Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00116.X
I. Dahl, L. Angervall, J. Säve‐Söderbergh
A case report of a girl with two foetal rhabdomyomas is presented. One tumour was a small cutaneous lesion present at birth in the left thigh and the other was located in the chest wall deeply in the subcutaneous tissue and attached to the adjacent intercostal muscle. The patient also had the naevoid basal cell carcinoma syndrome which lends credence to the opinion that foetal rhabdomyoma is a malformation rather than a true neoplasm.
{"title":"Foetal rhabdomyoma. Case report of a patient with two tumours.","authors":"I. Dahl, L. Angervall, J. Säve‐Söderbergh","doi":"10.1111/J.1699-0463.1976.TB00116.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00116.X","url":null,"abstract":"A case report of a girl with two foetal rhabdomyomas is presented. One tumour was a small cutaneous lesion present at birth in the left thigh and the other was located in the chest wall deeply in the subcutaneous tissue and attached to the adjacent intercostal muscle. The patient also had the naevoid basal cell carcinoma syndrome which lends credence to the opinion that foetal rhabdomyoma is a malformation rather than a true neoplasm.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"10 1","pages":"107-12"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79167137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00114.X
M. Järvinen
Vascular ingrowth into the injured area of a partially crushed gastrocnemius muscle was studied by micro-angiography 2 to 14 days after the trauma in 40 rats treated by mobilization or immobilization. In mobilized muscles, the sprouting of new capillaries occurred more rapidly and intensively than in injured muscles treated by immobilization. The sequence of events was found to be slightly delayed if mobilization was started after immobilization for two days. The speed and intensity of tissue repair, as studied histologically, was directly correlated with vascular ingrowth, especially during the first week.
{"title":"Healing of a crush injury in rat striated muscle. 3. A micro-angiographical study of the effect of early mobilization and immobilization on capillary ingrowth.","authors":"M. Järvinen","doi":"10.1111/J.1699-0463.1976.TB00114.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00114.X","url":null,"abstract":"Vascular ingrowth into the injured area of a partially crushed gastrocnemius muscle was studied by micro-angiography 2 to 14 days after the trauma in 40 rats treated by mobilization or immobilization. In mobilized muscles, the sprouting of new capillaries occurred more rapidly and intensively than in injured muscles treated by immobilization. The sequence of events was found to be slightly delayed if mobilization was started after immobilization for two days. The speed and intensity of tissue repair, as studied histologically, was directly correlated with vascular ingrowth, especially during the first week.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"28 1","pages":"85-94"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80964223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1977.TB03894.X
A. Nyfors, D. Hopwood
To show what damage occurs in the hepatocytes of psoriatics receiving Methotrexate (MTX) therapy liver biopsies from 24 psoriatics with severe psoriasis before and after MTX therapy were studied blind by light and electron microscopy. We also aimed to determine the severity of lesions and find possible correlations, and to seek a relationship of these observations with light microscopical and clinical findings. The present study has shown that MTX probably caused damage to the hepatocytes reflected in the membrane whorls (p less than 0.05) and the accumulation of lipid droplets (p less than 0.05). There was an increase (p less than 0.05) in autophagic vacuoles, which mostly contained glycogen and cell sap with residual bodies. These residual bodies were then found in an increased number in the nearby Kupffer cells. Crystals were found in megamitochondria in most patients before and after MTX therapy. Some of these crystals were found free in the cytoplasm. Mitochondria containing crystals were shown in autophagic vacoules, representing possible pathways of their breakdown. Bile canaliculi commonly contained debris but only one patient had evidence of cholestasis. There was no significant change in nuclei, Golgi apparatus, or the endoplasmic reticulum and no statistically significant correlation between the shown changes and the total dose of MTX given.
{"title":"Liver ultrastructure in psoriatics related to methotrexate therapy. 1. A prospective study of findings in hepatocytes from 24 patients before and after methotrexate treatment.","authors":"A. Nyfors, D. Hopwood","doi":"10.1111/J.1699-0463.1977.TB03894.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB03894.X","url":null,"abstract":"To show what damage occurs in the hepatocytes of psoriatics receiving Methotrexate (MTX) therapy liver biopsies from 24 psoriatics with severe psoriasis before and after MTX therapy were studied blind by light and electron microscopy. We also aimed to determine the severity of lesions and find possible correlations, and to seek a relationship of these observations with light microscopical and clinical findings. The present study has shown that MTX probably caused damage to the hepatocytes reflected in the membrane whorls (p less than 0.05) and the accumulation of lipid droplets (p less than 0.05). There was an increase (p less than 0.05) in autophagic vacuoles, which mostly contained glycogen and cell sap with residual bodies. These residual bodies were then found in an increased number in the nearby Kupffer cells. Crystals were found in megamitochondria in most patients before and after MTX therapy. Some of these crystals were found free in the cytoplasm. Mitochondria containing crystals were shown in autophagic vacoules, representing possible pathways of their breakdown. Bile canaliculi commonly contained debris but only one patient had evidence of cholestasis. There was no significant change in nuclei, Golgi apparatus, or the endoplasmic reticulum and no statistically significant correlation between the shown changes and the total dose of MTX given.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"203 1","pages":"787-800"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77409108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1981.TB00238.X
P. Thórhallsson, H. Tulinius
Malignant tumours of the kidney occurring in Iceland during the year 1955-1974 were studied pathologically and typed histologically according to a classification proposed, but not yet published, by the World Health Organisation. Histological material was available from 89.2% and 84.0% of registered male and female patients respectively. Among males, renal cell carcinomas constituted 91.8%, transitional pelvic carcinomas 5.5% and nephroblastomas 2.7% of classified tumours. The corresponding figures for females were renal cell carcinomas 96.7%, transitional pelvic carcinomas 0.8%, and nephroblastomas 2.5%. The most frequent cell type of renal cell carcinoma group in both sexes was the combination of clear and granular cells, and the most frequent architecture was the combination of solid and tubular patterns. Renal cell carcinomas composed of pure granular cells were found in 22% of males and in 14% of females, and granular cells in combinations with all other cell types were also more common in males. In Iceland renal cell carcinoma is the fifth commonest malignant tumour in males and the tenth in females. The excess of granular cell tumours among males corresponds roughly to, and may account for, the sex difference in the frequency of renal cell carcinomas.
{"title":"Tumours in Iceland. 3. Malignant tumours of kidney. A histological classification.","authors":"P. Thórhallsson, H. Tulinius","doi":"10.1111/J.1699-0463.1981.TB00238.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00238.X","url":null,"abstract":"Malignant tumours of the kidney occurring in Iceland during the year 1955-1974 were studied pathologically and typed histologically according to a classification proposed, but not yet published, by the World Health Organisation. Histological material was available from 89.2% and 84.0% of registered male and female patients respectively. Among males, renal cell carcinomas constituted 91.8%, transitional pelvic carcinomas 5.5% and nephroblastomas 2.7% of classified tumours. The corresponding figures for females were renal cell carcinomas 96.7%, transitional pelvic carcinomas 0.8%, and nephroblastomas 2.5%. The most frequent cell type of renal cell carcinoma group in both sexes was the combination of clear and granular cells, and the most frequent architecture was the combination of solid and tubular patterns. Renal cell carcinomas composed of pure granular cells were found in 22% of males and in 14% of females, and granular cells in combinations with all other cell types were also more common in males. In Iceland renal cell carcinoma is the fifth commonest malignant tumour in males and the tenth in females. The excess of granular cell tumours among males corresponds roughly to, and may account for, the sex difference in the frequency of renal cell carcinomas.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"58 1","pages":"403-10"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80988783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1981.TB00197.X
M. Anniko
The in vitro system was used to study early ultrastructural effects following gamma irradiation of human pituitary adenomas and neurinomas with 30 and 70 Gy single doses, respectively. The acoustic neurinoma cells showed a large number of intracellular myelin figures and vesiculation of cytoplasm. The pituitary tumour cells showed vacuolization of cytoplasm and cell organelles. Occasionally, electron-dense cytoplasmic inclusion bodies with a fibrillar substructure occurred. The differences between the two types of tumours in irradiation-induced morphological changes may indicate differences in their biochemical structure and metabolic activities. The morphological findings after irradiation of specimens from all four neurinomas were rather similar after the same length of time but the structural alterations of pituitary cells differed considerably between individual tumours. The 70 Gy dose caused more rapidly-occurring morphological alterations than the 30 Gy single dose.
{"title":"Early morphological changes following gamma irradiation. A comparison of human pituitary tumours and human acoustic neurinomas (schwannomas).","authors":"M. Anniko","doi":"10.1111/J.1699-0463.1981.TB00197.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00197.X","url":null,"abstract":"The in vitro system was used to study early ultrastructural effects following gamma irradiation of human pituitary adenomas and neurinomas with 30 and 70 Gy single doses, respectively. The acoustic neurinoma cells showed a large number of intracellular myelin figures and vesiculation of cytoplasm. The pituitary tumour cells showed vacuolization of cytoplasm and cell organelles. Occasionally, electron-dense cytoplasmic inclusion bodies with a fibrillar substructure occurred. The differences between the two types of tumours in irradiation-induced morphological changes may indicate differences in their biochemical structure and metabolic activities. The morphological findings after irradiation of specimens from all four neurinomas were rather similar after the same length of time but the structural alterations of pituitary cells differed considerably between individual tumours. The 70 Gy dose caused more rapidly-occurring morphological alterations than the 30 Gy single dose.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"24 1","pages":"113-24"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81727282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00085.X
L. Kortelainen, L. Korhonen
Kurloff cells (KB cells) containing a glycoprotein inclusion body appear in femal guinea pigs and can be induced in males by oestrogen administration. These cells are found in bone marrow, thymus, and in the red pulp of the spleen, but not in the lymph nodes. Gradually growing inclusion bodies were observed in a series of cells in these organs. Morphological and histochemical features suggested an active synthesis of the inclusion body material: cisternae of the endoplasmic reticulum fused with the membrane surrounding the inclusion body and by way of electron histochemical methods periodate reactive material was demonstrated in the endoplasmic reticulum, in the Golgi cisternae, and in the inclusion body. Enzymatic activities were not observed in the inclusion body, but otherwise the KB cells showed enzymatic activities of oxidative and glycolytic pathways. Marker enzymes for the granulocytes series, the plasma cells, the mast cells, and the monocyte-reticulum cell group were negative in the KB cells and thus, classification of the KB cells into a particular cell type was not possible, although these cells obviously belong to the lymphoreticuar system. Phagocytosis was not observed, either. The possible role of the KB cells in the immune system are discussed.
{"title":"Kurloff cells. 2. Histochemical and morphological characteristics of the Kurloff cells.","authors":"L. Kortelainen, L. Korhonen","doi":"10.1111/J.1699-0463.1976.TB00085.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00085.X","url":null,"abstract":"Kurloff cells (KB cells) containing a glycoprotein inclusion body appear in femal guinea pigs and can be induced in males by oestrogen administration. These cells are found in bone marrow, thymus, and in the red pulp of the spleen, but not in the lymph nodes. Gradually growing inclusion bodies were observed in a series of cells in these organs. Morphological and histochemical features suggested an active synthesis of the inclusion body material: cisternae of the endoplasmic reticulum fused with the membrane surrounding the inclusion body and by way of electron histochemical methods periodate reactive material was demonstrated in the endoplasmic reticulum, in the Golgi cisternae, and in the inclusion body. Enzymatic activities were not observed in the inclusion body, but otherwise the KB cells showed enzymatic activities of oxidative and glycolytic pathways. Marker enzymes for the granulocytes series, the plasma cells, the mast cells, and the monocyte-reticulum cell group were negative in the KB cells and thus, classification of the KB cells into a particular cell type was not possible, although these cells obviously belong to the lymphoreticuar system. Phagocytosis was not observed, either. The possible role of the KB cells in the immune system are discussed.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"53 1","pages":"154-64"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74478940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1981.TB00206.X
L. Kindblom, T. Seidal
A clinico-pathologic study of a 69-year-old woman with a malignant giant cell tumor of the uterus compatible with malignant giant tumor of soft tissues is presented. The diagnosis was based mainly on light- and electron-microscopic findings, including the demonstration of phagocytic activity of the neoplastic cells. The tumor metastasized to the lung and the patient died a short time after clinical onset. The classification of uterine sarcomas and the differential diagnosis are briefly discussed.
{"title":"Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case.","authors":"L. Kindblom, T. Seidal","doi":"10.1111/J.1699-0463.1981.TB00206.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00206.X","url":null,"abstract":"A clinico-pathologic study of a 69-year-old woman with a malignant giant cell tumor of the uterus compatible with malignant giant tumor of soft tissues is presented. The diagnosis was based mainly on light- and electron-microscopic findings, including the demonstration of phagocytic activity of the neoplastic cells. The tumor metastasized to the lung and the patient died a short time after clinical onset. The classification of uterine sarcomas and the differential diagnosis are briefly discussed.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"115 1","pages":"179-84"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89053962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1970.TB02524.X
F. Olsen
In the days following the termination of a five hours experimental angiotensin-hypertension in rats the total number of mononuclear cells of the peripheral blood which reacted positively for acid phosphatase was increased by 20–40 per cent, while the number of those containing more than five acid phosphatase granules increased by 65–155 per cent. This changed content of lysosomes supports the view that mononuclear cells from the blood are cells of importance in the catabolism of products from hypertensively damaged arterioles. In sections of damaged arterioles the mononuclear cells increased their number of acid phosphatase granules during their passage from the luminal side through the media to the adventitia, indicating that their function was phagocytic and catabolic. The regional lymph nodes showed morphological changes: An increment of large pyroninophilic cells in the paracortical areas and in the medulla 2–4 days after the termination of the hypertensive period, and an obliteration of the medulla with pyronine-negative cells with a morphology like lymphocytes 5–6 days after. These findings are much like those to be found in the lymph nodes during a development of delayed hypersensitivity in experimental animals.
{"title":"Lysosomes and pyroninophilia in mononuclear cells in hypertensive arterioles. Studies on the blood, arterioles and regional lymph nodes in experimental angiotensin-hypertension in rats.","authors":"F. Olsen","doi":"10.1111/J.1699-0463.1970.TB02524.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1970.TB02524.X","url":null,"abstract":"In the days following the termination of a five hours experimental angiotensin-hypertension in rats the total number of mononuclear cells of the peripheral blood which reacted positively for acid phosphatase was increased by 20–40 per cent, while the number of those containing more than five acid phosphatase granules increased by 65–155 per cent. This changed content of lysosomes supports the view that mononuclear cells from the blood are cells of importance in the catabolism of products from hypertensively damaged arterioles. In sections of damaged arterioles the mononuclear cells increased their number of acid phosphatase granules during their passage from the luminal side through the media to the adventitia, indicating that their function was phagocytic and catabolic. The regional lymph nodes showed morphological changes: An increment of large pyroninophilic cells in the paracortical areas and in the medulla 2–4 days after the termination of the hypertensive period, and an obliteration of the medulla with pyronine-negative cells with a morphology like lymphocytes 5–6 days after. These findings are much like those to be found in the lymph nodes during a development of delayed hypersensitivity in experimental animals.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"124 1","pages":"443-50"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87830912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/j.1699-0463.1977.tb03885.x
D. Francis
On correlating our cytological classification of aspirated malignant tumour cells from intrathoracic lesions with the histological classification of the same lesions, agreement was found in 75 per cent. The cytological criteria used for the classification of the differentiated types of tumour cells were convenient. It is proposed to utilize the cytological classification in the planning of an individualized tumour therapy in cases not accessible to pretreatment bioptic histological classification.
{"title":"Transthoracic aspiration biopsy. Cytological classification of aspirated malignant tumour cells.","authors":"D. Francis","doi":"10.1111/j.1699-0463.1977.tb03885.x","DOIUrl":"https://doi.org/10.1111/j.1699-0463.1977.tb03885.x","url":null,"abstract":"On correlating our cytological classification of aspirated malignant tumour cells from intrathoracic lesions with the histological classification of the same lesions, agreement was found in 75 per cent. The cytological criteria used for the classification of the differentiated types of tumour cells were convenient. It is proposed to utilize the cytological classification in the planning of an individualized tumour therapy in cases not accessible to pretreatment bioptic histological classification.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"164 1","pages":"535-8"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86206774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-15DOI: 10.1111/J.1699-0463.1976.TB00091.X
P. Krogh, F. Elling, B. Hald, B. Jylling, V. Petersen, E. Skadhauge, C. Svendsen
One-day-old chickens were fed ochratoxin A-contaminated diets at 2 levels: 0.3 and 1 mg ochratoxin A per kg feed, for 341 days. The only observable lesion to develop was a kidney damage comparable with the naturally occurring avian nephropathy. The changes in renal function were characterized by impairment of glomerular and tubular function, indicated by a decreased inulin clearance, TmPAH and decreased urine concentrating capacity. The changes of renal structure included degeneration of the tubular epithelium accompanied by regeneration. At slaughter, the kidneys, liver and muscular tissue of the birds contained residues of ochratoxin A (up to 50 mug per kg). As all the birds would have passed the meat inspection because no macroscopical lesions were present, this represents a possible health problem.
{"title":"Experimental avian nephropathy. Changes of renal function and structure induced by ochratoxin A-contaminated feed.","authors":"P. Krogh, F. Elling, B. Hald, B. Jylling, V. Petersen, E. Skadhauge, C. Svendsen","doi":"10.1111/J.1699-0463.1976.TB00091.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00091.X","url":null,"abstract":"One-day-old chickens were fed ochratoxin A-contaminated diets at 2 levels: 0.3 and 1 mg ochratoxin A per kg feed, for 341 days. The only observable lesion to develop was a kidney damage comparable with the naturally occurring avian nephropathy. The changes in renal function were characterized by impairment of glomerular and tubular function, indicated by a decreased inulin clearance, TmPAH and decreased urine concentrating capacity. The changes of renal structure included degeneration of the tubular epithelium accompanied by regeneration. At slaughter, the kidneys, liver and muscular tissue of the birds contained residues of ochratoxin A (up to 50 mug per kg). As all the birds would have passed the meat inspection because no macroscopical lesions were present, this represents a possible health problem.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"50 1","pages":"215-21"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86346033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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