Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00362.X
B. Hagmar
{"title":"MCG101-AA, a new ascites tumour in C57 mice. 3. Studies of spontaneous metastasis formation from the resectable solid ascites tumour in comparison with the solid tumour of origin.","authors":"B. Hagmar","doi":"10.1111/J.1699-0463.1974.TB00362.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00362.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"554 1","pages":"379-85"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78922528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1970.TB02125.X
R. Heyden, I. Hägerstrand, F. Linell, G. Nordén, B. Åkesson, G. Ostberg
{"title":"Proliferative myositis. Report of two cases.","authors":"R. Heyden, I. Hägerstrand, F. Linell, G. Nordén, B. Åkesson, G. Ostberg","doi":"10.1111/J.1699-0463.1970.TB02125.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1970.TB02125.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"20 1","pages":"33-5"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83874954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB03875.X
M. Bojsen-Møller
Six cases of primary malignant melanoma of the leptomeninges and brain are reported. Three were diagnosed histologically at surgery, three at autopsy. Four presented as solitary brain tumours which is unusual compared to other reported cases. In all six there was infiltration of the leptomeninges which must be regarded as the site of origin. Three of the cases have had a relatively long survival, two of them have died 2 years after the operation, and the third patient is still alive 18 months after surgery. It is suggested that the frequency of these tumours is underestimated on account of their resemblance to astroblastomas and poorly differentiated astrocytomas, and because biopsies are not always taken from small and atypical haematomas.
{"title":"Primary cerebral melanomas. Report of six cases and a review of the literature.","authors":"M. Bojsen-Møller","doi":"10.1111/J.1699-0463.1977.TB03875.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB03875.X","url":null,"abstract":"Six cases of primary malignant melanoma of the leptomeninges and brain are reported. Three were diagnosed histologically at surgery, three at autopsy. Four presented as solitary brain tumours which is unusual compared to other reported cases. In all six there was infiltration of the leptomeninges which must be regarded as the site of origin. Three of the cases have had a relatively long survival, two of them have died 2 years after the operation, and the third patient is still alive 18 months after surgery. It is suggested that the frequency of these tumours is underestimated on account of their resemblance to astroblastomas and poorly differentiated astrocytomas, and because biopsies are not always taken from small and atypical haematomas.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"65 1","pages":"447-54"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76835771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00399.X
J. Andersen
During a follow-up period averaging 17 years (2–30 years), 64 breast tissue specimens were removed in 52 females with lobular carcinoma in situ of the breast (LCIS) before, simultaneous with or subsequent to the detection of LCIS. In 8 out of 25 cases the LCIS was bilateral, and in 9 out of 19 it was multicentric. The present study does not reveal the actual multicentric and bilateral appearance of LCIS, but the “spontaneous” appearance in a series of specimens which were not removed or investigated primarily with the object of detecting this breast disease.
{"title":"MULTICENTRIC AND BILATERAL APPEARANCE OF LOBULAR CARCINOMA IN SITU OF THE BREAST","authors":"J. Andersen","doi":"10.1111/J.1699-0463.1974.TB00399.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00399.X","url":null,"abstract":"During a follow-up period averaging 17 years (2–30 years), 64 breast tissue specimens were removed in 52 females with lobular carcinoma in situ of the breast (LCIS) before, simultaneous with or subsequent to the detection of LCIS. In 8 out of 25 cases the LCIS was bilateral, and in 9 out of 19 it was multicentric. The present study does not reveal the actual multicentric and bilateral appearance of LCIS, but the “spontaneous” appearance in a series of specimens which were not removed or investigated primarily with the object of detecting this breast disease.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"36 1","pages":"730-734"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76348342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1975.TB01886.X
J. Visfeldt, G. Jensen, E. Hippe
Results are presented of chromosome studies of bone marrow cells from a 62-year-old woman. The patient had been given 40 ml of Thorotrast in connection with a neuro-radiological examination 34 years earlier. Clinically, the patient was now considered to be in an incipient myeloid leucaemic phase. Ninety-seven per cent of the bone marrow cells belonged to a clone with characteristic marker chromosomes induced by radiation. Few data are available on chromosome analysis of bone marrow cells from Thorotrast patients. Therefore, the results of the present study are compared with data from chromosome analyses of 32P-treated patients with polycythaemia vera, in whom large clones were found in the bone marrow. The results of chromosome analysis of bone marrow cells from the Thorotrast patient support previous hypotheses concerning the carcinogenesis in radiation-induced leucaemia in patients with polycythaemia vera, treated with 32P. In the latter patients, the clone cells are pressumed to represent cell populations with selective qualities, originating from radiation-damaged cells, which possibly possess an increased tendency to malignant transformation because of a more pronounced sensitivity to carcinogenic agents. The cells might also be potentially malignant and manifest themselves as leucaemic cells, if the patient's immunological defence mechanism is broken.
{"title":"On thorotrast leucaemia. Evolution of clone of bone marrow cells with radiation-induced chromosome aberrations.","authors":"J. Visfeldt, G. Jensen, E. Hippe","doi":"10.1111/J.1699-0463.1975.TB01886.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1975.TB01886.X","url":null,"abstract":"Results are presented of chromosome studies of bone marrow cells from a 62-year-old woman. The patient had been given 40 ml of Thorotrast in connection with a neuro-radiological examination 34 years earlier. Clinically, the patient was now considered to be in an incipient myeloid leucaemic phase. Ninety-seven per cent of the bone marrow cells belonged to a clone with characteristic marker chromosomes induced by radiation. Few data are available on chromosome analysis of bone marrow cells from Thorotrast patients. Therefore, the results of the present study are compared with data from chromosome analyses of 32P-treated patients with polycythaemia vera, in whom large clones were found in the bone marrow. The results of chromosome analysis of bone marrow cells from the Thorotrast patient support previous hypotheses concerning the carcinogenesis in radiation-induced leucaemia in patients with polycythaemia vera, treated with 32P. In the latter patients, the clone cells are pressumed to represent cell populations with selective qualities, originating from radiation-damaged cells, which possibly possess an increased tendency to malignant transformation because of a more pronounced sensitivity to carcinogenic agents. The cells might also be potentially malignant and manifest themselves as leucaemic cells, if the patient's immunological defence mechanism is broken.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"18 1","pages":"373-8"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81727163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB03895.X
D. Hopwood, A. Nyfors
To determinate what damage occurred in the bile ducts of psoriatics receiving Methotrexate (MTX) therapy liver biopsies from 11 patients were studied with the light and electron microscope and compared with normal material. Thick sections (1 micrometer) showed light and dark cells in biliary epithelium and lipofuscin granules. At the ultrastructural level these were confirmed. The lumen of the bile ducts contained debris. The microvilli were decreased in number and damaged forms appeared. Damage to the biliary epithelial mitochondria was widespread and there were foci of intracellular oedema. The Golgi apparatus was hypertrophied and dilated. Atrophic cells were seen. The lateral intercellular spaces were dilated and contained debris and the basement membrane showed zones of duplication. Similar changes were found in the ducts of Hering.
{"title":"Liver ultrastructure in psoriatics related to methotrexate therapy. 2. Findings in bile ducts from 11 methotrexate treated psoriatics and 2 controls.","authors":"D. Hopwood, A. Nyfors","doi":"10.1111/J.1699-0463.1977.TB03895.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB03895.X","url":null,"abstract":"To determinate what damage occurred in the bile ducts of psoriatics receiving Methotrexate (MTX) therapy liver biopsies from 11 patients were studied with the light and electron microscope and compared with normal material. Thick sections (1 micrometer) showed light and dark cells in biliary epithelium and lipofuscin granules. At the ultrastructural level these were confirmed. The lumen of the bile ducts contained debris. The microvilli were decreased in number and damaged forms appeared. Damage to the biliary epithelial mitochondria was widespread and there were foci of intracellular oedema. The Golgi apparatus was hypertrophied and dilated. Atrophic cells were seen. The lateral intercellular spaces were dilated and contained debris and the basement membrane showed zones of duplication. Similar changes were found in the ducts of Hering.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"25 1","pages":"801-11"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89927954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00403.X
J. Jørgensen
In slices of pregnant and post partum rabbit uterus 80 per cent of the endogenous renin was gradually inactivated during incubation in vitro at 37°C for 44 hours. In slices of rabbit kidney only 30 per cent was inactivated. Contrary to this there was only a slight, inconsistent, decrease in renin content in similarly incubated homogenates and extracts of uterine and renal tissue. The results show that intact tissue from both the kidney and especially the uterus have a capacity for inactivation of renin.
{"title":"Renin inactivation in vitro in pregnant and post partum rabbit uterine and kidney tissue.","authors":"J. Jørgensen","doi":"10.1111/J.1699-0463.1974.TB00403.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00403.X","url":null,"abstract":"In slices of pregnant and post partum rabbit uterus 80 per cent of the endogenous renin was gradually inactivated during incubation in vitro at 37°C for 44 hours. In slices of rabbit kidney only 30 per cent was inactivated. Contrary to this there was only a slight, inconsistent, decrease in renin content in similarly incubated homogenates and extracts of uterine and renal tissue. The results show that intact tissue from both the kidney and especially the uterus have a capacity for inactivation of renin.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"44 1","pages":"760-6"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86130301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1981.TB00243.X
P. Vedtofte, E. Dabelsteen
The histological distribution of receptors for the lectins Wheat germ (WGA). Ricinus communis I (RCA I) and Soybean (SBA) was examined in ameloblastomas and normal oral mucosa from 12 patients. The study utilized fluorescein-conjugated WGA, RCA I and SBA. Cell-membrane bound receptors for these 3 lectins were demonstrated in the spinous cell layer of the normal oral mucosa. WGA and RCA I receptors were also located in the basal cell layer, whereas SBA receptors were not detectable there. Cell-membrane bound WGA receptors were shown in the epithelial cells of the ameloblastomas. Titrations showed significant differences in staining reactivity related to the morphology of the peripheral epithelial cells of the ameloblastomas. The distribution of RCA I and SBA receptors in the peripheral cells was also related to the morphology of these cells and was independent of the histological types of the tumours. It is suggested that the distribution of these receptors is related to cellular activities such as cell differentiation and cell migration in the tumour and therefore possibly reflects the biological behavior of the tumours.
{"title":"Receptors for the lectins wheat germ. Ricinus communis I and soybean in ameloblastomas and normal oral mucosa.","authors":"P. Vedtofte, E. Dabelsteen","doi":"10.1111/J.1699-0463.1981.TB00243.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00243.X","url":null,"abstract":"The histological distribution of receptors for the lectins Wheat germ (WGA). Ricinus communis I (RCA I) and Soybean (SBA) was examined in ameloblastomas and normal oral mucosa from 12 patients. The study utilized fluorescein-conjugated WGA, RCA I and SBA. Cell-membrane bound receptors for these 3 lectins were demonstrated in the spinous cell layer of the normal oral mucosa. WGA and RCA I receptors were also located in the basal cell layer, whereas SBA receptors were not detectable there. Cell-membrane bound WGA receptors were shown in the epithelial cells of the ameloblastomas. Titrations showed significant differences in staining reactivity related to the morphology of the peripheral epithelial cells of the ameloblastomas. The distribution of RCA I and SBA receptors in the peripheral cells was also related to the morphology of these cells and was independent of the histological types of the tumours. It is suggested that the distribution of these receptors is related to cellular activities such as cell differentiation and cell migration in the tumour and therefore possibly reflects the biological behavior of the tumours.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"16 1","pages":"439-49"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86163390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB00437.X
F. H. Sørensen
A quantitative examination including total and differential counts of nuclei and determination of total glomerular and mesangial areas was carried out in a consecutive series of biopsies from 14 patients with acute renal allograft rejections. The biopsies included in the study were taken within 4--30 days after transplantation because of suspected acute rejection, and histological examination revealed interstitial and vascular signs of rejection without the presence of cortical infarcts. Mesangial area per cent of total area was found to be significantly higher in allografts than in control kidneys, just as a statistically significant increase in the number of mesangial nuclei was demonstrated. Three of the 14 allografts had to be rechanges in these 3 biopsies were more pronounced than those in the remaining biopsies. It is suggested that quantitative glomerular studies might yield data of significance for prediction of the ultimate fate of the graft.
{"title":"A quantitative study of the renal corpuscles in acute renal allograft rejection.","authors":"F. H. Sørensen","doi":"10.1111/J.1699-0463.1977.TB00437.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00437.X","url":null,"abstract":"A quantitative examination including total and differential counts of nuclei and determination of total glomerular and mesangial areas was carried out in a consecutive series of biopsies from 14 patients with acute renal allograft rejections. The biopsies included in the study were taken within 4--30 days after transplantation because of suspected acute rejection, and histological examination revealed interstitial and vascular signs of rejection without the presence of cortical infarcts. Mesangial area per cent of total area was found to be significantly higher in allografts than in control kidneys, just as a statistically significant increase in the number of mesangial nuclei was demonstrated. Three of the 14 allografts had to be rechanges in these 3 biopsies were more pronounced than those in the remaining biopsies. It is suggested that quantitative glomerular studies might yield data of significance for prediction of the ultimate fate of the graft.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"23 1","pages":"367-72"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83266336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1975.TB00161.X
R. Albrechtsen, H. Jensen
Histochemical investigations of leucine aminopeptidase using LNA (L-leucyl-beta-napthylamide) as a substrate reveals a marked enzyme activity selectively localized to the granular layer with inconspicuous reaction in the stratum moleculare and the Purkinje cells in the rat cerebellum. The LNA-splitting enzyme differs from the well-known leucine aminopeptidase (LAP) by its optimum at pH 5.5. The necessary long incubation period used in the present study, and its focal precipitation of the enzyme reaction product in the same place, like acid phosphatases, in the granular layer, suggest a lysosomal localization. The functional role of the LNA-splitting enzyme has been discussed; it is considered that it is involved not only in the protein transformation for synaptic function, but may perhaps also play an important pathogenic role in necrosis, atrophy or even autolysis.
{"title":"Histochemical demonstration of an LNA-splitting enzyme in the cerebellum of the rat. A aminopeptidase-like reaction localized selectively in the granular layer with acid pH optimum.","authors":"R. Albrechtsen, H. Jensen","doi":"10.1111/J.1699-0463.1975.TB00161.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1975.TB00161.X","url":null,"abstract":"Histochemical investigations of leucine aminopeptidase using LNA (L-leucyl-beta-napthylamide) as a substrate reveals a marked enzyme activity selectively localized to the granular layer with inconspicuous reaction in the stratum moleculare and the Purkinje cells in the rat cerebellum. The LNA-splitting enzyme differs from the well-known leucine aminopeptidase (LAP) by its optimum at pH 5.5. The necessary long incubation period used in the present study, and its focal precipitation of the enzyme reaction product in the same place, like acid phosphatases, in the granular layer, suggest a lysosomal localization. The functional role of the LNA-splitting enzyme has been discussed; it is considered that it is involved not only in the protein transformation for synaptic function, but may perhaps also play an important pathogenic role in necrosis, atrophy or even autolysis.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"29 1","pages":"503-10"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83427963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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