Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1970.TB03515.X
Rolf Kåresen
Thyroiditis was induced in guinea-pigs by the injection of (NH4)2S04 purified thyroglobulin in complete Freund's adjuvant, and the development of the disease was studied at intervals between 5 and 40 days after immunization. Inflammatory reactions, varying from small focal to severe, confluent infiltrations, were observed. In inflamed areas the follicular cells were hypertrophied. In perfusion-fixed thyroids focal accumulations of leucocytes adherent to the vessel wall of capillaries and venules could be seen. Studies with fluorescein isothiocyanate conjugated anti-γ-globulin serum revealed that the inflammatory cells contained γ-globulin. In general the intensity of the fluorescence was moderate, but especially in the more severe forms of thyroiditis scattered strongly labelled cells were seen in the interstitium. In the electron microscope the leucocytes adhering to the vessel wall turned out to be almost exclusively lymphocytes in different stages of transformation, from small lymphocytes to immunoblasts. The transformed lymphocytes traversed the vessel wall through the endothelial cell cytoplasm, and not through the intercellular junctions. Most of the inflammatory cells in the interstitium were lymphocytes exhibiting the same continuous picture of transformation as intravascularly. Further differentiated cells, from the plasmablast, through the proplasmacyte to the mature plasma cell were, however, also found. The thyroid follicles and their lumina were invaded by leucocytes, mainly transformed lymphocytes, but also a few granulocytes. Some of the lymphocytes bulged deeply into the cytoplasm of the follicular cell, often indenting its nucleus, but true emperipolesis was not observed. Penetration of the leucocytes into the follicular lumina appeared to take place through the intercellular spaces. The only changes noted in the follicular cells were the hypertrophy and their occasional deformation by the lymphocytes.
{"title":"Experimental allergic thyroiditis in the guinea-pig. A light, fluorescence and electron microscopic study, with particular reference to the migration of lymphocytes through the vessel walls.","authors":"Rolf Kåresen","doi":"10.1111/J.1699-0463.1970.TB03515.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1970.TB03515.X","url":null,"abstract":"Thyroiditis was induced in guinea-pigs by the injection of (NH4)2S04 purified thyroglobulin in complete Freund's adjuvant, and the development of the disease was studied at intervals between 5 and 40 days after immunization. Inflammatory reactions, varying from small focal to severe, confluent infiltrations, were observed. In inflamed areas the follicular cells were hypertrophied. In perfusion-fixed thyroids focal accumulations of leucocytes adherent to the vessel wall of capillaries and venules could be seen. Studies with fluorescein isothiocyanate conjugated anti-γ-globulin serum revealed that the inflammatory cells contained γ-globulin. In general the intensity of the fluorescence was moderate, but especially in the more severe forms of thyroiditis scattered strongly labelled cells were seen in the interstitium. In the electron microscope the leucocytes adhering to the vessel wall turned out to be almost exclusively lymphocytes in different stages of transformation, from small lymphocytes to immunoblasts. The transformed lymphocytes traversed the vessel wall through the endothelial cell cytoplasm, and not through the intercellular junctions. Most of the inflammatory cells in the interstitium were lymphocytes exhibiting the same continuous picture of transformation as intravascularly. Further differentiated cells, from the plasmablast, through the proplasmacyte to the mature plasma cell were, however, also found. The thyroid follicles and their lumina were invaded by leucocytes, mainly transformed lymphocytes, but also a few granulocytes. Some of the lymphocytes bulged deeply into the cytoplasm of the follicular cell, often indenting its nucleus, but true emperipolesis was not observed. Penetration of the leucocytes into the follicular lumina appeared to take place through the intercellular spaces. The only changes noted in the follicular cells were the hypertrophy and their occasional deformation by the lymphocytes.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"4 1","pages":"625-48"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80630994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1971.TB01853.X
J. Visfeldt
{"title":"Primary polycythaemia. 2. Types of chromosome aberrations in 21 clones found in bone marrow samples from 50 patients.","authors":"J. Visfeldt","doi":"10.1111/J.1699-0463.1971.TB01853.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1971.TB01853.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"178 1","pages":"513-23"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79158772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB00401.X
J. Jørgensen
The content of renin in rabbit uterus is known to increase many fold during pregnancy followed by a rapid fall to normal levels within a few days after delivery. In order to study this mechanism the blood concentrations of renin and its substrate were measured. Contrary to the concentration of renin in uterus, the plasma renin concentrations were not increased either during pregnancy or in the post partum period. The renin-substrate concentration was unchanged during the first part of pregnancy but was increased 2–3-fold in the days around delivery. This increase resulted in a corresponding increase in plasma renin activity. It was concluded that the rapid inactivation of uterine renin post partum was due to a local inactivation and not to a release of renin to the blood.
{"title":"Concentrations of renin and renin substrate in plasma of rabbits during pregnancy and the post partum period.","authors":"J. Jørgensen","doi":"10.1111/J.1699-0463.1974.TB00401.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00401.X","url":null,"abstract":"The content of renin in rabbit uterus is known to increase many fold during pregnancy followed by a rapid fall to normal levels within a few days after delivery. In order to study this mechanism the blood concentrations of renin and its substrate were measured. Contrary to the concentration of renin in uterus, the plasma renin concentrations were not increased either during pregnancy or in the post partum period. The renin-substrate concentration was unchanged during the first part of pregnancy but was increased 2–3-fold in the days around delivery. This increase resulted in a corresponding increase in plasma renin activity. It was concluded that the rapid inactivation of uterine renin post partum was due to a local inactivation and not to a release of renin to the blood.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"20 1","pages":"742-6"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88942769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB00408.X
J. Moesner, P. Baunsgaard, H. Starklint, N. Thommesen
In a series of 18 patients with focal nodular hyperplasia of the liver characteristic histological changes were found in the lesion of 5 patients receiving female reproductive steroids, e.g, four women taking oral contraceptives for several years, and one man treated with synthetic estrogenic compound for carcinoma of the prostate. These lesions contained young, connective tissue septa with abundant proliferation of bile ducts, piecemeal necroses and lymphocytic infiltration. Much less or no activity, was found in the lesion of 11 women and 2 men without hormone treatment. Possible mechanisms for this activity are discussed, and it is proposed that focal nodular hyperplasia represents a congenital malformation, possibly a hamartoma, the liver cells of which may suffer from enzymatic defects, which may render them especially vulnerable to female sex hormones.
{"title":"Focal nodular hyperplasia of the liver. Possible influence of female reproductive steroids on the histological picture.","authors":"J. Moesner, P. Baunsgaard, H. Starklint, N. Thommesen","doi":"10.1111/J.1699-0463.1977.TB00408.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00408.X","url":null,"abstract":"In a series of 18 patients with focal nodular hyperplasia of the liver characteristic histological changes were found in the lesion of 5 patients receiving female reproductive steroids, e.g, four women taking oral contraceptives for several years, and one man treated with synthetic estrogenic compound for carcinoma of the prostate. These lesions contained young, connective tissue septa with abundant proliferation of bile ducts, piecemeal necroses and lymphocytic infiltration. Much less or no activity, was found in the lesion of 11 women and 2 men without hormone treatment. Possible mechanisms for this activity are discussed, and it is proposed that focal nodular hyperplasia represents a congenital malformation, possibly a hamartoma, the liver cells of which may suffer from enzymatic defects, which may render them especially vulnerable to female sex hormones.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"8 1","pages":"113-21"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75298223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00084.X
L. Kortelainen, L. Korhonen
Kurloff cells, characterized by a large inclusion body in ill-defined lymphoreticular cells, were induced in male guinea pigs by oestrogen administration. The inclusion body material was characterized by way of light- and electron microscopy and histochemical staining reactions. Nucleo-protein were not detected, but certian tests for amino acids were observed and, at the peripheral parts of the inclusion bodies, phospholipid tests were positive. However, forced proteolysis of lipid extractions failed to abolish the reactions for detection of carbohydrate-rich compounds in the inclusion bodies thus confirming that their main characteristics were those of glycoproteins. Series of histochemical tests demonstrated the presence of periodate-reactive 1, 2-glycol groups and sulphate radicals. Periodate-reactive material and sulphomucins represented two separate substances, as demonstrated by extractions and combined staining tests. Some characteristics common with chondroitin sulphates were observed but, on the other hand, the observed differences suggested a different type of sulphation. The inclusion body failed to show any hydrolytic, dehydrogenase or oxidative enzyme activities, thus being metabolically inactive, although the cells showed certain enzyme activities in their cytoplasm and cell organelles.
{"title":"Kurloff cells. 1. Histochemical characteristics of the Kurloff bodies.","authors":"L. Kortelainen, L. Korhonen","doi":"10.1111/J.1699-0463.1976.TB00084.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00084.X","url":null,"abstract":"Kurloff cells, characterized by a large inclusion body in ill-defined lymphoreticular cells, were induced in male guinea pigs by oestrogen administration. The inclusion body material was characterized by way of light- and electron microscopy and histochemical staining reactions. Nucleo-protein were not detected, but certian tests for amino acids were observed and, at the peripheral parts of the inclusion bodies, phospholipid tests were positive. However, forced proteolysis of lipid extractions failed to abolish the reactions for detection of carbohydrate-rich compounds in the inclusion bodies thus confirming that their main characteristics were those of glycoproteins. Series of histochemical tests demonstrated the presence of periodate-reactive 1, 2-glycol groups and sulphate radicals. Periodate-reactive material and sulphomucins represented two separate substances, as demonstrated by extractions and combined staining tests. Some characteristics common with chondroitin sulphates were observed but, on the other hand, the observed differences suggested a different type of sulphation. The inclusion body failed to show any hydrolytic, dehydrogenase or oxidative enzyme activities, thus being metabolically inactive, although the cells showed certain enzyme activities in their cytoplasm and cell organelles.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"43 1","pages":"143-53"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72878106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1974.TB03585.X
Rosenquist Jb
{"title":"Effects of supply and withdrawal of fluoride. Experimental studies on growing and adult rabbits. 6. The mineral content of microdissected fluorotic bone.","authors":"Rosenquist Jb","doi":"10.1111/J.1699-0463.1974.TB03585.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB03585.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"7 1","pages":"618-622"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74826309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00122.X
The frequency of carcinoids was studied in a 12-year-period (1958-1969) in Malmo, a town with a population of 220,000 at the beginning of the period and 250,000 at the end of it. Of all persons who had died in Malmo, 46 per cent were necropsied in the first year of the study and 70 per cent in the last (altogether 62.6 per cent). The series was examined in a uniform way at one department of pathology. Carcinoid tumours were found in 1.22 per cent (199 patients) of patients comprised in the entire necropsy series (16,294 autopsies). Bronchial carcinoid accounted for 0.1 percent, the remaining lesions were found in the digestive tract. About 90 per cent of the carcinoids were found incidentally at necropsy. During the same period, 44 carcinoids were diagnosed in surgical specimens examined in Malmo. The average annual frequency of carcinoid in the entire series was about 8.4 per 100,000 inhabitants, which is about 7 times as high as that recorded in the National Cancer Register applying to the whole of Sweden. The value of such country-wide reports is discussed. The carcinoid syndrome is extremely rare and was observed only once during the entire 12-year-period. The localization, frequency of metastases and sex-distribution of carcinoids are described and discussed in detail.
{"title":"Carcinoid tumours. Frequency in a defined population during a 12-year period.","authors":"","doi":"10.1111/J.1699-0463.1976.TB00122.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00122.X","url":null,"abstract":"The frequency of carcinoids was studied in a 12-year-period (1958-1969) in Malmo, a town with a population of 220,000 at the beginning of the period and 250,000 at the end of it. Of all persons who had died in Malmo, 46 per cent were necropsied in the first year of the study and 70 per cent in the last (altogether 62.6 per cent). The series was examined in a uniform way at one department of pathology. Carcinoid tumours were found in 1.22 per cent (199 patients) of patients comprised in the entire necropsy series (16,294 autopsies). Bronchial carcinoid accounted for 0.1 percent, the remaining lesions were found in the digestive tract. About 90 per cent of the carcinoids were found incidentally at necropsy. During the same period, 44 carcinoids were diagnosed in surgical specimens examined in Malmo. The average annual frequency of carcinoid in the entire series was about 8.4 per 100,000 inhabitants, which is about 7 times as high as that recorded in the National Cancer Register applying to the whole of Sweden. The value of such country-wide reports is discussed. The carcinoid syndrome is extremely rare and was observed only once during the entire 12-year-period. The localization, frequency of metastases and sex-distribution of carcinoids are described and discussed in detail.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"107 1","pages":"322-330"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85589813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00088.X
I. Dahl
A retrospective study of 57 patients with atypical fibroxanthoma of the skin is presented. The light microscopy is described and the differential diagnosis is discussed. Most of the atypical fibroxanthomas (32 out of 57 cases) were originally diagnosed as soft tissue sarcomas, e.g. fibrosarcoma, dermatofibrosarcoma, neurofibrosarcoma, myosarcoma and unspecified sarcoma. The tumour occurred chiefly in middle-aged and elderly patients; three patients were 15 years old or younger. The median age was 73 years in patients in whom the tumour occurred in the head and neck, and 34 years in patients in whom the tumour developed on the extremities and trunk. The sex ratio (male to female) was almost equal. Follow-up information about 43 patients was available. The follow-up period ranged from 1 year to 25 years with a median of 9 years. Eight patients died from intercurrent disease; all the other 35 patients are alive and well. The clinical course was benign in all but one patient in whom a recurrence developed and metastases to the regional lymph nodes appeared 7 years after the initial excision. The tumour in this case did not differ histologically from the other atypical fibroxanthomas with respect to cellularity, cellular and nuclear atypia or mitotic activity. It is suggested that the recurrence per se might be of prognostic importance.
{"title":"Atypical fibroxanthoma of the skin. A clinico-pathological study of 57 cases.","authors":"I. Dahl","doi":"10.1111/J.1699-0463.1976.TB00088.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00088.X","url":null,"abstract":"A retrospective study of 57 patients with atypical fibroxanthoma of the skin is presented. The light microscopy is described and the differential diagnosis is discussed. Most of the atypical fibroxanthomas (32 out of 57 cases) were originally diagnosed as soft tissue sarcomas, e.g. fibrosarcoma, dermatofibrosarcoma, neurofibrosarcoma, myosarcoma and unspecified sarcoma. The tumour occurred chiefly in middle-aged and elderly patients; three patients were 15 years old or younger. The median age was 73 years in patients in whom the tumour occurred in the head and neck, and 34 years in patients in whom the tumour developed on the extremities and trunk. The sex ratio (male to female) was almost equal. Follow-up information about 43 patients was available. The follow-up period ranged from 1 year to 25 years with a median of 9 years. Eight patients died from intercurrent disease; all the other 35 patients are alive and well. The clinical course was benign in all but one patient in whom a recurrence developed and metastases to the regional lymph nodes appeared 7 years after the initial excision. The tumour in this case did not differ histologically from the other atypical fibroxanthomas with respect to cellularity, cellular and nuclear atypia or mitotic activity. It is suggested that the recurrence per se might be of prognostic importance.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"37 1","pages":"183-197"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86160470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB00451.X
S. Fosså
: Histologically atypical urothelium taken from bladder mucosa neighbouring transitional cell carcinoma showed similar, though less marked, DNA-changes as observed in the corresponding tumours. A definite increase in the number of non-diploid DNA-values was found in 6 (of 12 urothelial specimens. The clinical significance of urothelial DNA-changes is discussed.
{"title":"DNA-VARIATIONS IN NEIGHBOURING EPITHELIUM IN PATIENTS WITH BLADDER CARCINOMA","authors":"S. Fosså","doi":"10.1111/J.1699-0463.1977.TB00451.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00451.X","url":null,"abstract":": Histologically atypical urothelium taken from bladder mucosa neighbouring transitional cell carcinoma showed similar, though less marked, DNA-changes as observed in the corresponding tumours. A definite increase in the number of non-diploid DNA-values was found in 6 (of 12 urothelial specimens. The clinical significance of urothelial DNA-changes is discussed.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"65 1","pages":"603-610"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82842496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1981.TB00221.X
L. Kindblom, A. Fassina
A clinical, light and electron microscopic study of four patients with angiolymphoid hyperplasia with eosinophilia of the skin is presented. Light-microscopically, the lesions were characterized by the small size and superficial location, the proliferation of mostly delicate vessels with prominent endothelial hyperplasia and cellular areas without distinct vessel structures, but with infiltrates of eosinophilic leukocytes, lymphocytes and plasma cells. Ultrastructurally, a marked proliferation of both endothelial cells and pericytes could be demonstrated and the solid cellular areas were shown to be composed of solid vascular buds. A multi-layered basal lamina was enclosing pericytes and external surfaces of endothelial cells. The differential diagnosis is discussed and it is emphasized that this lesion may be misinterpreted as angiosarcoma.
{"title":"Angiolymphoid hyperplasia with eosinophilia of the skin. Light microscopic and ultrastructural study of 4 cases.","authors":"L. Kindblom, A. Fassina","doi":"10.1111/J.1699-0463.1981.TB00221.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00221.X","url":null,"abstract":"A clinical, light and electron microscopic study of four patients with angiolymphoid hyperplasia with eosinophilia of the skin is presented. Light-microscopically, the lesions were characterized by the small size and superficial location, the proliferation of mostly delicate vessels with prominent endothelial hyperplasia and cellular areas without distinct vessel structures, but with infiltrates of eosinophilic leukocytes, lymphocytes and plasma cells. Ultrastructurally, a marked proliferation of both endothelial cells and pericytes could be demonstrated and the solid cellular areas were shown to be composed of solid vascular buds. A multi-layered basal lamina was enclosing pericytes and external surfaces of endothelial cells. The differential diagnosis is discussed and it is emphasized that this lesion may be misinterpreted as angiosarcoma.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"75 1","pages":"271-83"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87039780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：