Bei-Yun Wang, C. Cao, Ruixiang Li, Yan An, Fang Wang, Yuxiang Huang, Jinjin Qin
Objective: To investigate the correlation between serum secretory frizzled-related protein 5 (SFRP-5) expression levels and insulin resistance and glucolipid metabolism in patients with gestational diabetes mellitus (GDM). Methods: Baseline data were collected from 58 patients with GDM and 51 healthy controls who were admitted Affiliated Hospital of Hebei University from May 2020 to June 2022. sSTRA5 concentrations in peripheral blood of pregnant women were measured, and SFRP-5 levels in patients with different GDM types and normal controls were analyzed by logistic regression models. Results: The levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), fasting insulin (FINS), hemoglobin A1c (HbA1c), and homeostasis model assessment-estimated insulin resistance (HOMA-IR) were higher in the observation group than in the control group, with statistically significant differences (P < 0.05), while the expression levels of high-density lipoprotein cholesterol (HDL-C) and serum SFRP-5 were lower than in the control group, with statistically significant differences (P < 0.05); serum SFRP-5, TG, TC, FBG, and HOMA-IR were all risk factors for GDM (P < 0.05). Conclusion: Elevated serum sSTRA5 may be involved in the regulation of insulin resistance in the body and the regulation of blood glucose in the body by affecting lipid metabolism and inflammatory response.
{"title":"Study on the Correlation Between SFRP-5 Expression Level, Insulin Resistance, and Glycolipid Metabolism in Gestational Diabetes Mellitus","authors":"Bei-Yun Wang, C. Cao, Ruixiang Li, Yan An, Fang Wang, Yuxiang Huang, Jinjin Qin","doi":"10.26689/jcnr.v7i2.4777","DOIUrl":"https://doi.org/10.26689/jcnr.v7i2.4777","url":null,"abstract":"Objective: To investigate the correlation between serum secretory frizzled-related protein 5 (SFRP-5) expression levels and insulin resistance and glucolipid metabolism in patients with gestational diabetes mellitus (GDM). Methods: Baseline data were collected from 58 patients with GDM and 51 healthy controls who were admitted Affiliated Hospital of Hebei University from May 2020 to June 2022. sSTRA5 concentrations in peripheral blood of pregnant women were measured, and SFRP-5 levels in patients with different GDM types and normal controls were analyzed by logistic regression models. Results: The levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), fasting insulin (FINS), hemoglobin A1c (HbA1c), and homeostasis model assessment-estimated insulin resistance (HOMA-IR) were higher in the observation group than in the control group, with statistically significant differences (P < 0.05), while the expression levels of high-density lipoprotein cholesterol (HDL-C) and serum SFRP-5 were lower than in the control group, with statistically significant differences (P < 0.05); serum SFRP-5, TG, TC, FBG, and HOMA-IR were all risk factors for GDM (P < 0.05). Conclusion: Elevated serum sSTRA5 may be involved in the regulation of insulin resistance in the body and the regulation of blood glucose in the body by affecting lipid metabolism and inflammatory response.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43083353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zehui Pang, Mei Ma, Chenfei Qu, Chun-Hui Liu, Xia Sheng
This paper summarizes the background of the formation of the Modified Early Warning System (MEWS) evaluation system, its current status of clinical teaching applications in different fields of hospitals, and its significance on the medical and nursing career, aiming to provide specific theoretical basis for medical staff and lay a foundation for continuing to carry out related work on MEWS.
本文综述了修正预警系统(Modified Early Warning System, MEWS)评价体系形成的背景、在医院不同领域临床教学应用的现状以及对医疗护理事业的意义，旨在为医护人员提供具体的理论依据，为继续开展MEWS相关工作奠定基础。
{"title":"The Latest Research Progress in the Application of MEWS Scoring System in Clinical Nursing","authors":"Zehui Pang, Mei Ma, Chenfei Qu, Chun-Hui Liu, Xia Sheng","doi":"10.26689/jcnr.v7i2.4689","DOIUrl":"https://doi.org/10.26689/jcnr.v7i2.4689","url":null,"abstract":"This paper summarizes the background of the formation of the Modified Early Warning System (MEWS) evaluation system, its current status of clinical teaching applications in different fields of hospitals, and its significance on the medical and nursing career, aiming to provide specific theoretical basis for medical staff and lay a foundation for continuing to carry out related work on MEWS.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44578227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To observe the clinical efficacy of 30% supramolecular salicylic acid combined with Yufa spray dressing in the treatment of moderate to severe seborrheic dermatitis (seborrheic dermatitis of the scalp, SDS). Methods: From January 2020 to December 2021, 150 patients with SDS, who were treated in the Dermatology Clinic of the First Affiliated Hospital of Xi’an Medical University, were randomly divided into two groups, a treatment group and a control group, with 75 cases in each group. The treatment group was given 30% supramolecular salicylic acid combined with Yufa spray dressing on the basis of external medicine given to the control group, while the control group was given oral medicine combined with external medicine. Results: The difference in scores of erythema, scales, pruritus, and folliculitis of the treatment group before and after treatment was significant (P < 0.01), indicating that supramolecular salicylic acid combined with Yufa spray dressing can relieve the symptoms of SDS. The difference in scores of erythema of the control group before and after treatment was significant as well (P < 0.05), indicating that traditional antibiotics are also effective in treating SDS; however, there was no significant difference (P > 0.05) in the scores of other signs and symptoms, such as scales, pruritus, and folliculitis, before and after treatment, indicating that traditional antibiotics have no obvious curative effect on SDS. After 12 weeks of treatment, the improvement in erythema, scaling, and folliculitis was significantly greater in the treatment group compared with the control group (P < 0.05). Curative effect comparison showed that the total effective rate of the treatment group was 80.00%, compared with 25.67% of the control group, and the difference was statistically significant (P < 0.05). Conclusion: 30% supramolecular salicylic acid combined with Yufa spray dressing can significantly improve the therapeutic effect in moderate to severe SDS; the recurrence rate is lower, the course of treatment is shorted, and patients generally feel better; thus, it is a new option for the treatment of dermatitis.
{"title":"Curative Effect of 30% Supramolecular Salicylic Acid Combined with Yufa Spray Dressing on Moderate to Severe Scalp Seborrheic Dermatitis","authors":"Jing Wang, Xinjiang Zhu, Yao Bai, Zhuo Fan","doi":"10.26689/jcnr.v7i2.4770","DOIUrl":"https://doi.org/10.26689/jcnr.v7i2.4770","url":null,"abstract":"Objective: To observe the clinical efficacy of 30% supramolecular salicylic acid combined with Yufa spray dressing in the treatment of moderate to severe seborrheic dermatitis (seborrheic dermatitis of the scalp, SDS). Methods: From January 2020 to December 2021, 150 patients with SDS, who were treated in the Dermatology Clinic of the First Affiliated Hospital of Xi’an Medical University, were randomly divided into two groups, a treatment group and a control group, with 75 cases in each group. The treatment group was given 30% supramolecular salicylic acid combined with Yufa spray dressing on the basis of external medicine given to the control group, while the control group was given oral medicine combined with external medicine. Results: The difference in scores of erythema, scales, pruritus, and folliculitis of the treatment group before and after treatment was significant (P < 0.01), indicating that supramolecular salicylic acid combined with Yufa spray dressing can relieve the symptoms of SDS. The difference in scores of erythema of the control group before and after treatment was significant as well (P < 0.05), indicating that traditional antibiotics are also effective in treating SDS; however, there was no significant difference (P > 0.05) in the scores of other signs and symptoms, such as scales, pruritus, and folliculitis, before and after treatment, indicating that traditional antibiotics have no obvious curative effect on SDS. After 12 weeks of treatment, the improvement in erythema, scaling, and folliculitis was significantly greater in the treatment group compared with the control group (P < 0.05). Curative effect comparison showed that the total effective rate of the treatment group was 80.00%, compared with 25.67% of the control group, and the difference was statistically significant (P < 0.05). Conclusion: 30% supramolecular salicylic acid combined with Yufa spray dressing can significantly improve the therapeutic effect in moderate to severe SDS; the recurrence rate is lower, the course of treatment is shorted, and patients generally feel better; thus, it is a new option for the treatment of dermatitis.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":"54 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41267188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Inflammatory bowel disease (IBD) has been linked to an increased risk of prostate cancer (PC) in numerous studies. However, the exact relationship between them remains conflicting. In this meta-analysis, we focus on determining the relationship between PC incidence and IBD. Methods: A comprehensive literature search was conducted up until January 2022, selecting 14 studies, comprising 127,323 subjects with IBD, at the beginning of the study, among which 61,985 were patients with ulcerative colitis (UC) and 37,802 were with Crohn’s disease (CD). The studies reported the differences between subjects with IBD and controls with regard to the incidence of PC. In order to investigate the relationship between IBD and the prevalence of PC, we estimated the odds ratio (OR) with 95% confidence intervals (CIs). Results: IBD significantly increased the incidence of PC (OR, 3.46; 95% CI, 1.40–8.54, P = 0.007) compared to controls. UC significantly increased the incidence of PC (OR, 1.43; 95% CI, 1.03–1.98, P = 0.03) compared to controls. Yet, no significant difference was observed between CD and controls in relation to PC incidence (OR, 0.89; 95% CI, 0.75–1.06, P = 0.18). Conclusion: IBD, particularly UC, may increase the risk of developing PC. This relationship prompts us to advocate for increased PC and IBD screening to reduce the risk for possible complications that could occur in these subjects.
背景:许多研究表明，炎症性肠病(IBD)与前列腺癌(PC)风险增加有关。然而，它们之间的确切关系仍然存在矛盾。在本荟萃分析中，我们着重于确定PC发病率与IBD之间的关系。方法:截至2022年1月，我们进行了全面的文献检索，在研究开始时选择了14项研究，包括127,323名IBD患者，其中溃疡性结肠炎(UC)患者61,985名，克罗恩病(CD)患者37,802名。这些研究报告了IBD患者和对照组在PC发病率方面的差异。为了研究IBD和PC患病率之间的关系，我们估计了95%置信区间(ci)的比值比(OR)。结果:IBD显著增加PC的发生率(OR, 3.46;95% CI, 1.40-8.54, P = 0.007)。UC显著增加PC的发生率(OR, 1.43;95% CI, 1.03-1.98, P = 0.03)。然而，CD和对照组之间的PC发病率没有显著差异(OR, 0.89;95% ci, 0.75-1.06, p = 0.18)。结论:IBD，尤其是UC，可能增加发展为PC的风险。这种关系提示我们提倡增加PC和IBD筛查，以降低这些受试者可能发生并发症的风险。
{"title":"Inflammatory Bowel Disease Patients’ Risk of Developing Prostate Cancer: A Meta-Analysis","authors":"M. A. Amin, Mina Nicola, Mohamed E. A. Abdelrahim","doi":"10.26689/jcnr.v7i2.4476","DOIUrl":"https://doi.org/10.26689/jcnr.v7i2.4476","url":null,"abstract":"Background: Inflammatory bowel disease (IBD) has been linked to an increased risk of prostate cancer (PC) in numerous studies. However, the exact relationship between them remains conflicting. In this meta-analysis, we focus on determining the relationship between PC incidence and IBD. Methods: A comprehensive literature search was conducted up until January 2022, selecting 14 studies, comprising 127,323 subjects with IBD, at the beginning of the study, among which 61,985 were patients with ulcerative colitis (UC) and 37,802 were with Crohn’s disease (CD). The studies reported the differences between subjects with IBD and controls with regard to the incidence of PC. In order to investigate the relationship between IBD and the prevalence of PC, we estimated the odds ratio (OR) with 95% confidence intervals (CIs). Results: IBD significantly increased the incidence of PC (OR, 3.46; 95% CI, 1.40–8.54, P = 0.007) compared to controls. UC significantly increased the incidence of PC (OR, 1.43; 95% CI, 1.03–1.98, P = 0.03) compared to controls. Yet, no significant difference was observed between CD and controls in relation to PC incidence (OR, 0.89; 95% CI, 0.75–1.06, P = 0.18). Conclusion: IBD, particularly UC, may increase the risk of developing PC. This relationship prompts us to advocate for increased PC and IBD screening to reduce the risk for possible complications that could occur in these subjects.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69072723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Yao, Siyu Li, Jing Zhou, Yao Tian, Jinzhao Zhang, Yaming Li, Shengyu Wang
Objective: To explore the role of NLRP3 in mucus hypersecretion in asthmatic patients. Methods: From January 2020 to June 2022, 90 patients with asthma and 60 healthy patients under the Department of Pulmonary and Critical Care Medicine of the First Affiliated Hospital of Xi’an Medical University were selected. Immunohistochemistry and enzyme-linked immunosorbent assay were performed. NLRP3 inflammasome and mucins MUC5AC and MUC5B levels in lung tissue and sputum were detected. Results: Compared to the healthy control group, the asthma group had significantly higher sputum MUC5A (20.12 ± 5 .07 versus 36.21 ± 6.13) and NLRP3 (72.31 ± 15.13 versus 119.21 ± 31.21) levels (P < 0.05) but lower MUC5B levels (1.35 ± 0.12 versus 0.53 ± 0.11, P < 0.05). Immunohistochemistry showed that NLRP3, MUC5AC, and MUC5B expressions were consistent with the sputum results. Conclusion: NLRP3 and MUC5AC levels are significantly increased in asthmatic patients, whereas MUC5B levels are reduced in these patients. They can be used as targets for the diagnosis and treatment of asthma.
{"title":"Clinical Significance and Levels of NLRP3, MUC5AC, and MUC5B in Asthma","authors":"Yang Yao, Siyu Li, Jing Zhou, Yao Tian, Jinzhao Zhang, Yaming Li, Shengyu Wang","doi":"10.26689/jcnr.v7i2.4769","DOIUrl":"https://doi.org/10.26689/jcnr.v7i2.4769","url":null,"abstract":"Objective: To explore the role of NLRP3 in mucus hypersecretion in asthmatic patients. Methods: From January 2020 to June 2022, 90 patients with asthma and 60 healthy patients under the Department of Pulmonary and Critical Care Medicine of the First Affiliated Hospital of Xi’an Medical University were selected. Immunohistochemistry and enzyme-linked immunosorbent assay were performed. NLRP3 inflammasome and mucins MUC5AC and MUC5B levels in lung tissue and sputum were detected. Results: Compared to the healthy control group, the asthma group had significantly higher sputum MUC5A (20.12 ± 5 .07 versus 36.21 ± 6.13) and NLRP3 (72.31 ± 15.13 versus 119.21 ± 31.21) levels (P < 0.05) but lower MUC5B levels (1.35 ± 0.12 versus 0.53 ± 0.11, P < 0.05). Immunohistochemistry showed that NLRP3, MUC5AC, and MUC5B expressions were consistent with the sputum results. Conclusion: NLRP3 and MUC5AC levels are significantly increased in asthmatic patients, whereas MUC5B levels are reduced in these patients. They can be used as targets for the diagnosis and treatment of asthma.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49352640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To understand the clinical characteristics of patients with embryonic posterior cerebral artery and its correlation with abnormal vascular development. Methods: The clinical data of 396 patients with embryonic posterior cerebral artery confirmed by magnetic resonance angiography (MRA) and computed tomography angiography (CTA) were analyzed. Results: Two-hundred patients had clinical manifestations of posterior circulation ischemia, including recurrent dizziness, vertigo, and tinnitus; 45 had headaches, 97 had limb weakness, and 16 patients had syncope or impaired consciousness. Seventy-six patients with circulatory infarction were admitted to the hospital. There were 251 patients with history of hypertension, 74 with diabetes, 113 with hyperlipidemia, 13 with dominant vertebral artery, 10 with intracranial aneurysm, and 19 with absence of A1 segment of the anterior cerebral artery (considering developmental variation). Conclusion: Embryonic posterior cerebral artery develops abnormally during the embryonic period, often accompanied by abnormal vascular access. Due to abnormal hemodynamics, the incidence of posterior circulation ischemia, aneurysm, and infarction increases in such patients.
{"title":"Clinical Analysis of Embryonic Posterior Cerebral Artery","authors":"Minshi Lin, Chao-Ge Liang, Ke Ma","doi":"10.26689/jcnr.v7i2.4738","DOIUrl":"https://doi.org/10.26689/jcnr.v7i2.4738","url":null,"abstract":"Objective: To understand the clinical characteristics of patients with embryonic posterior cerebral artery and its correlation with abnormal vascular development. Methods: The clinical data of 396 patients with embryonic posterior cerebral artery confirmed by magnetic resonance angiography (MRA) and computed tomography angiography (CTA) were analyzed. Results: Two-hundred patients had clinical manifestations of posterior circulation ischemia, including recurrent dizziness, vertigo, and tinnitus; 45 had headaches, 97 had limb weakness, and 16 patients had syncope or impaired consciousness. Seventy-six patients with circulatory infarction were admitted to the hospital. There were 251 patients with history of hypertension, 74 with diabetes, 113 with hyperlipidemia, 13 with dominant vertebral artery, 10 with intracranial aneurysm, and 19 with absence of A1 segment of the anterior cerebral artery (considering developmental variation). Conclusion: Embryonic posterior cerebral artery develops abnormally during the embryonic period, often accompanied by abnormal vascular access. Due to abnormal hemodynamics, the incidence of posterior circulation ischemia, aneurysm, and infarction increases in such patients.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43308122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pancreatic cancer is a malignant tumor of the gastrointestinal tract. Due to its insidious onset, most patients with newly diagnosed pancreatic cancer have missed the opportunity for radical surgery, which offers patients the best chance of survival. The 5-year survival rate of patients with pancreatic cancer can be improved with early diagnosis, and serum tumor makers are an inexpensive and convenient diagnostic tool that is widely used in the diagnosis of malignancies. Objective: To determine the diagnostic value of vascular endothelial growth factor (VEGF), carbohydrate antigen 19-9 (CA 19-9), and carcinoembryonic antigen (CEA) in patients with pancreatic cancer and the risk factors of vascular invasion. Methods: An experimental group comprising 52 patients with pancreatic cancer admitted to our department from July 2021 to July 2022 and a control group comprising 21 patients with benign pancreatic diseases during the same period were included in our study. Their serum VEGF, CA 19-9, and CEA levels were detected and compared between the two groups, and the correlation between the three markers in the invaded vessel and non-invaded vessel groups was investigated. The diagnostic value of a single tumor marker and in combination for pancreatic cancer was analyzed, and the three tumor marker levels of the experimental group in different pathological characteristics were detected and compared. Results: The experimental group had higher serum VEGF, CA 19-9, and CEA levels than the control group (P < 0.05). Through a receiver operating characteristic (ROC) curve analysis, the combined detection had the highest value for the diagnosis of pancreatic cancer, in which the area under the curve (AUC) was 0.9158 (95% CI: 0.8415–0.9900), while the sensitivity and specificity were 76.19% and 98.08%, respectively. Serum VEGF and CA 19-9 levels were higher in stage III–IV pancreatic cancer patients and those with tumor metastasis compared with stage I–II patients and those without metastasis (P < 0.05), respectively. Binary logistic regression analysis was performed to determine the risk factors of vascular invasion in pancreatic cancer, and the results showed that only serum VEGF was a risk factor (P < 0.05), OR (95% CI): 1.001–1.006. Conclusion: Patients with pancreatic cancer have significantly higher serum VEGF, CA 19-9, and CEA levels, and the combined detection of tumor markers is of high clinical value in its diagnosis. In addition, serum VEGF is an independent risk factor of vascular invasion in pancreatic cancer, which can predict vascular invasion to a certain extent.
{"title":"Study on the diagnostic value of VEGF, CA19-9 and CEA in pancreatic cancer and the risk factors of vascular invasion","authors":"Anke Chen, Yong Chen","doi":"10.26689/jcnr.v7i2.4723","DOIUrl":"https://doi.org/10.26689/jcnr.v7i2.4723","url":null,"abstract":"Background: Pancreatic cancer is a malignant tumor of the gastrointestinal tract. Due to its insidious onset, most patients with newly diagnosed pancreatic cancer have missed the opportunity for radical surgery, which offers patients the best chance of survival. The 5-year survival rate of patients with pancreatic cancer can be improved with early diagnosis, and serum tumor makers are an inexpensive and convenient diagnostic tool that is widely used in the diagnosis of malignancies. Objective: To determine the diagnostic value of vascular endothelial growth factor (VEGF), carbohydrate antigen 19-9 (CA 19-9), and carcinoembryonic antigen (CEA) in patients with pancreatic cancer and the risk factors of vascular invasion. Methods: An experimental group comprising 52 patients with pancreatic cancer admitted to our department from July 2021 to July 2022 and a control group comprising 21 patients with benign pancreatic diseases during the same period were included in our study. Their serum VEGF, CA 19-9, and CEA levels were detected and compared between the two groups, and the correlation between the three markers in the invaded vessel and non-invaded vessel groups was investigated. The diagnostic value of a single tumor marker and in combination for pancreatic cancer was analyzed, and the three tumor marker levels of the experimental group in different pathological characteristics were detected and compared. Results: The experimental group had higher serum VEGF, CA 19-9, and CEA levels than the control group (P < 0.05). Through a receiver operating characteristic (ROC) curve analysis, the combined detection had the highest value for the diagnosis of pancreatic cancer, in which the area under the curve (AUC) was 0.9158 (95% CI: 0.8415–0.9900), while the sensitivity and specificity were 76.19% and 98.08%, respectively. Serum VEGF and CA 19-9 levels were higher in stage III–IV pancreatic cancer patients and those with tumor metastasis compared with stage I–II patients and those without metastasis (P < 0.05), respectively. Binary logistic regression analysis was performed to determine the risk factors of vascular invasion in pancreatic cancer, and the results showed that only serum VEGF was a risk factor (P < 0.05), OR (95% CI): 1.001–1.006. Conclusion: Patients with pancreatic cancer have significantly higher serum VEGF, CA 19-9, and CEA levels, and the combined detection of tumor markers is of high clinical value in its diagnosis. In addition, serum VEGF is an independent risk factor of vascular invasion in pancreatic cancer, which can predict vascular invasion to a certain extent.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43477364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To optimize the magnetic resonance imaging (MRI) detection process in view of the COVID-19 pandemic, standardize and strengthen the infection control and management MRI rooms. Methods: According to the Technical Guide for COVID-19 Prevention and Control in Medical Institutions (3rd Edition), with reference to the current COVID-19 infection control plan, there are three aspects involved in the planning of MRI examination: MRI room management, medical staff management and protection, and patient management, especially the use of full plastic nose strip medical masks. Infection prevention measures are formulated, scientific prevention and control are made, and accurate policies are implemented. Results: MRI examination was carried out according to the infection control and management of MRI room plan during the epidemic, so as to ensure the safety of examination, the safety of patients and the safety of medical staff and no cross infection in hospital. Conclusion: The implementation of proper infection prevention measures during MRI examination in light of COVID-19 ensures that patients wear medical surgical masks with full plastic nose strips throughout the process to avoid cross-infection, ensure the safety of doctors and patients, and maintain the health of the population.
{"title":"The Infection Control Measures Taken in MRI Examination During the COVID-19 Pandemic Prevention and Control Period","authors":"Xinying Zhang, Hangfeng Ying, Qin Yan, Minghui Zhao","doi":"10.26689/jcnr.v7i1.4702","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4702","url":null,"abstract":"Objective: To optimize the magnetic resonance imaging (MRI) detection process in view of the COVID-19 pandemic, standardize and strengthen the infection control and management MRI rooms. Methods: According to the Technical Guide for COVID-19 Prevention and Control in Medical Institutions (3rd Edition), with reference to the current COVID-19 infection control plan, there are three aspects involved in the planning of MRI examination: MRI room management, medical staff management and protection, and patient management, especially the use of full plastic nose strip medical masks. Infection prevention measures are formulated, scientific prevention and control are made, and accurate policies are implemented. Results: MRI examination was carried out according to the infection control and management of MRI room plan during the epidemic, so as to ensure the safety of examination, the safety of patients and the safety of medical staff and no cross infection in hospital. Conclusion: The implementation of proper infection prevention measures during MRI examination in light of COVID-19 ensures that patients wear medical surgical masks with full plastic nose strips throughout the process to avoid cross-infection, ensure the safety of doctors and patients, and maintain the health of the population.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47845897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the effect of psychological nursing combined with biofeedback on the rehabilitation of patients with anxiety disorder. Methods: 100 patients with anxiety disorders in our hospital from January to December 2021 were randomly divided into two groups: control group (n = 50) and study group (n = 50). The control group was given routine nursing, while the study group was given psychological nursing combined with biofeedback. The changes of self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score, symptom score, and quality of life of the two groups were compared before and after nursing. Results: Before nursing, there was no significant difference in the scores of SAS and SDS between the two groups, but after nursing, the scores of SAS and SDS in the study group were lower than those in the control group, and the degree of improvement in the study group was higher than that of the control group. Before nursing, there was no significant difference in the scores of symptoms between the two groups (P > 0.05), but after nursing, the scores of stress, crying spells, tremor, and general discomfort in the study group were lower than those of the control group (P < 0.05). Besides, before nursing, there was no significant difference in the quality of life between the two groups (P > 0.05), but after nursing, the scores of physical function, psychological activity, social ability, and material life in the study group were higher than those in the control group (P < 0.05). Moreover, the degree of improvement after nursing in the study group was better than that of the control group. Conclusion: Psychological nursing combined with biofeedback to promote the rehabilitation of patients with anxiety disorder effectively improves the negative emotion of patients, reduces stress, depression, tremor, and general discomfort, and improve the overall quality of life. Therefore, it is worth further popularization.
{"title":"Psychological Nursing Combined with Biofeedback to Promote the Rehabilitation of Patients with Anxiety Disorder","authors":"Xianzhu Yang","doi":"10.26689/jcnr.v7i1.4698","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4698","url":null,"abstract":"Objective: To explore the effect of psychological nursing combined with biofeedback on the rehabilitation of patients with anxiety disorder. Methods: 100 patients with anxiety disorders in our hospital from January to December 2021 were randomly divided into two groups: control group (n = 50) and study group (n = 50). The control group was given routine nursing, while the study group was given psychological nursing combined with biofeedback. The changes of self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score, symptom score, and quality of life of the two groups were compared before and after nursing. Results: Before nursing, there was no significant difference in the scores of SAS and SDS between the two groups, but after nursing, the scores of SAS and SDS in the study group were lower than those in the control group, and the degree of improvement in the study group was higher than that of the control group. Before nursing, there was no significant difference in the scores of symptoms between the two groups (P > 0.05), but after nursing, the scores of stress, crying spells, tremor, and general discomfort in the study group were lower than those of the control group (P < 0.05). Besides, before nursing, there was no significant difference in the quality of life between the two groups (P > 0.05), but after nursing, the scores of physical function, psychological activity, social ability, and material life in the study group were higher than those in the control group (P < 0.05). Moreover, the degree of improvement after nursing in the study group was better than that of the control group. Conclusion: Psychological nursing combined with biofeedback to promote the rehabilitation of patients with anxiety disorder effectively improves the negative emotion of patients, reduces stress, depression, tremor, and general discomfort, and improve the overall quality of life. Therefore, it is worth further popularization.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48958499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marfan syndrome is a rare genetic disease, and the condition of most patients deteriorates with age. The lesions are mainly cardiovascular, skeletal, and ocular lesions. Its clinical manifestations are characterized by congenital heart disease, ectopic lens, slender body, slender limbs, spider fingers (toes), and general muscle dysplasia. In the early stage of this disease, when the symptoms are not yet clearly manifested, some patients came to the hospital for treatment due to decreased vision. According to the particularity of crystal dislocation patients with Marfan syndrome, this article provides home nursing education in terms of physiological and psychological aspects, and builds an effective home nursing model to promote the physical and mental recovery of patients.
{"title":"Summary of Home Nursing for Lens Dislocation Among Patients with Marfan Syndrome","authors":"Jingyu He, Xiaojin Liu, Huili Jiang","doi":"10.26689/jcnr.v7i1.4704","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4704","url":null,"abstract":"Marfan syndrome is a rare genetic disease, and the condition of most patients deteriorates with age. The lesions are mainly cardiovascular, skeletal, and ocular lesions. Its clinical manifestations are characterized by congenital heart disease, ectopic lens, slender body, slender limbs, spider fingers (toes), and general muscle dysplasia. In the early stage of this disease, when the symptoms are not yet clearly manifested, some patients came to the hospital for treatment due to decreased vision. According to the particularity of crystal dislocation patients with Marfan syndrome, this article provides home nursing education in terms of physiological and psychological aspects, and builds an effective home nursing model to promote the physical and mental recovery of patients.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48646841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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