the future. However, there are still many unclear pathogenic mechanisms and more effective treatments are needed for further research on AD in the future.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"51 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240589
Kexin Li
Insulin analogs are currently the most often prescribed medications for treating type 2 diabetes mellitus (T2DM). However, because of the inherent flaws of the medications and the restrictions of the administration methods, there is no comprehensive plan for managing diabetes. As a result, its crucial to research comprehensive treatment plans based on the available medications and the traits of T2DM. Natural products play as key role in drug discovery. Although many articles have been published on the antidiabetic potential of natural products, few natural product-based molecules have been approved for the treatment of T2DM. It has been established that the compound 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one from Nigella glandulifera Freyn et Sint (N. glandulifera) possesses antidiabetic activity, but little attention has been dedicated to its total synthesis. Herein, we attempt to reveal a new total synthesis of 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one. The synthesis is simple, with few steps, and has potential for industrialization.
{"title":"Proposed total synthesis of the potential antidiabetic compound 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one","authors":"Kexin Li","doi":"10.54254/2753-8818/33/20240589","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240589","url":null,"abstract":"Insulin analogs are currently the most often prescribed medications for treating type 2 diabetes mellitus (T2DM). However, because of the inherent flaws of the medications and the restrictions of the administration methods, there is no comprehensive plan for managing diabetes. As a result, its crucial to research comprehensive treatment plans based on the available medications and the traits of T2DM. Natural products play as key role in drug discovery. Although many articles have been published on the antidiabetic potential of natural products, few natural product-based molecules have been approved for the treatment of T2DM. It has been established that the compound 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one from Nigella glandulifera Freyn et Sint (N. glandulifera) possesses antidiabetic activity, but little attention has been dedicated to its total synthesis. Herein, we attempt to reveal a new total synthesis of 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one. The synthesis is simple, with few steps, and has potential for industrialization.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"27 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240821
Ruoning Gu
Alzheimers disease (AD) is a neurodegenerative disease with a worldwide prevalence of 760.5 per 100,000 inhabitants. Environment factors and genetic predispositions can influence an individuals risk of developing AD. Recent research provided insights into the genetic mechanisms of AD, but a comprehensive database of drug-like molecules that can exacerbate or reduce AD risk remains unavailable. Here, we use machine learning to create a similarity map that reveals new putative drugs structurally similar to existing compounds known to be targeting pathways relevant in AD. We trained an autoencoder on a large drug database of over 14,000 drugs, with features derived from several modalities including molecular fingerprints. We then computed similarity scores based on these reduced dimensions. We show that our model is able to identify new compounds structurally similar to existing drugs linked to AD. We conclude that our model holds the potential to elucidate new compounds based on structural similarity and can be used to identify new drugs that affect critical pathways in AD.
{"title":"Transfer learning-enabled classification of drugs for Alzheimers Disease","authors":"Ruoning Gu","doi":"10.54254/2753-8818/33/20240821","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240821","url":null,"abstract":"Alzheimers disease (AD) is a neurodegenerative disease with a worldwide prevalence of 760.5 per 100,000 inhabitants. Environment factors and genetic predispositions can influence an individuals risk of developing AD. Recent research provided insights into the genetic mechanisms of AD, but a comprehensive database of drug-like molecules that can exacerbate or reduce AD risk remains unavailable. Here, we use machine learning to create a similarity map that reveals new putative drugs structurally similar to existing compounds known to be targeting pathways relevant in AD. We trained an autoencoder on a large drug database of over 14,000 drugs, with features derived from several modalities including molecular fingerprints. We then computed similarity scores based on these reduced dimensions. We show that our model is able to identify new compounds structurally similar to existing drugs linked to AD. We conclude that our model holds the potential to elucidate new compounds based on structural similarity and can be used to identify new drugs that affect critical pathways in AD.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"20 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240957
Yuchen Jiang
This paper provides insight into the key role of the Nucleoside Triphosphate Diphosphohydrolase (NTPDase) family in thrombosis and its therapeutic potential. Thrombosis is an important mechanism to prevent bleeding, but its abnormal formation can lead to serious health problems such as myocardial infarction and stroke. This paper employs the method of literature analysis, obtaining materials through the investigation of previous literature, thereby conducting a literature review on the biochemical characteristics of some members of the NTPDase family. This paper begins with a description of the basic mechanisms of thrombosis and the biochemical characterization of the NTPDase family, including the structure, function, and specific substrate specificity of its members. The NTPDase enzymes regulate platelet activation by hydrolyzing extracellular Adenosine Triphosphate (ATP) and Adenosine Diphosphate (ADP), thereby preventing excessive thrombosis. The article describes in detail the catalytic roles of the NTPDase family members, their relationship to platelets and thrombosis, and discusses their role in regulating platelet function and blood coagulation. Finally, the article identifies NTPDase family members as promising targets for the treatment of thrombosis and explores the possibility of utilizing these enzymes in the clinical prevention and treatment of thrombosis-related diseases, highlighting their therapeutic potential in the control of inflammatory vascular diseases.
{"title":"Biochemical characterization of the NTPDases family and thrombosis","authors":"Yuchen Jiang","doi":"10.54254/2753-8818/33/20240957","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240957","url":null,"abstract":"This paper provides insight into the key role of the Nucleoside Triphosphate Diphosphohydrolase (NTPDase) family in thrombosis and its therapeutic potential. Thrombosis is an important mechanism to prevent bleeding, but its abnormal formation can lead to serious health problems such as myocardial infarction and stroke. This paper employs the method of literature analysis, obtaining materials through the investigation of previous literature, thereby conducting a literature review on the biochemical characteristics of some members of the NTPDase family. This paper begins with a description of the basic mechanisms of thrombosis and the biochemical characterization of the NTPDase family, including the structure, function, and specific substrate specificity of its members. The NTPDase enzymes regulate platelet activation by hydrolyzing extracellular Adenosine Triphosphate (ATP) and Adenosine Diphosphate (ADP), thereby preventing excessive thrombosis. The article describes in detail the catalytic roles of the NTPDase family members, their relationship to platelets and thrombosis, and discusses their role in regulating platelet function and blood coagulation. Finally, the article identifies NTPDase family members as promising targets for the treatment of thrombosis and explores the possibility of utilizing these enzymes in the clinical prevention and treatment of thrombosis-related diseases, highlighting their therapeutic potential in the control of inflammatory vascular diseases.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"44 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140076959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240789
Junxi Li
Healthcare, as a fundamental component of human well-being, plays a pivotal role in shaping overall quality of life. This research investigates the extensive ramifications of the COVID-19 epidemic on the healthcare sector, encompassing the challenges and opportunities that have emerged in its wake. This study investigates the implications for hospital infrastructure through a comprehensive analysis of pertinent literature. The findings reveal significant deficiencies in essential resources such as ventilators and personal protective equipment (PPE). The evident manifestation of the psychological burden experienced by healthcare personnel highlights the imperative of allocating additional resources to support them. The advent of the pandemic has given rise to telemedicine and other digital alternatives, leading to a significant transformation in the field of healthcare delivery. Lockdowns, mask mandates, and other public health interventions are crucial in mitigating the transmission of the pathogen. Despite facing significant challenges, the ongoing pandemic has accelerated advancements in the field of medicine. This study contributes to the existing body of knowledge regarding effective strategies for addressing future pandemics and underscores the imperative of establishing a healthcare system that is adaptable and responsive. In the era following the COVID-19 pandemic, it is imperative to proactively tackle challenges and explore untapped opportunities in the healthcare sector by continuous research and assertive endeavors.
{"title":"The influence of COVID-19 on the health sector","authors":"Junxi Li","doi":"10.54254/2753-8818/33/20240789","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240789","url":null,"abstract":"Healthcare, as a fundamental component of human well-being, plays a pivotal role in shaping overall quality of life. This research investigates the extensive ramifications of the COVID-19 epidemic on the healthcare sector, encompassing the challenges and opportunities that have emerged in its wake. This study investigates the implications for hospital infrastructure through a comprehensive analysis of pertinent literature. The findings reveal significant deficiencies in essential resources such as ventilators and personal protective equipment (PPE). The evident manifestation of the psychological burden experienced by healthcare personnel highlights the imperative of allocating additional resources to support them. The advent of the pandemic has given rise to telemedicine and other digital alternatives, leading to a significant transformation in the field of healthcare delivery. Lockdowns, mask mandates, and other public health interventions are crucial in mitigating the transmission of the pathogen. Despite facing significant challenges, the ongoing pandemic has accelerated advancements in the field of medicine. This study contributes to the existing body of knowledge regarding effective strategies for addressing future pandemics and underscores the imperative of establishing a healthcare system that is adaptable and responsive. In the era following the COVID-19 pandemic, it is imperative to proactively tackle challenges and explore untapped opportunities in the healthcare sector by continuous research and assertive endeavors.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"99 S99","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140256949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240915
Jiayi Han
Lipid oxidation and microbial action have long been attributed to reduced food quality, but the effect on quality has only been gradually noticed in recent years. In food systems, protein oxidation can occur naturally and can also be triggered by processing. Therefore, the oxidation phenomenon is very common in the processing process of protein food. It is very important to study the detailed oxidation mechanism of protein. The new problem is the intake of oxidized protein impacts the health of the human body and intestinal microorganisms in its role, microorganisms in the human body intake of oxidized protein's detailed role is not clear. However, it is undeniable that the gut microbiota plays a vital role in human gut health, and it is very important to study the detailed function of the human gut microbiota after ingestion of oxidized proteins. This study conducted a detailed analysis of food processing to create a protein oxidation environment, protein oxidation mechanism, protein oxidation modification on human intestinal health, and digestion characteristics. Besides, the study also analyzes the role of microorganisms and puts forward the insufficiency. The paper also provides references and help for protein oxidation research.
{"title":"Protein oxidation in dairy products and effects on intestinal health","authors":"Jiayi Han","doi":"10.54254/2753-8818/33/20240915","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240915","url":null,"abstract":"Lipid oxidation and microbial action have long been attributed to reduced food quality, but the effect on quality has only been gradually noticed in recent years. In food systems, protein oxidation can occur naturally and can also be triggered by processing. Therefore, the oxidation phenomenon is very common in the processing process of protein food. It is very important to study the detailed oxidation mechanism of protein. The new problem is the intake of oxidized protein impacts the health of the human body and intestinal microorganisms in its role, microorganisms in the human body intake of oxidized protein's detailed role is not clear. However, it is undeniable that the gut microbiota plays a vital role in human gut health, and it is very important to study the detailed function of the human gut microbiota after ingestion of oxidized proteins. This study conducted a detailed analysis of food processing to create a protein oxidation environment, protein oxidation mechanism, protein oxidation modification on human intestinal health, and digestion characteristics. Besides, the study also analyzes the role of microorganisms and puts forward the insufficiency. The paper also provides references and help for protein oxidation research.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"47 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the acute phase of sudden hearing loss, in patients for whom two weeks of standardized treatment is ineffective or unsatisfactory, or patients for whom the condition has accumulated for more than three weeks, remedial treatment for about 1 week-1 month can be actively pursued to provide an opportunity for hearing recovery. The mainstay of remedial therapy is intratympanic and retro auricular hormone injections. If the disease has progressed beyond 6 weeks and there is still no significant improvement with local hormone injections, the overall efficacy of the treatment can be improved by a combination of Chinese and Western medicine, such as hyperbaric oxygen chambers, acupuncture, and massage (tui na). However, remedial treatments combining Chinese and Western medicine have not been standardized, and attention should be paid to the diagnosis and treatment during the remedial period.
{"title":"An overview of remedial treatment for sudden hearing loss","authors":"Wenchen Ling, Zheng Wei, Suwei Jie, Zhao Xinyu, Zhihui Xu, Huang Pin","doi":"10.54254/2753-8818/33/20240823","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240823","url":null,"abstract":"In the acute phase of sudden hearing loss, in patients for whom two weeks of standardized treatment is ineffective or unsatisfactory, or patients for whom the condition has accumulated for more than three weeks, remedial treatment for about 1 week-1 month can be actively pursued to provide an opportunity for hearing recovery. The mainstay of remedial therapy is intratympanic and retro auricular hormone injections. If the disease has progressed beyond 6 weeks and there is still no significant improvement with local hormone injections, the overall efficacy of the treatment can be improved by a combination of Chinese and Western medicine, such as hyperbaric oxygen chambers, acupuncture, and massage (tui na). However, remedial treatments combining Chinese and Western medicine have not been standardized, and attention should be paid to the diagnosis and treatment during the remedial period.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"51 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240843
Yunqiu Gongye, Ling Feng
Despite rapid advancements in modern medicine, the treatment and prevention of cardiovascular diseases have achieved significant progress. However, issues such as high incidence, recurrence rates, and poor prognosis still profoundly threaten human life and quality of living. The correlation between the heart and brain in anatomy and function, supported by neurological regulation and pathological foundations, validates the association between them. Traditional medicine, characterized by holistic concepts and differential treatment, presents the therapeutic principle of treating different diseases similarly, offering new insights into the clinical treatment of cardiovascular diseases. This paper aims to summarize the theoretical basis of the heart-brain correlation from functional, material, neurologic, and pathological perspectives, aiming to provide more evidence for the theory of treating the brain and heart simultaneously.
{"title":"Review of the theoretical basis of the heart-brain correlation","authors":"Yunqiu Gongye, Ling Feng","doi":"10.54254/2753-8818/33/20240843","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240843","url":null,"abstract":"Despite rapid advancements in modern medicine, the treatment and prevention of cardiovascular diseases have achieved significant progress. However, issues such as high incidence, recurrence rates, and poor prognosis still profoundly threaten human life and quality of living. The correlation between the heart and brain in anatomy and function, supported by neurological regulation and pathological foundations, validates the association between them. Traditional medicine, characterized by holistic concepts and differential treatment, presents the therapeutic principle of treating different diseases similarly, offering new insights into the clinical treatment of cardiovascular diseases. This paper aims to summarize the theoretical basis of the heart-brain correlation from functional, material, neurologic, and pathological perspectives, aiming to provide more evidence for the theory of treating the brain and heart simultaneously.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"44 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140076813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240882
Jiaxuan Liao
This paper discusses the gut-brain axis (GBA) and how it takes part in various neurological diseases, including Alzheimers disease (AD), Attention-deficit hyperactivity disorder (ADHD), and Tourette syndrome. The gut microbiota, inducing vital communications with the brain through the GBA, is not to be neglected in maintaining physiological balance, with the potential to become a source of new therapeutic opportunities for treating these diseases. Current studies show that methods such as personalized diets, oral bacteriotherapy, and multi-strain probiotics like SLAB51 and DEX have promising results in treating AD and ADHD through manipulation of the biotas. Based on the analysis of previous research, this paper finds how changes in gut microbiota amount in feces between healthy and TS mice, in particular the decrease in Firmicutes and Actinobacteria, and the increase in Bacteroidetes and Proteobacteria. However, future studies and experiments are required to evaluate potential side effects of microbiome alterations in humans, and potential treatments for Tourettes syndrome based on gut microbiota analysis. The GBA is a promising area for developing new therapeutic approaches for neurological diseases, and future research in this field holds great potential for advancements in the treatment of these disorders currently with no verified cures.
本文讨论了肠道-大脑轴（GBA）及其在阿尔茨海默病（AD）、注意力缺陷多动障碍（ADHD）和抽动秽语综合征等各种神经系统疾病中的作用。肠道微生物群通过 GBA 与大脑进行重要的交流，在维持生理平衡方面的作用不容忽视，有可能成为治疗这些疾病的新疗法。目前的研究表明，个性化饮食、口服细菌疗法以及多菌株益生菌（如 SLAB51 和 DEX）等方法通过操纵生物菌群在治疗注意力缺失症和多动症方面具有良好的效果。基于对以往研究的分析，本文发现了健康小鼠和 TS 小鼠粪便中肠道微生物群数量的变化，尤其是固缩菌和放线菌的减少，以及类杆菌和蛋白菌的增加。不过，今后还需要进行研究和实验，以评估微生物群改变对人类的潜在副作用，以及基于肠道微生物群分析的妥瑞症潜在治疗方法。肠道微生物群是开发神经系统疾病新疗法的一个前景广阔的领域，该领域的未来研究将为治疗目前尚无确切疗法的这些疾病带来巨大的进步潜力。
{"title":"GBA-related diseases and the application in Tourette syndrome treatment","authors":"Jiaxuan Liao","doi":"10.54254/2753-8818/33/20240882","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240882","url":null,"abstract":"This paper discusses the gut-brain axis (GBA) and how it takes part in various neurological diseases, including Alzheimers disease (AD), Attention-deficit hyperactivity disorder (ADHD), and Tourette syndrome. The gut microbiota, inducing vital communications with the brain through the GBA, is not to be neglected in maintaining physiological balance, with the potential to become a source of new therapeutic opportunities for treating these diseases. Current studies show that methods such as personalized diets, oral bacteriotherapy, and multi-strain probiotics like SLAB51 and DEX have promising results in treating AD and ADHD through manipulation of the biotas. Based on the analysis of previous research, this paper finds how changes in gut microbiota amount in feces between healthy and TS mice, in particular the decrease in Firmicutes and Actinobacteria, and the increase in Bacteroidetes and Proteobacteria. However, future studies and experiments are required to evaluate potential side effects of microbiome alterations in humans, and potential treatments for Tourettes syndrome based on gut microbiota analysis. The GBA is a promising area for developing new therapeutic approaches for neurological diseases, and future research in this field holds great potential for advancements in the treatment of these disorders currently with no verified cures.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"51 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.54254/2753-8818/33/20240928
Kaichen Yan
At present, the arable land area in China is continuously decreasing, but the population is steadily increasing, and the demand for food quality among people is also increasing. Genetically modified food, with its high yield, disease and insect resistance, high survival rate, and excellent quality, will be rapidly developed, and the development prospects of genetically modified food are bright. Compared with non-genetically modified foods, genetically modified foods have similar nutrition, equal safety, and excellent quality. It will bring greater economic benefits. With the development of the times, science and technology are constantly changing, and genetically modified engineering is gradually entering our lives, affecting our lives. Food is one aspect of it. The application of genetically modified technology in food is increasingly attracting people's attention. The research method used in this article is a literature review, which studies the benefits and disadvantages of genetically modified technology on food, as well as the advantages and disadvantages of genetically modified technology on food, and our measures. Advantages: Increase crop yield and quality, and improve nutritional value. Disadvantages have an impact on human health or the management and use of genetically modified foods, the following targeted measures can be taken: strict safety assessment and supervision, strengthening research and development, etc. The conclusion of this study is to continue to refine genetically modified technology and comprehensively strengthen the regulation of genetically modified foods, to benefit humanity better. The study provides suggestions about public health security, food safety, and supply, accumulation of scientific knowledge
{"title":"Application of genetically modified technology in food","authors":"Kaichen Yan","doi":"10.54254/2753-8818/33/20240928","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240928","url":null,"abstract":"At present, the arable land area in China is continuously decreasing, but the population is steadily increasing, and the demand for food quality among people is also increasing. Genetically modified food, with its high yield, disease and insect resistance, high survival rate, and excellent quality, will be rapidly developed, and the development prospects of genetically modified food are bright. Compared with non-genetically modified foods, genetically modified foods have similar nutrition, equal safety, and excellent quality. It will bring greater economic benefits. With the development of the times, science and technology are constantly changing, and genetically modified engineering is gradually entering our lives, affecting our lives. Food is one aspect of it. The application of genetically modified technology in food is increasingly attracting people's attention. The research method used in this article is a literature review, which studies the benefits and disadvantages of genetically modified technology on food, as well as the advantages and disadvantages of genetically modified technology on food, and our measures. Advantages: Increase crop yield and quality, and improve nutritional value. Disadvantages have an impact on human health or the management and use of genetically modified foods, the following targeted measures can be taken: strict safety assessment and supervision, strengthening research and development, etc. The conclusion of this study is to continue to refine genetically modified technology and comprehensively strengthen the regulation of genetically modified foods, to benefit humanity better. The study provides suggestions about public health security, food safety, and supply, accumulation of scientific knowledge","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"95 S89","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140256951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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