Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00388.X
A. Myking, A. Abro
Particles with morphological features similar to mouse leukaemia virus have been detected in a transplant of Ehrlich's ascites carcinoma (EAC) and in two reticulum cell neoplasms (RCN) of histological type B. One RCN arose in a mouse subsequent to inoculation with vital EAC cells; the other, in a sham-treated mouse. The virus is considered a possible agent causing enhanced development of reticulum cell neoplasms.
{"title":"Particles similar to mouse leukaemia virus in Ehrlich's ascites carcinoma and in reticulum cell noeplasms type B. An electron microscopic study in mice.","authors":"A. Myking, A. Abro","doi":"10.1111/J.1699-0463.1974.TB00388.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00388.X","url":null,"abstract":"Particles with morphological features similar to mouse leukaemia virus have been detected in a transplant of Ehrlich's ascites carcinoma (EAC) and in two reticulum cell neoplasms (RCN) of histological type B. One RCN arose in a mouse subsequent to inoculation with vital EAC cells; the other, in a sham-treated mouse. The virus is considered a possible agent causing enhanced development of reticulum cell neoplasms.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"5 1","pages":"571-7"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89147385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1970.TB02520.X
T. Lund, S. Olsen
Two cases of dark-brown or black discoloration of the human kidney are described and the condition compared with two previously reported cases. The abnormal colour is due to a deposition of brown pigment in the epithelium of the proximal tubules. The staining properties and histochemistry of the pigment granules seem to allow identification of the pigment as a lipofuscin. In one case the patient is still alive and the condition does not seeto have had any harmful effect on kidney function. This abnormality seems to be extremely rare. It is perhaps analogous to the disease, “Black Kidney” in cattle.
{"title":"Idiopathic renal lipofuscinosis. Two cases.","authors":"T. Lund, S. Olsen","doi":"10.1111/J.1699-0463.1970.TB02520.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1970.TB02520.X","url":null,"abstract":"Two cases of dark-brown or black discoloration of the human kidney are described and the condition compared with two previously reported cases. The abnormal colour is due to a deposition of brown pigment in the epithelium of the proximal tubules. The staining properties and histochemistry of the pigment granules seem to allow identification of the pigment as a lipofuscin. In one case the patient is still alive and the condition does not seeto have had any harmful effect on kidney function. This abnormality seems to be extremely rare. It is perhaps analogous to the disease, “Black Kidney” in cattle.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"106 1","pages":"414-20"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79037109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1981.TB00222.X
I. Dahl, B. Hagmar, L. Angervall
Leiomyosarcoma of the soft tissues is a well-defined and characteristic entity histologically but correlative cytomorphological studies are lacking. A correlative histological and cytological study of 11 cases is presented. The leiomyosarcomas were characterized histologically by elongated tumour cells arranged in bundles intersecting each other at wide angles. The nuclei were elongated and often blunt-ended, tending to be aligned in tandem-position or in rows. The smears from leiomyosarcoma were poor in tumour cells and most cells were arranged in clusters of strands. The characteristic blunt-ended cells and nuclei of leiomyosarcoma could be identified in the smears and the nuclei were focally arranged in rows and sometimes in parallel. Nuclear atypia permits diagnosis of malignancy, although the atypia was generally not very pronounced. We consider that a knowledge of the corresponding histological features is mandatory for differentiating cytologically between various soft tissue sarcomas, including leiomyosarcomas. Further correlative cytological and histological studies of other soft tissue sarcomas are necessary for a more valid interpretation of the smears from leiomyosarcomas.
{"title":"Leiomyosarcoma of the soft tissue. A correlative cytological and histological study of 11 cases.","authors":"I. Dahl, B. Hagmar, L. Angervall","doi":"10.1111/J.1699-0463.1981.TB00222.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00222.X","url":null,"abstract":"Leiomyosarcoma of the soft tissues is a well-defined and characteristic entity histologically but correlative cytomorphological studies are lacking. A correlative histological and cytological study of 11 cases is presented. The leiomyosarcomas were characterized histologically by elongated tumour cells arranged in bundles intersecting each other at wide angles. The nuclei were elongated and often blunt-ended, tending to be aligned in tandem-position or in rows. The smears from leiomyosarcoma were poor in tumour cells and most cells were arranged in clusters of strands. The characteristic blunt-ended cells and nuclei of leiomyosarcoma could be identified in the smears and the nuclei were focally arranged in rows and sometimes in parallel. Nuclear atypia permits diagnosis of malignancy, although the atypia was generally not very pronounced. We consider that a knowledge of the corresponding histological features is mandatory for differentiating cytologically between various soft tissue sarcomas, including leiomyosarcomas. Further correlative cytological and histological studies of other soft tissue sarcomas are necessary for a more valid interpretation of the smears from leiomyosarcomas.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"283 1","pages":"285-91"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79582218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00361.X
B. Hagmar
{"title":"MCG101-AA, a new ascites tumour in C57 mice. 2. Protocol of vivo transplantation studies in comparison with the solid (SS) and solid ascites (AS) tumours.","authors":"B. Hagmar","doi":"10.1111/J.1699-0463.1974.TB00361.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00361.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"22 10","pages":"369-78"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91515432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB03877.X
K. Nørredam
Among 7763 autopsies performed in Greater Copenhagen in 1973, there were 309 cases of cirrhosis of the liver and 52 cases of primary carcinoma of the liver (PCL). Of the latter, 45 were hepatocellular carcinoma (HCC), 4 combined HCC and cholangiocarcinoma (CCC) and 3 CCC. HCC was found in 7.8 per cent of the cirrhotic livers and was in 57.1 per cent accompagnied by cirrhosis. The criteria of WHO, Peters (modified) and Anthony were used for classification. The degree of differentiation of the tumours was estimated using the criteria of WHO and Edmondson. The apparently small number of CCC may be due to the fact that this tumour is often overdiagnosed at the expense of HCC. The incidence of combined tumours is probably higher than generally assumed. The reticulin stain was found very valuable in HCC, both for descriptive and diagnostic purposes. In contrast to the situation in sub-Saharan Africa where hepatitis B virus is incriminated as the most important etiologic factor of HCC, it was found in the present study that alcoholism was a very essential cause of cirrhosis and thereby of HCC.
{"title":"Primary carcinoma of the liver. A histological study of 27 cases of primary carcinoma of the liver from Malawi.","authors":"K. Nørredam","doi":"10.1111/J.1699-0463.1977.TB03877.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB03877.X","url":null,"abstract":"Among 7763 autopsies performed in Greater Copenhagen in 1973, there were 309 cases of cirrhosis of the liver and 52 cases of primary carcinoma of the liver (PCL). Of the latter, 45 were hepatocellular carcinoma (HCC), 4 combined HCC and cholangiocarcinoma (CCC) and 3 CCC. HCC was found in 7.8 per cent of the cirrhotic livers and was in 57.1 per cent accompagnied by cirrhosis. The criteria of WHO, Peters (modified) and Anthony were used for classification. The degree of differentiation of the tumours was estimated using the criteria of WHO and Edmondson. The apparently small number of CCC may be due to the fact that this tumour is often overdiagnosed at the expense of HCC. The incidence of combined tumours is probably higher than generally assumed. The reticulin stain was found very valuable in HCC, both for descriptive and diagnostic purposes. In contrast to the situation in sub-Saharan Africa where hepatitis B virus is incriminated as the most important etiologic factor of HCC, it was found in the present study that alcoholism was a very essential cause of cirrhosis and thereby of HCC.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"32 1","pages":"461-469"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75617732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB03831.X
J. Rygaard
{"title":"Skin grafts in nude mice. 3. Fate of grafts from man and donors of other taxonomic classes.","authors":"J. Rygaard","doi":"10.1111/J.1699-0463.1974.TB03831.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB03831.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"8 1","pages":"105-12"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88249075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1971.TB00506.X
P. Heimann, G. Hansson, Oiov Nilssonl
A 47-year-old man with clinical manifestations of hyperparathyroidism was shown to have a parathyroid adenoma which in light-microscopy chiefly consists of oxyphilic cells and transitional forms of chief cells and oxyphilic cells. Electron-microscopy shows that the oxyphilic cells contain tightly packed mitochondria and that the transitory cells are rich in mitochondria. In these latter cells there are signs of stimulated protein synthesis. It is probable that these cells produce the excess of parathyroid hormone. Oxyphilic cells would seem to be developed from the chief cells.
{"title":"Primary Hyperparathyroidism In a case of Oxyphilic Adenoma","authors":"P. Heimann, G. Hansson, Oiov Nilssonl","doi":"10.1111/J.1699-0463.1971.TB00506.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1971.TB00506.X","url":null,"abstract":"A 47-year-old man with clinical manifestations of hyperparathyroidism was shown to have a parathyroid adenoma which in light-microscopy chiefly consists of oxyphilic cells and transitional forms of chief cells and oxyphilic cells. Electron-microscopy shows that the oxyphilic cells contain tightly packed mitochondria and that the transitory cells are rich in mitochondria. In these latter cells there are signs of stimulated protein synthesis. It is probable that these cells produce the excess of parathyroid hormone. Oxyphilic cells would seem to be developed from the chief cells.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"56 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88224021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB03823.X
M. Jorgensen
{"title":"A stereological study of intrahepatic bile ducts. 4. Congenital hepatic fibrosis.","authors":"M. Jorgensen","doi":"10.1111/J.1699-0463.1974.TB03823.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB03823.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"5 1","pages":"21-9"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84487203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB00456.X
L. Kindblom, P. Dalén, G. Edmar, H. Kjellbo
A 57-year-old man and a 70-year-old woman with relapsing polychondritis are reported. The man, suffering from arthralgias, respiratory obstruction, external ear and sanddle-nose deformities, conjunctivitis and irido-cyclitis, died after 4 years from airway obstruction because of tracheal and bronchial collapse. The woman is alive 8 months after the development of respiratory obstruction, probably caused by radiographically demonstrated tracheal obstruction, a saddle-nose deformity and hearing impairment. Microscopically, the involved cartilages showed degenerative and slight inflammatory changes and were eventually replaced by fibrous tissue. Histochemical studies, utilizing staining with Alcian blue at controlled electrolyte concentrations (Scott technique) and at controlled pH:s, with or without digestion with bacterial chondroitinase ABC; and staining with the PAS-method, with or without diastase digestion, revealed a complete or relative loss of glucosaminoglycans and glycogen. A biosynthetic defect is considered unlikely to be the primary pathogenetic mechanism of relapsing polychondritis. Histological and histochemical examination of biopsies from involved cartilages contribute to a definite diagnosis.
{"title":"Relapsing polychondritis. A clinical, pathologic-anatomic and histochemical study of 2 cases.","authors":"L. Kindblom, P. Dalén, G. Edmar, H. Kjellbo","doi":"10.1111/J.1699-0463.1977.TB00456.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00456.X","url":null,"abstract":"A 57-year-old man and a 70-year-old woman with relapsing polychondritis are reported. The man, suffering from arthralgias, respiratory obstruction, external ear and sanddle-nose deformities, conjunctivitis and irido-cyclitis, died after 4 years from airway obstruction because of tracheal and bronchial collapse. The woman is alive 8 months after the development of respiratory obstruction, probably caused by radiographically demonstrated tracheal obstruction, a saddle-nose deformity and hearing impairment. Microscopically, the involved cartilages showed degenerative and slight inflammatory changes and were eventually replaced by fibrous tissue. Histochemical studies, utilizing staining with Alcian blue at controlled electrolyte concentrations (Scott technique) and at controlled pH:s, with or without digestion with bacterial chondroitinase ABC; and staining with the PAS-method, with or without diastase digestion, revealed a complete or relative loss of glucosaminoglycans and glycogen. A biosynthetic defect is considered unlikely to be the primary pathogenetic mechanism of relapsing polychondritis. Histological and histochemical examination of biopsies from involved cartilages contribute to a definite diagnosis.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"1 1","pages":"656-64"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77710104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00089.X
K. Aspegren
Since mammary tumours and sarcomas in the rat both have been shown to be sensitive to steroid hormone in vitro, a search for a non-steroid sensitive rat tissue was made. Neonatal cerebellar medulloblasts in the rat did not respond to high concentrations of steroids if cultured as organ culture. The relevance of this finding to the specificity of steroid response assays in vitro is discussed.
{"title":"Specificity of hormonal responsiveness in vitro. Effect of sex steroids on non-malignant rat cells compared with the effect on cells from rat tumours.","authors":"K. Aspegren","doi":"10.1111/J.1699-0463.1976.TB00089.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00089.X","url":null,"abstract":"Since mammary tumours and sarcomas in the rat both have been shown to be sensitive to steroid hormone in vitro, a search for a non-steroid sensitive rat tissue was made. Neonatal cerebellar medulloblasts in the rat did not respond to high concentrations of steroids if cultured as organ culture. The relevance of this finding to the specificity of steroid response assays in vitro is discussed.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"60 1","pages":"198-200"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75398601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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