Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB00441.X
H. Diederichsen, K. Riisom, I. Andersen
By means of indirect immunofluorescence microscopy, a peripheral fluorescence reaction with hepatocytes was found, surrounding the entire cell, with sera from patients with cancer and acute hepatitis and from normal blood donors. It was proved that this reaction was not related to bile canaliculi, contrary to bile canaliculi antibody demonstrated previously from patients with chronic active liver disease. By using fluorescein-conjugated anti-human IgG, the reaction with the periphery of the hepatocytes was produced to a more or less pronounced degree with almost all sera studied. The reaction seems not to be directed against contractile proteins on the liver cell membrane as only a minor part of these sera had also IgG smooth-muscle antibody, and anti actomyosin antibody obtained by affinity chromatografy did not react with the hepatocyte. When applying fluorescein-conjugated anti-human IgM the reaction with the periphery of the hepatocytes was observed in one fourth of the patients with acute hepatitis and only sera which contained also IgM smooth-muscle antibody.
{"title":"Peripheral immunofluorescence of hepatocytes. Relation to smooth muscle antibodies and bile canaliculi.","authors":"H. Diederichsen, K. Riisom, I. Andersen","doi":"10.1111/J.1699-0463.1977.TB00441.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00441.X","url":null,"abstract":"By means of indirect immunofluorescence microscopy, a peripheral fluorescence reaction with hepatocytes was found, surrounding the entire cell, with sera from patients with cancer and acute hepatitis and from normal blood donors. It was proved that this reaction was not related to bile canaliculi, contrary to bile canaliculi antibody demonstrated previously from patients with chronic active liver disease. By using fluorescein-conjugated anti-human IgG, the reaction with the periphery of the hepatocytes was produced to a more or less pronounced degree with almost all sera studied. The reaction seems not to be directed against contractile proteins on the liver cell membrane as only a minor part of these sera had also IgG smooth-muscle antibody, and anti actomyosin antibody obtained by affinity chromatografy did not react with the hepatocyte. When applying fluorescein-conjugated anti-human IgM the reaction with the periphery of the hepatocytes was observed in one fourth of the patients with acute hepatitis and only sera which contained also IgM smooth-muscle antibody.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"95 1","pages":"399-404"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75455886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00081.X
J. Jørgensen
During the first 2 days post-partum there is a rapid fall in the uterine renin content of the rabbit. A similar loss of renin can be reproduced in vitro when pregnant and post-partum and to a lesser degree non-pregnant uterine tissue slices are incubated at pH 7.4 at 37 degrees C. When a secondary incubation of these previously incubated preparations is performed at pH 4.8 an activation of renin is seen. There was not an inverse correlation between the amounts of renin lost during the primary incubation at pH 7.4 and the amounts of renin activated during the secondary incubation at pH 4.8. In similarly incubated preparations of kidney cortex, where only a small per cent of the initial renin content is lost during the primary incubation at pH 7.4, no activatable renin is seen.
{"title":"Acid activation of renin in rabbit uterus.","authors":"J. Jørgensen","doi":"10.1111/J.1699-0463.1976.TB00081.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00081.X","url":null,"abstract":"During the first 2 days post-partum there is a rapid fall in the uterine renin content of the rabbit. A similar loss of renin can be reproduced in vitro when pregnant and post-partum and to a lesser degree non-pregnant uterine tissue slices are incubated at pH 7.4 at 37 degrees C. When a secondary incubation of these previously incubated preparations is performed at pH 4.8 an activation of renin is seen. There was not an inverse correlation between the amounts of renin lost during the primary incubation at pH 7.4 and the amounts of renin activated during the secondary incubation at pH 4.8. In similarly incubated preparations of kidney cortex, where only a small per cent of the initial renin content is lost during the primary incubation at pH 7.4, no activatable renin is seen.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"53 1","pages":"123-9"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78726264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/j.1699-0463.1977.tb00433.x
H. Moe
The acute effect of vinblastine sulphate at a dosage of 0.2 mg per 100 g body weight on ameloblasts in the progress of differentiation in rat incisors, and the ability of these cells to develop into secretory ameloblasts after exposure to the drug, were studied under the light microscope. In the early stages of differentiation (exclusively dividing cells) no changes were seen. In more advanced stages of differentiation the cell apices were altered and the nuclei normally placed near the cell base were located at all levels in the ameloblast layer. These changes were reversible and the cells developed into secretory ameloblasts of normal appearance and function. Ameloblasts in the most advanced stage of differentiation in which secretion had begun were severely damaged, and the mature secretory ameloblast population derived from these cells was decimated and produced enamel matrix with abnormal structure. It is concluded that differentiating ameloblasts are relatively invulnerable to vinblastine, whereas in secretory ameloblasts the organelles directly engaged in the secretory processes are particularly exposed to damage from the drug.
{"title":"On the effect of vinblastine on ameloblasts of rat incisors in vivo. 3. Acute and protracted effect on differentiating ameloblasts. A light microscopical study.","authors":"H. Moe","doi":"10.1111/j.1699-0463.1977.tb00433.x","DOIUrl":"https://doi.org/10.1111/j.1699-0463.1977.tb00433.x","url":null,"abstract":"The acute effect of vinblastine sulphate at a dosage of 0.2 mg per 100 g body weight on ameloblasts in the progress of differentiation in rat incisors, and the ability of these cells to develop into secretory ameloblasts after exposure to the drug, were studied under the light microscope. In the early stages of differentiation (exclusively dividing cells) no changes were seen. In more advanced stages of differentiation the cell apices were altered and the nuclei normally placed near the cell base were located at all levels in the ameloblast layer. These changes were reversible and the cells developed into secretory ameloblasts of normal appearance and function. Ameloblasts in the most advanced stage of differentiation in which secretion had begun were severely damaged, and the mature secretory ameloblast population derived from these cells was decimated and produced enamel matrix with abnormal structure. It is concluded that differentiating ameloblasts are relatively invulnerable to vinblastine, whereas in secretory ameloblasts the organelles directly engaged in the secretory processes are particularly exposed to damage from the drug.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"27 1","pages":"330-4"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80224229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00112.X
A. Sima, B. Brådvik
The first case of central pontine myelinolysis in Scandinavia is presented. A premortem diagnosis was established on the basis of the history of chronic alcoholism, the picture of severe electrolyte disturbance and the development of the neurological syndrome. The postmortem findings verified the clinical diagnosis. A possible aetiological mechanism is postulated. The cause is believed to be a damage to the energy dependent electrolyte transport across the cell membrane, resulting in a cytotoxic oedema and death of the oligodendroglial cells of the brainstem which are particularly vulnerable.
{"title":"Central pontine myelinolysis. A case report.","authors":"A. Sima, B. Brådvik","doi":"10.1111/J.1699-0463.1976.TB00112.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00112.X","url":null,"abstract":"The first case of central pontine myelinolysis in Scandinavia is presented. A premortem diagnosis was established on the basis of the history of chronic alcoholism, the picture of severe electrolyte disturbance and the development of the neurological syndrome. The postmortem findings verified the clinical diagnosis. A possible aetiological mechanism is postulated. The cause is believed to be a damage to the energy dependent electrolyte transport across the cell membrane, resulting in a cytotoxic oedema and death of the oligodendroglial cells of the brainstem which are particularly vulnerable.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"29 1","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81882961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00398.X
J. Andersen
This paper demonstrates lobular involvement of two morphological different types: Lobular carcinoma in situ and carcinomatous extension to the lobule in 70 non-selected cases of invasive breast carcinoma. Carcinomatous involvement of the lobules was found in 34 cases. In 16 of these cases, it was not possible to distinguish the lobular changes morphologically from lobular carcinoma in situ whereas, in 13 cases, carcinomatous extension to the lobules was found. In 5 cases the type of carcinomatous involvement of the lobules could not be established with certainty. In the 16 cases with lobular carcinoma in situ, 5 of the lesions were found at the edge of the invasive carcinoma, 4 were completely outside the tumour area, and in 7 cases the lesions were found both at the edge and completely outside the tumour area. In 59 per cent of cases the lesions were multicentric. Thirteen of the 16 cases presented lobular carcinoma in situ also in the upper quadrants. The diameter of the tumour was not related to the occurrence of lobular carcinoma in situ or to carcinomatous extension to the lobules. On the other hand, lobular carcinoma in situ was most frequent in highly differentiated carcinomas. A more detailed study of the biology of lobular carcinoma in situ, associated with invasive breast carcinoma, is considered necessary.
{"title":"Invasive breast carcinoma with lobular involvement. Frequency and location of lobular carcinoma in situ.","authors":"J. Andersen","doi":"10.1111/J.1699-0463.1974.TB00398.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00398.X","url":null,"abstract":"This paper demonstrates lobular involvement of two morphological different types: Lobular carcinoma in situ and carcinomatous extension to the lobule in 70 non-selected cases of invasive breast carcinoma. Carcinomatous involvement of the lobules was found in 34 cases. In 16 of these cases, it was not possible to distinguish the lobular changes morphologically from lobular carcinoma in situ whereas, in 13 cases, carcinomatous extension to the lobules was found. In 5 cases the type of carcinomatous involvement of the lobules could not be established with certainty. In the 16 cases with lobular carcinoma in situ, 5 of the lesions were found at the edge of the invasive carcinoma, 4 were completely outside the tumour area, and in 7 cases the lesions were found both at the edge and completely outside the tumour area. In 59 per cent of cases the lesions were multicentric. Thirteen of the 16 cases presented lobular carcinoma in situ also in the upper quadrants. The diameter of the tumour was not related to the occurrence of lobular carcinoma in situ or to carcinomatous extension to the lobules. On the other hand, lobular carcinoma in situ was most frequent in highly differentiated carcinomas. A more detailed study of the biology of lobular carcinoma in situ, associated with invasive breast carcinoma, is considered necessary.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"174 1","pages":"719-729"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79645302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00400.X
Johan A. Andersen
In 52 cases of lobular carcinoma in situ of the breast (LCIS) without simultaneous invasive carcinoma, the actual lesion and the adjacent breast tissue were evaluated histologically and the findings related to the overall occurrence of invasive breast carcinoma. No single histological parameter appeared to any significant degree in cases with invasive carcinoma, whereas, in a few instances, this was the case when certain parameters were found concurrently. However, with our present knowledge, the result of a histological subclassification of LCIS cannot be decisive in the choice of treatment. Out of the 52 cases, 49 had fibro-adenomatosis concurrently; of these, 6 were of a high degree of severity, 4 had fibroadenoma, 1 had papilloma, 8 had ductectasia, 5 non-specific mastitis and 2 fat necrosis. Only occasionally was intracellular mucin found in cases of LCIS, whereas PAS-positive material was frequent. In a few cases very large mast cells were seen in the adjacent stroma, but the significance of this finding remains unclarified.
{"title":"Lobular carcinoma in situ. A histological study of 52 cases.","authors":"Johan A. Andersen","doi":"10.1111/J.1699-0463.1974.TB00400.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00400.X","url":null,"abstract":"In 52 cases of lobular carcinoma in situ of the breast (LCIS) without simultaneous invasive carcinoma, the actual lesion and the adjacent breast tissue were evaluated histologically and the findings related to the overall occurrence of invasive breast carcinoma. No single histological parameter appeared to any significant degree in cases with invasive carcinoma, whereas, in a few instances, this was the case when certain parameters were found concurrently. However, with our present knowledge, the result of a histological subclassification of LCIS cannot be decisive in the choice of treatment. Out of the 52 cases, 49 had fibro-adenomatosis concurrently; of these, 6 were of a high degree of severity, 4 had fibroadenoma, 1 had papilloma, 8 had ductectasia, 5 non-specific mastitis and 2 fat necrosis. Only occasionally was intracellular mucin found in cases of LCIS, whereas PAS-positive material was frequent. In a few cases very large mast cells were seen in the adjacent stroma, but the significance of this finding remains unclarified.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"56 1","pages":"735-741"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79733352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB03872.X
F. Melsen, H. E. Nielsen
Morphometric and dynamic studies of bone obtained by biopsy from a standard locality on the iliac crest were carried out in 10 patients with and 7 patients without radiological signs of osteonecrosis. All the patients had normally functioning kidney transplants. The results obtained in the two groups were compared and both groups were compared with a series of noraml subjects where the age and sex distribution was the same. In the group of patients with osteonecrosis, the reduction in the amount of cancellous bone was found to be highly significant as compared with that in normal subjects and with that in the other group of patients. Apart from the reduction in bone, changes in all patients were characterized by an increased amount of osteoid and a low rate of mineralization, determined by double labelling with tetracycline. As there were no changes in the width of osteoid seams indicating osteomalacia, it is suggested that these patients suffered from a severe corticosteroid osteopenia.
{"title":"Osteonecrosis following renal allotransplantation. A quantitative histological study of iliac bone.","authors":"F. Melsen, H. E. Nielsen","doi":"10.1111/J.1699-0463.1977.TB03872.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB03872.X","url":null,"abstract":"Morphometric and dynamic studies of bone obtained by biopsy from a standard locality on the iliac crest were carried out in 10 patients with and 7 patients without radiological signs of osteonecrosis. All the patients had normally functioning kidney transplants. The results obtained in the two groups were compared and both groups were compared with a series of noraml subjects where the age and sex distribution was the same. In the group of patients with osteonecrosis, the reduction in the amount of cancellous bone was found to be highly significant as compared with that in normal subjects and with that in the other group of patients. Apart from the reduction in bone, changes in all patients were characterized by an increased amount of osteoid and a low rate of mineralization, determined by double labelling with tetracycline. As there were no changes in the width of osteoid seams indicating osteomalacia, it is suggested that these patients suffered from a severe corticosteroid osteopenia.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"38 1","pages":"99-104"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91288341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB03850.X
P. Petersen
A modified method for cutting thin section for electron microscopic studies from tissue rich in lipid is presented. Cutting procedure was performed at 8°(C) and results in flat sections and larger areas sectioned. Liver biopsy specimens from 9 patients with fatty liver are studied. A highly varied morphology of the lipid vacuoles is revealed. Droplets with triglyceride, vacuoles emptied of fat, some with a fine network and a capsule like arrangement, and transition stages between the two patterns are studied electron microscopically and histochemically by OTAN and Oil Red O staining. In some of the droplets small, dense granules of varied size and morphology are found.
提出了一种从富含脂肪的组织中切割薄片用于电镜研究的改进方法。切割过程在8°(C)下进行，结果是平坦的切片和更大面积的切片。对9例脂肪肝患者的肝活检标本进行了研究。脂泡形态变化很大。通过OTAN和Oil Red O染色，在电镜和组织化学上研究了甘油三酯液滴，空泡脂肪，一些具有精细的网络和胶囊状排列，以及两种模式之间的过渡阶段。在一些液滴中发现了大小和形态各异的小而致密的颗粒。
{"title":"Lipid droplets in fatty liver. An electron microscopic study on ultrasections obtained by a new cutting technique.","authors":"P. Petersen","doi":"10.1111/J.1699-0463.1974.TB03850.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB03850.X","url":null,"abstract":"A modified method for cutting thin section for electron microscopic studies from tissue rich in lipid is presented. Cutting procedure was performed at 8°(C) and results in flat sections and larger areas sectioned. Liver biopsy specimens from 9 patients with fatty liver are studied. A highly varied morphology of the lipid vacuoles is revealed. Droplets with triglyceride, vacuoles emptied of fat, some with a fine network and a capsule like arrangement, and transition stages between the two patterns are studied electron microscopically and histochemically by OTAN and Oil Red O staining. In some of the droplets small, dense granules of varied size and morphology are found.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"35 1","pages":"255-63"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85069186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1981.TB00223.X
N. Ho, K. Lauritsen, Christiansen La
Examination of the antral G-cell density, acid secretion and fasting levels of serum-gastrin were carried out on 20 patients with prepyloric ulcer (within 2 cm of the pyloric ring) and 76 patients with duodenal bulb ulcer. No difference was found in respect to the G-cell density between the group of prepyloric and that with duodenal bulb ulcer, although a lower pentagastrin stimulated acid output and consequently a smaller parietal cell mass appeared to be present in the first group as compared to the second. No relationship was found in either group between fasting levels of serum-gastrin and G-cell density, suggesting that no constant relationship exists between G-cell density and activity under basal conditions. A positive relationship, although statistically insignificant (0.05 less than P less than 0.1) between peak acid output and G-cell density in patients with duodenal bulb ulcer, indicates that in these patients the parietal cell mass and G-cell density are interrelated. The present study could not confirm the entity of antral G-cell hyperplasia in duodenal ulcer patients.
对20例幽门前溃疡(距幽门环2 cm以内)患者和76例十二指肠球部溃疡患者进行胃窦g细胞密度、胃酸分泌及空腹血清胃泌素水平检测。幽门前溃疡组和十二指肠球部溃疡组之间的g细胞密度没有差异，尽管与第二组相比，第一组的胃酸分泌量较低，因此壁细胞团较小。两组空腹血清胃泌素水平与g细胞密度之间均未发现相关性，提示在基础条件下g细胞密度与活性之间不存在恒定的关系。十二指肠球部溃疡患者的峰值酸输出量与g细胞密度呈显著正相关，但差异无统计学意义(0.05 < P < 0.1)，说明十二指肠球部溃疡患者的壁细胞质量与g细胞密度相关。本研究不能证实十二指肠溃疡患者是否存在胃窦g细胞增生。
{"title":"The antral gastrin-producing cells in duodenal ulcer patients. Study of the relationship between G-cell density, gastric acid secretion and fasting serum-gastrin.","authors":"N. Ho, K. Lauritsen, Christiansen La","doi":"10.1111/J.1699-0463.1981.TB00223.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00223.X","url":null,"abstract":"Examination of the antral G-cell density, acid secretion and fasting levels of serum-gastrin were carried out on 20 patients with prepyloric ulcer (within 2 cm of the pyloric ring) and 76 patients with duodenal bulb ulcer. No difference was found in respect to the G-cell density between the group of prepyloric and that with duodenal bulb ulcer, although a lower pentagastrin stimulated acid output and consequently a smaller parietal cell mass appeared to be present in the first group as compared to the second. No relationship was found in either group between fasting levels of serum-gastrin and G-cell density, suggesting that no constant relationship exists between G-cell density and activity under basal conditions. A positive relationship, although statistically insignificant (0.05 less than P less than 0.1) between peak acid output and G-cell density in patients with duodenal bulb ulcer, indicates that in these patients the parietal cell mass and G-cell density are interrelated. The present study could not confirm the entity of antral G-cell hyperplasia in duodenal ulcer patients.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"13 1","pages":"293-296"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82372656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00379.X
T. Berge
{"title":"Splenic metastases. Frequencies and patterns.","authors":"T. Berge","doi":"10.1111/J.1699-0463.1974.TB00379.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00379.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"43 1","pages":"499-506"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82625580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：