Objective: To explore the diagnostic value of conventional ultrasonography combined with contrast-enhanced ultrasonography in thyroid nodules. Methods: From June 2021 to July 2022, 163 patients with thyroid nodules enrolled in our hospital were selected as research subjects. After pathological diagnosis, 24 cases were malignant thyroid nodules, and 139 cases were benign thyroid nodules. The diagnosis rate of malignant and benign thyroid nodules was observed and analyzed, with 95% CI. Results: Among them, the malignant and benign detection rates of routine ultrasound were 88.63% and 75.00%, respectively, and the malignant and benign detection rates of contrast-enhanced ultrasound were 81.82% and 81.25%, respectively. The malignant and benign detection rates of conventional ultrasound combined with contrast-enhanced ultrasound were 93.18% and 87.50%, respectively, and the 95% CI was greater than 0.7. Conclusion: Conventional ultrasound combined with contrast-enhanced ultrasound can help improve the diagnostic accuracy of benign and malignant thyroid nodules and reduce the misdiagnosis rate.
{"title":"Diagnostic Value and Misdiagnosis Analysis of Conventional Ultrasonography Combined with Contrast-Enhanced Ultrasonography in Thyroid Nodules","authors":"Meiqing He, Xixi Zhang, Hui Li, Tianshu Wang","doi":"10.26689/jcnr.v7i1.4703","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4703","url":null,"abstract":"Objective: To explore the diagnostic value of conventional ultrasonography combined with contrast-enhanced ultrasonography in thyroid nodules. Methods: From June 2021 to July 2022, 163 patients with thyroid nodules enrolled in our hospital were selected as research subjects. After pathological diagnosis, 24 cases were malignant thyroid nodules, and 139 cases were benign thyroid nodules. The diagnosis rate of malignant and benign thyroid nodules was observed and analyzed, with 95% CI. Results: Among them, the malignant and benign detection rates of routine ultrasound were 88.63% and 75.00%, respectively, and the malignant and benign detection rates of contrast-enhanced ultrasound were 81.82% and 81.25%, respectively. The malignant and benign detection rates of conventional ultrasound combined with contrast-enhanced ultrasound were 93.18% and 87.50%, respectively, and the 95% CI was greater than 0.7. Conclusion: Conventional ultrasound combined with contrast-enhanced ultrasound can help improve the diagnostic accuracy of benign and malignant thyroid nodules and reduce the misdiagnosis rate.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43379181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To systematically evaluate the relationship between herpes simplex virus type II (HSV-2) infection in pregnant women and the adverse pregnancy outcomes (preterm delivery, spontaneous abortion, stillbirth, monstrum, low birth weight, intrauterine growth retardation, premature rupture of membranes), so as to provide clinical guidance for the prevention and treatment of adverse pregnancy outcomes caused by HSV-2 infection in pregnant women. Methods: 2140 articles were collected from PubMed, China National Knowledge Infrastructure (CNKI), and other databases for the past 20 years. According to the inclusion criteria, the literatures about the relationship between HSV-2 infection of pregnant women and adverse pregnancy outcomes were screened. The effect model was determined by heterogeneity test results, and the meta-analysis was carried out by RevMan 5.3 software. Results: The results of meta-analysis showed that the positive rate of HSV-2 was higher in the adverse pregnancy group than in the control group (odds ratio [OR]: 7.92, 95% confidence interval [Cl]: 3.91–16.01), and the difference was statistically significant. Conclusion: HSV-2 infection will increase the risk of adverse pregnancy outcomes. Prevention and effective control of HSV-2 infection in early pregnancy can reduce the rate of adverse pregnancy outcome, which is of great significance to the promotion of eugenics.
{"title":"A Meta-Analysis on the Correlation Between Herpes Simplex Virus Type II Infection and Adverse Pregnancy Outcomes in China","authors":"Li Wang, Yurong Zhang, Xin Wang","doi":"10.26689/jcnr.v7i1.4571","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4571","url":null,"abstract":"Objective: To systematically evaluate the relationship between herpes simplex virus type II (HSV-2) infection in pregnant women and the adverse pregnancy outcomes (preterm delivery, spontaneous abortion, stillbirth, monstrum, low birth weight, intrauterine growth retardation, premature rupture of membranes), so as to provide clinical guidance for the prevention and treatment of adverse pregnancy outcomes caused by HSV-2 infection in pregnant women. Methods: 2140 articles were collected from PubMed, China National Knowledge Infrastructure (CNKI), and other databases for the past 20 years. According to the inclusion criteria, the literatures about the relationship between HSV-2 infection of pregnant women and adverse pregnancy outcomes were screened. The effect model was determined by heterogeneity test results, and the meta-analysis was carried out by RevMan 5.3 software. Results: The results of meta-analysis showed that the positive rate of HSV-2 was higher in the adverse pregnancy group than in the control group (odds ratio [OR]: 7.92, 95% confidence interval [Cl]: 3.91–16.01), and the difference was statistically significant. Conclusion: HSV-2 infection will increase the risk of adverse pregnancy outcomes. Prevention and effective control of HSV-2 infection in early pregnancy can reduce the rate of adverse pregnancy outcome, which is of great significance to the promotion of eugenics.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49456002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper elaborates the core and essence of situation, background, assessment, recommendation (SBAR) communication model, clarify the application status of SBAR communication model in the clinical teaching of nursing students, and describe its effectiveness and limitations, so as to provide reference for improving clinical nursing teaching ability.
{"title":"Practical Progress of SBAR Communication Model-Related Teaching in Clinical Teaching","authors":"Xu Liu, Mei Ma, Chenfei Qu, Chun-Hui Liu, Yan Yin","doi":"10.26689/jcnr.v7i1.4688","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4688","url":null,"abstract":"This paper elaborates the core and essence of situation, background, assessment, recommendation (SBAR) communication model, clarify the application status of SBAR communication model in the clinical teaching of nursing students, and describe its effectiveness and limitations, so as to provide reference for improving clinical nursing teaching ability.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47920605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anxiety is a common disease in the modern society which significantly affects people’s daily lives and function, thus it has become an increasingly highlighted issue. Anxiety is regulated by neural circuits in the brain. Therefore, the basal mechanism of anxiety has been studied, especially research based on the related neural circuits. For a long time, due to the limitations of science and technology, there was no breakthrough in research regarding anxiety. However, in recent years, due to the progress of technology, the research on anxiety neural circuits has made great progress. For example, the interaction among various brain regions, such as the central nucleus of the amygdala (CeA), the ventral tegmental area (VTA), the ventral hippocampus (vHPC), and so on. This article focuses on three brain regions: including BLA, BNST, and VTA, and illustrate their different roles and mechanisms in regulating anxiety. On this basis, this intensive study of anxiety will further promote the progress of anxiety research and provide therapeutic targets for the related treatment.
{"title":"Research Progress on Mechanisms in Regulating Anxiety-Related Neural Circuits","authors":"Mengzhen Chen","doi":"10.26689/jcnr.v7i1.4573","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4573","url":null,"abstract":"Anxiety is a common disease in the modern society which significantly affects people’s daily lives and function, thus it has become an increasingly highlighted issue. Anxiety is regulated by neural circuits in the brain. Therefore, the basal mechanism of anxiety has been studied, especially research based on the related neural circuits. For a long time, due to the limitations of science and technology, there was no breakthrough in research regarding anxiety. However, in recent years, due to the progress of technology, the research on anxiety neural circuits has made great progress. For example, the interaction among various brain regions, such as the central nucleus of the amygdala (CeA), the ventral tegmental area (VTA), the ventral hippocampus (vHPC), and so on. This article focuses on three brain regions: including BLA, BNST, and VTA, and illustrate their different roles and mechanisms in regulating anxiety. On this basis, this intensive study of anxiety will further promote the progress of anxiety research and provide therapeutic targets for the related treatment.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47389687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As a “non-curable” disease, Alzheimer’s disease (AD) is the most common neurodegenerative disease in the aged population. Physical and mental pain exerts on every AD patient and their families. Even though there is no worldwide approved treatment against AD now, researchers have never given up on investigating and exploring potential approaches for curing AD. Gene therapy and drug treatment arise for alleviating AD symptoms. This paper illustrates the pathological mechanism of AD and focuses on the role of autophagy in AD pathology. Autophagy is a self-degrading mechanism to clear out dysfunctional cells; abnormal autophagy can directly trigger AD. This paper summarizes the effective and novel therapeutic approaches to treating AD by promoting autophagy activity, as well as AD diagnosis and assessment from early to severe stage, which provides promising approaches for researchers who are interested in AD treatments and feasible directions for science translational medicine.
{"title":"Analysis of Alzheimer’s Disease: From Pathological Mechanism to Therapeutic Approach in Autophagy","authors":"Qiaoqiao Zhang","doi":"10.26689/jcnr.v7i1.4566","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4566","url":null,"abstract":"As a “non-curable” disease, Alzheimer’s disease (AD) is the most common neurodegenerative disease in the aged population. Physical and mental pain exerts on every AD patient and their families. Even though there is no worldwide approved treatment against AD now, researchers have never given up on investigating and exploring potential approaches for curing AD. Gene therapy and drug treatment arise for alleviating AD symptoms. This paper illustrates the pathological mechanism of AD and focuses on the role of autophagy in AD pathology. Autophagy is a self-degrading mechanism to clear out dysfunctional cells; abnormal autophagy can directly trigger AD. This paper summarizes the effective and novel therapeutic approaches to treating AD by promoting autophagy activity, as well as AD diagnosis and assessment from early to severe stage, which provides promising approaches for researchers who are interested in AD treatments and feasible directions for science translational medicine.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48364649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The effectiveness of vitamin C in the prevention and treatment of pediatric upper respiratory tract infections was evaluated in a meta-analysis. Methods: A total 2,573 children with upper respiratory tract infections were included in the meta-analysis, 1,280 of whom received vitamin C and 1,293 who received control medication. The analysis of findings related to the studies included was done through random or fixed effects model to determine whether vitamin C supplementation could stop and control upper respiratory tract infections in children using mean difference (MD) with 95% confidence intervals (CIs). Results: On average, vitamin C-treated children had fewer upper respiratory tract infection bouts, their illness lasted shorter (MD -0.84; 95% CI -1.47 to -0.20, P = 0.009), and they were less contagious than the control. Conclusions: The number of episodes and illness duration of upper respiratory tract-infected pediatric subjects were considerably reduced in the intervention group (vitamin C) compared to the control. Due to the small sample size in four of 11 studies and the limited number of studies included for comparison, the outcomes should be carefully examined.
{"title":"A Meta-Analysis of the Effectiveness of Vitamin C in the Prevention and Treatment of Childhood Upper Respiratory Tract Infections","authors":"Haitham Saeed, Mohamed E A Abdelrahim","doi":"10.26689/jcnr.v7i1.4403","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4403","url":null,"abstract":"Background: The effectiveness of vitamin C in the prevention and treatment of pediatric upper respiratory tract infections was evaluated in a meta-analysis. Methods: A total 2,573 children with upper respiratory tract infections were included in the meta-analysis, 1,280 of whom received vitamin C and 1,293 who received control medication. The analysis of findings related to the studies included was done through random or fixed effects model to determine whether vitamin C supplementation could stop and control upper respiratory tract infections in children using mean difference (MD) with 95% confidence intervals (CIs). Results: On average, vitamin C-treated children had fewer upper respiratory tract infection bouts, their illness lasted shorter (MD -0.84; 95% CI -1.47 to -0.20, P = 0.009), and they were less contagious than the control. Conclusions: The number of episodes and illness duration of upper respiratory tract-infected pediatric subjects were considerably reduced in the intervention group (vitamin C) compared to the control. Due to the small sample size in four of 11 studies and the limited number of studies included for comparison, the outcomes should be carefully examined.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43712998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polycystic ovary syndrome (PCOS) is an endocrine disorder caused by hypothalamic-pituitary-ovarian (HPO) axis dysfunction. In the field of gynecology and reproduction, PCOS has emerged as both a research hot spot and a challenging area of study. According to Chinese medicine, this disease is related to kidney deficiency, phlegm and dampness obstruction, blood stasis and interconnection, Chong pulse impassability, the lack of Ren pulse, and the loss of uterine nourishment, all of which affect the normal development and maturation of eggs as well as the duration at which menstrual blood stores. In this paper, based on the theoretical basis of “liver collects blood, regulates the flow of qi, and is the master of drainage,” we explore the rationality of the treatment of this disease from the perspective of “liver and kidney have the same origin” and the development of PCOS-related infertility in relation to dysfunctional internal organs. We also explore the feasibility of treatment from the perspective of “liver and kidney homology,” expand the ideas for treatment, as well as develop and innovate the application of organ identification in PCOS in relation to infertility.
{"title":"Polycystic Ovary Syndrome-Related Infertility Based on the Theory of “Liver and Kidney Homology”","authors":"M. Dong, Hongli Zhu","doi":"10.26689/jcnr.v7i1.4346","DOIUrl":"https://doi.org/10.26689/jcnr.v7i1.4346","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is an endocrine disorder caused by hypothalamic-pituitary-ovarian (HPO) axis dysfunction. In the field of gynecology and reproduction, PCOS has emerged as both a research hot spot and a challenging area of study. According to Chinese medicine, this disease is related to kidney deficiency, phlegm and dampness obstruction, blood stasis and interconnection, Chong pulse impassability, the lack of Ren pulse, and the loss of uterine nourishment, all of which affect the normal development and maturation of eggs as well as the duration at which menstrual blood stores. In this paper, based on the theoretical basis of “liver collects blood, regulates the flow of qi, and is the master of drainage,” we explore the rationality of the treatment of this disease from the perspective of “liver and kidney have the same origin” and the development of PCOS-related infertility in relation to dysfunctional internal organs. We also explore the feasibility of treatment from the perspective of “liver and kidney homology,” expand the ideas for treatment, as well as develop and innovate the application of organ identification in PCOS in relation to infertility.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46378884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the efficacy of botulinum toxin type A combined with nanofat in the treatment of facial rejuvenation. Methods: from January 2020 to January 2021, 20 patients with facial wrinkles in our hospital (The First Affiliated Hospital of Dalian Medical University) were treated with botulinum toxin type A combined with nanofat, and the effect, duration and complications were observed. Results: After 1, 3 and 6 months of injection, the effective rates were 90%, 75% and 40%, respectively; there was no occurrence of postoperative infection, fat mass, granuloma, and other adverse reactions. Conclusion: Botulinum toxin type A combined with nanofat filling has a clear therapeutic effect in the facial rejuvenation treatment, and can improve the skin texture while improving wrinkles, which is worthy of further popularization and application in clinic.
{"title":"Clinical Observation of Botulinum Toxin Type A Combined with Nanofat in Facial Rejuvenation Treatment","authors":"Xi Yang, Hongzhi Qin","doi":"10.26689/jcnr.v6i6.4537","DOIUrl":"https://doi.org/10.26689/jcnr.v6i6.4537","url":null,"abstract":"Objective: To investigate the efficacy of botulinum toxin type A combined with nanofat in the treatment of facial rejuvenation. Methods: from January 2020 to January 2021, 20 patients with facial wrinkles in our hospital (The First Affiliated Hospital of Dalian Medical University) were treated with botulinum toxin type A combined with nanofat, and the effect, duration and complications were observed. Results: After 1, 3 and 6 months of injection, the effective rates were 90%, 75% and 40%, respectively; there was no occurrence of postoperative infection, fat mass, granuloma, and other adverse reactions. Conclusion: Botulinum toxin type A combined with nanofat filling has a clear therapeutic effect in the facial rejuvenation treatment, and can improve the skin texture while improving wrinkles, which is worthy of further popularization and application in clinic.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45951114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Liu, Jing Wang, Hongli Wu, Yuxiang Hang, Lingling Gong
Objective: To investigate the risk factors of postpartum cardiovascular disease in patients with gestational diabetes mellitus (GDM). Methods: From December 2020 to December 2021, pregnant women who underwent 75-g oral glucose tolerance test (OGTT) between 24 and 28 weeks of gestation and were diagnosed with GDM were selected as the research subjects. These women were followed-up after delivery. Results: The average fasting plasma glucose (FPG) levels of these women were 6.25 ± 1.36 mmol/L before discharge and 5.01 ± 1.45 mmol/L at 42 days after delivery; the average 2-hour plasma glucose (2hPG) levels were 11.23 ± 2.01 mmol/L before discharge and 7.98 ± 1.23 mmol/L at 42 days after delivery; the average insulin levels were 8.36 ± 1.98 mmol/L before discharge and 2.98 ± 1.36 mmol/L at 42 days after delivery. There were 46 patients with postpartum cardiovascular disease, with an incidence rate of 22.89%. Conclusion: By improving the postpartum management of patients, the weight of GDM patients can be better controlled, their insulin sensitivity can be increased, and the occurrence of glucose and lipid metabolism disorders can be reduced.
{"title":"Risk Factors of Postpartum Cardiovascular Disease in Patients with Gestational Diabetes Mellitus","authors":"W. Liu, Jing Wang, Hongli Wu, Yuxiang Hang, Lingling Gong","doi":"10.26689/jcnr.v6i6.4393","DOIUrl":"https://doi.org/10.26689/jcnr.v6i6.4393","url":null,"abstract":"Objective: To investigate the risk factors of postpartum cardiovascular disease in patients with gestational diabetes mellitus (GDM). Methods: From December 2020 to December 2021, pregnant women who underwent 75-g oral glucose tolerance test (OGTT) between 24 and 28 weeks of gestation and were diagnosed with GDM were selected as the research subjects. These women were followed-up after delivery. Results: The average fasting plasma glucose (FPG) levels of these women were 6.25 ± 1.36 mmol/L before discharge and 5.01 ± 1.45 mmol/L at 42 days after delivery; the average 2-hour plasma glucose (2hPG) levels were 11.23 ± 2.01 mmol/L before discharge and 7.98 ± 1.23 mmol/L at 42 days after delivery; the average insulin levels were 8.36 ± 1.98 mmol/L before discharge and 2.98 ± 1.36 mmol/L at 42 days after delivery. There were 46 patients with postpartum cardiovascular disease, with an incidence rate of 22.89%. Conclusion: By improving the postpartum management of patients, the weight of GDM patients can be better controlled, their insulin sensitivity can be increased, and the occurrence of glucose and lipid metabolism disorders can be reduced.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42532125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To understand the pathogenic bacteria isolated from patients and their drug resistance changes in general ICU of the Affiliated Hospital of Hebei University, so as to provide reference for appropriate selection of antibiotics in clinical practice. Methods: A retrospective investigation was conducted to analyze the bacteriological distribution and drug resistance of nosocomial pathogens isolated from the specimens of hospitalized patients in the comprehensive ICU of the hospital from 2019 to 2021. The US technology BD Phoenix 100 automatic bacterial identification analyzer was used for bacterial identification of the pathogen samples, disk diffusion method was used for drug susceptibility test, and SPSS 22.0 software was used to analyze the trend of drug resistance. Results: A total of 970 strains of nosocomial pathogens were detected in the three years. The main pathogens were Acinetobacter baumannii (133 strains, 13.71%), Klebsiella pneumoniae (106 strains, 10.93%), Pseudomonas aeruginosa (83 strains, 8.56%), Escherichia coli (76 strains, 7.84%) and Enterococcus faecium (69 strains, 7.11%). The resistance rate of Acinetobacter baumannii to antibiotics was high. Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli had low resistance rates to carbapenems. The situation of bacterial drug resistance is still serious. Conclusion: The drug resistance of pathogenic bacteria collected from Class III Grade A Hospital’s patients to antibiotics was generally high. Therefore, clinical departments should strengthen the inspection of specimens of infection and drug sensitivity test in order to grasp the resistance mechanisms and drug resistance of pathogenic bacteria changes, and select appropriate antimicrobial agents according to the test results. Besides, the formation of drug-resistant strains also needs to be prevented, and the treatment of patients with severe infection needs to be improved.
{"title":"Analysis on Distribution and Drug Resistance of Pathogenic Bacteria in ICU Patients with Nosocomial Infection from 2019 to 2021","authors":"Yamei Wang, Xinwen Zhang","doi":"10.26689/jcnr.v6i6.4436","DOIUrl":"https://doi.org/10.26689/jcnr.v6i6.4436","url":null,"abstract":"Objective: To understand the pathogenic bacteria isolated from patients and their drug resistance changes in general ICU of the Affiliated Hospital of Hebei University, so as to provide reference for appropriate selection of antibiotics in clinical practice. Methods: A retrospective investigation was conducted to analyze the bacteriological distribution and drug resistance of nosocomial pathogens isolated from the specimens of hospitalized patients in the comprehensive ICU of the hospital from 2019 to 2021. The US technology BD Phoenix 100 automatic bacterial identification analyzer was used for bacterial identification of the pathogen samples, disk diffusion method was used for drug susceptibility test, and SPSS 22.0 software was used to analyze the trend of drug resistance. Results: A total of 970 strains of nosocomial pathogens were detected in the three years. The main pathogens were Acinetobacter baumannii (133 strains, 13.71%), Klebsiella pneumoniae (106 strains, 10.93%), Pseudomonas aeruginosa (83 strains, 8.56%), Escherichia coli (76 strains, 7.84%) and Enterococcus faecium (69 strains, 7.11%). The resistance rate of Acinetobacter baumannii to antibiotics was high. Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli had low resistance rates to carbapenems. The situation of bacterial drug resistance is still serious. Conclusion: The drug resistance of pathogenic bacteria collected from Class III Grade A Hospital’s patients to antibiotics was generally high. Therefore, clinical departments should strengthen the inspection of specimens of infection and drug sensitivity test in order to grasp the resistance mechanisms and drug resistance of pathogenic bacteria changes, and select appropriate antimicrobial agents according to the test results. Besides, the formation of drug-resistant strains also needs to be prevented, and the treatment of patients with severe infection needs to be improved.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43055142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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